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| 1 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018,26,6: | 11 |
| 2 | Measurement and significance of sperm morphology显示文摘测量或评估和人的精子形态学的临床的意义总是是潜在的并且仍然是为男性的富饶的决心的精液分析的一个争论方面。在这评论,为精子形态学的评估标准的发展的背景将被讨论。严格的标准定义和为精子形态学评估的标准的使用上的批评的方面将在正常精子形态学价值为衰落象可能的原因一样被讨论并且我们怎么能为导致是的低正常参考价值的这现象妥协,出版了在 2010 用手为考试并且人的精液处理。可能的答案之一可以是把更多的注意给一小部分反常精子形态学范畴和精子形态学模式的包括。它在这评论被结束如果正确地并且小心并且用构画出在的存在指南的严格的申请做 2010 用手,精子形态学测量仍然有一个很重要的角色在男富饶潜力的临床的评估玩。 | Roelof Menkveld Cas AG Holleboom Johann PT Rhemrev | 2011 | Asian Journal of Andrology2011,13,1: | 11 |
| 3 | 2型糖尿病基线BMI水平与冠心病风险呈正相关显示文摘一项随访7年的研究显示,2型糖尿病患者的基线BMI水平越高,7年后患冠心病(CHD)的风险越高,且女性2型糖尿病患者的BMI水平和CHD风险或呈U型相关性。该研究发表于《糖尿病护理》杂志(Diabetes Care,2014 Sep 23)。 | Li N Katzmarzyk PT Horswell R | 2014 | 中国全科医学2014,17,32: | 8 |
| 4 | 可视耳模拟器在颞骨解剖虚拟训练中的应用显示文摘众所周知,颞骨空间构造复杂,其内部精细结构与面神经、中后颅底以及颈内动静脉等有着十分密切的关系。为了安全有效地施行手术和不断提高手术技能,耳外科医生必须熟知正常颞骨内部的解剖结构及其相互关系,并且要在真实的解剖环境中进行手术操作模拟练习。人类颞骨标本无疑是解剖手术训练最好的模型,但由于各种原因,目前在全世界范围内可用于该目的的人类颞骨资源十分有限, | 黄孝文 余洋 周良强 Sorensen MS Mosegaard J Noe K Mikkelsen PT | 2013 | 听力学及言语疾病杂志2013,21,4: | 7 |
| 5 | Pancreatitis: Preventing catastrophic haemorrhage显示文摘Pancreatitis represents nearly 3% of acute admissions to general surgery in United Kingdom hospitals and has a mortality of around 1%-7% which increases to around 10%-18% in patients with severe pancreatitis. Patients at greatest risk were those identified to have infected pancreatic necrosis and/or organ failure. This review seeks to highlight the potential vascular complications associated with pancreatitis that despite being relatively uncommon are associated with mortality in the region of 34%-52%. We examine the current evidence base to determine the most appropriate method by which to image and treat pseudo-aneurysms that arise as the result of acute and chronic inflammation of pancreas. We identify how early recognition of the presence of a pseudo-aneurysm can facilitate expedited care in an expert centre of a complex pathology that may require angiographic, percutaneous, endoscopic or surgical intervention to prevent catastrophic haemorrhage. | Richard PT Evans Moustafa Mabrouk Mourad Gunraj Pall Simon G Fisher Simon R Bramhall | 2017 | World Journal of Gastroenterology2017,23,30: | 6 |
| 6 | 乳腺柱状细胞病变显示文摘 | Simpson PT Gale T Reis-Filho JS 魏兵(摘译) 步宏(审校) | 2005 | 临床与实验病理学杂志2005,21,5: | 6 |
| 7 | 终末期骨关节炎患者全膝关节置换术前的躯体功能客观测定显示文摘目的:采集终末期骨关节炎患者接受全膝关节置换术前的功能全面评价指标,并与轻度骨关节炎患者进行比较,评价疼痛、患者自我报告量表、基于表现的躯体功能以及实际日常活动水平之间的相关性。方法:前瞻性研究设计,获取87例因终末期骨关节炎而接受单侧全膝关节置换术患者术前的全面躯体功能参数,并招募年龄接近的60例轻度骨关节炎患者[Kellgren-Lawrence(K-L)分级0-2级]采集相同的躯体功能参数。所采集的数据包括患者的年龄、身高、体重、30秒座椅站立测试(30 s chair stand test,30-CST)、40米快速步行测试(40 m fast-paced walk test,40-FPWT)、12级爬楼梯测试(12 steps stair climb test,12-SCT)、3米起立行走测试(timed up&go test,TUG)、6分钟步行测试(6 minute walk test,6-MWT)、美国西部Ontario和Mc Master大学骨关节炎指数评分(The Western Ontario and Mc Master Universities Osteoarthritis Index,WOMAC)、美国膝关节协会评分(knee society score,KSS)、可视化疼痛评分(visual analogue scale,VAS)以及连续7 d的每日步数。使用SPSS 22.0软件进行统计学分析,首先对各项数据的观察值进行描述性报告,使用Kolmogorv-Smirnov检验每一变量是否符合正态分布,结果两组的每一变量均不符合正态分布,因而采用非参数Mann-Whitney检验两组间差异,应用Spearman相关分析评估各项参数之间的相关性。结果:轻度骨关节炎组患者的VAS评分、WOMAC评分、KSS评分、日均步数以及各项基于表现的躯体功能测试结果均优于终末期骨关节炎组患者,两组间差异有统计学意义(P〈0.05)。轻度骨关节炎组内,各项躯体功能测试均与各项自我报告量表无显著相关性或有较弱相关性;终末期骨关节炎组内,各项躯体功能测试与各项自我报告量表之间有着不同强度的相关性。结论:描述了多项躯体功能参数在中国轻度骨关节炎与终末期骨关节炎患者中的应用,基于表现的躯体功能、实际日常活动水平、患者自我报告量表以及疼痛评分之间并不一定有较好的相关性,需要对骨关节炎患者进行更全面地评估并制定相应的全膝关节置换术手术决策标准。 | 李志昌 姜龙 张舒 秦雪英 Daniel K.White PT 侯云飞 周之伟 林剑浩 | 2016 | 北京大学学报(医学版)2016,48,2: | 5 |
| 8 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010,18,12: | 4 |
| 9 | 碱金属钾对Ni基催化剂纤维素水蒸气气化活性的影响显示文摘采用两段式催化气化方式研究了生物质热解气化过程中碱金属的挥发对Ni基催化剂活性的影响。实验结果表明,负载K盐的纤维素水蒸气催化气化过程中,K挥发后会在催化剂表面沉积,而少量K的存在和表面沉积不但能够提高镍基催化剂的抗积炭能力,而且有助于提高其催化活性,产生更多的氢气。然而纤维素中K的浓度过大,将会抑制Ni基催化剂的效果;K在催化剂上的沉积随催化剂循环次数的增加而增加,K的含量愈高,对催化剂的抑制效果愈明显,从而缩短了催化剂的使用寿命。 | 曾志伟 邹俊 杨海平 王贤华 吴春飞 PT William 陈汉平 | 2015 | 燃料化学学报2015,43,12: | 4 |
| 10 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018,15,4: | 3 |
| 11 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019,25,48: | 3 |
| 12 | 经颅磁刺激用于治疗帕金森病运动障碍显示文摘帕金森病(ParkinsoffsDisease,PD)是一种进展性神经退行性疾病,在60岁以上的老年人中接近1%罹患PD,在80岁以上的老年人中则为4%。目前的治疗方法包括药物治疗和手术治疗,后者包括深部脑刺激。在过去的二十年里,重复经颅磁刺激(RepetitiveTtranscranialMagneticStimulation,rTMS)~渐被认为或是治疗PD的方案。本荟萃分析旨在帮助医疗人员更好地理解rTMS用于治疗帕金森病运动障碍的疗效。 | Chou YH Hickey PT Sundman M 吴毅 | 2015 | 中国康复2015,30,5: | 3 |
| 13 | Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury显示文摘 | Wang, YX Cheung, PT Shen, GX Bhatia, I Wu, EX Qiu, DQ Khong, PL | 2007 | 中国生物学文摘2007,21,11: | 2 |
| 14 | Mutations in the DNA mismatch repair gene homologue hMLH1 is associated with HNPCC显示文摘 | Bronner CE Baker SM morrism PT | 1994 | Nature1994,368,6468: | 2 |
| 15 | Neuronal apoptosis: Current understanding of molecular mechanisms and potential role in ischemic brain injury显示文摘 | Johnson EM Jr Greenlund LJ Akins PT | 1995 | J Neurotrauma1995,12,84: | 2 |
| 16 | 牙生物工程与再生牙科学显示文摘在过去100年中,在牙组织工程和再生牙科医学(统称为“转化牙科”)领域取得了巨大进步。转化牙科受益于组织工程和再生医学(TERM)的更成熟领域,其建立的是生物相容性支架、细胞和生长因子可用于产生功能性、活的替代组织和器官的理念。TERM由跨学科的临床医生、生物医学工程师和基础研究科学家创建和开创,致力于创建生物工程替代组织,该组织至少可为患者提供足够的功能,以使其存活直至供体器官可用,最好是功能齐全的替代器官。最终,TERM和再生牙科的目标都是为诊所提供新的更有效的疗法,以治疗有需要的人。 | Yelick PC Sharpe PT 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019,17,6: | 2 |
| 17 | 东南亚地区卫生人力前进的道路显示文摘 | Jayaw ick ram arajah PT 丁可 | 2002 | 国外医学(医学教育分册)2002,23,4: | 2 |
| 18 | An fMRI study with written Chinese显示文摘 | Tan LH Feng CM Fox PT | 2001 | Neuroreport2001,12,1: | 2 |
| 19 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010,,12: | 2 |
| 20 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017,25,2: | 2 |