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    题名 作者 年代 出处 被引量
1Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma.Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber 2010World Journal of Gastroenterology2010,16,7:43
2白垩纪期间极端温暖的深海古温度记录显示文摘Brian T Huber 周立君 2002海洋地质动态2002,18,10:19
3In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin.Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz 2008World Journal of Gastroenterology2008,14,20:18
4阳离子蛋白衍生物助剂在染色莫代尔织物皂洗中的应用显示文摘将阳离子蛋白衍生物助剂WLS-20应用到活性染料染色莫代尔织物皂洗中,研究WLS-20在活性染料染色莫代尔织物皂洗中的应用效果,对比经WLS-20皂洗处理和未经该助剂处理织物的耐摩擦色牢度、耐洗色牢度、润湿性、透气性、抗皱性。结果表明,经WLS-20助剂防沾处理,皂洗时白布沾色明显减少,染色织物耐摩擦色牢度、耐洗色牢度和润湿性均有所提高,透气性和抗皱性均无明显变化,从而为有效利用废弃物,开发绿色环保助剂提供一条新途径。刘元军 赵晓明 拓晓 Anja Huber 2015丝绸2015,52,11:11
5新鲜颞骨模型建立在中耳传声机制研究中的作用显示文摘目的探讨中耳传声机制研究中的中耳模型建立,为深入研究中耳传声机制,指导耳外科手术,尤其在听骨链重建方面建立一个接近活体情况的研究模型。方法采用17例新鲜尸体颞骨标本,利用激光多普勒振动仪,在声刺激和不同强度的机械刺激下,研究了鼓膜和镫骨底板的运动。结果鼓膜和镫骨底板的运动与活体测量的数据接近。结论新鲜颞骨标本可以用于不同方面中耳传声机制的研究。在鼓膜脐部的电机械刺激可以模仿声刺激。马芙蓉 Thomas Linder Alex Huber Heidi Felix Anita Pollak 2005中国耳鼻咽喉头颈外科2005,12,6:9
6玻璃纤维膨体花式纱的性能研究显示文摘为了改善玻璃纤维膨体纱的织造性能,将玻璃纤维膨体纱加工成玻璃纤维膨体花式纱。以断裂强力、断裂伸长率和条干均匀率为评价指标,优化出最佳的玻璃纤维膨体花式纱制备工艺。然后,研究了玻璃纤维膨体花式纱的形态结构、导热系数及热防护性能。结果表明:速比为1.0,捻度为80捻/m时,玻璃纤维膨体花式纱的性能最佳;膨体花式纱具备良好的蓬松性及热防护性能,其导热系数为0.1 W/(m·K),是一种性能良好的保温材料。刘元军 赵晓明 李卫斌 拓晓 Anja Huber 2015丝绸2015,52,12:8
7比较3.0T膝关节成像中各向同性三维快速自旋回波成像与标准二维成像的影像质量及诊断价值显示文摘本研究的目的是比较新开发的脂肪抑制中间加权(IM-w)3D快速自旋回波(FSE)序列与标准2D IM-w FSE序列评价膝关节异常表现的影像质量及诊断价值。50例病人行3.0TMRI检查。影像由3名放射科医师独立评估。2DFSE序列的影像质量评定明显高于3D(P〈0.05)。3D序列对软骨病变的敏感度略高。但特异度较低。2D序列显示低对比的结构效果较好,而高对比的结构在3D序列显示更好。2D序列的可信度评分高于3D序列,但差异无统计学意义。O. Ristow L. Steinbach G. Sabo R. Krug M. Huber I. Rauscher 刘艳杰(译) 李威(校) 2009国际医学放射学杂志2009,32,4:8
8Anatomy of a eustatic event during the Turonian (Late Cretaceous) hot greenhouse climate显示文摘Sequence stratigraphic studies consider relative change in sea level(as regulated by eustasy,local tectonics and sediment supply)as the main builder of the stratigraphic record.Eustasy has generally been considered as a consequence of the growth and decay of continental ice sheets that would explain large,rapid changes in sea level,even during periods of relative global climatic warmth.However,such a mechanism has become increasingly difficult to envision during times of extreme global warmth such as the Turonian,when the equator-to-pole temperature gradient was very low and the presence of polar ice seems improbable.This paper investigates the timing and extent of sea level falls during the late Cenomanian through Turonian,especially the largest of those events,sequence boundary KTu4,which occurred during the middle to late Turonian peak of the Cretaceous hot greenhouse climate.We conclude that the amplitude of the widespread third-order sea level fall in the middle Turonian that is centered at^91.8 Ma varies at different locations depending on the influence of dynamic topography on local tectonics and regional climatic conditions.Ice volume variations seem unlikely as a mechanism for controlling sea level at this time.However,this causal factor cannot be ruled out completely since Antarctic highlands(if they existed in the Late Cretaceous)could sequester enough water as ice to cause eustatic falls.To ascertain this requires detailed tomographic imaging of Antarctica,followed by geodynamic modeling,to determine whether high plateaus could have existed to accumulate ephemeral ice sheets.Other mechanisms for sea level change,such as transference between ground water(a small amplitude shorter time scale effect)and the ocean and entrainment and release of water from the mantle to the oceanic reservoir(a potentially large amplitude and longer time scale process),are intriguing and need to be explored further to prove their efficacy at third-order time scales.Bilal U. HAQ Brian T. HUBER 2017Science China Earth Sciences2017,60,1:8
9Water Resource Monitoring Exploiting Sentinel-2 Satellite and Sentinel-2 Satellite Like Time Series;Application in Yangtze River Water Bodies显示文摘As part of the Dragon 4 project,the water extents of Wuchang and Shengjin lakes have been extracted from Sentinel-2 time series,using all exploitable images since the beginning of the acquisitions in 2015.The aim of the study is to assess the capability of the Sentinel-2 constellation and Landsat 8 over the Anhui region,especially the high temporal resolution.A total of 32 dates have been used and 10 Landsat 8 images(Libra)have been added to try to reduce the temporal gaps in the Sentinel-2 acquisitions caused by cloudy conditions.Extractions were done using a SERTIT-ICube automatized routine based on a supervised Maximum Likelihood Classification.These extractions allow to recreate the dynamic of the two lakes and show the drought and wet periods.During the 3 years interval,the surface peaks in July 2016 for both lakes.The lowest level appears at two different dates for each lake;in January 2018 for Wuchang,in February 2017 for Shengjin.Wuchang Lake surface area appears to be more variable than Shengjin Lake,with many local maximum and minimum between the end of 2017 and April 2018.In the case of Wuchang Lake,floating vegetation is a problem for automatic water surface area extraction.The lake is covered by vegetation during long periods of time and the water below can’t be detected by automatic radiometric means.Nevertheless,Sentinel-2 stays a pertinent and powerful tool for hydrological monitoring of lakes confirming the expectation from the remote sensing wetland community before launch.The presence of NIR and SWIR bands induces a strong discrimination between water and other classes,and the systematic acquisitions create dense time series,making analysis more consistent.It makes possible to sensor events occurring over short periods of time.Thanks to this a link can be done between endangered bird species,such as the Siberian Crane and the Lesser White-Fronted Goose and periodically flooded areas.These midterm results illustrated the pertinence and powerful of multi-source optical satellite data for environmental analysis.Julien BRIANT Huber CLAIRE Studer MATHIAS Lei CAO Kunpeng YI Yésou HERV 2020Journal of Geodesy and Geoinformation Science2020,3,4:8
10大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini 2021英国医学杂志中文版2021,24,8:7
11Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature显示文摘BACKGROUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing enteropathy.The disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and lymphopenia.Since the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among others.Although usually developing in early childhood,we present the case of a 34-yearold woman with PIL.Moreover,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in adults.CASE SUMMARY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower limbs.Interestingly,a striking collinearity of clinical symptoms with female hormone status was evident.Additionally,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were evident.Due to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and hypoalbuminemia.The diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via enteroscopy.Consecutively,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of follow-up.CONCLUSION PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in adulthood.Due to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and welltolerated.This leads to a significant disease burden in affected patients.PIL is increasingly been recognized in adults since the majority of case reports were published within the last 10 years,pointing towards an underestimation of the true prevalence.The association with female hormone status warrants further investigation.Rudolf Huber Georg Semmler Alexander Mayr Felix Offner Christian Datz 2020World Journal of Gastroenterology2020,26,48:6
12血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R 2010中华高血压杂志2010,18,12:6
13生物质和废弃油脂流化床共催化热解实验研究显示文摘本文在连续进料流化床实验台上采用ZSM-5催化剂对生物质和废弃油脂单独催化热解以及共催化热解进行了实验研究。主要考察了反应温度和质量空速对废弃油脂催化热解以及不同有效氢碳比对生物质和废弃油脂共催化热解的影响。结果表明,在温度为550℃、质量空速为0.35h^(-1)时,总化学品(芳香烃+烯烃+C5化合物)碳产率达到最大值(53.9%)。生物质和废弃油脂共催化热解能够大幅提高烯烃和芳香烃的产率,在较高有效氢碳比下(>0.8),丙烯的选择性高达60%。张会岩 肖睿 George W Huber 2013工程热物理学报2013,34,4:5
14早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G 2017中华高血压杂志2017,25,4:5
15NAD+metabolism:pathophysiologic mechanisms and therapeutic potential显示文摘Nicotinamide adenine dinucleotide(NAD^(+))and its metabolites function as critical regulators to maintain physiologic processes,enabling the plastic cells to adapt to environmental changes including nutrient perturbation,genotoxic factors,circadian disorder,infection,inflammation and xenobiotics.These effects are mainly achieved by the driving effect of NAD^(+)on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions.Besides,multiple NAD^(+)-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA,RNA and proteins,or releasing second messenger cyclic ADPribose(cADPR)and NAADP^(+).Prolonged disequilibrium of NAD^(+)metabolism disturbs the physiological functions,resulting in diseases including metabolic diseases,cancer,aging and neurodegeneration disorder.In this review,we summarize recent advances in our understanding of the molecular mechanisms of NAD^(+)-regulated physiological responses to stresses,the contribution of NAD^(+)deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.Na Xie Lu Zhang Wei Gao Canhua Huang Peter Ernst Huber Xiaobo Zhou Changlong Li Guobo Shen Bingwen Zou 2020Signal Transduction and Targeted Therapy2020,5,1:5
16Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen 2007Cell Stem Cell2007,,3:5
17Organizational Learning: The Contributing Processes and the Literatures显示文摘George P. Huber 1991Organization Science1991,,1:5
18内源乙烯与1-MCP互作对番茄成熟和细胞壁物质代谢的影响显示文摘【目的】探讨内源乙烯与1-MCP的相互作用对贮藏过程中番茄成熟和细胞壁代谢的影响。【方法】将破色期番茄('佛罗里达47')果实分为4组,其中2组经低压低氧(8kPa,1.7kPaO2)处理6h后,分别立即使用50μg/L液态1-MCP(HH+1-MCP)或去离子水(HH)浸泡1min;另外2组未经HH处理的番茄果实,也分别使用50μg/L1-MCP(1-MCP)或去离子水(对照)浸泡1min,测定处理后果实在贮藏(20℃)过程中成熟相关生理指标及细胞壁组分的变化。【结果】番茄果实经HH处理后,内源乙烯含量(IEC)急剧降低至对照水平的75.6%,且对1-MCP的反应敏感性有所提高。HH+1-MCP处理显著抑制了果实硬度的下降,其硬度值在贮藏第4~16天中,平均分别较对照和1-MCP处理高29.8%和15.6%;HH+1-MCP处理果实的呼吸和乙烯峰出现时间均较对照推迟4d,较1-MCP处理推迟2d,但对峰值影响未达到显著水平;与1-MCP处理相比,HH+1-MCP处理对多聚半乳糖醛酸酶(PG)、果胶甲脂酶(PME)、α-半乳糖苷酶(α-Gal)、β-半乳糖苷酶(β-Gal)等细胞壁降解酶活性的变化影响较大,对PG的影响尤为明显;HH+1-MCP处理还显著地抑制了番茄果实贮藏期水溶性和CDTA溶性糖醛酸(UA)含量的增加,其水溶性UA含量在贮藏的第6~12天平均值分别较对照和1-MCP处理低37.3%和21.9%,其CDTA溶性UA含量在贮藏的第6~12天平均值分别较1-MCP处理果实低31.4%和20.5%;凝胶渗透色谱分析结果显示,1-MCP和HH+1-MCP处理延缓了番茄果实多聚糖醛酸分子的降解过程,且后者效果更为明显。此外,本试验HH处理各项测定指标与对照无显著差异。【结论】内源乙烯含量是调节1-MCP反应能力的重要因素,解释了不同跃变型果实在成熟起始后对1-MCP反应敏感性差异的原因。张正科 HUBER Donald J LEE James H 饶景萍 2010西北农林科技大学学报(自然科学版)2010,38,11:5
19心脏磁共振灌注成像用于冠状动脉疾病功能评价:与冠状动脉造影和血流储备分数的比较显示文摘Aims: Cardiac magnetic resonance perfusion imaging(CMRI) is a promising technique for non-invasive measurement of myocardial perfusion reserve. Fractional flowreserve(FFR) is an established invasive method for functional assessment of coronary artery disease(CAD). To prospectively assess the diagnostic value of CMRI for the detection of haemodynamically significant coronary lesions, compared with coronary angiography(CA) and FFR. Methods and results: Forty-three patients with suspected or known CAD underwent CA, CMRI, and FFR measurement. First pass magnetic resonance perfusion examination was performed during hyperaemia(140 μg/kg/min adenosine over 6 min) and at rest. One hundred and twenty-nine perfusion territories were assessed by semi-quantitative evaluation of signal intensity-time curves using the myocardial perfusion reserve index(MPRI)[upslopestress(corrected)/ upsloperest(corrected)]. Perfusion territories were categorized as normal(coronary stenosis≤50%), intermediate(stenosis >50%and FFR >0.75), or severe(stenosis >50%and FFR≤0.75 or total occlusion). MPRI values(±SD) were significantly different between the three categories[normal, 2.2±0.5 vs. intermediate, 1.8±0.5(P=0.005) and intermediate vs. severe, 1.2±0.3(P< 0.001)]. An MPRI cut-off value of 1.5(derived from receiver operating characteristics analysis) distinguished haemodynamically relevant(severe) from non-relevant(normal and intermediate) stenoses with a sensitivity of 88%(CI 74-100%)and a specificity of 90%(CI 84-96%). Conclusion: In contrast to earlier studies that compared CMRI with morphological examination(CA) alone, the present study compared CMRI with CA plus a standard invasive functional assessment(FFR) and demonstrated that CMRI is able to distinguish haemodynamically relevant from non-relevant coronary lesions with a high sensitivity and specificity and may therefore contribute to clinical decision-making.Rieber J. Huber A. Erhard I. 郭俊 2006世界核心医学期刊文摘(心脏病学分册)2006,,12:4
20滤泡辅助性T细胞的研究进展显示文摘滤泡辅助性T细胞(Tfh)是最近发现的CD4^+辅助性T淋巴细胞亚群,其作用是辅助B细胞的抗体产生.其发生、分化和功能均独立于以往的Th1、Th2和Th17细胞,是体液免疫反应的关键.转录因子Bcl-6和Blimp-1在Tfh细胞的分化中起着关键的、相互拮抗的作用,调节趋化因子受体、表面分子和细胞因子等表达,这些因子对Tfh细胞募集和B细胞辅助功能非常重要.刘巍 Sally Huber 2010国际免疫学杂志2010,33,5:4
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