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| 1 | The Role and Function of Ras-association domain family in Cancer:A Review显示文摘Ras gene mutation has been observed in more than 30%of cancers,and 90%of pancreatic,lung and colon cancers.Ras proteins(K-Ras,H-Ras,N-Ras)act as molecular switches which are activated by binding to GTP.They play a role in the cascade of cell process control(proliferation and cell division).In the inactive state,transforming GTP to GDP leads to the activation of GTpase in Ras gene.However,the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the protein.The activated Ras can promote the cell death or stop cell growth,which are facilitated by Ras-association domain family.Various studies have been conducted to determine the importance of losing RASSF proteins in Rasinduced tumors.This paper examines the role of Ras and RASSF proteins.In general,RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors. | Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri | 2019 | Genes & Diseases2019，6，4： | 10 |
| 2 | The Nuclear Factor KappaB(NF-kB)signaling in cancer development and immune diseases显示文摘The nuclear factor kappa B(NF-kB)family of transcription factors plays an essential role as stressors in the cellular environment,and controls the expression of important regula-tory genes such as immunity,inflammation,death,and cell proliferation.NF-kB protein is located in the cytoplasm,and can be activated by various cellular stimuli.There are two path-ways for NF-kB activation,as the canonical and non-canonical pathways,which require com-plex molecular interactions with adapter proteins and phosphorylation and ubiquitinase enzymes.Accordingly,this increases NF-kB translocation in the nucleus and regulates gene expression.In this study,the concepts that emerge in different cellular systems allow the design of NF-kB function in humans.This would not only allow the development for rare dis-eases associated with NF-kB,but would also be used as a source of useful information to elim-inate widespread consequences such as cancer or inflammatory/immune diseases. | Mohammad Reza Zinatizadeh Bettina Schock Ghanbar Mahmoodi Chalbatani Peyman Kheirandish Zarandi Seyed Amir Jalali Seyed Rouhollah Miri | 2021 | Genes & Diseases2021，8，3： | 8 |
| 3 | The Hippo Tumor Suppressor Pathway(YAP/TAZ/TEAD/MST/LATS)and EGFR-RAS-RAF-MEK in cancer metastasis显示文摘Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth.This pathway is activated in response to cell cycle arrest signals(cell polarity,transduction,and DNA damage)and limited by growth factors or mitogens associated with EGF and LPA.The major pathway consists of the central kinase of Ste20 MAPK(Saccharomyces cerevisiae),Hpo(Drosophila melanogaster)or MST kinases(mammalian)that activates the mammalian AGC kinase dmWts or LATS effector(MST and LATS).YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation(TEA domain family,TEAD1-4),stem cells(Oct4 mononuclear factor and SMAD-related TGFb effector),differentiation(RUNX1),and Cell cycle/apoptosis control(p53,p63,and p73 family members).This is due to the diverse roles of YAP and may limit tumor progression and establishment.TEAD also coordinates various signal transduction pathways such as Hippo,WNT,TGFb and EGFR,and effects on lack of regulation of TEAD cancerous genes,such as KRAS,BRAF,LKB1,NF2 and MYC,which play essential roles in tumor progression,metastasis,cancer metabolism,immunity,and drug resistance.However,RAS signaling is a pivotal factor in the inactivation of Hippo,which controls EGFR-RAS-RAF-MEK-ERKmediated interaction of Hippo signaling.Thus,the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer. | Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Raposo Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh | 2021 | Genes & Diseases2021，8，1： | 5 |
| 4 | The E×B drift instability in Hall thruster using 1D PIC/MCC simulation显示文摘The E×B drift instability is studied in Hall thruster using one-dimensional particle in cell(PIC)simulation method.By using the dispersion relation,it is found that unstable modes occur only in discrete bands in k space at cyclotron harmonics.The results indicate that the number of unstable modes increases by increasing the external electric field and decreases by increasing the radial magnetic field.The ion mass does not affect the instability wavelength.Furthermore,the results confirm that there is an instability with short wavelength and high frequency.Finally,it is shown that the electron and ion distribution functions deviate from the initial state and eventually the instability is saturated by ion trapping in the azimuthal direction.Also for light mass ion,the frequency and phase velocity are very high that could lead to high electron mobility in the axial direction. | Zahra Asadi Mehdi Sharifian Mojtaba Hashemzadeh Mahmood Borhani Zarandi Hamidreza Ghomi Marzdashti | 2020 | Chinese Physics B2020，29，2： | 2 |
| 5 | A Hybrid Fuzzy-ontology Based Intelligent System to Determine Level of Severity and Treatment Recommendation for Benign Prostatic Hyperplasia 显示文摘 | Torshizi A D Zarandi M H F Torshizi G D | 2014 | Computer Methods and Programs in Biomedicine2014，113，1： | 1 |
| 6 | The combination of antagonists of LHRH with antagonists of GHRH improves inhibition of androgen sensitive MDA-PCa-2b and LuCaP-35 prostate cancers显示文摘 | Schally AV Zarandi M | 2007 | Prostate2007，67，12： | 1 |
| 7 | Effect of A1 and Mn additions on rolling and deformation behavior of AZ series magnesium alloys显示文摘 | Zarandi F Scale G Verma R | 2008 | Materials Science and Engineering A2008，496，： | 1 |
| 8 | A Fuzzy Rule-Based Expert System forEvaluating Intellectual Capital 显示文摘 | Moliatnmad Hossein Fazel Zarandi Neda Mohammadhasan Susan Bastani | 2012 | Advances in Fuzzy Sys-tems2012，15，5： | 1 |
| 9 | Fuzzy agent-based expert system for steel making process显示文摘 | Fazel Zarandi M H Ahmadpour P | 2009 | Expert Systems with Applications2009，36，5： | 1 |
| 10 | Interval type-2 relative entropy fuzzy C-means clustering 显示文摘 | Zarinbal M Fazel Zarandi M H Turksen I B | 2014 | Information Sciences2014，272，10： | 1 |
| 11 | Fuzzy community detection model in social networks显示文摘 | GOLSEFID S M M ZARANDI M H F BASTANI S | 2015 | Interna- tional Journal of Intelligent Systems2015，30，12： | 1 |
| 12 | Adipose tissue derived multipotent mesenchymal stromal cells can be isolated using serum-free media显示文摘 | Ahrari I Purhabibi Zarandi N Khosravi Maharlooei M | 2013 | Iran Red Crescent Med J2013，15，4： | 1 |
| 13 | Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane:binding sites and implications for Alzheimer's disease显示文摘 | Verdier Y Zarandi M Penke B | | 0，，05： | 1 |
| 14 | Inhibition of GH release in rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)显示文摘 | Andrwew V Schally Marta Zarandi Kate Groot | 1997 | Peptides1997，18，3： | 1 |
| 15 | Mitigation of soft errors in SRAM-based FPGAs using CAD tools显示文摘 | Bahramnejad S and Zarandi H R | 2011 | Computers and Electrical Er~gineering2011，37，6： | 1 |
| 16 | Maximal covering location problem(MCLP)with fuzzy travel times显示文摘 | Soheil Davari Mohammad Hossein Fazel Zarandi Ahmad Hemmati | 2011 | Expert Sys-tems with Application2011，，38： | 1 |
| 17 | Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling显示文摘 | Kanashiro CA Schally AV Zarandi M | 2004 | Intern J Cancer2004，112，4： | 1 |
| 18 | Mechanism for Loss of Hot Ductility due to Deformation During Solidification in Continuous Casting of Steel显示文摘 | Zarandi F Yue S | 2004 | ISIJ Int2004，44，10： | 1 |
| 19 | A multi-agent system to solve the production distribution planning problem for a supply chain:a genetic algorithm approach显示文摘 | Kazemi A Zarandi M Husseini S | 2009 | 44( 1 ) : 180-1932009，44，1： | 1 |
| 20 | A Hy- brid Modeling Approach for Forecasting the Volatility of S&P 500 Index Return 显示文摘 | HAJIZADEH E SEIFI A ZARANDI M H F | 2012 | Expert System with Applica- tions2012，39，1： | 1 |
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