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| 1 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 2 | Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome显示文摘Disordered signalling between the brain and the gut are generally accepted to underlie the functional bowel disorder, irritable bowel syndrome(IBS). However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. This common gastrointestinal disorder is characterised by alterations in bowel habit such as diarrhoea and/or constipation, bloating and abdominal pain, and symptom exacerbation has been linked with periods of stress, both psychosocial and infection-related. Indeed, a high level of comorbidity exists between IBS and stress-related mood disorders such as anxiety and depression. Moreover, studies have observed alterations in autonomic output and neuro-endocrine signalling in IBS patients. Accumulating evidence indicates that a maladaptive stress response, probably mediated by the stress hormone, corticotropin-releasing factor contributes to the initiation, persistence and severity of symptom flares.Other risk factors for developing IBS include a positive family history, childhood trauma, dietary factors and prior gastrointestinal infection. An emerging role has been attributed to the importance of immune factors in the pathophysiology of IBS with evidence of altered cytokine profiles and increased levels of mucosal immune cells. These factors have also been shown to have direct effects on neural signalling. This review discusses how pathological changes in neural, immune and endocrine pathways, and communication between these systems, contribute to symptom flares in IBS. | Maria M Buckley Siobhain M O'Mahony Dervla O'Malley | 2014 | World Journal of Gastroenterology2014，20，27： | 24 |
| 3 | Role of liver transplantation in the management of hepatoblastoma in the pediatric population显示文摘Hepatoblastoma(HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB(unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease(PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient's ranking on the liver transplant list, began to award additional 'exception' points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children's Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras. | Saira Khaderi Jacfranz Guiteau Ronald T Cotton Christine O'Mahony Abbas Rana John A Goss | 2014 | World Journal of Transplantation2014，4，4： | 23 |
| 4 | Central serotonergic and noradrenergic receptors in functional dyspepsia显示文摘机能性消化不良是上面的腹的不快或疼痛,早饱足,马达畸形,当器质性病不在时的腹的膨胀和恶心描述的综合征。中枢神经系统在进行并且处理内脏的信号起一个重要作用。在大脑处理疼痛,感觉和感情方面的回答的改变可以是在机能性消化不良的致病的关键因素。中央 serotonergic 和也不肾上腺素能的受体系统涉及处理马达,感觉并且胃肠道的分泌活动。内脏的超敏性当前在机能性消化不良被认为是为马达改变和腹的疼痛负责的机制。一些研究建议在中央 serotonergic 和可以部分解释一些机能性消化不良的症状的也不肾上腺素能的系统有改变。在自主神经系统的改变可以在在内脏的敏感的马达畸形和这些病人的增加被含有。去甲肾上腺素是在交感神经系统的主要 neurotransmitter,再,在这个系统工作的改变可以在运动机能导致变化。机能性消化不良在病人和社会上引起可观的负担。机能性消化不良的病理生理学充分没被理解,但是在由 serotonergic 和也不肾上腺素能的系统的中央处理的改变可以为症状的至少一些提供貌似合理的解释并且为未来提供可能的治疗目标。 | S O'Mahony TG Dinan PW Keeling ASB Chua | 2006 | World Journal of Gastroenterology2006，12，17： | 13 |
| 5 | Cultural Diversity and the Digital Humanities显示文摘 | Simon Mahony | 2018 | Fudan Journal of the Humanities and Social Sciences2018，11，3： | 6 |
| 6 | Three-dimensional Localization of Impacted Canines and Root Resorption Assessment Using Cone Beam Computed Tomography显示文摘The purpose of this study was to develop a new way to localize the impacted canines from three dimensions and to investigate the root resorption of the adjacent teeth by using cone beam computed tomography(CBCT). Forty-six patients undergoing orthodontic treatments and having impacted canines in Tongji Hospital were examined. The images of CBCT scans were obtained from KaVo 3D exam vision. Angular and linear measurements of the cusp tip and root apex according to the three planes(mid-sagittal, occlusal and frontal) have been taken using the cephalometric tool of the InVivo Dental Anatomage Version 5.1.10. The measurements of the angular and linear coordinates of the maxillary and mandibular canines were obtained. Using this technique the operators could envision the location of the impacted canine according to the three clinical planes. Adjacent teeth root resorption of 28.26 % was in the upper lateral incisors while 17.39% in upper central incisors, but no lower root resorption was found in our samples. Accurate and reliable localization of the impacted canines could be obtained from the novel analysis system, which offers a better surgical and orthodontic treatment for the patients with impacted canines. | Eyad Almuhtaseb 毛靖 Derek Mahony Rawan Bader 张智星 | 2014 | Journal of Huazhong University of Science and Technology(Medical Sciences)2014，34，3： | 5 |
| 7 | Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses显示文摘 | Siobhain M. O’Mahony Julian R. Marchesi Paul Scully Caroline Codling Anne-Marie Ceolho Eamonn M.M. Quigley John F. Cryan Timothy G. Dinan | 2009 | Biological Psychiatry2009，，3： | 4 |
| 8 | 老年人处方遗漏筛查工具第2版(中文版)显示文摘近年来我国老年人口数量迅速增加,2013年老年人口突破2亿大关。老年人常伴有多种疾病且同时服用多种药物,容易出现药物相互作用和药物不良反应,所以老年人用药问题是医务人员关注的重点。老年人不适当用药问题主要包括两个方面:老年人需要避免使用的药物和老年人需要使用而未使用的药物。 | Denis O'Mahony David O'Sullivan Stephen Byrne Marie Noelle O'Connor Cristin Ryan Paul Gallagher 侯凯旋 邢晓璇 闫素英 | 2017 | 药物不良反应杂志2017，19，5： | 4 |
| 9 | Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?显示文摘 | Timothy G. Dinan Eamonn M.M. Quigley Salah M.M. Ahmed Paul Scully Sinead O’Brien Liam O’Mahony Siobhan O’Mahony Fergus Shanahan P.W. Napoleon Keeling | 2006 | Gastroenterology2006，，2： | 3 |
| 10 | A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome显示文摘 | Caroline Codling Liam O’Mahony Fergus Shanahan Eamonn M. M. Quigley Julian R. Marchesi | 2010 | Digestive Diseases and Sciences2010，，2： | 3 |
| 11 | Local effects of mifepristone on the nonhuman primate endometrium显示文摘 | Victoria Jimenez-Moreno Michelle Billeter Cheng quan Liu Keith Gordon Mary Mahony | 2000 | Fertility and Sterility2000，，1： | 2 |
| 12 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 13 | Serotonin, tryptophan metabolism and the brain-gut-microbiome axis显示文摘 | S.M. O’Mahony G. Clarke Y.E. Borre T.G. Dinan J.F. Cryan | 2014 | Behavioural Brain Research2014，，： | 2 |
| 14 | Long-Term Outcomes Following Liver Transplantation for Hepatic Hemangioendothelioma: The UNOS Experience from 1987 to 2005显示文摘 | Joel A. Rodriguez Natasha S. Becker Christine A. O’Mahony John A. Goss Thomas A. Aloia | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 15 | The driving forces of change in energy-related CO 2 emissions in Ireland: A multi-sectoral decomposition from 1990 to 2007显示文摘 | Tadhg O’ Mahony Peng Zhou John Sweeney | 2012 | Energy Policy2012，，： | 2 |
| 16 | Agreement and conversion formula between mini-mental state examination and montreal cognitive assessment in an outpatient sample显示文摘AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two scales.METHODS Prospective study of consecutive patients attending outpatient services.Both tests were administered by the same researcher on the same day in random order.RESULTS The total sample(n = 135) was randomly divided into two groups.One to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was tested.The agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is modest.The conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations. | Luqman Helmi David Meagher Edmond O'Mahony Donagh O'Neill Owen Mulligan Sutha Murthy Geraldine McCarthy Dimitrios Adamis | 2016 | World Journal of Psychiatry2016，6，3： | 2 |
| 17 | 汽车干式离合器啮合时的产热和传热(英文)显示文摘目的:本研究旨在凸显热效应在离合系统动态摩擦分析中的重要性以及将其拓展到制动系统的可能性。创新点:采用一种未被报道过的新方法从根本上整合摩擦特性、微结构组分、产热机理、摩擦片磨损和传热机制。方法:基于能量守恒原理,针对由飞轮、摩擦片和压力板构成的离合系统提出一种适用于工业应用的热分区网络解析模型。结论:1.通过实测得到的μ-ν特性表明,新的摩擦片具有磨损片子所不具备的温度敏感性。2.通过对磨损片子的微结构分析以及热导率变化的测量显示,晶格结构中铜颗粒损耗会导致其导热性能减弱。3.使用摩擦计的测量结果显示新的摩擦片相对于磨损片子具有更高的摩擦系数;较高的摩擦系数减轻了离合器啮合时产生的界面滑移的程度,从而减小了由于产热导致的摩擦功率损耗。4.根据本文发展的热学模型,新的摩擦片可通过其优良的导热性将摩擦产生的热量释放出去。 | Theofilos GKINIS Ramin RAHMANI Homer RAHNEJAT Martin O'MAHONY | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，3： | 2 |
| 18 | Bacterial strain‐specific induction of Foxp3<sup>+</sup> T regulatory cells is protective in murine allergy models显示文摘 | A.Lyons D.O'Mahony F.O'Brien J.MacSharry B.Sheil M.Ceddia W. M.Russell P.Forsythe J.Bienenstock B.Kiely F.Shanahan L.O'Mahony | 2010 | Clinical & Experimental Allergy2010，，5： | 2 |
| 19 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 20 | Women's lived experience of breast biopsy:a phenomenological study显示文摘 | Mairin O'Mahony | 2001 | Journal of Clinical Nursing2001，10，： | 1 |
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