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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | 预测颈内动脉狭窄患者卒中风险的新工具显示文摘如果将所有患者均纳入考察范围的话,可以发现对无症状性颈内动脉(ICA)狭窄患者进行颈内动脉再通术使患者获益微小。因此,很重要的一点就是能够找出具有较高风险的一类患者,这样才能使颈内动脉再通术治疗成为最优选择。 | Reinhard M Schwarzer G Briel M 本刊编辑部 | 2014 | 临床荟萃2014，29，11： | 11 |
| 3 | Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization显示文摘临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那 probiotic。这里,我们在过敏促进感受性上分析了三选择乳杆菌紧张的 immunomodulatory 性质和他们的混合的影响赌 1 用一只 gnotobiotic 老鼠建模的 v。我们显示出那乳杆菌(L.) rhamnosus LOCK0900, L。rhamnosus LOCK0908 和 L。casei LOCK0919 经由像使用费的受体被认出 2 (TLR2 ) 并且核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产 cytokines 的导出髓的树枝状的房间。殖民无菌(GF ) 有所有三紧张(Lmix ) 的混合物的鼠标由加强 enterocytes 的顶端的 junctional 建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与 Lmix 开拓殖民地于并且敏化 1 变应原到赌注 v 的老鼠显著地象一个增加的转变生长因素(TGF ) 一样在 sera 和肠的 lavages 显示出变应原特定的 IgE, IgG1 和 IgG2a 和提高的全部的 IgA 水平的底层 -β与敏化的 GF 老鼠相比铺平。从开拓殖民地于 Lmix 的老鼠的 Splenocytes 和 mesenteric 淋巴节点房间显示出 TGF-β 的重要 upregulation;在以后在有赌注 v 的 vitro 刺激 1。我们的结果证明 Lmix 殖民改进了内脏对赌注 v 的上皮的障碍和减少的过敏促进感受性 1。而且,这些调查结果被传播和能分泌的 IgA 和规章的 cytokine TGF-β 的增加的生产伴随;。因此,三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。 | Hana Kozakova Martin Schwarzer Ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 4 | 睾丸主要血管或睾丸网旁取精点与取精成功率不具显著相关性:以220例非梗阻性无精子症患者行传统或显微睾丸取精术为例显示文摘采用传统与显微睾丸取精术相结合方式对220例梗阻性无精症患者行精子提取术,如果传统手术方式未见精子即为阴性取精位点,然后选取2—3个阴性取精位点行显微睾丸取精术。术中通过手术显微镜评价睾丸血管系统,同时记录阳性取精位点与睾丸血供的关系。总的精子获取率为58-2%,早期应用传统手术方式精子获取率为46.8%,而后行显微睾丸取精术则精子获取率增加11.7%。故显微睾丸取精术的应用可显著增加精子获取率(P=0.017),且在睾丸网或睾丸主要血管处并不能显著增加阳性取精位点。 | J Ullrich Schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann Wolfgang Würfel | 2013 | Asian Journal of Andrology2013，15，6： | 5 |
| 5 | Optimistic self-beliefs:Assessment of general perceived self-efficacy in thirteen euhures显示文摘 | Schwarzer R Aristi B | 1997 | World Psychology1997，3，12： | 1 |
| 6 | Measuring optimistic self-beliefs:A Chinese adaptation of the general self-efficacy scale显示文摘 | ZHANG J X SCHWARZER R | 1995 | Psychologia1995，38，3： | 1 |
| 7 | Measuring optimistic self-beliefs:a Chinese adaptation of the general self-efficacy scale显示文摘 | Zhang JX Schwarzer R | 1995 | Psychologia1995，38，3： | 1 |
| 8 | Optimistic self-beliefs assessment of gen- eral perceived self-efficacy in thirteen cultures显示文摘 | Schwarzer R Aristi B | 1997 | Word Psychology1997，3，12： | 1 |
| 9 | Optimistic self-beliefs: assessment of general perceived self-efficacy in thirteen cultures显示文摘 | Schwarzer R Aristi B | 1997 | World Psy- chol1997，3，12： | 1 |
| 10 | Biological reaction to vibration implications for sport显示文摘 | MESTER J SPITZENFEIL P SCHWARZER J | 1999 | Sci Med Sport1999，，： | 1 |
| 11 | Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice显示文摘 | Sainsbury A Schwarzer C Couzens M | 2002 | Diabetes2002，51，： | 1 |
| 12 | Measuring optimistic self - beliefs: A Chinese adaptation of the General Self - efficacy Scale 显示文摘 | ZHANG J X SCHWARZER R | 1995 | Psychologia1995，38，3： | 1 |
| 13 | On the misuse of artificial neural networks for prognostic and diagnostic classification in ontology 显示文摘 | Guido Schwarzer | 2000 | Statistics in Medicine2000，19，： | 1 |
| 14 | The re1 ative con- tributions of the disc and zygapophyseal joint in chronic low back pain 显示文摘 | Schwarzer AC Aprill CN Derby R | 1994 | Spine1994，19，7： | 1 |
| 15 | The ability of computed tomography to identify a painful zygapophysial joint in patients with chronic low back pain显示文摘 | Schwarzer AC Wang SC O'Driscoll D | 1995 | Spine1995，20，8： | 1 |
| 16 | Clinical and immunologiceffects of intranodal autologous tumor lysate-dendritic cell vaccinewith aldesleukin(interleukin 2)and IFN-alpha 2a therapy in me-tastatic renal cell carcinoma patients显示文摘 | Schwaab T Schwarzer A Wolf B | 2009 | Clin Cancer Res2009，15，15： | 1 |
| 17 | Standardized evalua- tion of magnetic resonance images using a metric TMJ analy- sis显示文摘 | Bumann A Schwarzer CL Nies RM | 1996 | EurJ Orthod1996，18，： | 1 |
| 18 | Measuring Optimistic Self-Beliefs: A Chinese Adaptation of the General Self-Efficacy Scale显示文摘 | Zhang J X Schwarzer R | 1995 | Psychologia1995，38，3： | 1 |
| 19 | Notch is an essential up- stream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells 显示文摘 | Schwarzer R Dorken B Jundt F | 2012 | Leukemia2012，26，4： | 1 |
| 20 | ART culture conditions change the probability of mouse enbryo gestation through defined cellular and molecular reponses 显示文摘 | SCHWARZER C ESTEVES TC ARAUZO-BRAVO MJ | 2012 | Hum Reprod2012，27，9： | 1 |
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