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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 3 | Novel coumarin–benzimidazole derivatives as antioxidants and safer anti-inflammatory agents显示文摘Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position.The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activities along with less gastric toxicity profile.Two series of coumarin–benzimidazole derivatives(4a–e and 5a–e)were synthesized and evaluated for anti-inflammatory activity and antioxidant activity.Compounds 4c,4d and 5a displayed good anti-inflammatory(45.45%,46.75%and 42.85%inhibition,respectively,versus 54.54% inhibition by indomethacin)and antioxidant(IC_(50) of 19.7,13.9 and 1.2 mmol/L,respectively,versus 23.4 mmol/L for butylatedhydroxytoluene)activities.Evaluation of ulcer index and in vivo biochemical estimations for oxidative stress revealed that compounds 4d and 5a remain safe on gastric mucosa and did not induce oxidative stress in tissues.Calculation of various molecular properties suggests the compounds to be sufficiently bioavailable. | Radha Krishan Arora Navneet Kaur Yogita Bansal Gulshan Bansal | 2014 | Acta Pharmaceutica Sinica B2014，4，5： | 6 |
| 4 | Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux显示文摘AIM: To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS: We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and af- ter 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symp- tom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbroncho- dilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS: Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antire- flux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morn- ing PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on compar-ing the mean change from baseline after 16 wk (P < 0.01). | Bhavneesh Sharma Manisha Sharma Mradul Kumar Daga Gopal Krishan Sachdev Elliott Bondi | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 5 | Accurate simulation of surfaces and interfaces of ten FCC metals and steel using Lennard–Jones potentials显示文摘The earlier integration of validated Lennard–Jones(LJ)potentials for 8 fcc metals into materials and biomolecular force fields has advanced multiple research fields,for example,metal–electrolyte interfaces,recognition of biomolecules,colloidal assembly of metal nanostructures,alloys,and catalysis.Here we introduce 12-6 and 9-6 LJ parameters for classical all-atom simulations of 10 further fcc metals(Ac,Ca(α),Ce(γ),Es(β),Fe(γ),Ir,Rh,Sr(α),Th(α),Yb(β))and stainless steel.The parameters reproduce lattice constants,surface energies,water interfacial energies,and interactions with(bio)organic molecules in 0.1 to 5%agreement with experiment,as well as qualitative mechanical properties under standard conditions.Deviations are reduced up to a factor of one hundred in comparison to earlier Lennard–Jones parameters,embedded atom models,and density functional theory.We also explain a quantitative correlation between atomization energies from experiments and surface energies that supports parameter development.The models are computationally very efficient and applicable to an exponential space of alloys.Compatibility with a wide range of force fields such as the Interface force field(IFF),AMBER,CHARMM,COMPASS,CVFF,DREIDING,OPLS-AA,and PCFF enables reliable simulations of nanostructures up to millions of atoms and microsecond time scales.User-friendly model building and input generation are available in the CHARMM-GUI Nanomaterial Modeler.As a limitation,deviations in mechanical properties vary and are comparable to DFT methods.We discuss the incorporation of reactivity and features of the electronic structure to expand the range of applications and further increase the accuracy. | Krishan Kanhaiya Seonghan Kim Wonpil Im Hendrik Heinz | 2021 | npj Computational Materials2021，，1： | 2 |
| 6 | 不同时间脓毒症核转录因子-κB对细胞因子表达调节的实验研究显示文摘目的探讨在不同时间段内脓毒症核转录因子-κB(NuclearTranscriptionFactor,NF-κB)对细胞因子表达的调节及其临床意义。方法将30只小鼠分为正常对照组、假手术(sham)组和盲肠结扎(CLP)组,采用酶联免疫吸附法(ELISA)和RT-PCR法分别检测血清细胞因子(TNFα、IL-6和IL-10)总量和脾细胞相应细胞因子基因表达量。同时采用电泳迁移率滞后分析法检测核转录因子NF-κBDNA结合活性。结果CLP组细胞因子TNFα、IL-6和IL-10高于正常对照组和sham组;CLP组有活性的NF-κB增多,以正调节促炎细胞因子TNFα和IL-6表达为主,TNFα和IL-6基因表达增高,且在4~18h调节IL-6(P<0.01)的作用高于TNFα(P<0.05),而对抗炎因子IL-10的强化调节作用略有下降(P>0.05)。结论随着脓毒症时间的推移,活性NF-κB增多,对促炎因子的正调节作用高于抗炎因子,是造成促炎因子与抗炎因子不平衡的重要原因。不同时间脓毒症细胞因子失衡程度不同,脓毒症的发展趋势亦不同。 | 苏建荣 张正 孙东旭 Aparna Krishan Gabriel Fernandas | 2005 | 中国现代医学杂志2005，15，15： | 2 |
| 7 | APACHE II score is superior to SOFA , CTP and MELD in predicting the short‐term mortality in patients with acute‐on‐chronic liver failure ( ACLF )显示文摘 | Ajay Duseja Narendra S Choudhary Sachin Gupta Radha Krishan Dhiman Yogesh Chawla | 2013 | Journal of Digestive Diseases2013，，9： | 2 |
| 8 | Speeds of Sound and Excess Isentropic Compressibilities of Butyl Acetate+Aromatic Hydrocarbons显示文摘为丁基 acetate+benzene 的健全数据的速度,或甲苯,或 o 二甲苯,或 m 二甲苯,或 p 二甲苯二进制代码混合物在 308.15 K 在鼹鼠部分的全部范围上被测量了。过量 isentropic 压缩的可能性(KES ) 从声音和密度数据的速度被计算,源于臼齿的过量音量数据。KES 价值被使用图分析理论途径。KES 价值由与他们的相应试验性的价值相当作比较很好的图理论评估了。KES 数据也以 Redlich-Kister 多项式方程被表示导出系数和标准差。 | Bal Raj Deshwal Anu Sharma Krishan Chander Singh | 2008 | Chinese Journal of Chemical Engineering2008，16，4： | 2 |
| 9 | Indian patients with nonalcoholic fatty liver disease presenting with raised transaminases are different at presentation显示文摘 | Ajay Duseja Ashim Das Radha Krishan Dhiman Yogesh Kumar Chawla Reena Das Sanjay Bhadada Ravinder Sialy Kiran Kumar Thumburu Anil Bhansali Naveen Kalra | 2007 | World Journal of Gastroenterology2007，13，4： | 2 |
| 10 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining显示文摘 | KRISHAN A | | 0，，01： | 1 |
| 11 | Genome-wide transcriptomic analysis of cotton under drought stress reveal significant down-regulation of genes and pathways involved in fibre elongation and up-regulation of defense responsive genes显示文摘 | Kethireddy Venkata Padmalatha Gurusamy Dhandapani Mogilicherla Kanakachari Saravanan Kumar Abhishek Dass Deepak Prabhakar Patil Vijayalakshmi Rajamani Krishan Kumar Ranjana Pathak Bhupendra Rawat Sadhu Leelavathi Palakolanu Sudhakar Reddy Neha Jain Kasu N | 2012 | Plant Molecular Biology2012，，3： | 1 |
| 12 | Identification of apoptotic cells by formamide-induced DNA denaturation in condensed chromatin显示文摘 | Frankfurt OS Krishan A | 2001 | Histochem Cytochem2001，49，： | 1 |
| 13 | Effective Diffusivity Changes Du-ring Calcinations,Carbonation,Recalcination,and Sulfation of Limestones显示文摘 | Krishan V Sotirchos S V | 1994 | Che m Engng Sci1994，49，： | 1 |
| 14 | A finite element approaeh for analysis of a multi leaf spring using CAE tools 显示文摘 | Kumar Krishan Aggarwal M L | 2012 | Research Journal of Recent Sciences2012，1，2： | 1 |
| 15 | Fracture toughness of a soft sandstone显示文摘 | Krishan G R Zhao X L Zarnfln M | 1998 | International Journal of Rocks Mechanics and Mining Seiences1998，35，6： | 1 |
| 16 | Vascular endothelial dysfunction: a tug of war in diabetic nephropa- thy? 显示文摘 | Balakumar P Chakkarwar VA Krishan P | 2009 | Biomed Pharmacother2009，63，： | 1 |
| 17 | LNG-IUS versus oral progestogen treatment for endometrial hyperplasia:a long-term comparative cohort study显示文摘 | Gallos ID Krishan P Shehmar M | 2013 | Hum Reprod2013，28，11： | 1 |
| 18 | Filtering and smoothing in Hoo setting显示文摘 | Krishan M Nagpal Pramod P Khargonekar | 1991 | IEEE Trans on Automatic Control1991，36，2： | 1 |
| 19 | PPAR dual agonists: Are they opening Pandora’s Box?显示文摘 | Pitchai Balakumar Madhankumar Rose Subrahmanya S. Ganti Pawan Krishan Manjeet Singh | 2007 | Pharmacological Research2007，，2： | 1 |
| 20 | IntrameduUary nailing and plate osteosynthesis for fractures of the distal metc^hyseal tibia and fibula 显示文摘 | Krishan A Peshin C Singh D | 2009 | J Orthop Surg(Hong Kong)2009，17，3： | 1 |
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