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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Retention of fiber posts on dependent resin cements显示文摘 | Wrbas KT Kampe MT SchirrmeisterJF | 2006 | Schweiz Monat sschr Zahnmed2006，116，1： | 1 |
| 3 | Centrilobular necrosis in autoimmune hepatitis:a histological feature associated with acute clinical presentation显示文摘 | Hofer H Oesterreicher C Wrba F | 2006 | J Clin Pathol2006，59，3： | 1 |
| 4 | Centrilobular necrosis in autoim- mune hepatitis : a histological feature associated with acute clinical pres- entation显示文摘 | Hofer H Oesterreicher C Wrba F | 2006 | J Clin Pathol2006，59，3： | 1 |
| 5 | 显示文摘 | Ott G Wrba J Lucke R | 2003 | J Magn Magn Mater2003，，： | 1 |
| 6 | In vivo comparison of working length determination with two electronic apex locators 显示文摘 | Wrbas K T Ziegler A A Altenburger M J | 2007 | Int Endod J2007，40，2： | 1 |
| 7 | Retention of fiber posts dependent on different resin cements 显示文摘 | Wrbas KT Kampe MT Sehirrmeister J F | 2006 | Schweiz Monat sschr Zahnmed2006，116，1： | 1 |
| 8 | In vivo com- parison of working length determination with two electronic apex locators 显示文摘 | Wrbas KT Ziegler AA Altenburger MJ | 2007 | International EndodonticJournal2007，40，8： | 1 |
| 9 | Down-regulation of miR-221 andmiR-222 correlates with pronounced Kit expression in gastrointesti-nal stromal tumors显示文摘 | Koelz M Lense J Wrba F | 2011 | International Journal of Oncology2011，38，2： | 1 |
| 10 | EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corre- sponding locoregional lymph node metastases 显示文摘 | Schmid K Oehl N Wrba F | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 11 | The implementation of minimally-invasive esophagectomy does not impact short-term outcome in a high-volume center 显示文摘 | Schwameis K Ba-Ssalamah A Wrba F | 2013 | Anticancer Res2013，33，5： | 1 |
| 12 | Recent developments of Mn-Zn ferrite for high permeability applications显示文摘 | Ott G Wrba J Lucke R | 2003 | J Magn Magn Mater2003，，： | 1 |
| 13 | In situ mRNA hybridization analysis and immunolocalization of the vitamin D receptor in normal and carcinomatous human colonic mucosa: relation to epidermal growth factor receptor expression显示文摘 | Yuri Sheinin Klaus Kaserer Friedrich Wrba Etienne Wenzl Stefan Kriwanek Meinrad Peterlik Heide S. Cross | 2000 | Virchows Archiv2000，，5： | 1 |
| 14 | Uhrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast显示文摘 | Wrba F Ellinger A Reiner G | 1988 | Virchows Arch A Pathol Anat Histopathol1988，413，5： | 1 |
| 15 | The relationship between strength,power and ballistic performance显示文摘 | WRBA(S)I(C) N DOWLING J J | | 0，，： | 1 |
| 16 | Effectiveness of a hand file and three nickel-titanium rotary instruments for removing gutta-percha in curved root canals during retreatment显示文摘 | Schirrmeister JF Wrbas KT Schneider FH | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，101，4： | 1 |
| 17 | EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases显示文摘 | Schnid K Oehl N Wrba F | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 18 | HPV infection and p16 expression in carcinomas of the minor salivary glands 显示文摘 | Markus Brunner Oskar Koperek Fritz Wrba | 2012 | Eur Arch Otorhinolaryngo12012，269，10： | 1 |
| 19 | Surgery for gastrointestinal stromal tumors of the stomach 显示文摘 | Silberhumer GR Hufschmid M Wrba F | 2009 | J Gastrointest Surg2009，13，7： | 1 |
| 20 | Lactate dehydrogenase from the extreme thermophile Thermotoga maritima显示文摘 | Wrba A Jaenicke R Huber R | 1990 | European Journal of Biochemistry1990，188，1： | 1 |
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