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| 1 | Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature显示文摘BACKGROUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing enteropathy.The disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and lymphopenia.Since the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among others.Although usually developing in early childhood,we present the case of a 34-yearold woman with PIL.Moreover,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in adults.CASE SUMMARY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower limbs.Interestingly,a striking collinearity of clinical symptoms with female hormone status was evident.Additionally,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were evident.Due to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and hypoalbuminemia.The diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via enteroscopy.Consecutively,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of follow-up.CONCLUSION PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in adulthood.Due to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and welltolerated.This leads to a significant disease burden in affected patients.PIL is increasingly been recognized in adults since the majority of case reports were published within the last 10 years,pointing towards an underestimation of the true prevalence.The association with female hormone status warrants further investigation. | Rudolf Huber Georg Semmler Alexander Mayr Felix Offner Christian Datz | 2020 | World Journal of Gastroenterology2020，26，48： | 6 |
| 2 | Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver显示文摘Elevated iron stores as indicated by hyperferritinemiawith normal or mildly elevated transferrin saturation a n d m o s t l y m i l d h e p a t i c i r o n d e p o s i t i o n a r e a characteristic finding in subjects with non-alcoholic fatty liver disease(NAFLD). Excess iron is observed in approximately one third of NAFLD patients and is commonly referred to as the 'dysmetabolic iron overload syndrome'. Clinical evidence suggests that elevated body iron stores aggravate the clinical course of NAFLD with regard to liver-related and extrahepatic disease complications which relates to the fact that excess iron catalyses the formation of toxic hydroxylradicals subsequently resulting in cellular damage. Iron removal improves insulin sensitivity, delays the onset of type 2 diabetes mellitus, improves pathologic liver function tests and likewise ameliorates NAFLD histology. Several mechanisms contribute to pathologic iron accumulation in NAFLD. These include impaired iron export from hepatocytes and mesenchymal Kupffer cells as a consequence of imbalances in the concentrations of iron regulatory factors, such as hepcidin, cytokines, copper or other dietary factors. This review summarizes the knowledge about iron homeostasis in NAFLD and the rationale for its therapeutic implications. | Elmar Aigner Gunter Weiss Christian Datz | 2015 | World Journal of Hepatology2015，7，2： | 6 |
| 3 | Exercise increases solid meal gastric emptying rates in men显示文摘 | Moore J G Datz F L Christian P E | 1990 | Dig Dis Sci1990，35，4： | 1 |
| 4 | Liver Microsomal Triglyceride Transfer Protein Is Involved in Hepatitis C Liver Steatosis显示文摘 | Silvia Mirandola Stefano Realdon Jahangir Iqbal Martina Gerotto Francesca Dal Pero Gladis Bortoletto Moira Marcolongo Alessandro Vario Christian Datz M. Mahmood Hussain Alfredo Alberti | 2006 | Gastroenterology2006，，6： | 1 |
| 5 | Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C显示文摘 | Albert Friedrich St?ttermayer Karoline Rutter Sandra Beinhardt Thomas-Matthias Scherzer Andreas Stadlmayr Harald Hofer Fritz Wrba Petra Steindl-Munda Michael Krebs Christian Datz Michael Trauner Peter Ferenci | 2012 | Journal of Hepatology2012，，3： | 1 |
| 6 | Hepatic steatosis in Wilson disease – Role of copper and PNPLA3 mutations显示文摘 | Albert Friedrich St?ttermayer Stefan Traussnigg Hans-Peter Dienes Elmar Aigner Rudolf Stauber Karoline Lackner Harald Hofer Judith Stift Friedrich Wrba Andreas Stadlmayr Christian Datz Michael Strasser Andreas Maieron Michael Trauner Peter Ferenci | 2015 | Journal of Hepatology2015，，1： | 1 |
| 7 | Targeted cytotoxic somatostatin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells显示文摘 | Florian Hohla Stefan Buchholz Andrew V. Schally Awtar Krishan Ferenc G. Rick Luca Szalontay Andrea Papadia Gabor Halmos Frank Koster Elmar Aigner Christian Datz Stephan Seitz | 2010 | Cancer Letters2010，，1： | 1 |
| 8 | Differential expression of GHRH receptor and its splice variant 1 inhuman normal and malignant mucosa of the oesophagus and colon显示文摘 | Florian Hohla Angelika Moder Ursula Mayrhauser Cornelia Hauser-Kronberger Andrew Schally Jozsef Varga Marta Zarandi Stefan Buchholz Rudolf Huber Elmar Aigner Markus Ritter Christian Datz | 2008 | International Journal of Oncology2008，，1： | 1 |
| 9 | Differences in gastric emptying rates between menstruating and postmenoopausal women显示文摘 | Datz FL Christian PE Moore J | 1987 | J Nucl Med1987，28，： | 1 |
| 10 | TGF-β1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis显示文摘 | Christoph H. ?sterreicher Christian Datz Felix Stickel Claus Hellerbrand Melitta Penz Harald Hofer Fritz Wrba Edward Penner Detlef Schuppan Peter Ferenci | 2005 | Cytokine2005，，2： | 1 |
| 11 | Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients显示文摘 | Thomas-Matthias Scherzer Albert Friedrich St?ttermayer Rudolf Stauber Andreas Maieron Michael Strasser Hermann Laferl Remy Schwarzer Christian Datz Karoline Rutter Sandra Beinhardt Petra Munda Harald Hofer Peter Ferenci | 2013 | Journal of Hepatology2013，，： | 1 |
| 12 | Austrian consensus on the definition and treatment of portal hypertension and its complications (Billroth II)显示文摘 | Markus Peck-Radosavljevic Bernhard Angermayr Christian Datz Arnulf Ferlitsch Monika Ferlitsch Valentin Fuhrmann Michael H?fner Ludwig Kramer Andreas Maieron Berit Payer Thomas Reiberger Rudolf Stauber Rudolf Steininger Michael Trauner Siegfried Thurnher G | 2013 | Wiener klinische Wochenschrift2013，，7： | 1 |
| 13 | Serum Level of IP-10 Increases Predictive Value of IL28B Polymorphisms for Spontaneous Clearance of Acute HCV Infection显示文摘 | Sandra Beinhardt Judith H. Aberle Michael Strasser Emina Dulic–Lakovic Andreas Maieron Anna Kreil Karoline Rutter Albert F. Staettermayer Christian Datz Thomas M. Scherzer Robert Strassl Martin Bischof Rudolf Stauber Gerd Bodlaj Hermann Laferl Heidemarie | 2012 | Gastroenterology2012，，1： | 1 |
| 14 | Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation显示文摘 | Beate Alinger Tobias Kiesslich Christian Datz | 2009 | Virehows Arch2009，454，4： | 1 |
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