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| 1 | Molecularly targeted therapy for advanced hepatocellular carcinoma-a drug development crisis?显示文摘Hepatocellular carcinoma is the fastest growing cause of cancer related death globally. Sorafenib,a multitargeted kinase inhibitor,is the only drug proven to improve outcomes in patients with advanced disease offering modest survival benefit. Although comprehensive genomic mapping has improved understanding of the genetic aberrations in hepatocellular cancer(HCC),this knowledge has not yet impacted clinical care. The last few years have seen the failure of several first and second line phase Ⅲ clinical trials of novel molecularly targeted therapies,warranting a change in the way new therapies are investigated in HCC. Potential reasons for these failures include clinical and molecular heterogeneity,trial design and a lack of biomarkers. This review discusses the current crisis in HCC drug development and how we should learn from recent trial failures to develop a more effective personalised treatment paradigm for patients with HCC. | Kiruthikah Thillai Paul Ross Debashis Sarker | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 9 |
| 2 | Planetary Wave Reflection and Its Impact on Tropospheric Cold Weather over Asia during January 2008显示文摘Reflection of stratospheric planetary waves and its impact on tropospheric cold weather over Asia during January 2008 were investigated by applying two dimensional Eliassen–Palm(EP) flux and three-dimensional Plumb wave activity fluxes. The planetary wave propagation can clearly be seen in the longitude–height and latitude–height sections of the Plumb wave activity flux and EP flux, respectively, when the stratospheric basic state is partially reflective. Primarily, a wave packet emanating from Baffin Island/coast of Labrador propagated eastward, equatorward and was reflected over Central Eurasia and parts of China, which in turn triggered the advection of cold wind from the northern part of the boreal forest regions and Siberia to the subtropics. The wide region of Central Eurasia and China experienced extreme cold weather during the second ten days of January 2008, whereas the extraordinary persistence of the event might have occurred due to an anomalous blocking high in the Urals–Siberia region. | Debashis NATH CHEN Wen WANG Lin MA Yin | 2014 | Advances in Atmospheric Sciences2014，31，4： | 8 |
| 3 | Ceric Ammonium Nitrate Catalyzed Oxidation of Aldehydes and Alcohols显示文摘许多芳香,脂肪族、结合的醛和白酒在水里与70% t-BuOOH 答案在高收益与量的变换被转变到相应的羧基的酸和酉同类面对 ceric 铵硝酸盐的催化数量[ Ce ( NH4 ) 2 ( NO3 ) 6 ](罐头)在空间下面,温度调节。我们的催化系统的范围是适用的为大量芳香,结合并且脂肪族的底层。这些醛在合理时间在好孤立的收益被变换成相应的羧基的酸。自从它能与不能容忍的另外的功能的组一起被使用,这个方法拥有大量能力氧化调节,为病情的检查包含相当简单的方法,展出 chemoselectivity 并且在周围的条件下面继续。产生产品在合理时间以内在好收益被获得。 | Gowda, Ravikumar R. Chakraborty, Debashis | 2011 | Chinese Journal of Chemistry2011，29，11： | 5 |
| 4 | Understanding the influence of petrographic parameters on strength of differently sized shale specimens using XRD and SEM显示文摘Ground failure is a major contributor to fatalities in underground mines in the US.Underground coal mines in the Northern Appalachian have weak roof rock composed of shale,which is prone to failure under high horizontal stress.Understanding the relationship among strength,specimen size and rock petrographic parameters is essential for developing an effective ground control plan.Size effect studies have found that rock strength varies with specimen size.This paper attempts to understand this strength variation using three specimen sizes(254-mm,508-mm,and 762-mm).The specimen strength was measured and the major petrographic parameters affecting the strength,namely grain size,grain shape,quartz content,clay content,etc.were analyzed using X-ray diffraction(XRD)and scanning electron microscopy(SEM).The petrographic parameters were then correlated with the strength of the three differently sized specimens.The results showed that 508-mm specimen had the lowest strength.Quartz content of the 508-mm specimen was lower than that of 254-mm and 762-mm specimens.Clay content and average grain size of the 508-mm specimen were higher than those of 254-mm and 762-mm specimens.These results clearly show that grain size,quartz content and clay content contribute to strength variation observed in differently sized shale specimens. | Debashis Das Brijes Mishra Neel Gupta | 2021 | International Journal of Mining Science and Technology2021，31，5： | 4 |
| 5 | WiGig and IEEE 802.11ad for Multi-Gigabyte-Per-Second WPAN and WLAN显示文摘The Wireless Gigabit Alliance (WiGig) and IEEE 802.11ad are developing a multigigabit wireless personal and local area network (WPAN/WLAN) specification in the 60 GHz millimeter wave band. Chipset manufacturers, original equipment manufacturers (OEMs), and telecom companies are also assisting in this development. 60 GHz millimeter wave transmission will scale the speed of WLANs and WPANs to 6.75 Gbit/s over distances less than 10 meters. This technology is the first of its kind and will eliminate the need for cable around personal computers, docking stations, and other consumer electronic devices. High-definition multimedia interface (HDMI), display port, USB 3.0, and peripheral component interconnect express (PCIe) 3.0 cables will all be eliminated. Fast downloads and uploads, wireless sync, and multi-gigabit-per-second WLANs will be possible over shorter distances. 60 GHz millimeter wave supports fast session transfer (FST) protocol, which makes it backward compatible with 5 GHz or 2.4 GHz WLAN so that end users experience the same range as in today's WLANs. IEEE 802.11ad specifies the physical (PHY) sublayer and medium access control (MAC) sublayer of the protocol stack. The MAC protocol is based on time-division multiple access (TDMA), and the PHY layer uses single carrier (SC) and orthogonal frequency division multiplexing (OFDM) to simultaneously enable low-power, high-performance applications. | Sai Shankar N Debashis Dash Hassan El Madi Guru Gopalakrishnan | 2012 | ZTE Communications2012，10，4： | 4 |
| 6 | Visible-light-promoted oxidative coupling of styrene with cyclic ethers显示文摘A new visible-light-promoted oxidative coupling of vinylarenes with cyclic ethers has been developed using rose bengal as photocatalyst and tert-butyl hydrogenperoxide(TBHP)as oxidant under ambient air at room temperature.A library ofα-oxyalkylated ketones with broad functionalities has been synthesized in moderate to good yields.A radical mechanism is suggested for the present protocol. | Golam Kibriya Debashis Ghosh Alakananda Hajra | 2020 | Science China Chemistry2020，63，1： | 4 |
| 7 | Impact of Planetary Wave Reflection on Tropospheric Blocking over the Urals–Siberia Region in January 2008显示文摘Planetary wave reflection from the stratosphere played a significant role in changing the tropospheric circulation pattern over Eurasia in mid-January 2008. We studied the 2008 event and compared with composite analysis(winters of 2002/2003,2004/2005, 2006/2007, 2007/2008, 2010/2011 and 2011/2012), when the downward coupling was stronger, by employing time-lagged singular value decomposition analysis on the geopotential height field. In the Northern Hemisphere, the geopotential fields were decomposed into zonal mean and wave components to compare the relative covariance patterns. It was found that the wavenumber 1(WN1) component was dominant compared with the wavenumber 2(WN2) component and zonal mean process. For the WN1 field, the covariance was much higher(lower) for the negative(positive) lag, with a prominent peak around +15 days when the leading stratosphere coupled strongly with the troposphere. It contributed to the downward coupling due to reflection, when the stratosphere exhibited a partially reflective background state. We also analyzed the evolution of the WN1 anomaly and heat flux anomaly, both in the troposphere and stratosphere, during January–March 2008. The amplitude of the tropospheric WN1 pattern reached a maximum and was consistent with a downward wave coupling event influenced by the stratospheric WN1 anomaly at 10 h Pa. This was consistent with the reflection of the WN1 component over Eurasia, which triggered an anomalous blocking high in the Urals–Siberia region. We further clarified the impact of reflection on the tropospheric WN1 field and hence the tropospheric circulation pattern by changing the propagation direction during and after the event. | Debashis NATH Wen CHEN | 2016 | Advances in Atmospheric Sciences2016，33，3： | 4 |
| 8 | Investigating the Dominant Source for the Generation of Gravity Waves during Indian Summer Monsoon Using Ground-based Measurements显示文摘Over the tropics,convection,wind shear(i.e.,vertical and horizontal shear of wind and/or geostrophic adjustment comprising spontaneous imbalance in jet streams) and topography are the major sources for the generation of gravity waves.During the summer monsoon season(June-August) over the Indian subcontinent,convection and wind shear coexist.To determine the dominant source of gravity waves during monsoon season,an experiment was conducted using mesosphere-stratosphere-troposphere(MST) radar situated at Gadanki(13.5 N,79.2 E),a tropical observatory in the southern part of the Indian subcontinent.MST radar was operated continuously for 72 h to capture high-frequency gravity waves.During this time,a radiosonde was released every 6 h in addition to the regular launch(once daily to study low-frequency gravity waves) throughout the season.These two data sets were utilized effectively to characterize the jet stream and the associated gravity waves.Data available from collocated instruments along with satellite-based brightness temperature(TBB) data were utilized to characterize the convection in and around Gadanki.Despite the presence of two major sources of gravity wave generation(i.e.,convection and wind shear) during the monsoon season,wind shear(both vertical shear and geostrophic adjustment) contributed the most to the generation of gravity waves on various scales. | Debashis NATH 陈文 | 2013 | Advances in Atmospheric Sciences2013，30，1： | 3 |
| 9 | Evaluating Fertilization Effects on Soil Physical Properties Using a Soil Quality Index in an Intensive Rice-Wheat Cropping System显示文摘Soil quality assessment has been suggested as an effective tool for evaluating sustainability of soil and crop management practices.The objective of this study was to develop a sensitive soil quality index(SQI) based on bulk density(BD),water-holding capacity(WHC),water-stable aggregates(WSA),aggregate mean weight diameter(AMWD),total organic C(TOC) and C input to evaluate the important rice-wheat cropping system on an Inceptisol in India.A long-term experiment has been conducted for 18 years at the Indian Council of Agricultural Research-Indian Institute of Farming Systems Research,Modipuram,India.The treatments selected for this study were comprised of a no-fertilizer control and N,P and K fertilizers(NPK) combined with Zn and S fertilizers(NPK+ Zn+S),farmyard manure(NPK+FYM),green gram residues(NPK+GR) and cereal residues(NPK+CR),laid out in a randomized complete block design with three replications.Soil samples were collected and analyzed for BD,WHC,WSA and TOC.Correlation analysis revealed that both rice and wheat yields signi?cantly increased with the increases in AMWD,TOC and C input,but decreased with the increase in BD.The SQI values were then generated based on regression analysis of BD,WSA,AMWD,TOC and C input with rice and wheat yields for the 0–15 and 15–30 cm soil layers,respectively.Regression analyses between crop yields and SQI values showed a quadratic type of relation with the coeffcient of determination(R^2) varying from 0.78 to 0.89.With regard to soil sustainability,applying crop residues to both rice and wheat could maintain soil quality for a longer period,whereas the highest yields of both the crops were recorded in the NPK+Zn+S treatment.The regression equations developed in this study could be used to monitor soil quality in a subhumid tropical rice-wheat cropping system. | Bappa DAS Debashis CHAKRABORTY Vinod Kumar SINGH Mukhtar AHMED Amit Kumar SINGH Arijit BARMAN | 2016 | Pedosphere2016，26，6： | 3 |
| 10 | Reversible binary subtractor design using quantum dot-cellular automata显示文摘在纳米技术领域,量子元胞自动机(quantum dot-cellular automata,QCA)可作为传统互补金属氧化物半导体(complementary metal oxide semiconductor,CMOS)电路的替代方案,具有可观的发展前景。QCA设备密度高,运行速度快,且功耗极低。在QCA中,可逆逻辑有着广泛应用。研究者已开发多个基于QCA的可逆逻辑电路,但基于QCA的可逆二进制减法器研究却不多见。QCA低功耗和高电流密度的特点,使其可用于设计纳米尺度节能逻辑电路。然而,其对大量逻辑门的需求和不利的无用输出,可能限制基于QCA逻辑电路的功能。我们利用QCA设计并实现了一个DG门,实现了DG门的普遍特征。利用该DG门的QCA部分,可以获得新的可逆二进制减法器。相比现有可逆减法器,我们设计的减法器量子成本低,无用输出少。电路设计与模拟基于QCA Designer-2.0.3软件。 | Jadav Chandra DAS Debashis DE | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，9： | 2 |
| 11 | Relationship Between Soil Temperature in May over Northwest China and the East Asian Summer Monsoon Precipitation显示文摘This study investigates the relationship between the soil temperature in May and the East Asian summer monsoon(EASM)precipitation in June and July using station observed soil temperature data over Northwest China from 1971 to 2000.It is found that the memory of the soil temperature at 80-cm depth can persist for at least 2 months,and the soil temperature in May is closely linked to the EASM precipitation in June and July.When the soil temperature is warmer in May over Northwest China,less rainfall occurs over the Yangtze and Huaihe River valley but more rainfall occurs over South China in June and July.It is proposed that positive anomalous soil temperature in May over Northwest China corresponds to higher geopotential heights over the most parts of the mainland of East Asia,which tend to weaken the ensuing EASM.Moreover,in June and July,a cyclonic circulation anomaly occurs over Southeast China and Northwest Pacific and an anticyclonic anomaly appears in the Yangtze and Huaihe River valley at 850 hPa.All the above tend to suppress the precipitation in the Yangtze and Huaihe River valley.The results also indicate that the soil temperature in May over Northwest China is closely related to the East Asia/Pacific(EAP)teleconnection pattern,and it may be employed as a useful predictor for the East Asian summer monsoon rainfall. | 王远皓 陈文 张井勇 Debashis NATH | 2013 | Acta meteorologica Sinica2013，27，5： | 2 |
| 12 | Impact of Drought on Agriculture in the Indo-Gangetic Plain,India显示文摘In this study, we investigate the spatiotemporal characteristics of drought in India and its impact on agriculture during the summer season(April–September). In the analysis, we use Standardized Precipitation Evapotranspiration Index(SPEI)datasets between 1982 and 2012 at the six-monthly timescale. Based on the criterion SPEI <-1, we obtain a map of the number of occurrences of drought and find that the humid subtropical Upper Middle Gangetic Plain(UMGP) region is highly drought-prone, with an occurrence frequency of 40%–45%. This UMGP region contributes at least 18%–20% of India's annual cereal production. Not only the probability of drought, but the UMGP region has become increasingly drought-prone in recent decades. Moreover, cereal production in the UMGP region has experienced a gradual declining trend from 2000 onwards, which is consistent with the increase in drought-affected areas from 20%–25% to 50%–60%, before and after 2000,respectively. A higher correlation coefficient(-0.69) between the cereal production changes and drought-affected areas confirms that at least 50% of the agricultural(cereal) losses are associated with drought. While analyzing the individual impact of precipitation and surface temperature on SPEI at 6 month timescale [SPEI(6)] we find that, in the UMGP region,surface temperature plays the primary role in the lowering of the SPEI. The linkage is further confirmed by correlation analysis between SPEI(6) and surface temperature, which exhibits strong negative values in the UMGP region. Higher temperatures may have caused more evaporation and drying, which therefore increased the area affected by drought in recent decades. | Reshmita NATH Debashis NATH Qian LI Wen CHEN Xuefeng CUI | 2017 | Advances in Atmospheric Sciences2017，34，3： | 2 |
| 13 | A protocol for piggy-backing on Markov based wavelength reservation in WDM optical networks 显示文摘 | Malabika Sengupta Swapan Kumar Mondal Debashis Saha | 2009 | Optical Switching and Networking2009，6，4： | 1 |
| 14 | Equal Pay for Unequal Work: LimitingSabotage in Teams 显示文摘 | Arup Bose Debashis Pal David E M Sappington | 2010 | Journal of Economics & Man- agement Strategy2010，，19： | 1 |
| 15 | Comparative performance study of polyethersulfone and polysulfone membranes for trypsin isolation from goat pancreas using affinity ultrafiltration显示文摘 | Sumana Mukherjee Debashis Roy Pinaki Bhattacharya | 2008 | Separation and Purification Technology2008，60，3： | 1 |
| 16 | Third Degree Price Discrimination in Lin- ear-Demand Markets:Effects on Number of Markets Served and So- cial Welfare 显示文摘 | Kaftal Victor Pal Debashis | 2008 | Southern Economic Journal2008，75，2： | 1 |
| 17 | Analysis of antiphase domain growth in ternary FeCo alloys after different cooling rates and annealing treatments using neutron diffraction and positron annihilation 显示文摘 | Ralph Gilles Michael Hofmann Francis Johnson Yan Gao Debashis Mukherji | 2011 | Journal of Alloys and Compounds2011，509，19： | 1 |
| 18 | A PSO based opti- mal switching technique for voltage harmonic reduction of multilevel inverter 显示文摘 | Rup N R Debashis C Swapan K G | 2010 | Expert Systems with Applica- tions2010，37，12： | 1 |
| 19 | Computational identification and characterization of conserved miRNAs and their target genes in garlic ( Allium sativum L.) expressed sequence tags显示文摘 | Debashis Panda Budheswar Dehury Jagajjit Sahu Madhumita Barooah Priyabrata Sen Mahendra K. Modi | 2014 | Gene2014，，2： | 1 |
| 20 | Effect of radiofrequency catheter ablation on the biochemical marker ischemia modified albumin显示文摘 | Debashis Roy Juan Quiles Manas Sinha Dimitrios Floros David Gaze Paul Collinson Gary F Baxter Juan Carlos Kaski | 2004 | The American Journal of Cardiology2004，，2： | 1 |
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