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| 1 | Mechanisms underlying the impaired contractility of diabetic cardiomyopathy显示文摘Cardiac dysfunction is a well-known consequence of diabetes,with sustained hyperglycaemia leading to the development of a cardiomyopathy that is independent of cardiovascular disease or hypertension.Animal models of diabetes are commonly used to study the pathophysiology of diabetic cardiomyopathy,with the hope that increased knowledge will lead ultimately to better therapeutic strategies being developed.At physiological temperature,left ventricular trabeculae isolated from the streptozotocin rat model of type 1 diabetes showed decreased stress and prolonged relaxation,but with no evidence that decreased contractility was a result of altered myocardial Ca2+handling.Although sarcoplasmic reticulum(SR)Ca2+reuptake appeared slower in diabetic trabeculae,it was offset by an increase in actionpotential duration,thereby maintaining SR Ca2+content and favouring increased contraction force.Frequency analysis of t-tubule distribution by confocal imaging of ventricular tissue labeled with wheat germ agglutinin or ryanodine receptor antibodies showed a reduced T-power for diabetic tissue,but the differences were minor in comparison to other models of heart failure.The contractile dysfunction appeared to be the result of disrupted F-actin in conjunction with the increased typeⅠcollagen,with decreased myofilament Ca2+sensitivity contributing to the slowed relaxation. | Marie-Louise Ward David J Crossman | 2014 | World Journal of Cardiology2014，6，7： | 13 |
| 2 | 对英国住宅区域几种新型雨水收集利用系统的初步可持续性评估(英文)显示文摘由于缺乏对住宅雨水收集利用(RWH)系统类型的创新,在英国日常生活中的雨水收集利用还不是很广泛.介绍了一系列传统和新型的住宅RWH系统的初步研究结果,并对这些RWH系统进行了研究,研究方法包括:专利申请搜索、对行业专家的非正式访问、成本效益分析和简单的多准则分析法(MCA).然后基于社会优先、经济优先和环境优先的标准,研究了这些系统的可持续性.其中,对2种新型的RWH系统进行了更为详细的分析,并与传统的RWH系统进行对比.多准则分析法结果表明,创新型系统在更少的资金消耗下,可持续性绩效要高于传统系统.进一步的研究重点在于模拟这些被鉴定的系统来产生经验性数据库,并应用于WLC/LACs,寻找设备安装中可能出现的挑战和问题. | Peter Melville-Shreeve Sarah Ward David Butler | 2014 | Journal of Southeast University(English Edition)2014，30，2： | 3 |
| 3 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 4 | Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.显示文摘 | Neil Woodford Matthew J. Ellington Juliana M. Coelho Jane F. Turton M. Elaina Ward Susan Brown Sebastian G.B. Amyes David M. Livermore | 2006 | International Journal of Antimicrobial Agents2006，，4： | 2 |
| 5 | FUSARIUM-ID v. 1.0: A DNA Sequence Database for Identifying Fusarium显示文摘 | David M. Geiser María del Mar Jiménez-Gasco Seogchan Kang Izabela Makalowska Narayanan Veeraraghavan Todd J. Ward Ning Zhang Gretchen A. Kuldau Kerry O’donnell | 2004 | European Journal of Plant Pathology (-)2004，，5： | 2 |
| 6 | Recent highlights in antimalarial drug resistance and chemotherapy research显示文摘 | David A. Fidock Richard T. Eastman Stephen A. Ward Steven R. Meshnick | 2008 | Trends in Parasitology2008，，12： | 2 |
| 7 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 8 | Multiple evolutionary origins of knockdown resistance ( kdr ) in pyrethroid-resistant Colorado potato beetle, Leptinotarsa decemlineata显示文摘 | Frank D. Rinkevich Cathy Su Tomás A. Lazo David J. Hawthorne Ward M. Tingey Samir Naimov Jeffrey G. Scott | 2012 | Pesticide Biochemistry and Physiology2012，，3： | 2 |
| 9 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 10 | Can fluorescence spectrometry be used as a surrogate for the Bio- chemical Oxygen Demand (BOD) test in water quality assess- ment? An example from South West England 显示文摘 | Naomi Hudson Andy Baker David Ward | 2008 | Science of The Total Environment2008，391，1： | 1 |
| 11 | Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome显示文摘 | Carole L. Marcus Lee J. Brooks Sally Davidson Ward Kari A. Draper David Gozal Ann C. Halbower Jacqueline Jones Christopher Lehmann Michael S. Schechter Stephen Sheldon Richard N. Shiffman Karen Spruyt | 2012 | PEDIATRICS2012，，3： | 1 |
| 12 | Determination of glass content and estimation of glass composition in fly ash using quantitative X-ray diffractometry显示文摘 | Colin R. Ward David French | 2006 | Fuel2006，，16： | 1 |
| 13 | Development of the Scottish Walkability Assessment Tool (SWAT)显示文摘 | Catherine Millington Catharine Ward Thompson David Rowe Peter Aspinall Claire Fitzsimons Norah Nelson Nanette Mutrie | | 0，，： | 1 |
| 14 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 15 | Prevention of Child Behavior Problems Through Universal Implementation of a Group Behavioral Family Intervention显示文摘 | Stephen R. Zubrick Kristine A. Ward Sven R. Silburn David Lawrence Anwen A. Williams Eve Blair Deborah Robertson Matthew R. Sanders | 2005 | Prevention Science2005，，4： | 1 |
| 16 | Identification of miRNA Changes in Alzheimer’s Disease Brain andCSF Yields Putative Biomarkers and Insights into Disease Pathways显示文摘 | John P. Cogswell James Ward Ian A. Taylor Michelle Waters Yunling Shi Brian Cannon Kevin Kelnar Jon Kemppainen David Brown Caifu Chen Rab K. Prinjha Jill C. Richardson Ann M. Saunders Allen D. Roses Cynthia A. Richards | 2008 | Journal of Alzheimer’s Disease2008，，1： | 1 |
| 17 | Prospective Memory and Pediatric Traumatic Brain Injury: Effects of Cognitive Demand显示文摘 | Ward Heather Shum David McKinlay Lyn | 2007 | Child Neuropsychology2007，13，3： | 1 |
| 18 | Therapeutic apheresis for renal disorders显示文摘 | Amber P.Sanchez David M Ward | | 0，，02： | 1 |
| 19 | Abscisic acid simultaneously decreases carboxylation efficiency and quantum yield in attached soybean leaves显示文摘 | James A Bunce | 1987 | J Exp Bot1987，38，192： | 1 |
| 20 | Polymerization of methyl methacrylate using zirconocene initiators: polymerization mechanisms and application 显示文摘 | Yufang L David G Ward | 1997 | Macromolecules1997，30，： | 1 |
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