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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | 抗氧化剂一、二级预防随机试验中的死亡率系统回顾及汇总分析显示文摘背景:抗氧化剂正用于多种疾病的预防。
目的:评估补充抗氧化剂对一、二级预防随机临床试验参试者死亡率的影响。数据来源及试验选择:检索2005年10月前的电子数据库以及发表的文献目录。所有于成人中进行的、比较单独或联合使用β胡萝卜素、维生素A、维生素C(抗坏血酸)、维生素E及硒剂的安慰剂或空白治疗对照随机试验均纳入分析。使用随机、盲法及随访作为评估入选试验偏倚的指标。采用随机效应分析法分析抗氧化剂对全因死亡率的影响,结果以相对危险度(relative risk,RR)及其95%可信区间(confidence interval,CI)表示。采用汇总回归评估试验协变量的影响。
数据提取:共入选68项随即试验,包括232606例参试者(385篇文章)。
数据整合:将所有低和高偏倚风险抗氧化剂试验汇总后发现,抗氧化剂对死亡率无显著影响(RR,1.02;95%CI,0.98~1.06)。多变量汇总回归分析表明,低偏倚风险试验(RR,1.16;95%CI,1.05~1.29)和硒剂(RR,0.998;95%CI,0.997~0.9995)与死亡率显著相关。在包括180938例参试者在内的47项低偏倚试验中,补充抗氧化剂显著增加死亡率(RR,1.05;95%CI,1.02~1.08)。排除硒剂试验后,在低偏倚风险试验中,β胡萝卜素(RR,1.07;95%CI,1.02~1,11)、维生素A(RR,1.16;95%CI,1.10~1.24)以及维生素E(RR,1.04;95%CI,1.01~1.07)单独或联合使用均显著增加死亡率。维生素C及硒剂对死亡率无显著影响。
结论:β胡萝卜素、维生素A及维生素E治疗可能增加死亡率。维生素C和硒剂对死亡率的影响需要进一步研究。 | Goran Bjelakovic Dimitrinka Nikolova Lise Lotte Gluud Rose G. Simonetti Christian Gluud 顾佳(译) | 2007 | 美国医学会杂志(中文版)2007，26，5： | 35 |
| 3 | 中国和澳大利亚宫颈癌患者人乳头状瘤病毒感染及其他危险因素的对比研究显示文摘目的 探讨中国和澳大利亚宫颈癌患者人乳头状瘤病毒 (HPV)感染及其型别分布 ,并比较两组患者其他危险因素和临床病理特征的差异。方法 采用聚合酶链反应方法分别检测 115例中国宫颈癌患者和 79例澳大利亚宫颈癌患者癌组织中HPVDNA ,用测序法和反向核酸杂交法对HPV进行分型。并分析HPV感染与临床病理特征的关系。结果 中国组HPV阳性率为 76 .8% ,澳大利亚组为 89.9% (P =0 .0 17)。两组间HPVl6和 18型阳性率差别无显著意义 (P =0 .80 6 ) ,HPV5 8和 5 9型在中国组比澳大利亚组多见。HPV阳性率与临床分期、肿瘤组织学类型和分级 ,以及淋巴结转移等无关 ,但HPV型别与组织学类型及分级相关。澳大利亚组中晚期及非鳞癌患者较中国组多。两组患者在宫颈涂片普查次数及一些危险因素方面差异有显著意义。结论 澳大利亚组子宫颈癌患者HPV感染率比中国组明显为高 ;在中国组中HPV5 8和 5 9型是并列第 3常见的感染类型 ;HPV18和 5 9型与恶性度高的宫颈癌相关。 | 刘继红 黄欣 廖革望 李俊东 李艳芳 李孟达 Barbara Rose Carol Thompson | 2003 | 中华医学杂志2003，83，9： | 27 |
| 4 | Interacting with Text:The Role of Dialogue in Learning to Read and Write显示文摘English language teachers in China are expressing growing interest in the model of language provided by systemic functional linguistics and genre theory. This paper offers further insights into the methods developed in this framework,for teaching reading and writing in school and academic contexts. These methods involve carefully planned interactions between teachers and students,that enable all students in a class to successfully practise skills in academic reading and writing. The paper outlines the models of language and language learning that underpin the methods,and illustrates the kinds of classroom interactions used for writing and reading. It concludes with a discussion of the implications of these methods for language teaching in China. | J. R. Martin David Rose | 2007 | 中国外语2007，4，5： | 23 |
| 5 | 基于似然率方法的语音证据评价显示文摘法庭话者识别技术引入我国已有二十多年,目前该技术已经广泛应用于各类刑事和民事案件中。纵观世界各国的法庭证据评价体系,除了DNA证据以外,其他证据检验鉴定结论的表述通常有三种:同一认定、否定排除和倾向性意见。简单肯定和否定的结论存在很大的弊端,即过高估计了证据的力度,因而有时可能会造成错案。鉴于此,国外一些学者提出在鉴定结论的表述和价值评判上引入基于贝叶斯理论的'似然率'方法。本文结合目前的法庭话者鉴别方法,重点介绍基于贝叶斯理论下的'似然率'理论体系,并阐明该方法的优越性、局限性以及一些亟待解决的问题。 | 张翠玲 Philip Rose | 2008 | 证据科学2008，16，3： | 18 |
| 6 | 反向的民主化:第三波民主的问题显示文摘第三波民主化浪潮中的国家,多在建立法治、公民社会、领导人问责制等现代国家的基本制度之前建立了自由选举制度。相反,第一波民主化的国家则在普选引入之前已经先建立了现代的国家制度。第三波民主化中这种反方向的民主化造成了在大多数国家中形成的是不完全的民主制度。不完全的民主有三种发展前景:(1)继续向前,完成民主化;(2)民主选举制度失败,转向一种不民主的制度;(3)在统治精英低效但公众对民主政治要求也低的情况下,更会堕入一种低水平平衡的陷阱。本文通过分析三个新民主国家的大众观念调查数据,展示这样一种不完全民主的各种问题。这三个国家的前身各不相同:过去属于专制体制的俄罗斯、过去曾有民主和专制的捷克、过去是专制军事政权的韩国。 | Richard Rose Doh Chull Shin 王正绪 方瑞丰 | 2007 | 开放时代2007，，3： | 16 |
| 7 | Adenoid cystic carcinoma of breast: Recent advances显示文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. | Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro | 2014 | World Journal of Clinical Cases2014，2，12： | 16 |
| 8 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 9 | 高温连续干燥与干燥-通风联合对稻谷品质的影响显示文摘利用不同的干燥方式对稻谷进行干燥,降至安全水分含量12%(湿基),测定干燥后稻谷的整精米率(head rice yield,HRY)、脂肪酸值以及RVA特征值。结果表明:对于连续干燥作业,缓苏过程中存在一个临界缓苏时间,达到临界缓苏时间能显著提高整精米率,且干燥温度越高,该临界缓苏时间的出现越明显;但干燥温度高于60℃,且一次降水幅度不小于9.4%,缓苏温度与干燥温度相同时,通过延长缓苏时间,整精米率难以达到70%;对于干燥-通风联合作业,干燥温度高于60℃,且缓苏温度不低于干燥温度时,虽能保持较高整精米率(>72%),但稻米的RVA特征值(峰值黏度、最低黏度、崩解值、最终黏度、回生值)总体上随着干燥温度、缓苏温度的升高和缓苏时间的延长而增加,且存在一些波动,干燥温度、缓苏时间对其影响显著性低于缓苏温度。两种干燥方式的脂肪酸值都存在不同于恒低温干燥持续增加的变化趋势。 | 杨国峰 周雯 Rose Prabin Kingsly Ambrose 夏宝林 仇红娟 刘强 张越 陈江 | 2014 | 食品科学2014，35，17： | 13 |
| 10 | Mechanical and wear behaviour of AZ91D magnesium matrix hybrid composite reinforced with boron carbide and graphite显示文摘In this experimental study,magnesium(AZ91D)based boron carbide(B4C)and graphite(Gr)particle reinforced hybrid composite materials were manufactured by stir casting.The tribological and mechanical properties of these composite materials were investigated.The results of the tests revealed that the graphite reinforced hybrid composites exhibited a lower wear loss compared to the unreinforced AZ91D alloy and AZ91D–B4C composites.It was found that with an increase in the B4C content,the wear resistance increased monotonically with hardness and ultimate tensile strength decreased.This study revealed that the addition of both a hard reinforcement(e.g.,B4C)and soft reinforcement(e.g.,graphite)significantly improves the wear resistance of magnesium composites.These entire results designate that the hybrid magnesium composites can be considered as an excellent material where high strength,ultimate tensile strength and wear-resistant components are of major importance,primarily in the aerospace and automotive engineering sectors. | I.Aatthisugan A.Razal Rose D.Selwyn Jebadurai | 2017 | Journal of Magnesium and Alloys2017，5，1： | 11 |
| 11 | Biliary tract schwannoma:A rare cause of obstructive jaundice in a young patient显示文摘Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastro-intestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumordid not recur in any of the resected cases. | Gilton Marques Fonseca André Luis Montagnini Manoel de Souza Rocha Rosely Antunes Patzina Mário Vinícius Angelete Alvarez Bernardes Ivan Cecconello José Jukemura | 2012 | World Journal of Gastroenterology2012，18，37： | 10 |
| 12 | Recent trends in the surgical management of inflammatory bowel disease显示文摘Surgery is required in the vast majority of patients with Crohn’s disease (CD) and in approximately one-third of patients with ulcerative colitis (UC). Similar to medical treatments for IBD, significant advances have occurred in surgery. Advances in CD include an emphasis upon conservatism as exemplified by more limited resections, strictureplasties, and laparoscopic resections. The use of probiotics in selected patients has improved the outcome in patients with pouchitis following restorative proctocolectomy for UC. It is anticipated that ongoing discoveries in the molecular basis of IBD will in turn identify those patients who will best respond to surgery. | Robert E Roses John L Rombeau | 2008 | World Journal of Gastroenterology2008，14，3： | 10 |
| 13 | 中国剖腹产决策中的知情选择与自主权显示文摘目的:探讨知情选择在中国3个地区中对于妇女的意义;探讨知情选择在剖腹产的决策过程中是怎样发挥其影响的。方法:研究使用普通话或上海、柳州、宜州的方言对这3个地区的5家医院及一些联络站的研究对象进行录音半结构式的个别访谈。样本包括3组人群:①行剖腹产后1周内的妇女;②行剖腹产后约8个月的妇女;③其他,包括临床医生、助产士和护士;不同阶层的公务员及一些妇女的亲属、朋友。访谈的内容全部录音,并使用原始笔记补充、分析研究和材料的收集同时进行,直至最后研究报告的完成。结果:知情选择是消息加工的产物,它通过'个体的'或'个人的'选择来决定它优先的、认知的或标准的尺度。在中国,对于'知情选择'和'自主权'的要求成为了促成妇女选择剖腹产的方法;'知情选择'的观念与妇女的选择权有所区别。结论:在中国,知情选择被视为与妇女选择剖腹产同义;我们的研究资料未支持文献中关于'妇女选择'剖腹产的解释;将来仍需要有价值的循证文献来完善妇女的'知情选择'。 | 陈焱 陆雯 张毅芬 Rose mary Mander | 2008 | 中国妇幼保健2008，23，1： | 9 |
| 14 | Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article显示文摘Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease. | Marco Aurélio Lumertz Saffi Mariana Vargas Furtado Carisi Anne Polanczyk Márlon Munhoz Montenegro Ingrid Webb Josephson Ribeiro Cassio Kampits Alex Nogueira Haas Cassiano Kuchenbecker Rosing Eneida Rejane Rabelo-Silva | 2015 | World Journal of Cardiology2015，7，1： | 9 |
| 15 | Potentially fatal haemobilia due to inappropriate use of an expanding biliary stent显示文摘AIM: To highlight the fatal complication caused by expanding biliary stents and the importance of avoiding use of expanding stent in potentially curable diseases.METHODS: Arteriobiliary fistula is an uncommon cause of haemobilia. We describe a case of right hepatic artery pseudoaneurysm causing arteriobiliary fistula and presenting as severe malena and cholangitis, in a patient with a mesh metal biliary stent. The patient had lymphoma causing bile duct obstruction.RESULTS: Gastroduodenoscopy failed to establish the exact source of bleeding and hepatic artery angiography and selective embolisation of the pseudo aneurysm successfully controlled the bleeding.CONCLUSION: Bleeding from the pseudo aneurysm of the hepatic artery can be fatal. Mesh metal stents in biliary tree can cause this complication as demonstrated in this case.So mesh metal stent insertion should be avoided in potentially benign or in curable conditions. Difficulty in diagnosis and management is discussed along with the review of the literature. | Rakesh Rai John Rose Derek Manas | 2003 | World Journal of Gastroenterology2003，9，10： | 9 |
| 16 | 真空干燥-常压缓苏后稻米品质指标的相关性研究显示文摘以不同干燥温度、相对真空度为因素对稻谷进行真空干燥-常压缓苏实验,研究其干燥后稻米爆腰增率、整精米率及蒸煮质构品质变化,分析其相关性,并通过扫描电镜观察不同干燥条件对稻谷籽粒显微形态的影响。结果表明:干燥温度和真空度对稻谷干燥后爆腰增率及整精米率影响极显著(p<0.01)。干燥温度、真空度且二者交互作用对米饭质构特性有极显著影响(p<0.01)。经过对稻谷干燥后各品质相关性分析,得出稻谷爆腰增率与其蒸煮硬度、胶黏性及胶着性呈极显著的正相关性(p<0.01),稻谷整精米率与硬度、胶黏性、胶着性呈极显著负相关性(p<0.01),且二者均与弹性、咀嚼性及内聚性没有相关性。干燥温度越高,相对真空度越大,干燥速率越大,淀粉粒与蛋白质的结合度越小,结构越稀松,干燥裂纹越粗大,数量越多。 | 刘兵 仇红娟 刘强 万忠民 杨国峰 陈江 Rose Prabin Kingsly Ambrose | 2016 | 食品工业科技2016，37，1： | 8 |
| 17 | Synovial sarcoma:a rare presentation of parapharyngeal mass显示文摘Synovial sarcoma is a rare soft tissue sarcoma of the head and neck region involving the parapharyngeal space.The diagnosis of synovial sarcoma can be very challenging to the pathologists.We present a rare case of parapharyngeal synovial sarcoma in a young female patient who had a two-month history of left cervical intumescent mass at level II.The fine needle aspiration cytology of the mass was proved inconclusive.Transcervical excision of the mass was performed and the first case of parapharyngeal sarcoma was identified in our center by fluorescence in situ hybridization(FISH) technique.Repeat imaging revealed residual tumor.The patient successfully underwent a second excision of the residual tumor and received adjuvant radiotherapy. | Mohd Mokhtar Shaariyah Ami Mazita Mansor Masaany Mohd Yunus Razif Mohamed Rose Isa Abdullah Asma1 | 2010 | Chinese Journal of Cancer2010，29，6： | 7 |
| 18 | A numerical optimization of high altitude testing facility for wind tunnel experiments显示文摘High altitude test facilities are required to test the high area ratio nozzles operating at the upper stages of rocket in the nozzle full flow conditions.It is typically achieved by creating the ambient pressure equal or less than the nozzle exit pressure.On average,air/GN2is used as active gas for ejector system that is stored in the high pressure cylinders.The wind tunnel facilities are used for conducting aerodynamic simulation experiments at/under various flow velocities and operating conditions.However,constructing both of these facilities require more laboratory space and expensive instruments.Because of this demerit,a novel scheme is implemented for conducting wind tunnel experiments by using the existing infrastructure available in the high altitude testing(HAT)facility.This article presents the details about the methods implemented for suitably modifying the sub-scale HAT facility to conduct wind tunnel experiments.Hence,the design of nozzle for required area ratio A/A*,realization of test section and the optimized configuration are focused in the present analysis.Specific insights into various rocket models including high thrust cryogenic engines and their holding mechanisms to conduct wind tunnel experiments in the HAT facility are analyzed.A detailed CFD analysis is done to propose this conversion without affecting the existing functional requirements of the HAT facility. | J.Bruce Ralphin Rose G.R.Jinu C.J.Brindha | 2015 | Chinese Journal of Aeronautics2015，28，3： | 7 |
| 19 | A review on photo-thermal catalytic conversion of carbon dioxide显示文摘The conversion of carbon dioxide into value-added products is of great industrial and environmental interest. However, as carbon dioxide is relatively stable, the input energy required for this conversion is a significant limiting factor in the system's performance. By utilising energy from the sun, through a range of key routes, this limitation can be overcome. In this review, we present a comprehensive and critical overview of the potential routes to harvest the sun's energy, primarily through solar-thermal technologies and plasmonic resonance effects. Focusing on the localised heating approach, this review shortlists and compares viable catalysts for the photo-thermal catalytic conversion of carbon dioxide.Further, the pathways and potential products of different carbon dioxide conversion routes are outlined with the reverse water gas shift,methanation, and methanol synthesis being of key interest. Finally, the challenges in implementing such systems and the outlook to the future are detailed. | Ee Teng Kho Tze Hao Tan Emma Lovell Roong Jien Wong Jason Scott Rose Amal | 2017 | Green Energy & Environment2017，2，3： | 7 |
| 20 | 轴向力对搅拌摩擦焊接AZ61A镁合金拉伸性能的影响(英文)显示文摘研究轴向力对搅拌摩擦焊接AZ61A镁合金拉伸性能的影响。在3~7kN范围内选择5个不同大小的轴向力制备接头。测试接头的拉伸性能,并研究其与搅拌区显微组织和硬度的相关性。结果表明,与其他轴向力下的接头相比,轴向力为5kN时制备的接头具有最好的拉伸性能。搅拌区生成的细晶组织和高硬度是获得高拉伸强度的主要原因。 | A.RAZAL ROSE K.MANISEKAR V.BALASUBRAMANIAN | 2011 | Transactions of Nonferrous Metals Society of China2011，21，5： | 7 |
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