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| 1 | CONSORT 2010说明与详述:报告平行对照随机临床试验指南的更新显示文摘大量证据显示随机对照临床试验(randomised controlled trial,RCT)的报告质量不理想。报告不透明,则读者既不能评判试验结果是否真实可靠,也不能从中提取可用于系统综述的信息。最近的方法学分析表明,报告不充分和设计不合理与对治疗效果产生评价偏倚有关。这种系统误差对RCT损害严重,而RCT正是以其能减少或避免偏倚而被视为评价干预措施的金标准。为了提高RCT的报告质量,一个由专家和编辑组成的工作组制定了临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)声明。CONSORT声明于1996年首次发表,并于2001年更新。声明由对照检查清单和流程图组成,供作者在报告RCT时使用。许多核心医学期刊和主要国际性编辑组织都已认可CONSORT声明。该声明促进了对RCT的严格评价和解释。2001年,在对CONSORT进行修订时,人们就已经清楚地认识到,解释和说明制定CONSORT声明的原理,有助于研究人员等撰写或评价临床试验报告。一篇CONSORT说明与详述文章于2001年同2001版CONSORT声明一起发表。2007年1月的专家会议之后,对CONSORT声明作了进一步修订并已发表,即'CONSORT2010声明'。这次更新对原版对照检查清单作了文字上的修改,使其更为明晰,并收入了与一些新近才认识到的主题相关的建议,如选择性报告结局产生的偏倚。说明与详述文件旨在加强人们对CONSORT声明的理解、应用和传播,这次也作了大量修订,对每一项新增或更新的清单条目的含义和增改理由进行了解释,提供了优秀的报告实例,还尽可能地提供了相关的经验性研究的参考文献。文中收入了若干流程图实例。'CONSORT2010声明'、其说明与详述文件,以及相关网站(www.consort-statement.org),对于改进随机临床试验报告必将有所裨益。 | David Moher Sally Hopewell Kenneth F Schulz Victor Montori Peter C Gφtzsche P J Devereaux Diana Elbourne Matthias Egger Douglas G Altman 周庆辉 卞兆祥 刘建平 | 2010 | 中西医结合学报2010，8，8： | 318 |
| 2 | 中文版职业生涯成功量表在三级甲等医院医护人员测量中的信效度研究显示文摘目的检验中文版职业生涯成功量表在三级甲等医院医护人员职业生涯测量中的信度和效度。方法使用由严圣阳等翻译和检验的中文版职业生涯成功量表,对1051名三级甲等医院临床医生和护士进行调查,分析量表的信度和效度。结果中文版职业生涯成功量表总的Cronbach’sd系数为0.909,分量表Cronbach’s α系数为0.870~0.901;总量表重测信度为0.885;各维度内容效度均大于0.825且有统计学意义;各条目在所提取的相应公因子上的载荷值均大于0.766.因子分析提取的3个因子共解释总变异的77.27%。结论中文版职业生涯成功量表具有较高的信度和效度。可用于三级甲等医院临床医护人员职业生涯成功测量和研究。 | 李泽楷 尤黎明 Sally W.C.Chan 林妙霞 林汉生 | 2013 | 中华护理杂志2013，48，9： | 56 |
| 3 | Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma显示文摘AIM: To characterise expression of known E-cadherin repressors; Snail, Slug and Twist in the development of esophageal adenocarcinoma. METHODS: E-cadherin, Slug, Snail and Twist mRNA expression in Barrett's metaplasia and esophageal adenocarcinoma specimens was examined by real-time reverse transcription-polymerase chain reaction (RT-PCR). Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein levels. The effect of Slug on epithelial mesenchymal transition (EMT) markers was examined by transfection of Slug into an adenocarcinoma line OE33.RESULTS: Cellular localisation of Slug in Barrett's metaplasia was largely cytoplasmic whilst in adenocarcinoma it was nuclear. Semi-quantitative analysis indicated that Slug was more abundant in adenocarcinoma compared to matched Barrett's metaplastic specimens. Snail and Twist were expressed in adenocarcinoma but were cytoplasmic in location and not induced compared to Barrett's mucosa. These observations were supported by mRNA studies where only Slug mRNA was shown to be over-expressed in adenocarcinoma and inversely correlated to E-cadherin expression. Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin.CONCLUSION: Progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing. | Paras Jethwa Mushal Naqvi Robert G Hardy Neil A Hotchin Sally Roberts Robert Spychal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，7： | 24 |
| 4 | Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance显示文摘The Hepatitis B Virus(HBV) has a worldwide distribu-tion and is endemic in many populations. It is constantly evolving and 10 genotypic strains have been identified with varying prevalences in different geographic regions. Numerous stable mutations in the core gene and in the su-rface gene of the HBV have also been identified in untreated HBV populations. The genotypes and viral variants have been associated with certain clinical featu-res of HBV related liver disease and Hepatocellu-lar carcinoma. For example Genotype C is associated withlater hepatitis B e antigen(HBe Ag) seroconversion, and more advanced liver disease. Genotype A is associated with a greater risk of progression to chronicity in adu-lt acqu-ired HBV infections. Genotype D is particu-larly associated with the precore mu-tation and HBe Ag negative chronic hepatitis B(CHB). The genotypes prevalent in parts of West Africa, Central and Sou-th America, E, F and H respectively, are less well stu-died. Viral variants especially the Basal Core Promotor mutation is associated with increased risk of fibrosis and cancer of the liver. Althou-gh not cu-rrently part of rou-tine clinical care, evalu-ation of genotype and viral variants may provide u-sefu-l adju-nctive information in predicting risk abou-t liver related morbidity in patients with CHB. | Catherine MN Croagh Paul V Desmond Sally J Bell | 2015 | World Journal of Hepatology2015，7，3： | 24 |
| 5 | 期刊与学术会议论文摘要中报告随机对照试验的CONSORT声明:说明与详述显示文摘背景:对于与随机对照试验(randomized controlled trial,RCT)有关的学术会议论文或期刊中发表的文章来说,清楚、明了、信息量充足的摘要是十分重要的,因为读者经常仅仅根据报告的摘要对一个临床试验作出评价。为此,我们需要对'临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)声明'进行扩充,制定一个期刊与学术会议论文摘要中报告RCT的必备条目清单。今后在任何期刊发表的论文或学术会议论文摘要中,作者对RCT结果的报告都要包含这些内容。方法与结果:我们根据现有的质量评价工具和基于经验的证据总结出一个条目清单。运用三轮修正式德尔菲法(modified-Delphi process)进行条目筛选。邀请共计109人参与电子网络调查,反馈率为61%。调查结果于2007年1月在加拿大蒙特贝罗举行的CONSORT小组会议中公布,与会的26人中有临床试验实施人员、统计学家、流行病学家以及生物医学编辑。经过讨论最终确定条目,随后对其进行修订以保证这些条目体现了会议期间以及会后的讨论思路。摘要CONSORT建议RCT报告的摘要需要有一个结构化的格式,其中应该包括具体的试验目的、试验设计(随机分配的方法、盲法或遮蔽等)、研究对象(对象描述、随机分组的样本量以及用于分析的样本量)、每组实施的干预、实施的干预对主要疗效结果的影响及其危害、试验结论、试验注册名称和编号以及资金来源。本文对每一条能够找到例子的纳入条目都配有良好报告范例、基本原理以及证据等,十分明了易懂,因此我们建议与清单同时使用。结论:摘要CONSORT旨在改善期刊与学术会议中发表的论文摘要的质量,这将有助于摘要提供详尽清晰的信息,这些信息能够帮助读者对试验的有效性和试验结果的适用性做出正确的评价。 | Sally Hopewell Mike Clarke David Moher Elizabeth Wager Philippa Middleton Douglas G.Altman Kenneth F.Schulz the CONSORT Group 李迅 刘建平 | 2008 | 中西医结合学报2008，6，3： | 23 |
| 6 | Synchronous colorectal cancer: Clinical, pathological and molecular implications显示文摘Synchronous colorectal carcinoma refers to more than one primary colorectal carcinoma detected in a single patient at initial presentation.A literature review has shown that the prevalence of the disease is approximately 3.5%of all colorectal carcinomas.This disease has a male to female ratio of 1.8:1.The mean age at presentation of patients with synchronous colorectal cancer is in the early half of the seventh decade.Patients with inflammatory bowel diseases(ulcerative colitis and Crohn’s disease),hereditary non-polyposis colorectal cancer,familial adenomatous polyposis and serrated polyps/hyperplastic polyposis are known to have a higher risk of synchronous colorectal carcinoma.These predisposing factors account for slightly more than 10%of synchronous colorectal carcinomas.Synchronous colorectal carcinoma is more common in the right colon when compared to solitary colorectal cancer.On pathological examination,some synchronous colorectal carcinomas are mucinous adenocarcinomas.They are usually associated with adenomas and metachronous colorectal carcinomas.Most of the patients with synchronous colorectal cancer have two carcinomas but up to six have been reported in one patient.Patients with synchronous colorectal carcinoma havea higher proportion of microsatellite instability cancer than patients with a solitary colorectal carcinoma.Also,limited data have revealed that in many synchronous colorectal carcinomas,carcinomas in the same patient have different patterns of microsatellite instability status,p53 mutation and K-ras mutation.Overall,the prognosis of patients with synchronous colorectal carcinoma is not significantly different from that in patients with solitary colorectal carcinoma,although a marginally better prognosis has been reported in patients with synchronous colorectal carcinoma in some series.A different management approach and long-term clinical follow-up are recommended for some patients with synchronous colorectal cancer. | Alfred King-Yin Lam Sally Sze-Yan Chan Melissa Leung | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 7 | 职业生涯测量及护士职业生涯研究工具的选择显示文摘分析人力资源管理领域中职业生涯测量方法的演进,借鉴社会科学领域对职业生涯发展的评价和测量方法,结合护士职业生涯的特点和研究现状,从职业生涯发展研究的角度,提出对研究中测量工具选择的建议。 | 李泽楷 Sally W.C.Chan 尤黎明 | 2012 | 护士进修杂志2012，27，3： | 21 |
| 8 | Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma显示文摘AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no major complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS. | Thomas J Vogl Nour-Eldin Nour-Eldin Sally Emad-Eldin Nagy NN Naguib Joerg Trojan Hans Ackermann Omar Abdelaziz | 2011 | World Journal of Gastroenterology2011，17，10： | 20 |
| 9 | Ni/Pd core/shell nanoparticles supported on graphene as a highly active and reusable catalyst for Suzuki- Miyaura cross-coupling reaction显示文摘 | Onder Metin Sally Fae Ho Cemalettin Alp Hasan Can Max N. Mankin Mehmet Serdar Gueltekin Miaofang Chi Shouheng Sun | 2013 | Nano Research2013，6，1： | 15 |
| 10 | 基质金属蛋白酶研究进展显示文摘炎症是众多疾病的共同病理过程,炎症反应的程度与疾病的临床预后息息相关。基质金属蛋白酶(matrix metalloproteinases,MMPs)作为一组蛋白水解酶类,在胚胎的发育、器官的重塑乃至炎症过程中起重要作用。近年来,随着基础研究的不断深入, | 刘巍 Sally A.Huber 李淑清 | 2011 | 哈尔滨医科大学学报2011，45，5： | 14 |
| 11 | Psychological controversies in gastroparesis: A systematic review显示文摘AIM To systematically review literature addressing three key psychologically-oriented controversies associated with gastroparesis. METHODS A comprehensive search of Pub Med, CINAHL, and PsycI NFO databases was performed to identify literature addressing the relationship between gastroparesis and psychological factors. Two researchers independently screened all references. Inclusion criteria were: an adult sample of gastroparesis patients, a quantitative methodology, and at least one of the following:(1) evaluation of the prevalence of psychopathology;(2) an outcome measure of anxiety, depression, or quality of life; and(3) evidence of a psychological intervention. Case studies, review articles, and publications in languages other than English were excluded from the current review. RESULTS Prevalence of psychopathology was evaluated by three studies(n = 378), which found that combined anxiety/depression was present in 24% of the gastroparesis cohort, severe anxiety in 12.4%, depression in 21.8%-23%, and somatization in 50%. Level of anxiety and depression was included as an outcome measure in six studies(n = 1408), and while limited research made it difficult to determine the level of anxiety and depression in the cohort, a clear positive relationship with gastroparesis symptom severity was evident.Quality of life was included as an outcome measure in 11 studies(n = 2076), with gastroparesis patients reporting lower quality of life than population norms, and a negative relationship between quality of life and symptom severity. One study assessed the use of a psychological intervention for gastroparesis patients(n = 120) and found that depression and gastric function were improved in patients who received psychological intervention, however the study had considerable methodological limitations. CONCLUSION Gastroparesis is associated with significant psychological distress and poor quality of life. Recommendations for future studies and the development of psychological interventions are provided. | Sally Woodhouse Geoff Hebbard Simon R Knowles | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 12 | 基于自我效能理论的乳腺癌化疗患者“乳康之韵”APP留言内容的定性分析显示文摘目的基于自我效能理论分析网络健康干预情境下乳腺癌化疗患者在'乳康之韵'APP上的留言。方法建立'乳康之韵'APP,从两所医院乳腺外科行乳腺癌手术且接受化疗的患者中选取57例作为研究对象,进行12周的干预,患者通过'乳康之韵'APP获取知识、观看视频、患患交流以及医患交流。应用演绎分析法对研究期间患者在APP中'讨论中心'和'专家咨询'两个模块留言进行定性分析。结果患者在APP上的留言涉及直接经验、间接经验、言语劝慰、症状感知4方面主题。结论'乳康之韵'APP从自我效能的4个方面帮助乳腺癌患者掌握相关技能,提供间接经验和情感支持,并改变了患者对化疗症状的感知。 | 朱海华 詹莉 林文华 朱杰敏 CHAN Wai-Chi Sally | 2019 | 护理管理杂志2019，19，12： | 10 |
| 13 | Involvement of cholangiocyte proliferation in biliary fibrosis显示文摘Cholangiocytes are the epithelial cells that line the biliary tree.In the adult liver,they are a mitotically dormant cell population,unless ductular reaction is triggered by injury.The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type,which are termed cholangiopathies(i.e.primary biliary cirrhosis,primary sclerosing cholangitis and biliary atresia).In our article,we provide background information on the morphological and functional heterogeneity of cholangiocytes,summarize what is currently known about their proliferative processes,and briefly describe the diseases that target these cells.In addition,we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis,and propose directions for future studies. | Sally Priester Candace Wise Shannon S Glaser | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 10 |
| 14 | Effects of Glomus mosseae on the toxicity of heavy metals to Vicia faba显示文摘A glasshouse pot experiment was conducted to investigate effects of th e arbuscular mycorrhizal fungus Glomus mosseae on the growth of Vicia faba and t oxicity induced by heavy metals (HMs) (Cu, Zn, Pb and Cd) in a field soil contam inated by a mixture of these metals. There was also uninoculation treatment (NM) simultaneously. Mycorrhizal (GM) plants have significantly increased growth and tolerance to toxicity induced by heavy metals compared with NM plants. P uptake was significantly increased in GM plants. Mycorrhizal symbiosis reduced the tra nsportation of HMs from root to shoot by immobilizing HMs in the mycorrhizal, sh own by increasing the ratios of HMs from root to shoot. Oxidative stress, which can induce DNA damage, is an important mechanism of heavy metal toxicity. GM tre atment decreased oxidative stress by intricating antioxidative systems such as p eroxidases and non-enzymic systems including soluble protein. The DNA damage ind uced by heavy metals was detected using comet assay, which showed DNA damage in the plants was decreased by the GM treatment. | ZHANG Xu-hong LIN Ai-jun CHEN Bao-dong WANG You-shan SMITH Sally E SMITH F Andrew | 2006 | Journal of Environmental Sciences2006，18，4： | 10 |
| 15 | 七氟醚中、低流量紧闭麻醉与双频指数监测下低流量紧闭麻醉的比较显示文摘目的 比较七氟醚中流量、低流量及双频指数监测下低流量循环紧闭麻醉,以探讨七氟醚的应用方法。方法 96例ASA Ⅰ~Ⅱ级择期全麻手术病人,随机分为三组,A组:中流量循环紧闭麻醉,氧流量1000 ml/min;B组:低流量循环紧闭麻醉,氧流量500 ml/min;C组:双频指数监测下低流量循环紧闭麻醉,氧流量500ml/min。各组均以七氟醚环路内吸入维持麻醉。A、B两组根据临床麻醉体征和手术刺激情况调节七氟醚浓度,C组根据BIS值调节七氟醚浓度。结果 A组、B组和C组呼气末七氟醚维持浓度分别为(1.4±0.2)MAC、(1.1±0.2)MAC和(0.8±0.2)MAC水平;七氟醚总耗量分别为(13.3±1.6)m1/h、(9.6±1.5)ml/h和(7.5±1.8)ml/h,C组七氟醚总耗量最低(P<0.01);苏醒时间分别为(14.3±3.3)min、(10.5±2.8)min和(7.5±2.6)min;意识恢复时间分别为(24.5±6.1)min、(17.4±5.5)min和(12.7±4.8)min,c组苏醒时间和意识恢复时间最快;恶心呕吐发生率分别为14.5%±2.6%、10.1%±2.3%和7.5%±2.1%,c组恶心呕吐发生率最低。结论 双频指数监测下七氟醚低流量循环紧闭麻醉具有节约麻醉药,苏醒时间短和恶心呕吐发生率低的优点,是一种良好的麻醉方法。 | 范秋维 Roger Eltringham Sally Ryder 于布为 | 2003 | 中华麻醉学杂志2003，23，5： | 9 |
| 16 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation. | Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy | 2017 | World Journal of Diabetes2017，8，2： | 8 |
| 17 | Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia显示文摘 | Tin Nguyen Alexander J.V. Thompson Scott Bowden Catherine Croagh Sally Bell Paul V. Desmond Miriam Levy Stephen A. Locarnini | 2010 | Journal of Hepatology2010，，4： | 7 |
| 18 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 19 | 青藏高原上发现世界最老的岩面艺术显示文摘青藏高原高寒、缺氧,属于地球上居住条件极端恶劣的环境.人类在什么时候克服生理和生存的重重困难去征服高原是人类演化历史中至关重要的科学问题.在第二次青藏高原综合科学考察过程中,研究团队在西藏邱桑温泉附近发现了一组由古人类有意留下的手印和脚印(简称手脚印).通过对这些手脚印进行详细的3D扫描,解剖学和沉积学分析,以及铀系法测年,发现这些手脚印是由古人类在泉华软泥上用其手脚压制而成,随后这些留有印记的软泥迅速脱水并固结成岩,得以长期保留.这些手脚印形成于距今16.9~22.6万年,是人类占据高原已知最早的记录.由于这些有意压制的手脚印排列有序并富于创造性,研究团队认为这是世界上最古老的岩面艺术,其中的手印也是世界上目前已知最古老有意创作的手印.该研究显示邱桑古人类比智人走出非洲的时间更早,但与最近在青藏高原边缘发现的丹尼索瓦人的年代相近.手脚印的创作者究底是丹尼索瓦人还是其他直立人?这给考古学家们留下了新的挑战. | 章典 Matthew R.Bennett 程海 王蕾彬 张海伟 Sally C.Reynolds 张盛达 王晓晴 李腾 Tommy Urban 裴卿 吴志峰 张普 刘春茹 汪亚峰 王聪 张冬菊 R.Lawrence Edwards | 2021 | Science Bulletin2021，66，24： | 7 |
| 20 | Feruloylated Arabinoxylans Are Oxidatively Cross- Linked by Extracellular Maize Peroxidase but Not by Horseradish Peroxidase显示文摘在生活玉米文化的可溶的细胞外的 arabinoxylans 的共有原子价 cross-linking,为墙界限 arabinoxylans 的 cross-linking 建模,由于到 oligoferuloyl 酉旨和醚的 feruloyl 酉旨的氧化。氧化系统负责 H2O2/peroxidase, O2/laccase,或反应的氧种类能 non-enzymically 正在行动。区分这些可能性,我们在 vivo 并且在 vitro 学习了 arabinoxylan cross-linking。在生活文化,外长,可溶,细胞外, feruloylated [pentosyl-3H ] arabinoxylans 经历了 cross-linking,突然地开始 8 ? 在再次培养以后的 d。Cross-linking 被碘化物压制, H2O2 scavenger,在内长的 H2O2 上显示依赖。然而,外长的 H2O2 没引起早熟的 cross-linking,尽管有内长的 peroxidases 的经常的存在,建议更年轻的文化包含了自然 cross-linking 禁止者。渗析的文化过滤 cross-linked [3H ] 在 vitro 的 arabinoxylans 仅当 H2O2 也被增加,显示一个 peroxidase 要求。这 cross-linking 是高度 ionic-strength-dependent。peroxidases 负责是热易变的,尽管相对热马厩 peroxidases (o-dianisidine 上的 assayed ) 也是现在。令人惊讶地,补充说甚至在热变性作用以后,山葵 peroxidase 堵住了玉米 peroxidases 的交叉结合 arabinoxylan 行动,建议山葵蛋白质是竞争底层为[3H ] 联合的 arabinoxylan。在结论,我们第一次证明在生活玉米文化的细胞外的 arabinoxylan 的 cross-linking 是 apoplastic peroxidases 的一个行动,我们报导其不平常的性质的一些。 | Sally J. Burr Stephen C. Fry | 2009 | Molecular Plant2009，2，5： | 6 |
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