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| 1 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 2 | 超声乳化致晶体碎块坠入玻璃体腔的手术治疗显示文摘目的评价玻璃体切除术治疗晶体坠落物的效果。方法对1992年10月至1995年10月澳大利亚墨尔本皇家维多利亚眼耳医院所做58例玻璃体切除术治疗晶体坠落物的病例,随访3个月以上资料进行回顾分析。结果最后随访时残留囊样黄斑水肿3例(5.2%),视网膜脱离2例(3.4%),低眼压l例(1.7%),其余并发症均消失。其中38只眼(65.5%)最后视力≥0.5,仅6只眼视力<0.05。结论白内障手术中一旦发生晶体成分坠落于玻璃体内,宜妥善处理眼前段,可能时植入人工晶体,并尽快行玻璃体切除术治疗。 | 韩丽荣 Camp.,WG | 1998 | 中华眼科杂志1998，34，6： | 13 |
| 3 | 脊柱侧凸内固定术后手术部位感染:有关感染率、危险因素和致病菌的一项多中心分析显示文摘目前有关儿童脊柱侧凸矫形术后手术部位感染的病例有较多报道,这些病例往往需要再次入院施行手术进行清创冲洗,亦可能需要去除内置物及进行翻修手术,增加了医疗成本。本研究目的在于评估不同病因、不同手术方式脊柱侧凸患者的手术部位感染发生率,并分析外科伤口感染的危险因素及致病菌。 | Mackenzie WG Matsumoto H Williams BA 张皓南 尹庆水 | 2013 | 中国骨科临床与基础研究杂志2013，5，3： | 9 |
| 4 | Integrated positron emission tomography and computed tomography in preoperative lymph node staging of non-small cell lung cancer显示文摘 | Xu N Jiao Y Fang WG Wang MZ Zhu ZH Zhang YQ | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 5 | Isotopic compositions of chlorine in brine and saline minerals显示文摘CHLORINE in the nature has two stable isotopes, 35Cl and 37Cl. Two methods of determining isotopic ratios of chlorine were once developed. Owen, Kaufmann and Long determined 37Cl/35Cl ratios based on the measurement of CH3Cl+ ion produced by ionization of methyl chlorine. The precision of the measurement of Cl-(NTIMS) was reported by Shields and Vengosh. The NTIMS has less precision. | Xiao, YK Liu, WG Zhou, YM Sun, DP | 1997 | Chinese Science Bulletin1997，42，5： | 7 |
| 6 | 热带和亚热带土壤中碳的含量,动态及贮存显示文摘 | Somb.,WG 鲍显诚 | 1993 | 人类环境杂志1993，22，7： | 7 |
| 7 | Prognostic values of tumor endothelial markers in patients with colorectal cancer显示文摘AIM: Tumor endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumor specificangiogenesis. This study sought to examine the levels of expression (qualitatively and quantitatively)for TEMs in human colon cancer.METHODS: Human colorectal cancer tissues (n = 48)and normal background tissues (n = 31) were obtained after surgery. RNA was extracted from frozen sections for gene amplification. The expression of TEMs (TEM-1to TEM-8) was assessed using RT-PCR and their transcript levels were determined using real-time-quantitative PCR(Q-RT-PCR).RESULTS: TEM-1 (P = 0.01), TEM-7 (P = 0.04), TEM-7R(P= 0.03), TEM-8 (P = 0.001) significantly raised in colon cancer tissues compared with the levels detected in normal background tissues. The expressions of TEM-2 and TEM-6were found to be not significantly different between tumor tissues and normal tissues (P>0.05). Patients who had cancer penetrating into and through the muscularis propria of the bowel wall and developed nodal involvement(Dukes C) exhibited significantly higher levels of TEM -8compared to patients who were node negative (P<0.05).TEM-7 and TEM-7R showed high level of transcripts in Dukes C, but they were not statistically significant.CONCLUSION: The level of the expression of TEM-1,TEM-7, TEM-7R and TEM-8 (but not TEM-2 and TEM-6)were associated with both nodal involvement and disease progression, and may therefore, have a prognostic value in colorectal cancer. | KA Rmali MCA Puntis WG Jiang | 2005 | World Journal of Gastroenterology2005，11，9： | 7 |
| 8 | 化妆品皮炎显示文摘化妆品皮炎LarsenWG①前言我很高兴参加由P&G公司举办的皮肤科讨论会,此会议为中国和世界其他各地的皮肤科专家加强了联系。由于目前有许多杂志可以利用以及电子信息的开发,使这种联系更为方便。尤其电子计算机的国际联网使皮肤科之间的联系和进行教育更快,... | Larsen WG 陈文萍 | 1996 | 临床皮肤科杂志1996，25，5： | 5 |
| 9 | Molecular as pects of tumor cell invasion and metastasis 显示文摘 | Aznavoorian S Murphy AN Stetler-Stevenson WG | 1993 | Carcinoma1993，71，4： | 3 |
| 10 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 11 | The p53 gene family显示文摘 | Kaelin WG J r | | 0，，： | 2 |
| 12 | Sequence-and region-specificity of oxaliplatin in naked and cellular DNA显示文摘 | Woynarowski JM Chapman WG Napier C | 1998 | Mol Pharmacol1998，54，5： | 2 |
| 13 | Cardiac resynchronization in chronic heart failure显示文摘 | Abraham WT Fisher WG Smith D | | New England Journal of Medicine0，，： | 2 |
| 14 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 15 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 16 | 幽门螺杆菌感染与结直肠肿瘤的风险:一项系统综述和荟萃分析显示文摘全世界约有一半人口感染了幽门螺杆菌,幽门螺杆菌感染是消化性溃疡和胃癌等消化道疾病的危险因素。据报道,幽门螺杆菌也与胃癌以外的恶性肿瘤有关,如结直肠肿瘤等。为评估幽门螺杆菌感染与结直肠肿瘤之间的关系,研究者对相关文献进行了系统综述和荟萃分析。通过检索Medline、Embase和Cochrane Library数据库中截至2019年9月发表的关于结直肠腺瘤、进展期结直肠腺瘤、结直肠癌和幽门螺杆菌感染的风险研究,进行荟萃分析。最终48项研究纳入荟萃分析,包括171045例患者,其中24项、8项和31项分别报告了幽门螺杆菌感染与结直肠腺瘤、进展期结直肠腺瘤和结直肠癌的风险。结果显示,幽门螺杆菌感染与结直肠腺瘤的风险显著相关(OR=1.49,95%CI:1.37~1.62);与进展期结直肠腺瘤的风险显著相关(OR=1.50,95%CI:1.28~1.75);也与结直肠癌的风险显著相关(OR=1.39,95%CI:1.27~1.52)。尽管这项基于观察性研究的荟萃分析不能显示因果关系,但它表明,结直肠腺瘤、进展期结直肠腺瘤和结直肠癌都与幽门螺杆菌感染有关。 | Choi DS Seo SI Shin WG 芦波(编译) | 2022 | 中华医学杂志2022，102，22： | 2 |
| 17 | Silicosis in jade workers显示文摘 | Ng TP Allan WG Tain TW | 1985 | Br J Ind Med1985，42，： | 2 |
| 18 | Nitric oxide inhibition of free radical-mediated cholesteral peroxidation in liposomal membranes 显示文摘 | Witold K Mariusz Z Albert WG | 2000 | Biochemistry2000，39，23： | 2 |
| 19 | Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues显示文摘 | Stetler-Stevenson WG Bromn PD Onisto M | 1990 | J Biol Chem1990，265，13： | 2 |
| 20 | E-cadherin and its associated protein catenins,carcinoma invasion and metastasis 显示文摘 | Jiang WG | 1996 | Br J Surg1996，83，4： | 2 |
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