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| 1 | Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases显示文摘AIM: To investigate the effect of vitamin D(VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease(IBD) patients. METHODS: A cohort of 220 IBD patients including 141 Crohn's disease(CD) and 79 ulcerative colitis(UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort(n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire(s IBDQ). VD serum concentration and s IBDQ score were assessed between August and October 2012(summer/autumn period) and between February and April 2013(winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter s IBDQ score were analyzed.RESULTS: During the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient(< 20 ng/m L), respectively. In the winter/spring period, there was a significant correlation between s IBDQ score and VD serum concentration in UC patients(r = 0.35, P = 0.02), with a trend towards significance in CD patients(r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients(< 30 ng/m L) had a significantly lower mean s IBDQ score than VD-sufficient patients; this was true of both UC(48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD(55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios(UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/m L. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the s IBDQ score.CONCLUSION: VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period. | Tibor Hlavaty Anna Krajcovicova Tomas Koller Jozef Toth Monika Nevidanska Martin Huorka Juraj Payer | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study显示文摘AIM To analyze 1-year liver injury burden in inflammatory bowel disease(IBD) patients. METHODS During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase(AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase(GGT) were measured at baseline, 3 mo prior to study entry and prospectively every 3 mo for 1 year. Liver injury patterns were predefined as: Grade 1 in ALT 1-3 × upper limit of normal(ULN), grade 2 in ALT > 3 × ULN, hepatocellular injury in ALT > 2 × ULN, cholestatic injury in simultaneous GGT and ALP elevation > ULN.Persisting injury was reported when AT elevations were found on > 1 measurement. Risk factors for the patterns of liver injury were identified among demographic parameters, disease phenotype and IBD treatment in univariate and multivariate analysis. Finally, implications for the change in IBD management were evaluated in cases with persisting hepatocellular or cholestatic injury.RESULTS Two hundred and fifty-one patients were included having 917 ALT and 895 ALP and GGT measurements. Over one year, grade 1 injury was found in 66(26.3%), grade 2 in 5(2%) and hepatocellular injury in 16 patients(6.4%). Persisting hepatocellular injury was found in 4 cases. Cholestasis appeared in 11 cases(4.4%) and persisted throughout the entire study period in 1 case. In multivariate analysis, hepatocellular injury was associated with BMI(OR = 1.13, 1.02-1.26), liver steatosis(OR = 10.61, 2.22-50.7), IBD duration(1.07, 1.00-1.15) and solo infliximab(OR = 4.57, 1.33-15.7). Cholestatic liver injury was associated with prior intestinal resection(OR = 32.7, 3.18-335), higher CRP(OR = 1.04, 1.00-1.08) and solo azathioprine(OR = 10.27, 1.46-72.3). In one case with transient hepatocellular injury azathioprine dose was decreased. In 4 cases with persisting hepatocellular injury, fatty liver or alcohol were most likely causes and IBD treatment was pursued without change. In the case with persisting cholestatic injury, no signs of portal hypertension were identified and treatment with infliximab continued.CONCLUSION Liver injury was frequent, mostly transient and rarely changed management. Infliximab or azathioprine were confirmed as its risk factors indicating the need for regular AT monitoring. | tomas koller martina galambosova simona filakovska michaela kubincova tibor hlavaty jozef toth anna krajcovicova juraj payer | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | Nonselective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis显示文摘 | T. Reiberger A. Ferlitsch B.A. Payer M. Mandorfer B.B. Heinisch H. Hayden F. Lammert M. Trauner M. Peck-Radosavljevic H. Vogelsang | 2012 | Journal of Hepatology2012，，： | 5 |
| 4 | Automated classification of duodenal imagery in celiac disease using evolved Fourier feature vectors显示文摘 | Andreas Vécsei Thomas Fuhrmann Michael Liedlgruber Leonhard Brunauer Hannes Payer Andreas Uhl | 2009 | Computer Methods and Programs in Biomedicine2009，，2： | 2 |
| 5 | Five‐year on‐treatment efficacy of lamivudine‐, tenofovir‐ and tenofovir + emtricitabine‐based HAART in HBV–HIV‐coinfected patients显示文摘 | L. Kosi T. Reiberger B. A. Payer K. Grabmeier‐Pfistershammer R. Strassl A. Rieger M. Peck‐Radosavljevic | 2012 | Journal of Viral Hepatitis2012，，11： | 2 |
| 6 | Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol显示文摘 | Thomas Reiberger Gregor Ulbrich Arnulf Ferlitsch Berit Anna Payer Philipp Schwabl Matthias Pinter Birgit B Heinisch Michael Trauner Ludwig Kramer Markus Peck-Radosavljevic | 2013 | Gut2013，，11： | 2 |
| 7 | Von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis显示文摘 | Monika Ferlitsch Thomas Reiberger Matthias Hoke Petra Salzl Bernadette Schwengerer Gregor Ulbrich Berit Anna Payer Michael Trauner Markus Peck‐Radosavljevic Arnulf Ferlitsch | 2012 | Hepatology2012，，4： | 2 |
| 8 | Blimpl is a critical determinant of the germ cell lineage in mice 显示文摘 | Ohinata Y Payer B O'Carroll D | 2005 | Nature2005，436，： | 1 |
| 9 | Metal oxide/metal pH sensor: effect of anions on pH measurements 显示文摘 | SONG I FINK K PAYER J H | 1998 | Corrosion1998，54，1： | 1 |
| 10 | Mstl and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yapl oncogene显示文摘 | Zhou D Conrad C Xia F Park JS Payer B Yin Y Lauwers GY Thasler W Lee JT Avruch J Bardeesy N | 2009 | Cancer Cell2009，16，5： | 1 |
| 11 | Evaluation of threedimensional changes after sinus floor augmentation with different grafting materials显示文摘 | Kirmeier R Payer M Wehrschuetz M | 2008 | Clin Oral Implants Res2008，19，4： | 1 |
| 12 | Mini-open anterior approach for corpectomy in the thoracolumbar spine 显示文摘 | Payer M Sottas C | 2008 | Surg Neurol2008，69，1： | 1 |
| 13 | Metal oxide metal pH sensor: Effect of anions on pH measurements显示文摘 | Song I Fink K Payer J H | 1998 | Corrosion1998，54，1： | 1 |
| 14 | Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task显示文摘 | Payer DE Lieberman MD Monterosso JR | 2008 | Drug Alcohol Depend2008，93，12： | 1 |
| 15 | Mini-open anterior approach for corpectomy in the thoracolumbar spine 显示文摘 | Payer M Sottas C | 2008 | Surg Neurol2008，69，5： | 1 |
| 16 | Blimpl and the emergence of the germ line during development in the mouse 显示文摘 | Saitou M Payer B O'Carroll D | 2005 | Cell Cycle2005，4，： | 1 |
| 17 | Evaluation of three-di- mensional changes after sinus floor augmentation with different grafting materials显示文摘 | Kirmeier R Payer M Wehrschuetz M | 2008 | Clin Oral Implants Res2008，19，4： | 1 |
| 18 | Corrosion and related mechanical properties of bulk metallic glasses显示文摘 | SCULLY J R GEBERT A PAYER J H | | 0，，2： | 1 |
| 19 | Acute traumatic central cord syndrome: a comprehensive review显示文摘 | Molliqaj G Payer M Schaller K | 2014 | Neurochirurgie2014，60，： | 1 |
| 20 | Treatment and outcome of pa- tients with metastatic NSCLC: a retrospective institution analysis of 493 patients显示文摘 | Reinmuth N Payer N Muley T | 2013 | Respir Res2013，14，： | 1 |
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