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| 1 | Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion显示文摘Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells(MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40(SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage. | Silke Schwarz Ralf Huss Michaela Schulz-Siegmund Breda Vogel Sven Brandau Stephan Lang Nicole Rotter | 2014 | International Journal of Oral Science2014，6，3： | 5 |
| 2 | Immunogenetic phenotypes in inflammatory bowel disease显示文摘当前接受的 etiopathogenic 假设建议长期的肠的发炎和煽动性的肠疾病(IBD ) 的相关全身的表明特征由于对居民钠的过分好攻击或病理学的有免疫力的回答细菌的成分。预先安排的因素是粘膜免疫者回答或障碍功能的基因 dysregulation,与环境刺激触发的发作。这些因素和他们的相互作用可以也是疾病显型和疾病前进的重要决定因素。免疫的出现基因显型把支持借给不同免疫者处理的危险性基因调整的建议假设,由钠抗原开车,表示了接着在 IBD 影响临床的显型的同样特定的有免疫力的显型病人。 | Maria C Dubinsky Kent Taylor Stephan R Targan Jerome I Rotter | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 3 | 猪营养中酶制剂的应用前景显示文摘前言近年来,人们对于使用酶来改善难消化的饲料的利用问题,兴趣日增。酶在家禽生产中的潜力已被认识了有许多年了,在这方面所做的工作大多数是关于富含β-葡聚糖(大麦和燕麦)和戊聚糖(黑麦)等的谷物。从营养的角度看,这些非淀粉多糖有着共同的作用。他们能够形成胶体,从而可增加肠内容物的粘稠度,而这就会降低内源酶和营养基质的扩散,再加上饲料通过消化道的速度加快。 | 张友明 B. A. Rotter | 1990 | 国外畜牧学(猪与禽)1990，，6： | 2 |
| 4 | ‘Cancer associated fibroblasts’ – more than meets the eye显示文摘 | Shalom Madar Ido Goldstein Varda Rotter | 2013 | Trends in Molecular Medicine2013，，： | 2 |
| 5 | Biomechanical In Vitro Testing of Human Osteoporotic Lumbar Vertebrae Following Prophylactic Kyphoplasty With Different Candidate Materials显示文摘 | Robert Rotter Robert Pflugmacher Frank Kandziora Andreas Ewert Georg Duda Thomas Mittlmeier | 2007 | Spine2007，，13： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Mutant p53-a potential player in shaping the tumor-stroma crosstalk显示文摘A plethora of studies suggest that the non-transformed cellularand non-ceHular comp on ents of the tumor,collectively known as the tumor microenvironment,have a significa nt impact on the tumorigenic process.It was suggested that the microenvironment,which initially restricts tumor development,is recruited by the tumor and main tains a crosstalk that further promotes cancer progression. | Yan Stein Ronit Aloni-Grinstein Varda Rotter | 2019 | Journal of Molecular Cell Biology2019，11，7： | 2 |
| 8 | Cooperatation between p53-dependent and p53-indepen-dent apototic pathways in myeloid cells显示文摘 | Peled A Zipori D Rotter V | 1996 | Cancer Res1996，569，9： | 1 |
| 9 | A framework for assessing RFID system security and privacy risks显示文摘 | Rotter P | 2008 | Pervasive Computing2008，7，4： | 1 |
| 10 | Neutrophil autoantibodies in ulcerative colitis familial aggregation and genetic heterogeneity 显示文摘 | Shanahan F Duerr R H Rotter J I | 1992 | Gastroenterology1992，103，2： | 1 |
| 11 | Tissue engineering and autologous transplant formation:practical approaches with resorbable biomaterials and new cell culture techniques显示文摘 | Sittinger M Bujia J Rotter J | 1996 | Biomaterials1996，17，： | 1 |
| 12 | Toxicology of deoxynivalenol (vomitoxin) 显示文摘 | Rotter BA Prelusky DB Pestka JJ | 1996 | Toxicol Environ Health1996，48，1： | 1 |
| 13 | Clinical pathways : effects on professional practice, patient outcomes, length of stay and hospital costs显示文摘 | Rotter T Koch R Kugler J | 2007 | Cochrane Database Syst Rev2007，17，3： | 1 |
| 14 | Generalized expectancies for internal versus external control of reinforcement显示文摘 | Rotter J B | 1966 | Psychological Monographs1966，80，1： | 1 |
| 15 | The effect of PPARgamma ligands on the adipose tissue in insulin resistance显示文摘 | Hammarstedt A Andersson CX Rotter Sopasakis V | 2005 | Prostaglandins Leukot Essent Fatty Ac- ids2005，73，1： | 1 |
| 16 | Internal Versus External Control of Reinforeement:A Case History of a Variable 显示文摘 | ROTTER J B | 1990 | American Psychologist1990，45，4： | 1 |
| 17 | Generalized Expectancies for Internal Versus External Control of Reinforcement显示文摘 | Rotter J B | 1966 | Psychol Mo Nogr1966，80，1： | 1 |
| 18 | Age dependence of cellular properties of human septal cartilage: implications for tissue engineering显示文摘 | Rotter N Bonassar LJ Tobias G | 2001 | Arch Otolaryngol Head Neck Surg2001，127，10： | 1 |
| 19 | Tissue engineering and autologous transplant formation:practical approaches with absorbable biomaterials and new culture techniques 显示文摘 | Sittinger M Bujia J Rotter N | 1996 | Biomaterials1996，17，： | 1 |
| 20 | Hygienic hand disinfection显示文摘 | | 1984 | Infection Control1984，1，： | 1 |
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