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| 1 | Blood loss,predictors of bleeding,transfusion practice and strategies of blood cell salvaging during liver transplantation显示文摘Blood loss during liver transplantation (OLTx) is a common consequence of pre-existing abnormalities of the hemostatic system,portal hypertension with multiple collateral vessels,portal vein thrombosis,previous abdominal surgery,splenomegaly,and poor 'functional' recovery of the new liver.The intrinsic coagulopathic features of end stage cirrhosis along with surgical technical difficulties make transfusion-free liver transplantation a major challenge,and,despite the improvements in understanding of intraoperative coagulation profiles and strategies to control blood loss,the requirements for blood or blood products remains high.The impact of blood transfusion has been shown to be significant and independent of other well-known predictors of posttransplant-outcome.Negative effects on immunomodulation and an increased risk of postoperative complications and mortality have been repeatedly demonstrated.Isovolemic hemodilution,the extensive utilization of thromboelastogram and the use of autotransfusion devices are among the commonly adopted procedures to limit the amount of blood transfusion.The use of intraoperative blood salvage and autologous blood transfusion should still be considered an important method to reduce the need for allogenic blood and the associated complications.In this article we report on the common preoperative and intraoperative factors contributing to blood loss,intraoperative transfusion practices,anesthesiologic and surgical strategies to prevent blood loss,and on intraoperative blood salvaging techniques and autologous blood transfusion.Even though the advances in surgical technique and anesthetic management,as well as a better understanding of the risk factors,have resulted in a steady decrease in intraoperative bleeding,most patients still bleed extensively.Blood transfusion therapy is still a critical feature during OLTx and various studies have shown a large variability in the use of blood products among different centers and even among individual anesthesiologists within the same center.Unfortunately,despite the large number of OLTx performed each year,there is still paucity of large randomized,multicentre,and controlled studies which indicate how to prevent bleeding,the transfusion needs and thresholds,and the 'evidence based' perioperative strategies to reduce the amount of transfusion. | Feltracco Paolo Brezzi Marialuisa Barbieri Stefania Galligioni Helmut Milevoj Moira Carollo Cristiana Ori Carlo | 2013 | World Journal of Hepatology2013，5，1： | 37 |
| 2 | Mouse models in male fertility research显示文摘男不孕的基因原因的有限知识导致了很少处理并且指向了治疗学的选择。尽管识别引起变化的不孕的理想的途径是在人的人口进行研究,这条途径由于此处描述的限制慢慢地进行了。给男富饶的复杂性,全部过程不能在 vitro 被建模。因此,动物当模特儿,特别地老鼠模型,为基因鉴定和试验提供一种珍贵选择。自从在动物模型生产的分子的生物学和最近的进展的介绍,在与许多疾病联系的基因的鉴定和描述有实质的加速,包括不孕。老鼠模型的三种主要类型通常在生物医学的研究被使用,包括 knockout/knockin/gene-trapped,转基因、导致化学药品的点异种老鼠。使用这些老鼠模型,在为男富饶的 400 基因必需品上被揭示了。然而,几千基因涉及男富饶的复杂过程的规定,这被估计了,当许多如此的基因尚待被描绘。当前的评论绝非是这些鼠标模型,的一张全面的表相当,它包含鼠标模型怎么推进了我们出生后的细菌房间开发和男富饶规定的知识的例子。 | Duangporn Jamsai Moira K O'Bryan | 2011 | Asian Journal of Andrology2011，13，1： | 10 |
| 3 | The role of cysteine-rich secretory proteins in male fertility显示文摘充满半胱氨酸的能分泌的蛋白质(CRISPs ) 是 CRISP,的亚群抗原 5 并且 Pr-1 (帽子) 蛋白质总科,并且仅仅在脊椎动物被发现。他们显示出强壮的表示偏爱到哺乳动物的男繁殖的道和有毒的爬行动物的毒液。在男繁殖的道以内, CRISPs 在跨越 haploid 细菌房间开发, epididymal 成熟, capacitation,活动性和授精的实际进程的男细菌房间生物学的许多方面被含有。在结构的水平, CRISPs 由二个领域,一个帽子领域,它在房间鈥揷e ll 粘附被含有,和一个松脆的领域组成,它被显示了越过多重种类调整离子隧道的几个班。此处,我们将在男富饶在 CRISPs 的角色上考察当前的文学,并且由到相关非哺乳动物的蛋白质的推理,推断潜在的生物化学的功能。 | Adam J Koppers Thulasimala Reddy Moira K O'Bryan | 2011 | Asian Journal of Andrology2011，13，1： | 8 |
| 4 | 北京和加拿大安大略省卒中/短暂性脑缺血发作基线和住院治疗的比较——来自中国国家卒中登记和加拿大卒中登记研究的结果显示文摘目的旨在比较中国北京和加拿大安大略省卒中/短暂性脑缺血发作(transient ischemic attack,TIA)住院患者的基线特征、卒中治疗和住院结局的差异。 方法中国国家卒中登记于2007年9月~2008年8月在北京地区的11个研究中心连续收集了1775例急性卒中及TIA患者。加拿大安大略省的数据来源于2007年4月~2008年3月安大略省的11个卒中中心的3551例卒中及TIA患者。本研究对北京地区患者的基线特征、卒中治疗和住院结局的数据进行了分析,并与加拿大卒中登记研究中安大略省的数据进行比较。 结果①基线信息:北京地区的患者较安大略省的患者年轻(64.5±12.9 vs 70.2±15.3,P<0.001),并且男性较多(64.8% vs 51.6%,P<0.001);既往史有吸烟、饮酒、卒中、高血压的比例北京地区均高于安大略省(P均<0.001),而既往史有TIA、高脂血症、心房颤动的人数安大略省高于北京地区(P均<0.001)。②院前信息:与安大略省的患者相比,北京地区的患者使用救护车到达急诊的比率较低(33.5% vs 78.4%,P<0.001),并且2.5 h内到达急诊的比例较低(21.0% vs 42.4%,P<0.001)。③治疗情况:北京地区的患者中,进行影像学检查的比例低于安大略省(93.9% vs 99.2%,P<0.001),并且进入卒中单元治疗的比例较低(23% vs 64.7%,P<0.001)。在缺血性卒中的患者中,北京地区的患者进行溶栓治疗的比例较低(8.1% vs 17.4%,P<0.001),然而伴有心房颤动的患者中,给与抗凝治疗的比例两者无明显的差异(75.9% vs 75.5%,P=0.945)。北京地区和安大略省地区缺血性卒中患者出院给予抗栓治疗的比例相近(77.0% vs 77.9%,P=0.544)。④结局事件:与安大略省地区相比,北京地区患者住院期间新发卒中的比例较低(3.4% vs 5.1%,P<0.001),然而住院期间肺炎的发生率较高(12.5% vs 7.6%,P<0.001)。北京地区患者的住院死亡率、7 d死亡率和30 d死亡率均显著低于安大略省地区(7.7% vs14.7%,5.7% vs9.3%,7.9% vs15.9%,P均<0.001)。 结论北京和安大略地区的卒中/TIA住院患者在基线信息、住院治疗和结局方面有较大的差异。认识到这些差异将有助于提高中国卒中住院治疗的质量,有助于更好地制订卒中的控制和预防策略。 | 刘改芬 房继明 宋彦丽 潘岳松 张润华 王伊龙 赵性泉 王春雪 Frank L.Silver Moira K.Kapral 王拥军 | 2014 | 中国卒中杂志2014，9，9： | 6 |
| 5 | Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy显示文摘 | Virginia Hernández-Gea Moira Hilscher Raphael Rozenfeld Maribel P. Lim Natalia Nieto Sabine Werner Lakshmi A. Devi Scott L. Friedman | 2013 | Journal of Hepatology2013，，1： | 2 |
| 6 | Exploring the effectiveness of bus rapid transit a prototype agent-based model of commuting behavior显示文摘 | Simon McDonnell Moira Zellner | 2011 | Transport Policy2011，，6： | 2 |
| 7 | General Practitioners'experiences of bereavement care and their educationalsupport needs:a qualitative study显示文摘 | Moira O ’ Connor Lauren J Breen | 2014 | BMC Med Educ2014，14，1： | 1 |
| 8 | Mediating Zones of Uncertainty: Interpreter Agency, the Interpreting Habitus and Political Asylum Adju- dication 显示文摘 | Moira Inghillefi | 2005 | The Translator2005，11，1： | 1 |
| 9 | The nystagmus-associated FRMD7 gene regulatesneuronal outgrowth and development显示文摘 | Betts-Henderson J Bartesaghi S Moira Crosier | 2010 | Hum Moler Genet2010，19，2： | 1 |
| 10 | Intralesional injection of herpes simplex virus 1716 in metastatic melanoma显示文摘 | Rona M MacKie Barry Stewart S Moira Brown | 2001 | The Lancet2001，，9255： | 1 |
| 11 | Moral Issues in Sport : The Child's Perspective显示文摘 | MOIRA E STUART | 2003 | Res Q Exe Sport2003，4，： | 1 |
| 12 | Experiences in the internationalization of educa- tion:Strategies to promote equality opportunity at Monterrey Tech 显示文摘 | Moira Murphy | 2007 | Higher Education2007，，53： | 1 |
| 13 | Online customer experience: A review of the business-to-consumer online purchase context显示文摘 | Susan Rose Neil Hair and Moira Clark | 2011 | International Journal of Management Reviews2011，13，1： | 1 |
| 14 | Bone strength and its determinants in pre-and early pubertal boys and girls显示文摘 | Heather Macdonald Saija Kontulainen Moira Petit | 2006 | Bone2006，39，： | 1 |
| 15 | Nowhere to hide: Awareness and perceptions of environmental change, and their influence on relationships with place显示文摘 | Ruth Rogan Moira O’Connor Pierre Horwitz | 2005 | Journal of Environmental Psychology2005，，2： | 1 |
| 16 | Signaling Aggression显示文摘 | Moira J. van Staaden William A. Searcy Roger T. Hanlon | 2011 | Advances in Genetics2011，，： | 1 |
| 17 | A Comparison of Two Sight Word Reading Fluency Drill Formats显示文摘 | Maureen Sullivan Moira Konrad LauriceM. Joseph KenC. T. Luu | 2013 | Preventing School Failure: Alternative Education for Children and Youth2013，，2： | 1 |
| 18 | Serum 25-Hydroxyvitamin D Levels Are Strongly Related to Systolic Blood Pressure But Do Not Predict Future Hypertension显示文摘 | Rolf Jorde Yngve Figenschau Nina Emaus Moira Hutchinson Guri Grimnes | 2010 | Hypertension2010，，3： | 1 |
| 19 | Customer experience quality:an exploration in business and consumer contexts using repertory grid technique显示文摘 | Fred Lemke Moira Clark Hugh Wilson | | 0，，： | 1 |
| 20 | A RANK / TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function显示文摘 | Allison P A Mark E T Moira G | 2002 | J Biol Chem2002，277，44： | 1 |
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