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| 1 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 2 | Definition and classification of cancer cachexia: an international consensus显示文摘 | Kenneth Fearon Florian Strasser Stefan D Anker Ingvar Bosaeus Eduardo Bruera Robin L Fainsinger Aminah Jatoi Charles Loprinzi Neil MacDonald Giovanni Mantovani Mellar Davis Maurizio Muscaritoli Faith Ottery Lukas Radbruch Paula Ravasco Declan Walsh Andrew | 2011 | Lancet Oncology2011，，5： | 8 |
| 3 | Abnormal Savda Syndrome:Long-Term Consequences of Emotional and Physical Stress on Endocrine and Immune Activities in An Animal Model显示文摘目的将调查在到 stressors 的感情的地位,寒冷干燥的环境和长期的有免疫力的回答之间的关系,和在反常 Savda 症候群(驴) 和到疾病的危险性的原因的因素之间的潜在的病理学的机制;因此澄清 ASS,并且第二在传统的 Uighur therapeutical 明确的表达上为进一步的研究当模特儿识别最佳的驴动物。六十只老鼠随机并且同等地被划分成 4 个组的方法:控制和 3 个压力组。寒冷干燥的环境被在一个气候的房间养老鼠使用。感情的压力被重复电的脚吃惊的申请在电的脚吃惊仪器导致。联合压力组的老鼠在是在气候的房间的 housed 前经历了重复电的脚吃惊处理。试验性的常规被重复 21 天。以便调查内分泌、有免疫力的压力回答, ELISA 被用来决定浆液荷尔蒙铺平释放促肾皮素的荷尔蒙( CRH ),促肾上腺皮质的荷尔蒙( ACTH ),贝它内啡肽(-END)和皮质脂酮( CORT ), cytokines interleukin 2 ( IL-2 ), interleukin 6 ( IL-6 ), interferon-gamma (INF-)和肿瘤坏死 factor-alpha (TNF-),并且免疫球蛋白免疫球蛋白 A ( IgA ),免疫球蛋白 M ( IgM )和免疫球蛋白 G ( IgG )。淋巴细胞子集被分析一式两份以便在 T 房间比率决定差别。在寒冷干燥的环境组, CRH 的浆液层次, ACTH 和 CORT 的结果比控制组的那些显著地高,而浆液结束没被发现显著地不同。在两个,象在浆液 CRH, ACTH,结束和 CORT 铺平的联合压力组一样的重复电的脚吃惊组是显著地更高级的。比作控制动物, INF- 的浆液集中在所有三个不同压力组是显著地更低的。而浆液 TNF- 水平显著地更高, IL-2 的浆液水平在联合压力组被减少。浆液 IgG 水平在所有三个压力组是显著地更高的,而 IgA 水平在两个长期的电的脚吃惊组是更低的并且联合了压力组。IgM 水平仅仅在联合压力组被发现显著地更高。在外部血的 CD4+ 房间的百分比戏剧性地在暴露于 colddry 环境,长期的电的脚吃惊和联合应力的老鼠被减少,而 CD8+ 子集的百分比不是显著地不同的。CD4+/CD8+ 比率在两个寒冷干燥的环境组是显著地更低的并且联合了压力组。联合应力能引起 HPA 轴的活动过度的结论,和在房间子集可以贡献的 Th1/Th2 的不平衡说明驴的部分病理学的机制。这研究在驴和相对治疗上为进一步的研究作为一个最佳的模型识别了物理、感情的应力的联合的这个动物模型。 | 阿地里江.阿布力米提 Harald Khnel Alois Strasser 哈木拉提.吾甫 | 2013 | Chinese Journal of Integrative Medicine2013，19，8： | 6 |
| 4 | Characteristics of Photosystem Ⅱ Behavior in Cotton(Gossypium hirsutum L.) Bract and Capsule Wall显示文摘Though bract and capsule wall of boll in cotton(Gossypium hirsutum L.) have different photosynthetic capacities,the features of photosystem Ⅱ(PS Ⅱ) in these organs are scarce.In this paper,chlorophyll a fluorescence emission was measured to investigate the difference in the photosynthetic apparatus of dark-acclimated(JIP-test) and light-acclimated(light-saturation pulse method) bract and capsule wall.Compared with leaves,the oxygen evolving system of non-foliar organs had lower efficiency.The pool size of PS Ⅱ electron acceptor of non-foliar organs was small,and the photochemical activity of leaves was higher than that of the bract and capsule wall.In regard to the photosystem I(PS I)electron acceptor side,the pool size of end electron acceptors of leaves was larger,and the quantum yield of electron transport from Q A(PS Ⅱ primary plastoquinone acceptor) further than the PS I electron acceptors of leaves was higher than that of bract and capsule wall.In all green organs,the actual quantum yield of photochemistry decreased with light.The thermal dissipation fraction of light absorbed by the PS Ⅱ antennae was the highest in bract and the lowest in capsule wall relative to leaves.Compared with leaves,capsule wall was characterized by less constitutive thermal dissipation and via dissipation as fluorescence emission.These results suggested that lower PS Ⅱ photochemical activity in non-foliar organs may be result from limitations at the donor side of PS Ⅱ and the acceptor sides of both photosystems. | ZHANG Ya-li LUO Hong-hai HU Yuan-yuan Reto J Strasser ZHANG Wang-feng | 2013 | Journal of Integrative Agriculture2013，12，11： | 4 |
| 5 | Donor side capacity of Photosystem II probed by chlorophyll a fluorescence transients显示文摘 | Bruno J Strasser | 1997 | Photosynthesis Research1997，，2： | 4 |
| 6 | Electrocatalytic hydrogen peroxide formation on mesoporous non-metal nitrogen-doped carbon catalyst显示文摘Direct electrochemical formation of hydrogen peroxide(H2O2) from pure O2 and H2on cheap metal-free earth abundant catalysts has emerged as the highest atom-efficient and environmentally friendly reaction pathway and is therefore of great interest from an academic and industrial point of view. Very recently,novel metal-free mesoporous nitrogen-doped carbon catalysts have attracted large attention due to the unique reactivity and selectivity for the electrochemical hydrogen peroxide formation [1–3]. In this work,we provide deeper insights into the electrocatalytic activity, selectivity and durability of novel metal-free mesoporous nitrogen-doped carbon catalyst for the peroxide formation with a particular emphasis on the influence of experimental reaction parameters such as p H value and electrode potential for three different electrolytes. We used two independent approaches for the investigation of electrochemical hydrogen peroxide formation, namely rotating ring-disk electrode(RRDE) technique and photometric UV–VIS technique. Our electrochemical and photometric results clearly revealed a considerable peroxide formation activity as well as high catalyst durability for the metal-free nitrogen-doped carbon catalyst material in both acidic as well as neutral medium at the same electrode potential under ambient temperature and pressure. In addition, the obtained electrochemical reactivity and selectivity indicate that the mechanisms for the electrochemical formation and decomposition of peroxide are strongly dependent on the p H value and electrode potential. | Frédéric Hasché Mehtap Oezaslan Peter Strasser Tim-Patrick Fellinger | 2016 | Journal of Energy Chemistry2016，25，2： | 3 |
| 7 | Measurement of bound states in the continuum by a detector embedded in a photonic crystal显示文摘We directly measure optical bound states in the continuum(BICs)by embedding a photodetector into a photonic crystal slab.The BICs observed in our experiment are the result of accidental phase matching between incident,reflected and in-plane waves at seemingly random wave vectors in the photonic band structure.Our measurements were confirmed through a rigorously coupled-wave analysis simulation in conjunction with temporal coupled mode theory.Polarization mixing between photonic crystal slab modes was observed and described using a plane wave expansion simulation.The ability to probe the field intensity inside the photonic crystal and thereby to directly measure BICs represents a milestone in the development of integrated opto-electronic devices based on BICs. | Roman Gansch Stefan Kalchmair Patrice Genevet Tobias Zederbauer Hermann Detz Aaron M Andrews Werner Schrenk Federico Capasso Marko Lončar Gottfried Strasser | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 8 | Resistance Training in the Treatment of the Metabolic Syndrome显示文摘 | Barbara Strasser Uwe Siebert Wolfgang Schobersberger | 2010 | Sports Medicine2010，，5： | 2 |
| 9 | Sub-Compartmental Organization of Golgi-Resident N-Glycan Processing Enzymes in Plants显示文摘在所有优核质, Golgi 仪器是蛋白质 glycosylation 的主要地点。涉及 N-glycan 处理的 glycosidases 和 glycosyltransferases 被发现在他们提供功能的 Golgi 栈以内集中了,这广泛地被接受。而迟了行动的酶主要定位到栈的 trans 方面,这意味着在处理小径催化早步的酶主要在 cis 方面被定位,创造沿着 Golgi 的 cistrans 轴的不一致的分布。为他们排序到特定的 Golgi cisternae 的信息取决于信号的引人注目的证据自己以及在认出这些信号的 trafficking 机械上被编码为蛋白质, cisternal 亚区分被保留和检索机制的联合完成并且维持,这被相信。然而,包含的信号,机制,和分子的因素仍然是未知的。这里,我们探讨最近的调查结果并且在植物房间生物学总结这个基本过程的当前的理解。 | Jennifer Schoberer Richard Strasser | 2011 | Molecular Plant2011，4，2： | 2 |
| 10 | BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death显示文摘 | David C.S Huang Andreas Strasser | 2000 | Cell2000，，6： | 2 |
| 11 | <ce:link locator='fx1'/> Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation显示文摘 | Edward J. Gane Peter W. Angus Simone Strasser Darrell H.G. Crawford John Ring Gary P. Jeffrey Geoffrey W. McCaughan | 2007 | Gastroenterology2007，，3： | 2 |
| 12 | αvβ3 and αvβ5 Integrin Expression in Glioma Periphery显示文摘 | Lorenzo Bello Maura Francolini Paola Marthyn Jianping Zhang Rona S. Carroll Demetrios C. Nikas Jon F. Strasser Roberto Villani David A. Cheresh Peter McL. Black | 2001 | Neurosurgery2001，，2： | 2 |
| 13 | MODIFIED MELT TEXTURING PROCESS FOR YBCO BASED ON THE POLYTHERMIC SECTION YO1.5-BA0.4CU0.6O IN THE Y-BA-CU-O PHASE DIAGRAM AT 0.21 BAR OXYGEN PRESSURE显示文摘 | Krabbes G Schatzle P Bieger W Wiesner U Stover G Wu M Strasser T Litzkendorf D Fischer K Gornert P | | 0，，： | 2 |
| 14 | Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction显示文摘 | Bernd Ebner Stefan A. Lange Thomas Eckert Clementine Wischniowski Annette Ebner Rüdiger C. Braun-Dullaeus Christof Weinbrenner Carsten Wunderlich Gregor Simonis Ruth H. Strasser | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 15 | Atheoretical and experimental analysis of the qP and qN coefficients of chlorophyll fluorescence quenching and their relation to photochemical land non photochemical event显示文摘 | Havaux M Strasser R J Greppin H | 1991 | Photosynthesis Res1991，27，： | 1 |
| 16 | Apoptosis-based dual molecular targeting by INNO-406,asecond generation Bcr-Abl inhibitor,and ABT-737,an inhibitor of antiapoptotic Bcl-2 proteins,against Bcr-Abl-positive leukemia显示文摘 | Kuroda J Kimura S Strasser A | 2007 | Cell Death Differ2007，14，9： | 1 |
| 17 | Effects of monounsaturated fatty acids on glycaemic control in patients with abnormal glucose metabolism: a systematic review and meta-analysis显示文摘 | Schwingshackl L Strasser B Hoffmann G | 2011 | Ann Nutr Metab2011，58，4： | 1 |
| 18 | The role of Bcl-2 and its pro-sur- vival relatives in tumourigenesis and cancer therapy 显示文摘 | Kelly PN Strasser A | 2011 | Cell Death Differ2011，18，9： | 1 |
| 19 | NMDA receptor-mediated K+efflux and neuronal apoptosis显示文摘 | Yeh CH Strasser U | 1999 | Science1999，284，5412： | 1 |
| 20 | Angiostatin supress maligant glioma growth in vivo 显示文摘 | Strasser J Allende R | 1998 | Cancer Res1998，58，： | 1 |
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