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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Molecular biology of high-grade gliomas: what should the clinician know?显示文摘The current World Health Organization classification system of primary brain tumors is solely based on morphologic criteria. However, there is accumulating evidence that tumors with similar histology have distinct molecular signatures that significantly impact treatment response and survival. Recent practice-changing clinical trials have defined a role for routine assessment of O-6-methylguanine-DNA methyltransferase(MGMT) promoter methylation in glioblastoma patients, especially in the elderly, and 1p and 19q codeletions in patients with anaplastic glial tumors. Recently discovered molecular alterations including mutations in IDH-1/2, epidermal growth factor receptor(EGFR), and BRAF also have the potential to become targets for future drug development. This article aims to summarize current knowledge on the molecular biology of high-grade gliomas relevant to daily practice. | Silvia Hofer Elisabeth Rushing Matthias Preusser Christine Marosi | 2014 | Chinese Journal of Cancer2014，33，1： | 7 |
| 3 | Geochemistry of fine-grained sediments of the upper Cretaceous to Paleogene Gosau Group(Austria,Slovakia):Implications for paleoenvironmental and provenance studies显示文摘到从地上凿穿和露头地区的 Paleogene Gosau 组(北石灰质的阿尔卑斯山脉,奥地利和斯洛伐克) 的上面的白垩纪的 169 件有细密纹理的沉积样品的体积岩石地球化学被执行分开非海洋、海洋的存款。用专业的不同 Gosau depositional 系统,盆和沉积起源的 Geochemical 特征 -- ,踪迹 -- ,并且稀土元素元素也被调查。象硼集中那样的 Geochemical 代理为寻求 paleosalinity 指示物的可能性被测试。由于几远洋的节被极其低的硼内容代表的事实, B/Al * | Gerald Hofer Michael Wagreich Stephanie Neuhuber | 2013 | Geoscience Frontiers2013，4，4： | 5 |
| 4 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 5 | Economic impact of minimally invasive lumbar surgery显示文摘Cost effectiveness has been demonstrated for traditional lumbar discectomy, lumbar laminectomy as well as for instrumented and noninstrumented arthrodesis. While emerging evidence suggests that minimally invasive spine surgery reduces morbidity, duration of hospitalization, and accelerates return to activites of daily living, data regarding cost effectiveness of these novel techniques is limited. The current study analyzes all available data on minimally invasive techniques for lumbar discectomy, decompression, short-segment fusion and deformity surgery. In general, minimallyinvasive spine procedures appear to hold promise in quicker patient recovery times and earlier return to work. Thus, minimally invasive lumbar spine surgery appears to have the potential to be a cost-effective intervention. Moreover, novel less invasive procedures are less destabilizing and may therefore be utilized in certain indications that traditionally required arthrodesis procedures. However, there is a lack of studies analyzing the economic impact of minimally invasive spine surgery. Future studies are necessary to confirm the durability and further define indications for minimally invasive lumbar spine procedures. | Christoph P Hofstetter Anna S Hofer Michael Y Wang | 2015 | World Journal of Orthopedics2015，6，2： | 4 |
| 6 | Spin in the extended electron model显示文摘扩大电子的一个模型是适合描述经由扫描掘显微镜获得的理论模拟和试验性的结果的更多,这被发现了,但是当动态性质容易被合并时,磁性,并且特别地电子旋转性质当测量不在时由于他们的构思的 isotropy 提出一个问题。一个电子的旋转与一个磁场反应并且因此有向量的性质。然而,电子纺纱也是各向同性的,建议它没有向量的性质。在对电子旋转的描述的这中央冲突,我们相信,矛盾的性质的许多的根为量旋转粒子被测量并且要求。利用电子旋转在真实三维的空间一致地在被描述的一个模型 -- 一个扩大电子模型 -- 我们证明纺纱可以被向量描述并且仍然维持它的 isotropy。在这个框架,我们重新估计连续大小的 Stern-Gerlach 实验, Einstein-Podolsky-Rosen 实验,和效果并且在所有情况中发现相当直觉的解释。 | Thomas Pope Werner Hofer | 2017 | Frontiers of physics2017，12，3： | 3 |
| 7 | Application of microprobe-based flank method analysis of Fe^3+ in garnet ofNorth Qilian eclogite and its geological implication显示文摘A newly developed microprobe-based methodology(the Flank Method)for Fe^(3+)/RFe quantification has been successfully applied to some natural garnets from the North Qilian eclogites by JEOL JXA-8100microprobe at Peking University.The results demonstrated an obvious discrepancy in comparison with the outcomes by conventional stoichiometric calculations.This methodology allows to measure theFe^(3+)/Rmeasurement of Fe^(3+)According to the compositional zonation displayed in the studied eclogitic garnets from North Qilian,a prograde metamorphic°C to 22 kbar,600°C was reconstructed.More interestingly,the measured Fe^(3+)/RFe ratios in garnets decreasing from core to rim may probably imply that the oxygen fugacity(f O_2)declines with the depth of the subduction zone. | Xiaoli Li Shuguang Song Lifei Zhang E. Heidi Hofer | 2018 | Science Bulletin2018，63，5： | 3 |
| 8 | Solving the Einstein-Podolsky-Rosen puzzle: The origin of non-locality in Aspect-type experiments显示文摘 | Werner A. Hofer | 2012 | Frontiers in Biology2012，7，5： | 3 |
| 9 | Estimating hospital deaths due to medical errors显示文摘 | Hayward RA Hofer TP | | 0，，： | 2 |
| 10 | Double-strand breaks from 125I incorporated in the DNA and cell death显示文摘 | Charlton DE Hofer KG Van Loon N | 1994 | Int J Radiat Biol1994，66，： | 2 |
| 11 | Heisenberg, uncertainty, and the scanning tunneling microscope显示文摘 | Werner A. Hofer (1) | 2012 | Frontiers of physics2012，7，2： | 2 |
| 12 | Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain显示文摘 | Hofer M Pagliusi SR Hohn A | 1990 | EM BO1990，9，： | 2 |
| 13 | The Adaptive Solar Facade: From concept to prototypes显示文摘 | Zoltan Nasy Bratislav Svetozarevic Praseeth Jayathissa Moritz Begle Johannes Hofer Gearoid Lydon Anja Willmann Arno Schlueter | 2016 | Frontiers of Architectural Research2016，5，2： | 2 |
| 14 | Template-directed assembly of pentacene molecules on epitaxial graphene on Ru(0001)显示文摘 | Haitao Zhou Lizhi Zhang Jinhai Mao Geng Li Yi Zhang Yeliang Wang Shixuan Du Werner A. Hofer Hong-Jun Gao | 2013 | Nano Research2013，6，2： | 2 |
| 15 | 面动脉穿支皮瓣修复口周缺损显示文摘背景面动脉穿支皮瓣概念的发展,让口周缺损的修复术有更多的自由性。面动脉的单个穿支可以为面部皮肤较大面积的带蒂穿支皮瓣供血。方法对5个新鲜尸体的10个面动脉注射填充液,并解剖,研究面动脉穿支的分布、数量、长度和直径。对5例肿瘤相关的口周缺损患者实施面动脉穿支皮瓣修复术。其中2例额外使用局部皮瓣。外科技术以美学单位原则和多普勒超声识别的面动脉为依据,面动脉作为识别相应面动脉穿支的标志。结果尸体解剖发现大量的均匀分布的面动脉穿支(平均5.7;范围3~9)。平均穿支长度为25.2mm(13.0~51.0mm)。平均穿支直径为1.2mm(0.6~1.8mm)。所有临床病例中,相应的面动脉穿支符合再造术的需求。皮瓣旋转180°。4例皮瓣全部存活。1例皮瓣显示较小的远端坏死。结论因为面动脉穿支皮瓣具有穿支较恒定、较大幅度旋转和供体位点美观等优点,其可提供通用的特制皮瓣。因其蒂较薄,其也是Ⅰ期再造术的理想皮瓣,而不需要Ⅱ期修整。 | Stefan O. P. Hofer Nicole A. Posch Xander Smit 朱利娜(译) 魏峰(译) 高景恒(译) | 2013 | 中国美容整形外科杂志2013，24，5： | 2 |
| 16 | Episodes of hypocarbia and early-onset sepsis are risk factors for cystic periventricular leukomalacia in the preterm infant显示文摘 | B. Resch K. Neubauer N. Hofer E. Resch U. Maurer J. Haas W. Müller | 2011 | Early Human Development2011，，1： | 2 |
| 17 | The role of metastasisassociated protein 1 in prostate cancer progression 显示文摘 | Hofer MD Kuefer R Varambally S | 2004 | Cancer Res2004，64，： | 1 |
| 18 | Advanced chronic lung disease:need for an active inter-disciplinary approach显示文摘 | Hofer M | 2007 | Swiss Med Wkly2007，137，4344： | 1 |
| 19 | Competition for cytokines : T (reg) cells take all 显示文摘 | Scheffold A Murphy KM Hofer T | 2007 | Nat Immunol2007，8，： | 1 |
| 20 | Inhibition of cyclooxygenase 2 in mice increases production of g esf and induces radioprotection显示文摘 | Hofer M Pospisil M Hola J | 2008 | Radiation Res2008，170，5： | 1 |
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