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| 1 | Silvicultural alternatives to conventional even-aged forest man-agement-what limits global adoption?显示文摘Background: The development of forestry as a scientific and management discipline over the last two centuries has mainly emphasized intensive management operations focused on increased commodity production, mostly wood. This 'conventional' forest management approach has typically favored production of even-aged, single-species stands. While alternative management regimes have generally received less attention, this has been changing over the last three decades, especially in countries with developed economies. Reasons for this change include a combination of new information and concerns about the ecological consequences of intensive forestry practices and a willingness on the part of many forest owners and society to embrace a wider set of management objectives. Alternative silvicultural approaches are characterized by a set of fundamental principles, including avoidance of clearcutting, an emphasis on structural diversity and small-scale variability, deployment of mixed species with natural regeneration,and avoidance of intensive site-preparation methods.Methods: Our compilation of the authors' experiences and perspectives from various parts of the world aims to initiate a larger discussion concerning the constraints to and the potential of adopting alternative silvicultural practices.Results: The results suggest that a wider adoption of alternative silvicultural practices is currently hindered by a suite of ecological, economic, logistical, informational, cultural, and historical constraints. Individual contexts display their own unique combinations and relative significance of these constraints, and accordingly, targeted efforts, such as regulations and incentives, may help to overcome specific challenges.Conclusions: In a broader context, we propose that less emphases on strict applications of principles and on stand structures might provide additional flexibility and facilitate the adoption of alternative silvicultural regimes in a broader set of circumstances. At the same time, the acceptance of alternative silvicultural systems as the 'preferred or default mode of management' wil necessitate and benefit from the continued development of the scientific basis and valuation of a variety of ecosystem goods and services. This publication is aimed to further the discussion in this context. | Klaus J Puettmann Scott McG Wilson Susan C Baker Pablo J Donoso Lars Dr?ssler Girma Amente Brian D Harvey Thomas Knoke Yuanchang Lu Susanna Nocentini Francis E Putz Toshiya Yoshida Jürgen Bauhus | 2015 | Forest Ecosystems2015，2，2： | 4 |
| 2 | Local Ablative Therapy of Oligoprogressive Disease Prolongs Disease Control by Tyrosine Kinase Inhibitors in Oncogene-Addicted Non–Small-Cell Lung Cancer显示文摘 | Andrew J. Weickhardt Benjamin Scheier Joseph Malachy Burke Gregory Gan Xian Lu Paul A. Bunn Dara L. Aisner Laurie E. Gaspar Brian D. Kavanagh Robert C. Doebele D. Ross Camidge | 2012 | Journal of Thoracic Oncology2012，，12： | 3 |
| 3 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 4 | Removing polybrominated diphenyl ethers in pure water using Fe/Pd bimetallic nanoparticles显示文摘Polybrominated diphenyl 醚(PBDE ) 广泛地被用作 fire-retardants。由于他们的高生产体积,普遍用法,和环境坚持, PBDE 在各种各样的 environments.Nanoscale zero-valent 铁(ZVI ) 成为了无所不在的沾染物是为许多 halogenated 有机化合物的有效 reductant。提高降级效率, ZVI/Palladium 二金属的 nanoparticles (nZVI/Pd ) 在这研究被综合降级水里的 decabromodiphenyl 醚(BDE209 ) 。约 90% BDE209 被 nZVI/Pd 很快在 80 min 以内移开,而大约 25% BDE209 被 nZVI 移开。由 nZVI/Pd 的 BDE209 的降级适合伪 first-order 动力学。pH 的增加严厉地导致了减少 BDE209 的率降级。在有在 9.0 点的起始的 pH 的处理的降级率常数是超过 6.8 ? ?? 猠数瑣潲桰瑯浯瑥祲 ????????? 焠慵瑮晩捩瑡潩吗?? | Min ZHANG Jian LU ZhenchengXU Yiliang HF Bo ZHANG Song JIN Brian BOMAN | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 2 |
| 5 | Chronic exposure to high-density polyethylene microplastic through feeding alters the nutrient metabolism of juvenile yellow perch (Perca flavescens)显示文摘Microplastics are emergent contaminants threatening aquatic organisms including aquacultured fish.This study investigated the effects of high-density polyethylene(HDPE,100 to 125 mm)on yellow perch(Perca flavescens)based on integrative evaluation including growth performance,nutritional status,nutrient metabolism,fish health,and gut microbial community.Five test diets(0,1,2,4,or 8 g HDPE/100 g diet)containing 41%protein and 10.5%lipid were fed to juvenile perch(average body weight,25.9±0.2 g;n=15)at a feeding rate of 1.5%to 2.0%body weight daily.The feeding trial was conducted in a flow-through water system for 9 wk with 3 tanks per treatment and 15 yellow perch per tank.No mortality or HDPE accumulation in the fish was found in any treatments.Weight gain and condition factor of fish were not significantly impacted by HDPE(P>0.05).Compared to the control group,fish fed the 8%HDPE diet had significantly decreased levels of protein and ash(P<0.05).In response to the increasing levels of HDPE exposure,the hepatosomatic index value,hepatocyte size,and liver glycogen level were increased,but lipid content was reduced in the liver tissues.Compared to the control treatment,fish fed the 8%HDPE diet had significant accumulations of total bile acids and different metabolism pathways such as bile acid biosynthesis,pyruvate metabolism,and carnitine synthesis.Significant enterocyte necrosis was documented in the foregut of fish fed the 2%or 8%HDPE diet;and significant cell sloughing was observed in the midgut and hindgut of fish fed the 8%HDPE diet.Fish fed the 2%HDPE diet harbored different microbiota communities compared to the control fish.This study demonstrates that HDPE ranging from 100 to 125 mm in feed can be evacuated by yellow perch with no impact on growth.However,dietary exposure to HDPE decreased whole fish nutrition quality,altered nutrient metabolism and the intestinal histopathology as well as microbiota community of yellow perch.The results indicate that extended exposure may pose a risk to fish health and jeopardize the nutrition quality of aquacultured end product.This hypothesis remains to be investigated further. | Xing Lu Dong-Fang Deng Fei Huang Fabio Casu Emma Kraco Ryan J.Newton Merry Zohn Swee J.Teh Aaron M.Watson Brian Shepherd Ying Ma Mahmound A.O.Dawood Lorena M.Rios Mendoza | 2022 | Animal Nutrition2022，，2： | 1 |
| 6 | Application of digital image analysis and flow cytometry to enumerate marine viruses stained with SYBR Gold显示文摘 | Chen F Lu J R Brian J B | 2001 | Appl Environ Mierobiol2001，67，2： | 1 |
| 7 | Effects of benzo( a )pyrene exposure on killifish ( Fundulus heteroclitus ) aromatase activities and mRNA显示文摘 | Monali R. Patel Brian E. Scheffler Lu Wang Kristine L. Willett | 2006 | Aquatic Toxicology2006，，3： | 1 |
| 8 | Aromatase expression in the human breast显示文摘 | Angela Brodie Brian Long Qing Lu | 1998 | Breast Cancer Research and Treatment1998，，1： | 1 |
| 9 | Factors contributing to the efficacy of concurrent–adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Combined analyses of NPC-9901 and NPC-9902 Trials显示文摘 | Anne W.M. Lee Stewart Y. Tung Roger K.C. Ngan Rick Chappell Daniel T.T. Chua T.X. Lu Lillian Siu Terence Tan L.K. Chan W.T. Ng T.W. Leung Y.T. Fu Gordon K.H. Au C. Zhao Brian O’Sullivan E.H. Tan W.H. Lau | 2010 | European Journal of Cancer2010，，5： | 1 |
| 10 | Unraveling female reproductive senescence to enhance healthy longevity显示文摘In a society where women often want successful careers and equal opportunities to men,the early nature of ovarian aging often forces women to make difficult life choices between career and family development.Fertility in women begins to decline after the age of 37 years and it is rare for pregnancies to occur after 45.This reproductive decline in women is inevitable and culminates in menopause,which is a major driver of age-related diseases.In a world where biomedical advances are leading to modifiable biological outcomes,it is time to focus on mitigating female reproductive senescence to maintain fertility and preserve age-related hormonal functions,with the goal of providing increased life choices and enhancing healthspan.To date,reproductive longevity research remains an understudied field.More needs to be done to unravel the biology of the ovarian follicles,which are the functional units of reproductive lifespan and are comprised of cell types including the oocyte(female gamete)and a group of specialized supporting somatic cells.Biological attempts to maintain the quality and quantity of follicles in animal models through manipulating pathways involved in aging can potentially prolong female reproductive lifespan and healthspan.Here,we summarize the molecular events driving ovarian aging and menopause and the interventional strategies to offset these events.Developing solutions to female reproductive senescence will open doors to discover ways to enhance true healthy longevity for both men and women. | Lu Dong Daniel Boon Loong Teh Brian Keith Kennedy Zhongwei Huang | 2023 | Cell Research2023，33，1： | 1 |
| 11 | Mass and charge transport relevant to the formation of toroidal lithium peroxide nanoparticles in an aprotic lithium-oxygen battery: An experimental and theoretical modeling study显示文摘 | Xiangyi Luo Rachid Amine Kah Chun Lau Jun Lu Chun Zhan Larry A. Curtiss Said AI Hallaj Brian P. Chaplin Khalil Amine | 2017 | Nano Research2017，10，12： | 1 |
| 12 | A Comparison of Patients With Hepatitis B– or Hepatitis C–Based Advanced-Stage Hepatocellular Carcinoma显示文摘 | Brian I. Carr Vito Guerra Jennifer L. Steel Sheng-Nan Lu | 2015 | Seminars in Oncology2015，，2： | 1 |
| 13 | An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress显示文摘 | Heather P. Harding Yuhong Zhang Huiquing Zeng Isabel Novoa Phoebe D. Lu Marcella Calfon Navid Sadri Chi Yun Brian Popko Richard Paules David F. Stojdl John C. Bell Thore Hettmann Jeffrey M. Leiden David Ron | 2003 | Molecular Cell2003，，3： | 1 |
| 14 | Peroxisome proliferator-activated receptory promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2 显示文摘 | Lu C Brian MN Weidong S | 2006 | J Biol Chem2006，34，24： | 1 |
| 15 | Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs显示文摘 | Paul Nkansah Amy Antipas Ying Lu Manthena Varma Charles Rotter Brian Rago Ayman El-Kattan Graeme Taylor Mario Rubio John Litchfield | 2013 | Journal of Controlled Release (-)2013，，1： | 1 |
| 16 | Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease显示文摘Background In Alzheimer’s Disease(AD),about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways.Among them,the Ras and Rab Interactor 3(RIN3)is a guanine nucleotide exchange factor(GEF)for the Rab5 small GTPase family and has been implicated to be a risk factor for both late onset AD(LOAD)and sporadic early onset AD(sEOAD).However,how RIN3 is linked to AD pathogenesis is currently undefined.Methods Quantitative PCR and immunoblotting were used to measure the RIN3 expression level in mouse brain tissues and cultured basal forebrain cholinergic neuron(BFCNs).Immunostaining was used to define subcellular localization of RIN3 and to visualize endosomal changes in cultured primary BFCNs and PC12 cells.Recombinant flag-tagged RIN3 protein was purified from HEK293T cells and was used to define RIN3-interactomes by mass spectrometry.RIN3-interacting partners were validated by co-immunoprecipitation,immunofluorescence and yeast two hybrid assays.Live imaging of primary neurons was used to examine axonal transport of amyloid precursor protein(APP)andβ-secretase 1(BACE1).Immunoblotting was used to detect protein expression,processing of APP and phosphorylated forms of Tau.Results We have shown that RIN3 mRNA level was significantly increased in the hippocampus and cortex of APP/PS1 mouse brain.Basal forebrain cholinergic neurons(BFCNs)cultured from E18 APP/PS1 mouse embryos also showed increased RIN3 expression accompanied by early endosome enlargement.In addition,via its proline rich domain,RIN3 recruited BIN1(bridging integrator 1)and CD2AP(CD2 associated protein),two other AD risk factors,to early endosomes.Interestingly,overexpression of RIN3 or CD2AP promoted APP cleavage to increase its carboxyl terminal fragments(CTFs)in PC12 cells.Upregulation of RIN3 or the neuronal isoform of BIN1 increased phosphorylated Tau level.Therefore,upregulation of RIN3 expression promoted accumulation of APP CTFs and increased phosphorylated Tau.These effects by RIN3 was rescued by the expression of a dominant negative Rab5(Rab5S34N)construct.Our study has thus pointed to that RIN3 acts through Rab5 to impact endosomal trafficking and signaling.Conclusion RIN3 is significantly upregulated and correlated with endosomal dysfunction in APP/PS1 mouse.Through interacting with BIN1 and CD2AP,increased RIN3 expression alters axonal trafficking and procession of APP.Together with our previous studies,our current work has thus provided important insights into the role of RIN3 in regulating endosomal signaling and trafficking. | Ruinan Shen Xiaobei Zhao Lu He Yongbo Ding Wei Xu Suzhen Lin Savannah Fang Wanlin Yang Kijung Sung Brian Spencer Robert A.Rissman Ming Lei Jianqing Ding Chengbiao Wu | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 17 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 18 | Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer显示文摘 | Xiaoyi Huang Tiezheng Yuan Meihua Liang Meijun Du Shu Xia Rachel Dittmar Dian Wang William See Brian A. Costello Fernando Quevedo Winston Tan Debashis Nandy Graham H. Bevan Sherri Longenbach Zhifu Sun Yan Lu Tao Wang Stephen N. Thibodeau Lisa Boardman Man | 2014 | European Urology2014，，： | 1 |
| 19 | Modifying the surface properties of super paramagnetic iron oxide nanoparticles through a sol-gel approach显示文摘 | Lu Yu Yin Yadong Mayers Brian T | 2002 | Nano Letter2002，3，： | 1 |
| 20 | Late Status of Fontan Patients With Persistent Surgical Fenestration显示文摘 | Andrew M. Atz Thomas G. Travison Brian W. McCrindle Lynn Mahony Michael Quartermain Richard V. Williams Roger E. Breitbart Minmin Lu Elizabeth Radojewski Renee Margossian Wesley Covitz Welton M. Gersony | 2011 | Journal of the American College of Cardiology2011，，24： | 1 |
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