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| 1 | 急性心肌梗塞溶栓治疗对比研究显示文摘37所医院对急性心肌梗塞患者528例,随机分为尿激酶组(272例)和去纤酶组(256例)均为静脉法给药,尿激酶组并辅以阿司匹林和肝素,对比两组溶栓疗效。尿激酶组与去纤酶组比较:血管再通率分别为58.1%对40.6%(P<0.001);4周病死率分别为8.1%对17.6%(P<0.005);出血并发症分别为11.0%对27.0%(P<0.001)。说明尿激酶组疗效明显优于去纤酶组,且出血并发症较少。血管再通者较血管未通者严重并发症和梗塞延展明显减少,明显降低急性期病死率。 | (Collaborative Research Group. Fu Wai Hospital,CAMS, Bei jing 100037) | 1994 | 中华心血管病杂志1994，22，1： | 141 |
| 2 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 3 | 瑞舒伐他汀治疗中国高胆固醇血症患者疗效和安全性的随机双盲多中心对照研究显示文摘目的评价瑞舒伐他汀治疗中国高胆固醇血症患者的疗效和安全性。方法采用随机、双盲、多中心研究。患者经6周筛选后符合 LDL-C≥4.14 mmol/L(160 mg/dl),<6.50 mmol/L(250 mg/dl)、TG<4.52 mmol/L(400 mg/dl)者以2:1随机接受瑞舒伐他汀10 mg/d 或阿托伐他汀10mg/d 治疗。12周后瑞舒伐他汀组 LDL-C 未达到 ATPⅢ治疗目标者,予瑞舒伐他汀20 mg 延续治疗8周。结果 304例进入随机治疗阶段,瑞舒伐他汀10 mg/d 组201例,阿托伐他汀10 mg/d 组103例。意向治疗人群290例,符合方案人群263例。瑞舒伐他汀组治疗12周后血 LDL-C 显著下降,下降幅度为45.6%,显著大于阿托伐他汀组的39.0%(P<0.001)。瑞舒伐他汀组患者 LDL-C 达标率也较阿托伐他汀组(78.0%比72.7%)有增高趋势,且在高危人群中优势更为明显(56.5%比35.0%),但差异未达到统计学意义。瑞舒伐他汀降低 TG(-22.8%)以及升高 HDL-C(+6.6%)和ApoA-1(+12.5%)的幅度与阿托伐他汀组差别无统计学意义(分别为-16.6%,+4.3%和+9.8%)。29例患者接受20 mg/d 瑞舒伐他汀延续治疗,22例完成治疗患者中10例(45.5%)LDL-C达标。研究中未发现药物相关的严重不良反应事件。结论本组研究显示瑞舒伐他汀10 mg 降低LDL-C 的疗效优于同等剂量的阿托伐他汀,治疗3个月安全性与之类似。 | Rosuvastatin Registration Clinical Trial Group.Cardiovascular Institute and Fu Wai Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China | 2007 | 中华心血管病杂志2007，35，3： | 117 |
| 4 | 长江三角洲地区大气O3和PM10的区域污染特征模拟显示文摘以TRACE-P污染源资料及上海市地方排放清单为基础,采用Models-3/CMAQ环境空气质量模型和中尺度气象模式MM5,模拟研究了2001-01和2001-07长三角近地面二次污染物O3及PM10的浓度分布及输送状况,并以上海市国控点2001年冬、夏季各10 d的小时监测数据对模型进行了验证.验证结果显示,Models-3/CMAQ对O3和PM10的模拟结果与监测值的相关系数分别为0.77和0.52;一致性指数分别达到0.81和0.99.模型对O3小时最高浓度的估算偏低27%,标准偏差为-3.1%;对PM10小时平均浓度的估算偏低10%,标准偏差为46%.模型已具备再现和模拟长三角大气污染输送过程的能力,且误差落在可接受的范围之内.模拟结果显示,2001-07长三角区域16个主要城市中,有14个城市O3小时最大浓度超过国家二级标准,高浓度O3可覆盖苏南和浙北广大区域.2001-01泰州、扬州、南京、镇江、常州等城市受本地排放源和北部大气污染输送的影响显著,大气PM10日均浓度超过PM10国家二级标准.长三角地区环境空气质量与污染类型受大气污染传输与化学转化的影响十分明显.夏季太阳辐射较强时,南部城市排放的污染物常以二次污染物的形式影响下风向城市;太阳辐射较弱的情况下,则以一次污染物输送为主的形式影响周边地区.冬季长三角区域颗粒物污染总体水平较高,这与我国北方地区排放的颗粒物在西北风作用下向长三角输送造成的影响密切相关.长三角地区的大气污染已逐渐从局地转为区域问题. | 李莉 陈长虹 黄成 黄海英 李作攀 Joshua S. Fu Carey J. Jang David G. Streets | 2008 | 环境科学2008，29，1： | 91 |
| 5 | Uplift of the Longmen Shan range and the Wenchuan earthquake显示文摘 | Zhiqin Xu Shaocheng Ji Haibing Li Liwei Hou Xiaofang Fu Zhihui Cai | 2008 | Episodes2008，31，3： | 106 |
| 6 | 人工湿地系统对污水磷的净化效果显示文摘建立以亚热带湿生、水生植物为主的十二套下行流—上行流人工湿地系统作为处理城镇生活污水的对策。以其中四套研究其在不同的水力负荷及气候条件下对污水中磷的去除效果。人工湿地系统随处理运行时间的推移趋于稳定 ,对污水中的总磷、无机磷显示较好的净化效率 ,平均去除率在冬季达到 40 %以上 ,夏季达到 60 %以上 ,出水达到国家地面水Ⅲ级标准。水生植物在系统中起到明显作用 ,有植物系统的除磷效率及稳定性均高于无植物对照 ,其中 2号茭白—石菖蒲系统的效果最好 ,总磷平均去除率为 65%。 4号草—苔草系统在高水力负荷下的净化效果优于 2号。 | WU Zhen-bin CHEN Hui-rong HE Feng CHENG Shui-ping FU Gui-ping JIN Jian-ming QIU Dong-ru REN Ming-xun 任明迅 金建明 贺锋 陈辉蓉 付贵萍 吴振斌 邱东茹 成水平 | 2001 | 水生生物学报2001，25，1： | 188 |
| 7 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 8 | Current status and progress of pancreatic cancer in China显示文摘Cancer is currently one of the most important public health problems in the world.Pancreatic cancer is a fatal disease with poor prognosis.As in most other countries,the health burden of pancreatic cancer in China is increasing,with annual mortality rates almost equal to incidence rates.The increasing trend of pancreatic cancer incidence is more significant in the rural areas than in the urban areas.Annual diagnoses and deaths of pancreatic cancer in China are now beyond the number of cases in the United States.GLOBOCAN 2012 estimates that cases in China account for 19.45%(65727/337872) of all newly diagnosed pancreatic cancer and 19.27%(63662/330391) of all deaths from pancreatic cancer worldwide.The population's growing socioeconomic status contributes to the rapid increase of China's proportional contribution to global rates.Here,we present an overview of control programs for pancreatic cancer in China focusing on prevention,early diagnosis and treatment.In addition,we describe key epidemiological,demographic,and socioeconomic differences between China and developed countries.Facts including no nationwide screening program for pancreatic cancer,delay in early detection resulting in a late stage at presentation,lack of awareness of pancreatic cancer in the Chinese population,and low investment compared with other cancer types by government have led to backwardness in China's pancreatic cancer diagnosis and treatment.Finally,we suggest measures to improve health outcomes of pancreatic cancer patients in China. | Quan-Jun Lin Feng Yang Chen Jin De-Liang Fu | 2015 | World Journal of Gastroenterology2015，21，26： | 93 |
| 9 | 乳腺癌患者术后淋巴水肿与其相关症状的关系研究显示文摘目的调查乳腺癌患者术后不同程度淋巴水肿发生状况及其相关症状情况,分析两者之间的关系。方法采用便利抽样及目的抽样方法,选择乳腺癌行腋窝淋巴结清扫术后患者224例,采用肢体周径测量法判断淋巴水肿严重程度,采用乳腺癌淋巴水肿症状体验指数(Breast Cancer and Lymphedema Symptom Experience Index,BCLE-SEI)评估患者淋巴水肿相关症状体验。结果 224例患者中,无水肿94例(42.0%),轻度水肿46例(20.5%),重度水肿84例(37.5%)。轻度淋巴水肿患者的症状个数、症状严重程度及症状困扰总分高于无淋巴水肿患者(P=0.007);重度淋巴水肿患者的症状个数、症状严重程度及症状困扰总分高于轻度淋巴水肿患者(P=0.017)。轻度水肿患者的上肢肿胀、患肢沉重、患肢疲乏、患肢紧绷、患肢僵硬、手臂受限、肘部受限、手腕受限的发生率高于无水肿患者。结论淋巴水肿早期就出现相应症状,且症状体验随着水肿加重而越发严重。关注患肢肿胀、患肢沉重等淋巴液积聚症状,可早期发现淋巴水肿并给予早期干预,阻止或延缓水肿程度的进展。 | 刘飞 路潜 欧阳倩 刘超 吕静 王影新 Fu R Mei | 2016 | 中华护理杂志2016，51，5： | 95 |
| 10 | 精准护理的应用领域及发展方向显示文摘通过对精准护理的应用领域进行介绍,强调基因谱学在护理实践与研究中的应用过程,突出精准护理对精准健康和精准医学的贡献,并对如何在精准健康的基础上构建精准护理的知识和能力提出建议,为促进我国精准护理的发展提供借鉴。 | Fu, Mei.R. 田亚丽 冯先琼 路潜 胡雁 王艳艳 姜小鹰 胡秀英 | 2017 | 中华护理杂志2017，52，10： | 108 |
| 11 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 12 | Some evidence of drying trend over northern China from 1951 to 2004显示文摘The surface wetness index, Palmer drought sererity index and the retrieval of soil moisture over China were calculated using monthly precipitation and monthly mean surface air temperature. Based on the contrast analysis of the variation of the above three indices and precipitation, the dry/wet spatio-temporal pattern of northern China in the last 54 years was revealed, and the evidence of drying trend over northern China was analyzed, especially. The results show the following four facts: (1) The drying trend is the main characteristic of the eastern part of Northwest China and the central part of North China since the 1980s and it was enhanced in the last 15 years mainly due to the precipitation decrease and the temperature increase; (2) During the last 54 years, there was only one dry/wet shift at the interdecadal scale occurring in the eastern part of Northwest China and the central part of North China in the late 1970s, which was related to 1977/1978 global abrupt change, whereas there were three shifts in Northeast China, one was in the mid 1990s and the other two were in 1965 and 1983, respectively; (3) Unlike the variation trend of other subregions of northern China, the western part of Northwest China is currently located in a relatively wetting period, which is weak-ened due to the temperature increase; (4) The extreme drought frequency is obviously increasing in the eastern part of Northwest China, the central part of North China and Northeast China since the 1980s, which is closely related to the precipitation decrease and temperature increase in these subregions. | MA Zhuguo1,2 & FU Congbin1,2 1. Key Laboratory of Regional Climate-Environment for Temperate East Asia, Chinese Academy of Sciences, Beijing 100029, China 2. START Regional Center for Temperate East Asia, Institute of Atmos-pheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2006 | Chinese Science Bulletin2006，51，23： | 63 |
| 13 | LAZY1 controls rice shoot gravitropism through regulating polar auxin transport显示文摘米饭(Oryza sativa L.) 的分蘖角度是贡献粮谷生产的一个重要农学的特点,并且长为完成理想的植物建筑学改进谷物产量吸引了品种 ers 的注意。尽管庞大的努力在过去的十年被作了与极其传播或协议到 ers 为止学习异种,位于谷物庄稼的分蘖角度的控制下面的分子的机制仍然保持未知。这里,我们报导克隆调整米饭分蘖角度被控制的射击 gravitropism 的 LAZY1 (LA1 ) 基因。我们显示出那 LA1,新奇草特定的基因,是速度集合并且空间地表示,并且在极的植物生长素运输起一个否定作用(轻拍) 。LA1 的 Loss-of-function PATgreatly 提高并且因此在射击改变内长的 IAA 分发,导致 reducedgravitropism,并且因此,米饭的分蘖,枝散布显型种。 | Peijin Li Yonghong Wang Qian Qian Zhiming Fu Mei Wang Dali Zeng Baohua Li Xiujie Wang Jiayang Li | 2007 | Cell Research2007，17，5： | 79 |
| 14 | Chemical characteristics of PM_(2.5) during a typical haze episode in Guangzhou显示文摘The chemical characteristics(water-soluble ions and carbonaceous species) of PM2.5 in Guangzhou were measured during a typical haze episode.Most of the chemical species in PM2.5 showed significant difference between normal and haze days.The highest contributors to PM2.5 were organic carbon(OC),nitrate,and sulfate in haze days and were OC,sulfate,and elemental carbon(EC) in normal days.The concentrations of secondary species such as,NO3-,SO42-,and NH4+ in haze days were 6.5,3.9,and 5.3 times higher than those in normal days,respectively,while primary species(EC,Ca2+,K+) show similar increase from normal to haze days by a factor about 2.2-2.4.OC/EC ratio ranged from 2.8 to 6.2 with an average of 4.7 and the estimation on a minimum OC/EC ratio showed that SOC(secondary organic carbon) accounted more than 36.6% for the total organic carbon in haze days.The significantly increase in the secondary species(SOC,NO3-,SO42-,and NH4+),especially in NO3-,caused the worst air quality in this region.Simultaneously,the result illustrated that the serious air pollution in haze episodes was strongly correlated with the meteorological conditions.During the sampling periods,air pollution and visibility had a good relationship with the air mass transport distance;the shorter air masses transport distance,the worse air quality and visibility in Guangzhou,indicating the strong domination of local sources contributing to haze formation.High concentration of the secondary aerosol in haze episodes was likely due to the higher oxidation rates of sulfur and nitrogen species. | TAN Jihua DUAN Jingchun HE Kebin MA Yongliang DUAN Fengkui CHEN Yuan FU Jiamo | 2009 | Journal of Environmental Sciences2009，21，6： | 71 |
| 15 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 16 | Five-year plans, China finance and their consequences显示文摘An important factor influencing corporate finance and economic growth in China lies in its government sponsored industrial policies. Examining China's five-year plans during 1991–2010, we find that state-owned firms in government supported industries enjoy faster growth in initial public offerings and higher offer prices. Further, they enjoy faster growth in loans granted by major national banks. However, this preferential access to capital by state-owned firms appears to be achieved at the expense of non-state-owned firms which are crowded out. Government support induces more investment but also brings more overinvestment, which mainly comes from the non-state sector.Finally, supported industries have higher stock market returns and cash flow growth that dampen when state ownership increases. | Donghua Chen Oliver Zhen Li Fu Xin | 2017 | China Journal of Accounting Research2017，，3： | 76 |
| 17 | Optical vortices 30 years on:OAM manipulation from topological charge to multiple singularities显示文摘Thirty years ago,Coullet et al.proposed that a special optical field exists in laser cavities bearing some analogy with the superfluid vortex.Since then,optical vortices have been widely studied,inspired by the hydrodynamics sharing similar mathematics.Akin to a fluid vortex with a central flow singularity,an optical vortex beam has a phase singularity with a certain topological charge,giving rise to a hollow intensity distribution.Such a beam with helical phase fronts and orbital angular momentum reveals a subtle connection between macroscopic physical optics and microscopic quantum optics.These amazing properties provide a new understanding of a wide range of optical and physical phenomena,including twisting photons,spin–orbital interactions,Bose-Einstein condensates,etc.,while the associated technologies for manipulating optical vortices have become increasingly tunable and flexible.Hitherto,owing to these salient properties and optical manipulation technologies,tunable vortex beams have engendered tremendous advanced applications such as optical tweezers,high-order quantum entanglement,and nonlinear optics.This article reviews the recent progress in tunable vortex technologies along with their advanced applications. | Yijie Shen Xuejiao Wang Zhenwei Xie Changjun Min Xing Fu Qiang Liu Mali Gong Xiaocong Yuan | 2019 | Light(Science & Applications)2019，8，1： | 77 |
| 18 | Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas显示文摘AIM: To observe the relationship between the expression of vascular endothelial growth factor (VEGF), microvascular density (MVD) and the pathological characteristics of esophageal and gastric carcinomas.METHODS: S-P immunohistochemical staining was used to investigate the expression of VEGF in all the specimens.The antibody against factor VIII-related antigen was used to display vascular endothelial cells, and MVD was examined by counting the factor VIII-positive vascular endothelial cells.RESULTS: The positive rates of VEGF expression in esophageal carcinoma and gastric carcinoma were 81.36 %and 67.5 % respectively, and the MVD averaged 41.81±8.44and 34.36±9.67 respectively, which were higher than those in benign diseases. The expression of VEGF and MVD were closely correlated with the degree of differentiation, lymphatic metastasis, but not related to depth of cancer invasion. In early stage gastric carcinoma, the rate of expression of VEGF and MVD was lower than that in progressive gastric carcinomas. CONCLUSION: The expression of VEGF is correlated with tumor angiogenesis, and VEGF plays an important role in new blood vessels formation, the expression of VEGF and MVD play an important role in tumor growth and metastasis.MVD and the expression of VEGF may be two important indexes for patients′ prognosis. | Jin-Rong Du Ying Jiang Yan-Mei Zhang Hong Fu, Department of Pathology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China | 2003 | World Journal of Gastroenterology2003，9，7： | 75 |
| 19 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 20 | Mathematic principles of interrupted-sampling repeater jamming (ISRJ)显示文摘Coherent jamming is one of the important trends in modern radar electronic war- fare. High-speed sampling of wideband radio frequency (RF) signals and high iso- lation of two receive-transmit antennas are key technologies for the realization of coherent jamming. However, these technologies present significant challenges to engineering application. In this paper, a novel repeater jamming based on inter- rupted sampling technique is presented. For a jammer with a receive-transmit time-sharing antenna, a radar signal is sampled with a low rate by the jammer. Then, a train of false targets will be achieved after the jamming signal feed the matched filter of a pulse compression radar. For the case of the linear frequency modulated (LFM) pulse compression radars, mathematic principles of the interrupted-sam- pling repeater jamming is developed, and then the efficiency of the jamming is de- scribed and stated as expressions of key parameters which are also beneficial to the jamming design for other coherent radars. | WANG XueSong LIU JianCheng ZHANG WenMing FU QiXiang LIU Zhong XIE XiaoXia | 2007 | Science in China(Series F)2007，50，1： | 53 |
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