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| 1 | Recurrent thrombotic occlusion of a transjugular intrahepatic portosystemic stent-shunt due to activated protein C resistance显示文摘The transjugular intrahepatic portosystemic stent-shunt (TIPS) has successfully been used in the management of refractory variceal bleeding and ascites in patients with portal hypertension. Major drawbacks are the induction of hepatic encephalopathy and shunt dysfunction. We present a 59-year-old woman with alcoholic liver cirrhosis who received a TIPS because of recurrent bleeding from esophageal varices. Stent occlusion occurred 4 mo after placement of the TIPS. Laboratory testing revealed resistance to activated protein C (APC). Combination therapy with low-dose enoxaparin and clopidogrel could not prevent her recurrent stent occlusion. Finally, therapy with high-dose enoxaparin was sufficient to prevent further shunt complications up to now (follow-up period of 1 year). In conclusion, early occlusion of a TIPS warrants testing for thrombophilia. If risk factors are confirmed,anticoagulation should be intensified. There are currently no evidence-based recommendations regarding the best available anticoagulant therapy and surveillance protocol for patients with TIPS. | Elmar Siewert Jan Salzmann Edmund Purucker Karl Schürmann Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，32： | 7 |
| 2 | Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver显示文摘Elevated iron stores as indicated by hyperferritinemiawith normal or mildly elevated transferrin saturation a n d m o s t l y m i l d h e p a t i c i r o n d e p o s i t i o n a r e a characteristic finding in subjects with non-alcoholic fatty liver disease(NAFLD). Excess iron is observed in approximately one third of NAFLD patients and is commonly referred to as the 'dysmetabolic iron overload syndrome'. Clinical evidence suggests that elevated body iron stores aggravate the clinical course of NAFLD with regard to liver-related and extrahepatic disease complications which relates to the fact that excess iron catalyses the formation of toxic hydroxylradicals subsequently resulting in cellular damage. Iron removal improves insulin sensitivity, delays the onset of type 2 diabetes mellitus, improves pathologic liver function tests and likewise ameliorates NAFLD histology. Several mechanisms contribute to pathologic iron accumulation in NAFLD. These include impaired iron export from hepatocytes and mesenchymal Kupffer cells as a consequence of imbalances in the concentrations of iron regulatory factors, such as hepcidin, cytokines, copper or other dietary factors. This review summarizes the knowledge about iron homeostasis in NAFLD and the rationale for its therapeutic implications. | Elmar Aigner Gunter Weiss Christian Datz | 2015 | World Journal of Hepatology2015，7，2： | 6 |
| 3 | Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua显示文摘Artemisinin,a constituent of Artemisia annua L.,is a well-known antimalarial drug.Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo.Herbal extracts of A.annua inhibit the growth of cancer cell lines.Here,we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma.The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A.annua.One cat and one dog with fibrosarcoma survived 40 and 37 months,respectively,without tumor relapse.Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months,respectively.A.annua was well tolerated without noticeable side effects.These four cases indicate that A.annua may be a promising herbal drug for cancer therapy. | Elmar Breuer Thomas Efferth | 2014 | Natural Products and Bioprospecting2014，4，2： | 4 |
| 4 | Risk Assessment for Tuzla Naval Base Breakwater显示文摘In the applications of reliability-based risk assessment methodology in Turkey, only wave characteristics, tidal range, storm surge, wave set-up, and structural system parameters were included in the past. Tsunami risk was not considered as a major design parameter and thus, was not included in the computation. After a strong earthquake (M w= 7.4) occurred near the town of Golcuk, Izmit Bay, Western Turkey at 00:01 GMT on August 17, 1999, chaotic water movements were observed on the coast of the Marmara Sea. Rubble mound breakwaters demonstrated very little damage, as predicted by the reliability-based risk assessment model developed in this study for the Tuzla Naval Base. For determination of the probability of occurrence under design conditions, which is a function of storm waves, tidal range, storm surge, and tsunami height, the Monte Carlo simulation was interrelated with the β Ⅱ method. For the Tuzla Naval Base main breakwater, tsunami was not the key design parameter when compared to storm waves, however, in places with great seismic activity, tsunami risk can be significant depending on the probability of occurrence and the magnitude of the tsunami. | Can Elmar BALAS | 2003 | 海洋工程:英文版2003，17，3： | 4 |
| 5 | 从中欧博士生培养模式比较探索创新型博士的培养显示文摘创新能力是博士生培养的核心内容和重要任务,与西方发达国家相比,我国博士生创新能力培养目前还存在一些缺憾。本文通过实地考察和文献调研,深入剖析欧洲博士生培养模式,并从选拔方式、课程设置、导师指导和考核评价四个方面对中欧博士生的培养模式进行分析比较,提出构建我国创新型博士培养模式的对策建议。 | 成花林 黄雨 Elmar Schmaltz Stefan Steger | 2017 | 研究生教育研究2017，，1： | 3 |
| 6 | Importance of intellectual property generated by biomedical research at universities and academic hospitals显示文摘Biomedical research has many different facets.Researchers and clinicians study disease biology and biochemistry to discover novel therapeutic targets,unravel biochemical pathways and identify biomarkers to improve diagnosis,or devise new approaches to clinically manage diseases more effectively.In all instances,the overall goal of biomedical research is to ensure that results thereof(such as a therapy,a device,or a method which may be broadly referred to as“inventions”)are clinically implemented.Most of the researchers’efforts are centered on the advance of technical and scientific aspects of an invention.The development and implementation of an invention can be arduous and very costly.Historically,it has proven to be crucial to protect intellectual property rights(IPR)to an invention(i.e.,a patent)to ensure that companies can obtain a fair return on their investment that is needed to develop an academic invention into a product for the benefit of patients.However,the importance of IPR is not generally acknowledged among researchers at academic institutions active in biomedical research.Therefore this paper aims to(1)raise IP awareness amongst clinical and translational researchers;(2)provide a concise overview of what the patenting trajectory entails;and(3)highlight the importance of patenting for research and the researcher.Importance for patients:Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions,and indirectly enables the financing of clinical studies,mainly by opening up funding opportunities(e.g.specific grants aimed at start-ups,pre-seed and seed capital)that otherwise would not be accessible.As a consequence,patented inventions are more likely to become clinically tested and reach the market,providing patients with more treatment options. | Joris J.Heus Elmar S.de Pauw Mirjam Leloux Margherita Morpurgo Michael R Hamblin Michal Heger | 2017 | Journal of Clinical & Translational Research2017，3，2： | 3 |
| 7 | Gore-Tex膜引导骨再生技术在种植体周围炎治疗中的应用显示文摘目的 :评价Gore_Tex膜引导骨再生技术治疗种植体周围炎的临床疗效。方法 :对3例种植体周围炎患者局部冲冼和药物治疗控制感染后行翻瓣刮治 ,应用Gore_Tex膜覆盖骨缺损 ,术后6月去除膜 ,摄X线片及进行临床评价。结果 :3例骨缺损者均完全再生修复 ,种植体稳定。结论 :局部冲冼和翻瓣刮治后 ,应用Gore_Tex膜覆盖骨缺损治疗种植体周围炎 ,可获得骨组织再生修复。 | 黄盛兴 Erenhard Reuter Elmar Kassan | 2000 | 中国口腔种植学杂志2000，5，4： | 3 |
| 8 | Effect of Vachellia tortilis on understory vegetation,herbaceous biomass and soil nutrients along a grazing gradient in a semi-arid African savanna显示文摘The spatial pattern and abundance of herbaceous vegetation in semi-arid savannas are dictated by a complex and dynamic interaction between trees and grasses. Scattered trees alter the composition and spatial distribution of herbaceous vegetation under their canopies. Therefore, we studied the effect of Vachellia tortilis on herbaceous vegetation composition, biomass and basal area, and soil nutrients on sites with varying grazing intensities in the central rift valley of Ethiopia. Data were collected on species composition, cover and biomass of herbs and grasses, and soil moisture and nutrient contents under light,medium, and heavy grazing pressures, both under the inside and outside of V. tortilis canopies. Species richness was similar in both locations but decreased with increased grazing. Only the overall biomass and herb cover were significantly greater under the canopy than outside, and overall biomass showed significant unchanging decline with increased grazing. However, vegetation cover was significantly greater on moderately grazed sites compared to low and heavily grazed sites. All soil variables were significantly higher under V. tortilis canopies than outside.Our findings suggest that V. tortilis has more effect on composition and diversity of herbaceous vegetation than on species richness, and that V. tortilis promotes the herbaceous layer biomass by reducing soil moisture loss and increasing soil fertility under the inside than outside the canopies. Therefore, we suggest that management practices should be directed on reducing pressure on V. tortilis by regulating grazing. Low to moderate grazing levels(i.e., a stocking rate less than 39.6 TLU ha^(-1) yr^(-1)) seems to be tolerable to ensure sustainable conservation of the species in the study area in particular and in semi-arid savannas in general. | Temesgen Yadeta Elmar Veenendaal Karle Sykora Zewdu K.Tessema Addisu Asefa | 2018 | Journal of Forestry Research2018，29，6： | 3 |
| 9 | Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction显示文摘 | Andreas H. Mahnken Ralf Koos Marcus Katoh Elmar Spuentrup Petra Busch Joachim E. Wildberger Harald P. Kühl Rolf W. Günther | 2005 | European Radiology2005，，4： | 2 |
| 10 | Damage visualization and deformation measurement in glass laminates during projectile penetration显示文摘Transparent armor consists of glass-polymer laminates in most cases.The formation and propagation of damage in the different glass layers has a strong influence on the ballistic resistance of such laminates.In order to clarify(he course of events during projectile penetration,an experimental technique was developed,which allows visualizing the onset and propagation of damage in each single layer of the laminate.A telecentric objective lens was used together with a microsecond video camera that allows recording 100 frames at a maximum rate of 1 MHz in a backlit photography set-up.With this technique,the damage evolution could be visualized in glass laminates consisting of four glass layers with lateral dimensions 500 mm x 500 mm.Damage evolution was recorded during penetration of 7.62 mm AP projectiles with tungsten carbide core and a total mass of 1 1.1 g in the impact velocity range from 800 to 880 m/s.In order to measure the deformation of single glass plates within the laminates,a piece of reflecting tape was attached to the corresponding glass plate,and photonic Doppler velocimetry(PDV) was applied.With the photonic Doppler velocimeter.an infrared laser is used to illuminate an object to be measured and the Doppler-shifted light is superimposed to a reference light beam at the detector.The simultaneous visualization and PDV measurement of the glass deformation allow determining the deformation at the time of the onset of fracture.The analysis of the experimental data was supported by numerical simulations,using the AUTODYN commercial hydro-code. | Elmar STRASSBURGER Steffen BAUER Gregor POPKO | 2014 | Defence Technology(防务技术)2014，10，2： | 2 |
| 11 | Computed tomography in gastrointestinal stromal tumors显示文摘 | Nadir Ghanem Carsten Altehoefer Alex Furtw?ngler Jan Winterer Oliver Sch?fer Oliver Springer Elmar Kotter Mathias Langer | 2003 | European Radiology2003，，7： | 2 |
| 12 | Hepatitis B core particles as a universal display model: a structure-function basis for development显示文摘 | Paul Pumpens Elmars Grens | 1999 | FEBS Letters1999，，1： | 2 |
| 13 | Flash X-ray cinematography analysis of dwell and penetration of smallcaliber projectiles with three types of SiC ceramics显示文摘In order to improve the performance of ceramic composite armor it is essential to know the mechanisms during each phase of the projectile–target interaction and their influence on the penetration resistance.Since the view on the crater zone and the tip of a projectile penetrating a ceramic is rapidly getting obscured by damaged material,a flash X-ray technique has to be applied in order to visualize projectile penetration.For this purpose,usually several flash X-ray tubes are arranged around the target and the radiographs are recorded on film.At EMI a flash X-ray imaging method has been developed,which provides up to eight flash radiographs in one experiment.A multi-anode 450 k V flash X-ray tube is utilized with this method.The radiation transmitted through the target is then detected on a fluorescent screen.The fluorescent screen converts the radiograph into an image in the visible wavelength range,which is photographed by means of a high-speed camera.This technique has been applied to visualize and analyze the penetration of 7.62 mm AP projectiles into three different types of Si C ceramics.Two commercial Si C grades and MICASIC(Metal Infiltrated Carbon derived Si C),a C-Si Si C ceramic developed by DLR,have been studied.The influences,not only of the ceramic but also the backing material,on dwell time and projectile erosion have been studied.Penetration curves have been determined and their relevance to the ballistic resistance is discussed. | Elmar STRASSBURGER Steffen BAUER Steffen WEBER Heiner GEDON | 2016 | Defence Technology(防务技术)2016，12，3： | 2 |
| 14 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 15 | Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line HepG2 显示文摘 | Jens N Fozia N Elmar H | 2009 | Toxicol Appl Pharm2009，240，： | 1 |
| 16 | Phosphorus-based flame retardants for thermoplastics 显示文摘 | ELMAR S | 2007 | Plastics Additives and Compounding2007，9，3： | 1 |
| 17 | Preoperative acute hypervolemic hemodilution with hydroxyethylstarch:an alternative to acute normovolemic hemodilution?显示文摘 | Mielke L Elmar K Mickael K | 1997 | Anesth Analg1997，84，： | 1 |
| 18 | Preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII显示文摘 | Sabine B. Zollner Elmar Raquet Jochen Müller-Cohrs Hubert J. Metzner Thomas Weimer Ingo Pragst Gerhard Dickneite Stefan Schulte | 2013 | Thrombosis Research2013，，： | 1 |
| 19 | 干旱气候条件下石膏板小区法海滩幼龄白蜡林水分消耗量评价(英文)显示文摘在奥地利东部深厚的黄土区 ,利用石膏板小区法 ,通过测量土壤水分平衡 ,对生长在海滩的幼龄白蜡水青冈树混交林的蒸散量进行了估算 ,发现在 2 0 0 0年 4月到 2 0 0 4年 3月观察期间 ,幼龄白蜡林的年实际蒸散量达 712mm/a ,消耗了所有 6 44mm年降雨量以及 2 6 8mm的土壤储水量 ,并且没有明显深层渗漏。在根部土壤剖面平均土壤水吸力小于 0 4MPa状况下 ,主要生长季节 (6月到 9月 )的彭曼公式作物系数为 1 4 ,同时发现 ,当根部土壤剖面平均土壤水吸力为 1 7MPa时 ,该系数会线性递减至 0 2。 | Eduard Klaghofer Elmar Stenitzer | 2004 | 中国水土保持科学2004，2，3： | 1 |
| 20 | Phosphorus-based Flame Retardants for Thermoplastics显示文摘 | ELMAR Schmitt | 2007 | Plastics Additives and Compounding2007，9，3： | 1 |
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