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| 1 | Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome显示文摘 | Carole L. Marcus Lee J. Brooks Sally Davidson Ward Kari A. Draper David Gozal Ann C. Halbower Jacqueline Jones Christopher Lehmann Michael S. Schechter Stephen Sheldon Richard N. Shiffman Karen Spruyt | 2012 | PEDIATRICS2012，，3： | 1 |
| 2 | The trial of infant response to diphenhydramine: the TIRED study - a randomized, controlled, patient-oriented trial 显示文摘 | Merenstein D Diener-West M Halbower AC | 2006 | Arch Pediatr Adolesc Med2006，160，7： | 1 |
| 3 | Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury显示文摘 | Halbower AC Degaonkar M Barker PB | 2006 | PLoS Med2006，3，8： | 1 |
| 4 | Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury显示文摘 | Halbower A Degaonkar M Barker P | 2006 | PLoS Med2006，3，8： | 1 |
| 5 | Chilhood obstructive sleep-disordered breathing: a clinical update and discussion of technological innovations and challenges 显示文摘 | Halbower AC Ishman SL McGinley BM | 2007 | Chest2007，132，6： | 1 |
| 6 | Sleep disorders in children显示文摘 | Halbower AC Marcus CL | 2003 | Curr Opin Pulm Med2003，9，6： | 1 |
| 7 | Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury显示文摘 | Halbower AC Degaonkar M Barker PB | 2006 | PLoS Med2006，3，8： | 1 |
| 8 | Sleep disorders in children 显示文摘 | HALBOWER AC MARCUS CL | 2003 | Curr Opin Pulmon Med2003，9，6： | 1 |
| 9 | Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury显示文摘 | Halbower AC Degaonkar M Barker PB | 2006 | PLoS Med2006，3，8： | 1 |
| 10 | Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease显示文摘 | Kinsella JP Parker TA Galan H Sheridan BC Halbower AC Abman SH | 1997 | Pediatr Res1997，41，41： | 1 |
| 11 | Relief of upper airway obstruction with mandibular distraction surgery:Long-term quantitative results in young children显示文摘 | Lin SY Halbower AC Tunkel DE | 2006 | Arch Otolaryngol Head Neck Surg2006，132，： | 1 |
| 12 | Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury 显示文摘 | Halbower AC Degaonkar M Barker PB | 2006 | PLoS Med2006，3，8： | 1 |
| 13 | Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury显示文摘 | Halbower AC Degaonkar M Barker PB | 2006 | PLoS Med2006，3，： | 1 |
| 14 | 婴儿对苯海拉明的敏感性试验:TIRED研究——一项随机对照及以患者为导向的试验显示文摘Objective:To determine if infants aged 6 to 15 months with frequent parent-reported nighttime awakenings require reduced parental aid during a week of diphenhydramine hydrochloride treatment and 2 and 4 weeks after its discontinuation. Design:Double-blind,randomized,controlled clinical trial. Setting:The study was conducted from May 1,2004,through May 1,2005; patients were recruited nationally. Participants:Forty four participants aged 6 to 15months. Interventions:Placebo or diphenhydraminewas administered in infants 30 minutes before anticipated bedtime. Main Outcome Measures:The primary outcome was dichotomous:a parental report of improvement in the number of night awakenings requiring parental assistance during the intervention week,which ended on day 14.Secondary outcomes were improved sleep during the 2 weeks before days 29 and 43,parental overall happiness with sleep,and improved sleep latency. Results:On June 6,2005,the data safety monitoring board voted unanimously to stop the trial early because of lack of effectiveness of diphenhydramine over placebo. Only 1 of 22 children receiving diphenhydramine showed improvement compared with 3 of 22 receiving placebo.To reach the a priori determined sample size and have a positive outcome (ie,rejecting the null hypothesis),the trial would have needed to enroll 16 more participants in each arm,with 15 of the 16 in the diphenhydramine group and 0 of 16 in the placebo group improving. Conclusion:During 1 week of therapy and at follow-up 2 and 4 weeks later,diphenhydramine was no more effective than placebo in reducing nighttime awakening or improving overall parental happiness with sleep for infants. | Merenstein D. Diener-West M. Halbower A.C. 陈莉萍 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，12： | 0 |
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