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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | 继发于视网膜圆形裂孔的视网膜脱离的临床特点及手术方式 | Ung T. Comer M.B. Ang A.J.S. M.P. Snead 王大江 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，10： | 2 |
| 3 | Involvement of excitatory amino acid mechanisms in gamma-hydroxybutyrate model of generalized absence seizures in rats显示文摘 | Snead OC | 1992 | Neuropharmacology1992，31，10： | 1 |
| 4 | Stickler syndrome:correlation between vitreoretinal phenotypes and linkage to COL 2A1显示文摘 | Snead MP Payne SJ Barton DE Yates JR Al-Imara L Pope FM | 1994 | Eye1994，8，： | 1 |
| 5 | Nitric oxide differentially regulates induction of type II nitric oxide synthase in rat vascular smooth muscle cells versus macrophages显示文摘 | Hanfang Zhang Connie Snead Catravas JD | 2001 | Arterioscler Thromb Vasc Biol2001，21，4： | 1 |
| 6 | Masked confirmation of linkage between type 1 congenital vitreous anomaly and COL 2A1 in Stickler syndrome显示文摘 | Snead MP Yates JR Pope FM Temple IK Scott JD | 1996 | Graefe Arch Clin Exp Ophthalmol1996，234，： | 1 |
| 7 | Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthal- mologist显示文摘 | Snead MP McNinch AM Poulson AV | 2011 | Eye2011，25，： | 1 |
| 8 | Magnetoencephalography and magnetic source imaging in children 显示文摘 | Otsubo H Snead OC | 2001 | J Child Neurol2001，16，4： | 1 |
| 9 | Molecular mechanisms of iNOS induction by IL- 1 beta and IFN- gamma in rat aortic smooth muscle cells显示文摘 | Teng X Zhang H Snead C | 2002 | Am J Physiol2002，282，1： | 1 |
| 10 | Reproductive hormones and bone mineral density in women runners 显示文摘 | Snead D B Weltman A Wehman J Y | 1992 | J Appl Physiol1992，72，6： | 1 |
| 11 | Predictors of seizure outcomes in children with tuberous sclerosis com- plex and intractable epilepsy undergoing resective epilepsy surgery: an individual participant data meta-analysis 显示文摘 | Fallah A Guyatt GH Snead OR 3rd et d | 2013 | PLoS One2013，8，53： | 1 |
| 12 | GABA, gamma- hydroxybutyric acid, and neurological disease显示文摘 | Wong C Bottiglieri T Snead O | 2003 | Annals of Neurology2003，54，： | 1 |
| 13 | The murine amelogenin promoter: developmentally regulated expression in transgenic animals 显示文摘 | Snead ML Paine ML Chen LS | 1996 | Connect Tissue Res1996，35，14： | 1 |
| 14 | Clinical and moleculargenetics of Stickler syndrome显示文摘 | Snead MP Yates JRW | 1999 | J Med Genet1999，36，： | 1 |
| 15 | Gamma-hydroxybutyric acid 显示文摘 | Snead OC Gibson KM | 2005 | N Engl J Med2005，352，26： | 1 |
| 16 | gamma- hydroxybutyrate model ofgeneralized absence seizures: further characterization and comparison with other ab- sence models显示文摘 | Snead O | 1988 | Epliepsia1988，29，4： | 1 |
| 17 | Benign epilepsy with centrotempo-ral spikes显示文摘 | Shields WD Snead OC 3rd | 2009 | Epilepsia2009，50，8： | 1 |
| 18 | Msx2 expression and glucocorticoid-induced overexpression in embryonic mouse submandibular glands显示文摘 | Jaskoll T Luo W Snead ML | 1998 | J Craniofac Genet Dev Biol1998，18，： | 1 |
| 19 | Identification of CCAAT/Enhancer-binding protein as a transactivator of the mouse amelogenin gene 显示文摘 | Zhou YL Snead ML | 2000 | J Biol Chem2000，275，12： | 1 |
| 20 | Silicon carbide composites as fusion power reactor structural materials显示文摘 | Snead L L Nozawa T Ferraris M | 2011 | J Nuclear Mater2011，417，13： | 1 |
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