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| 1 | Extracorporeal shock wave lithotripsy for pancreatic and large common bile duct stones显示文摘Extraction of large pancreatic and common bile duct(CBD)calculi has always challenged the therapeutic endoscopist.Extracorporeal shockwave lithotripsy(ESWL)is an excellent tool for patients with large pancreatic and CBD calculi that are not amenable to routine endotherapy.Pancreatic calculi in the head and body are targeted by ESWL,with an aim to fragment them to<3 mm diameter so that they can be extracted by subsequent endoscopic retrograde cholangio-pancreatography(ERCP).In our experience,complete clearance of the pancreatic duct was achieved in 76% and partial clearance in 17%of 1006 patients.Short-term pain relief with reduction in the number of analgesics ingested was seen in 84%of these patients.For large CBD calculi,a nasobiliary tube is placed to help target the calculi,as well as bathe the calculi in salinea simple maneuver which helps to facilitate fragmenta-tion.The aim is to fragment calculi to<5 mm size and clear the same during ERCP.Complete clearance of the CBD was achieved in 84.4%of and partial clearance in 12.3%of 283 patients.More than 90%of the patients with pancreatic and biliary calculi needed three or fewer sessions of ESWL with 5000 shocks being de-livered at each session.The use of epidural anesthesia helped in reducing patient movement.This,together with the better focus achieved with newer third-gen-eration lithotripters,prevents collateral tissue damage and minimizes the complications.Complications in our experience with nearly 1300 patients were minimal,and no extension of hospital stay was required.Similar rates of clearance of pancreatic and biliary calculi with minimal adverse effects have been reported from the centers where ESWL is performed regularly.In view of its high efficiency,non-invasive nature and low complication rates,ESWL can be offered as the first-line therapy for selected patients with large pancreatic and CBD calculi. | Manu Tandan D Nageshwar Reddy | 2011 | World Journal of Gastroenterology2011，17，39： | 36 |
| 2 | 水牛化疗控制鄱阳湖地区血吸虫病传播的现场实验研究显示文摘目的探索水牛治疗是否在湖沼地区血吸虫病传播中的作用,为制定防治策略提供依据.方法将江西省鄱阳湖区2个血吸虫病重度流行村,分为实验(干预)组及对照组.实验组用吡喹酮治疗所有耕牛,以消灭可能血吸虫传染源;对照组,不治疗耕牛.两村居民按常规方法进行血吸虫病防治.结果连续5年观察结果表明,实验组居民感染率比对照组下降70%;3岁以下水牛感染率为2%~18%,3岁以上水牛感染率为0~2.9%.结论通过干预和对照组的研究表明,在血吸虫重度感染区,单纯对居民进行化疗是难以有效地控制血吸虫病的传播的,而通过化疗水牛在一定程度上能降低居民的再感染.本研究通过5年的观察,证实了对水牛进行治疗对控制血吸虫病的传播的效果可达70%,同时也证实了在感染的水牛中的大部分(89%)是小于3岁的水牛,这对我们今后制定有效的控制湖沼地区的血吸虫病对策提供了依据. | 郭家钢 宁安 胡广汉 陈红根 党辉 朱蓉 Gail Williams 李岳生 冯正 DonMc Manus | 2005 | 中国人兽共患病杂志2005，21，10： | 23 |
| 3 | 世界腹腔间隙学会腹内高压和腹腔间隙综合征2013版专家共识与诊疗指南显示文摘随着人们对腹内压(intra-abdominal pressure,IAP)的重视,大量研究开始关注腹内高压(intraabdominal hypertension,IAH)和腹腔间隙综合征(abdominal compartment syndrome,ACS).世界腹腔间隙学会(The abdominal compartment society,WSACS)先后在2006年提出了IAH和ACS的专家共识,2007年发表了诊疗指南,2009年明确了疾病相关研究的推荐方向.2013年WSACS发布了新的IAH和ACS专家共识与诊疗指南.该指南由多学科专家共同参与制定,大部分是外科专家和重症监护专家.专家们首先明确24个临床医师关心的IAH和ACS问题,随后进行了系统有序的文献整理. | Andrew W.Kirkpatrick Derek J.Roberts Jan De Waele Roman Jaeschke Manu L.N.G.Malbrain Bart De Keulenaer Juan Duchesne Martin Bjorc Ari Leppaniemi | 2015 | 中华外科杂志2015，53，3： | 15 |
| 4 | Epidural anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and biliary calculi显示文摘AIM: To evaluate the efficacy of thoracic epidural analgesia for extracorporeal shock wave lithotripsy (ESWL). METHODS: ESWL is an effective, non-invasive technique for the treatment of difficult pancreatic and large bile duct calculi. The procedure is often painful and requires large doses of analgesics. Many different anesthetic techniques have been used. Patients with either large bile duct calculi or pancreatic duct calculi which could not be extracted by routine endoscopic methods were selected. Thoracic epidural anesthesia (TEA) was routinely used in all the subjects unless contraindicated. Bupivacaine 0.25% with or without clonidine was used to block the segments D6 to D12. The dose was calculated depending on the age, height and weight of the patient. It was usually 1-2 mL per segment blocked.RESULTS: Ninety eight percent of the 1509 patients underwent ESWL under TEA. The subjects selected were within American Society of Anesthesiologists grade Ⅰ to Ⅲ. ESWL using EA permitted successful elimination of bile duct or pancreatic calculi with minimal morbidity. The procedure time was shorter in patients with TEA than in those who underwent ESWL under total intravenous anesthesia. CONCLUSION: Almost all patients undergoing ESWL with EA had effective blocks with a single catheter insertion and local anesthetic injection. | Santosh Darisetty Manu Tandan Duvvuru Nageshwar Reddy Rama Kotla Rajesh Gupta Mohan Ramchandani Sandeep Lakhtakia Guduru Venkat Rao Rupa Banerjee | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 13 |
| 5 | 3种方法检测粪便中溶组织内阿米巴的结果比较显示文摘目的比较生理盐水直接涂片法、醛醚沉淀法及ELISA 3种方法检测粪便中溶组织内阿米巴的优缺点。方法采集受检者粪便标本278份.分别采用3种方法进行阿米巴原虫感染检测,检测结果进行统计学处理,分析3种方法的阳性检出率、准确率、敏感性、特异性及费用。结果生理盐水直接涂片法、醛醚沉淀法和ELISA法的阳性率分别为9.71%、10.79%和12.23%,差异无统计学意义(P>0.05);阳性标本经PCR确证,3种方法的阳性符合率分别为48.71%、51.11%和77.36%,差异有统计学意义(P<0.05)。生理盐水直接涂片法费用低(1元/份),耗时少(0.1 h~0.2 h)。结论粪便溶组织内阿米巴检测推荐使用ELISA法,其次是醛醚沉淀法,如果用生理盐水涂片法,至少要重复检测3次。 | 刘慧 孙晓东 聂仁华 邓艳 沈旭 Sophia Manue 郭晓芳 李春富 杨亚明 李崇珍 张苍林 | 2008 | 中国病原生物学杂志2008，3，9： | 12 |
| 6 | Effects of live yeast on differential genetic and functional attributes of rumen microbiota in beef cattle显示文摘Several studies have evaluated the effects of live yeast supplementation on rumen microbial population;however,its effect on differential microbial genes and their functional potential has not been described. Thus, this study applied shotgun metagenomic sequencing to evaluate the effects of live yeast supplementation on genetic and functional potential of the rumen microbiota in beef cattle. Eight rumen-cannulated Holstein steers were randomly assigned to two treatments in a cross-over design with two 25-day experimental periods and a 10-day wash-out between the two periods. The steers were housed in individual pens and fed 50% concentrate-mix and 50% red clover/orchard hay ad libitum. Treatments were(1) control(CON;basal diet without additive) and(2) yeast(YEA;basal diet plus 15 g/d of live yeast product). Rumen fluid samples were collected at 3, 6, and 9 h after feeding on the last d of each period. Sequencing was done on an Illumina Hi Seq 2500 platform. Dietary yeast supplementation increased the relative abundance of carbohydrate-fermenting bacteria(such as Ruminococcus albus, R.champanellensis, R. bromii, and R. obeum) and lactate-utilizing bacteria(such as Megasphaera elsdenii, Desulfovibrio desulfuricans, and D. vulgaris). A total of 154 differentially abundant genes(DEGs) were obtained(false discovery rate < 0.01). Kyoto Encyclopedia of Genes and Genomes(KEGG) annotation analysis of the DEGs revealed that 10 pathways, including amino sugar and nucleotide sugar metabolism, oxidative phosphorylation, lipopolysaccharide biosynthesis, pantothenate and coenzyme A biosynthesis, glutathione metabolism, beta-alanine metabolism,polyketide sugar unit biosynthesis, protein export, ribosome, and bacterial secretory system, were enriched in steers fed YEA. Annotation analysis of the DEGs in the carbohydrate-active enzymes(CAZy) database revealed that the abundance of genes coding for enzymes belonging to glycoside hydrolases, glycosyltransferases, and carbohydrate binding modules were enriched in steers fed YEA. These results confirm the effectiveness of a live S. cerevisiae product for improving rumen function in beef steers by increasing the abundance of cellulolytic bacteria, lactic acid-utilizing bacteria, and carbohydrate-active enzymes in the rumen. | Ibukun M.Ogunade Jerusha Lay Kenneth Andries Christina J.Mc Manus Frederick Bebe | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 11 |
| 7 | Efficacy of low dose peginterferon alpha-2b with ribavirin on chronic hepatitis C显示文摘AIM: To assess the effi cacy of peginterferon alpha 2b at doses of 50 μg weekly and 80 μg weekly (based on body weight) plus ribavirin in HCV genotype 2 and genotype 3 chronic hepatitis C patients. METHODS: During the study period of Jan 2002 to Dec 2003, all patients diagnosed as chronic hepatitis C or HCV related compensated cirrhosis were treated with peginterferon alpha 2b 50 μg S/C weekly (body weight < 60 kg) or 80 μg S/C weekly (body weight > 60 kg) plus ribavirin 800 mg/d for 24 wk. RESULTS: Overall 28 patients, 14 patients in each group (based on body weight) were treated during the period. Out of 28 patients, 75% were genotype 3, 18% were genotype 2 and 7% were genotype 1. The mean dose of peginterferon alpha 2b was 0.91 μg/kg in group 1 and 1.23 μg/kg in group 2 respectively. The end of treatment and sustained virologic response rates were 82% and 78% respectively. Serious adverse effects were seen in 3.5% patients. CONCLUSION: Low dose peginterferon alpha 2b in combination with ribavirin for 24 wk is effective in HCV genotype 2 and 3 chronic hepatitis C patients. | Rajesh Gupta CH Ramakrishna Sandeep Lakhtakia Manu Tandan Rupa Banerjee D Nageshwar Reddy | 2006 | World Journal of Gastroenterology2006，12，34： | 10 |
| 8 | Per oral cholangiopancreatoscopy in pancreatico biliary diseases- Expert consensus statements显示文摘AIM: To provide consensus statements on the use of per-oral cholangiopancreatoscopy(POCPS).METHODS: A workgroup of experts in endoscopic retrograde cholangiopancreatography(ERCP), endosonography, and POCPS generated consensus statements summarizing the utility of POCPS in pancreaticobiliary disease. Recommendation grades used validated evidence ratings of publications from an extensive literature review.RESULTS: Six consensus statements were generated:(1) POCPS is now an important additional tool during ERCP;(2) in patients with indeterminate biliary strictures, POCS and POCS-guided targeted biopsy are useful for establishing a definitive diagnosis;(3) POCS and POCS-guided lithotripsy are recommended for treatment of difficult common bile duct stones when standard techniques fail;(4) in patients with main duct intraductal papillary mucinous neoplasms(IPMN) POPS may be used to assess extent of tumor to assist surgicalresection;(5) in difficult pancreatic ductal stones,POPS-guided lithotripsy may be useful in fragmentation and extraction of stones; and(6) additional indications for POCPS include selective guidewire placement,unexplained hemobilia, assessing intraductal biliary ablation therapy, and extracting migrated stents. CONCLUSION: POCPS is important in association with ERCP, particularly for diagnosis of indeterminate biliary strictures and for intra-ductal lithotripsy when other techniques failed, and may be useful for preoperative assessment of extent of main duct IPMN, for extraction of difficult pancreatic stones, and for unusua indications involving selective guidewire placement,assessing unexplained hemobilia or intraductal biliary ablation therapy, and extracting migrated stents. | Mohan Ramchandani Duvvur Nageshwar Reddy Sundeep Lakhtakia Manu Tandan Amit Maydeo Thoguluva Seshadri Chandrashekhar Ajay Kumar Randhir Sud Rungsun Rerknimitr Dadang Makmun Christopher Khor | 2015 | World Journal of Gastroenterology2015，21，15： | 8 |
| 9 | Oral allopurinol to prevent hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography显示文摘AIM:To assess the efficacy of allopurinol to prevent hyperamylasemia and pancreatitis after endoscopic retrograde cholangiopancreatography(PEP).METHODS:One hundred and seventy patients were enrolled and randomized to two groups:a study group(n=85)who received 300 mg of oral allopurinol at 15 h and 3 h before endoscopic retrograde cholangiopancreatography(ERCP)and a control group(n=85)receiving an oral placebo at the same times.Main Outcome Measurements included serum amylase levels and the number severity of the episodes of pancreatitis.Serum amylase levels were classified as normal(<150 IU/L)or hyperamylasemia(>151 IU/L).Episodes of PEP were classified following Ranson's criteria and CT severity index.RESULTS:Gender distribution was similar between groups.Mean age was 53.5±18.9 years for study group and 52.8±19.8 years for controls.Also,the distribution of benign pathology was similar between groups.Hyperamylasemia was more common in the control group(P=0.003).Mild PEP developed in two patients from the study group(2.3%)and eight(9.4%) from control group(P=0.04),seven episodes were observed in high-risk patients of the control group(25%) and one in the allopurinol group(3.3%,P=0.02).Risk factors for PEP were precut sphincterotomy(P=0.02),pancreatic duct manipulation(P=0.002)and multiple procedures(P=0.000).There were no deaths or side effects.CONCLUSION:Oral allopurinol before ERCP decreased the incidences of hyperamylasemia and pancreatitis in patients submitted to high-risk procedures. | Hector Martinez-Torres Xochilt Rodriguez-Lomeli Carlo Davalos-Cobian Jesus Garcia-Correa Juan Manue Maldonado-Martinez Fabiola Medrano-Muoz Clotilde Fuentes-Orozco Alejandr Gonzalez-Ojeda | 2009 | World Journal of Gastroenterology2009，15，13： | 7 |
| 10 | 重组日本血吸虫副肌球蛋白诱导水牛保护性免疫的研究显示文摘为观察重组日本血吸虫副肌球蛋白 (r Sj97)对水牛的保护效果。 2 0头水牛随机分为佐剂 (Quil A)对照组和抗原 (r Sj97)免疫组。对照组仅注射 Quil A,而免疫组注射 Quil A加 r Sj97,在第 0、2、15周肌肉注射。第 3次免疫后两周经腹部贴片攻击感染 10 0 0条日本血吸虫尾蚴 ,感染后第 49d剖杀冲虫 ,计数虫数和肝卵数。结果显示 ,与对照组相比 ,r Sj97免疫组的减虫率为 49.9% (P<0 .0 5 ) ,肝脏减卵率 5 7.3% (P<0 .0 1)。提示 r Sj97可诱导水牛产生一定程度的抗血吸虫攻击感染的保护性免疫力 ,并具有一定程度的抗病作用 ,进一步证实了副肌球蛋白可作为抗血吸虫病的候选疫苗分子。 | 周金春 易新元 曾宪芳 张顺科 曾庆仁 蔡春 Joanna Wong Don Mc Manus | 2000 | 中国寄生虫病防治杂志2000，13，4： | 6 |
| 11 | Parametric study of turbine NGV blade lean and vortex design显示文摘The effects of blade lean and vortex design on the aerodynamics of a turbine entry nozzle guide vane(NGV) are considered using computational fluid dynamics. The aim of the work is to address some of the uncertainties which have arisen from previous studies where conflicting results have been reported for the effect on the NGV. The configuration was initially based on the energy efficient engine turbine which also served as the validation case for the computational method. A total of 17 NGV configurations were evaluated to study the effects of lean and vortex design on row efficiency and secondary kinetic energy. The distribution of mass flow ratio is introduced as an additional factor in the assessment of blade lean effects. The results show that in the turbine entry NGV, the secondary flow strength is not a dominant factor that determines NGV losses and therefore the changes of loading distribution due to blade lean and the associated loss mechanisms should be regarded as a key factor. Radial mass flow redistribution under different NGV lean and twist is demonstrated as an addition key factor influencing row efficiency. | Zhang Shaowen David G.Mac Manus Luo Jianqiao | 2016 | Chinese Journal of Aeronautics2016，29，1： | 5 |
| 12 | 溶组织内阿米巴ELISA试剂盒在阿米巴病调查的应用显示文摘目的了解景洪市爱尼族人群阿米巴病流行情况,为阿米巴病监测和防治提供依据,并评价ELISA试剂盒在阿米巴病调查应用的效果。方法以整群随机抽样爱尼族村寨,逐户收集新鲜粪便标本,用观察法、碘液涂片镜检法和TECHLAB第二代溶组织内阿米巴ELISA试剂盒对照检测粪便标本溶内阿米巴。结果镜检278例,E·h/E·d感染为9·71%;ELISA检测366例,E·h感染率为9·29%;镜检和ELISA共同阳性15例,占镜检阳性的55·56%;粪便观察和ELISA检测结果诊断5例为肠阿米巴病,发病率为1·37%,E·h致病率为14·71%。结论景洪爱尼族阿米巴病流行严重,应加强阿米巴病的监测和防治工作,同时积极推广新技术。 | 孙晓东 Sophia Manue 张晓阳 刘惠 邓艳 杨亚明 汪丽波 李春富 郭晓芳 张苍林 | 2006 | 中国热带医学2006，6，11： | 5 |
| 13 | 直流电压下玻璃纤维的荷电运动过程及桥接放电现象显示文摘气体绝缘全封闭组合电器/气体绝缘金属封闭输电线路(gas insulated switchgear/gas insulated metal-enclosed transmission line,GIS/GIL)在制造、运输、装配过程中容易引入绝缘纤维,是造成设备放电故障的原因之一。该文通过搭建封闭式平行电极板实验平台,获得玻璃纤维的启举与运动特性;进一步通过理论计算建立纤维的荷电与受力模型,研究直流电压下玻璃纤维的运动与放电特性。结果表明,玻璃纤维的临界启举电压与纤维直径的1/2次方近似呈正比关系,与纤维长度基本无关。玻璃纤维荷电启举后,在电极间往复运动中会分散成若干纤维簇,而带有不同极性电荷的纤维簇首尾相接,贯通电极,引发“桥接”现象。玻璃纤维的跳动会严重畸变纤维尖端电场,降低气隙的击穿电压,较无纤维时下降约7%~20%。当玻璃纤维出现桥接现象时,放电会沿着纤维小桥表面发生,气隙击穿电压下降约34%。所得结果阐释了直流应力下玻璃纤维的运动行为及放电规律,可为GIS/GIL设备的异物防护提供基础依据。 | 胡琦 李庆民 刘智鹏 刘衡 梁瑞雪 MANU Haddad | 2022 | 中国电机工程学报2022，42，6： | 4 |
| 14 | 功能梯度铜基复合材料的制备及干摩擦磨损性能(英文)显示文摘采用水平离心铸造工艺,制备功能梯度铜基复合材料,并对其非润滑滑动性能进行了研究.采用基于Taguchi的L27正交实验对石墨颗粒含量较高的空心圆柱铸件内壁厚度的磨损速率和摩擦系数进行分析.直接或间接影响磨损速率的工艺参数包括:施加的载荷(15,25和35 N)、滑动速度(1.5,2.5和3.5 m/s)和滑动距离(750,1500和2250 m).磨损速率和摩擦系数与施加的载荷和滑动距离呈比例的依赖性,而在中间滑动速度期间表现出下降.信噪比在'较小-较好'的基础上预测最小三波条件.方差分析量化参数的影响及其相互作用.采用回归分析对实验数据进行验证.在磨损表面分析过程中,通过显微镜和扫描电子显微镜发现磨损机制和机械混合层的形成. | N.RADHIKA Manu SAM | 2019 | Journal of Central South University2019，26，11： | 4 |
| 15 | Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems显示文摘 | Annika Reintam Blaser Manu L. N. G. Malbrain Joel Starkopf Sonja Fruhwald Stephan M. Jakob Jan Waele Jan-Peter Braun Martijn Poeze Claudia Spies | 2012 | Intensive Care Medicine2012，，3： | 4 |
| 16 | Disruption of Arabidopsis CHY1 Reveals an Important Role of Metabolic Status in Plant Cold Stress Signaling显示文摘到学习寒冷发信号,我们与 CBF3 倡导者(CBF3-LUC ) 驾驶的萤火虫酶记者基因的改变的导致寒冷的抄写为 Arabidopsis 屏蔽了异种。一异种, chy1-10,显示减少 CBF3-LUC 冷正式就职光。RNA 胶化污点分析表明内长的 CBF 的那表情也在 chy1 异种被减少。chy1-10 异种植物对冻结处理比更敏感在冷环境适应以后野类型。两野类型并且 chy1 异种植物对在温暖的温度的导致黑暗的饥饿敏感,尽管 chy1 植物是稍微更敏感的。这黑暗敏感被冷温度压制在野类型然而并非在 chy1。组成的 CBF3 表示部分在寒冷救 chy1-10 植物的敏感到黑暗处理。chy1 异种积累 CBF3-LUC 冷正式就职的氢过氧化物罐头还原剂的反应的氧种类,和申请的高水平在野类型。在异种的基因有缺陷者的基于地图的克隆在 CHY1 揭示了一个胡说八道变化,它编码 CoA hydrolase 为缬氨酸分解代谢和丰满的酸氧化需要的 peroxisomal -hydroxyisobutyryl (HIBYL ) 。我们的结果在冷应力发信号为 peroxisomal 新陈代谢建议一个角色,并且种忍耐到冷应力和导致黑暗的饥饿。 | Chun-Hai Dong Bethany K. Zolman Bonnie Bartel Byeong-ha Lee Becky Stevenson Manu Agarwal Jian-Kang Zhu | 2009 | Molecular Plant2009，2，1： | 4 |
| 17 | Self-lubricating bidirectional carbon fiber reinforced smart aluminum composites by squeeze infiltration process显示文摘Self-lubrication is one of the smart material properties required for producing components with enhanced wear resistance and low coefficient of friction.Bidirectional(BD)satin weave polyacrylonitrile(PAN)based carbon fiber(Cf)fabric preform was successfully infiltrated with Al 6061 alloy by squeeze infiltration process.The infiltrated composite shows uniform distribution of carbon fibers in the matrix with the elimination of porosities,fiber damage and close control on the formation of deleterious aluminum carbide(Al4C3)phase.Cf/Al composite exhibits remarkable wear resistance compared to unreinforced alloy due to the formation of self-lubricating tribolayer on the pin surface,which intercepts the contact of matrix metal to counter surface.The BD carbon fiber enhanced the hardness and compressive strength of the composite by restraining the plastic flow behavior of matrix.High resolution transmission electron microscopy shows the presence of Al2O3 and MgAl2O4 spinel,confirmed by EDS and SAD pattern,at the composite interface.The composite shows a lower density of 2.16 g/cm^3 which is a major ad vantage for weight reduction compared to the monolithic alloy(2.7 g/cm^3). | K.M.Sree Manu L.Ajay Raag T.P.D.Rajan B.C.Pai Vijay Petley Shweta Namdeo Verma | 2019 | Journal of Materials Science & Technology2019，35，11： | 4 |
| 18 | Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study显示文摘 | Annika Reintam Blaser Martijn Poeze Manu L. N. G. Malbrain Martin Bj?rck Heleen M. Oudemans-van Straaten Joel Starkopf | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 19 | Fatty Pancreas:Linking Pancreas Pathophysiology to Nonalcoholic Fatty Liver Disease显示文摘Currently,scientific interest has focused on fat accumulation outside of subcutaneous adipose tissue.As various imaging modalities are available to quantify fat accumulation in partic-ular organs,fatty pancreas has become an important area of research over the last decade.The pancreas has an essential role in regulating glucose metabolism and insulin secretion by responding to changes in nutrients under various metabolic circumstances.Mounting evidence has revealed that fatty pancreas is linked to impairedβ-cell function and affects in-sulin secretion with metabolic consequences of impaired glu-cose metabolism,type 2 diabetes,and metabolic syndrome.It has been shown that there is a connection between fatty pancreas and the presence and severity of nonalcoholic fatty liver disease(NAFLD),which has become the predominant cause of chronic liver disease worldwide.Therefore,it is nec-essary to better understand the pathogenic mechanisms of fat accumulation in the pancreas and its relationship with NAFLD.This review summarizes the epidemiology,diagnosis,risk factors,and metabolic consequences of fatty pancreas and discusses its pathophysiology links to NAFLD. | Manus Rugivarodom Tanawat Geeratragool Nonthalee Pausawasdi Phunchai Charatcharoenwitthaya | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 3 |
| 20 | Morphological Characterization and Hydrodynamic Behavior of Shortfin Mako Shark(Isurus oxyrinchus)Dorsal Fin Denticles显示文摘The shortfin mako shark(Isurus oxyrinchus)is one of the fastest marine fishes,reaching speeds of up to 70 km·h^-1.Their speed is related to the skin surface design composed of dermal denticles.Denticles vary in size and shape according to placement on the body and minimize turbulence around the body.The objective of this study is to analyze the interaction between seawater flow and denticles on the dorsal fin.High-resolution microscopy(scanning electron microscopy and confocal microscopy)were used to measure defined parts of the dermal denticles.These measurements,along with ratios based on length-to-width define three morphologies(rounded,semi-rounded,long)that were 3D reconstructed.Computational fluid dynamics simulated fluid passage over reconstructed denticles and describe hy-drodynamic efficiency under different conditions.An increase in angle of inclination produced a relevant increase in the drag coefficient,especially for high velocity inlets.The lowest drag coefficient values were found in long and semi-rounded,followed by rounded mor-phologies.The hydrodynamic behavior of shark skin demonstrates a relation to the morphological characteristics of dermal denticles on the dorsal fin.It is concluded that the best hydroefficiency relies on the rounded morphology and may serve to design hydrodynamically efficient surfaces or manmade assemblies. | Fernandez-Waid Patricia Diez Guzman Bidaguren Inigo Izagirre Urtzi Blanco Jesus Maria Soto Manu | 2019 | Journal of Bionic Engineering2019，16，4： | 3 |
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