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| 1 | A benchmark for visual analysis of insider threat detection显示文摘Dear editor,Malicious insiders are trusted entities that are given the power to violate rules in a given security policy,and insider threats occur when trusted entities abuse such a power.In modern networked work environments,malicious insiders and their malicious activities pose serious threats to organizations and businesses.Trusted employees travel the intranet of an organization with a high degree of freedom. | Ying ZHAO Kui YANG Siming CHEN Zhuo ZHANG Xin HUANG Qiusheng LI Qi MA Xinyue LUAN Xiaoping FAN | 2022 | Science China(Information Sciences)2022，65，9： | 1 |
| 2 | Epidemiology and clinical characteristics of burns in China's Mainland from 2009 to 2018显示文摘Background:Burn injuries place a heavy burden on the global healthcare system.However,there is still a lack of nationwide studies on the epidemiological characteristics of burn patients in China's Mainland.The present study aims to accurately analyze the clinical characteristics of burn patients by collecting data in China's Mainland from 2009 to 2018,which will provide effective strategies for healthcare systems and the government in China's Mainland.Methods:Patients admitted for burn injuries to 196 hospitals in 31 provinces,autonomous regions and municipalities in China's Mainland from 2009 to 2018 were included.The data collected included sex,age,month distribution,etiology,region,clinical outcome,injury anatomical location,total burn surface area and mortality.SPSS 19.0 software was used to analyze the data.Results:From 2009 to 2018,the burn patients were 333,995(0.76%),which included 222,480(66.61%)males and 111,515(33.39%)females.From 2009 to 2018,the number of individuals admit-ted to hospitals for burns showed a downward trend year by year.The burn patients accounted for the highest proportion of inpatients in 0-10 years(38.10%),followed by 40-50 years(13.14%).The highest cure ratio of burn inpatients was in the 20-30 age group(31394,71.53%).Among 31 provinces,autonomous regions and municipalities,the province with the highest proportion of total inpatients caused by burns was Inner Mongolia(4.61%),followed by Zhejiang(3.17%),Hainan(2.88%)and Xinjiang(2.64%).Summer(29.16%)was the season with the highest incidence of burn patients admitted to hospitals,followed by spring(25.6%).Scalding(60.19%)was the most frequent kind of burn treated,followed by fire(20.45%).The patients had multiple burn sites(68.89%)most often,followed by burns on the lower limbs(10.91%).From 0%to 10%total body surface area(TBSA)accounted for the highest ratio(37.19%),followed by 90-100%TBSA(21.74%).Conclusions:The present study is the first to describe the associated situation and trends of burn patients in China's Mainland from 2009 to 2018.Our findings will serve as the latest clinical evidence for healthcare planning and prevention efforts in China and other countries. | Jie Yang Guanglei Tian Jianchao Liu Huajuan Bai Shuxu Yang Mingzi Ran Hongyu Li Kui Ma Siming Yang Xiaobing Fu | 2022 | Burns & Trauma2022，10，1： | 1 |
| 3 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 4 | Envelop Extrac-tion of Anaesthesia Breathing Sound Signal on HilbertHuang Transform 显示文摘 | Lu Liu Siming Ma Shaohua Feng | 2012 | Procedia Engineering2012，29，： | 1 |
| 5 | Molecular weight and chain conformation of amylopectin from rice starch显示文摘 | MA Zhaocheng ZHAO Siming CHENG Ke | 2007 | Journal of Applied Polymer Science2007，104，5： | 1 |
| 6 | A Class of Cyclic Queue with Priority Batch Service 显示文摘 | Ma Zili Wang Siming Li Qinglan | 1991 | Applied Mathematical Modelling (S0307- 904X)1991，15，9： | 1 |
| 7 | Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis显示文摘 | Wen Cai Zhang Ng Shyh-Chang He Yang Amit Rai Shivshankar Umashankar Siming Ma Boon Seng Soh Li Li Sun Bee Choo Tai Min En Nga Kishore Kumar Bhakoo Senthil Raja Jayapal Massimo Nichane Qiang Yu Dokeu A. Ahmed Christie Tan Wong Poo Sing John Tam Agasthian T | 2012 | Cell2012，，1： | 1 |
| 8 | A class of cyclic queue with priority batch service显示文摘 | Ma Zili Wang Siming Li Qinglan | 1991 | Appl Math Modelling1991，15，9： | 1 |
| 9 | Room-temperature continuous-wave topological Dirac-vortex microcavity lasers on silicon显示文摘Robust laser sources are a fundamental building block for contemporary information technologies.Originating from condensed-matter physics,the concept of topology has recently entered the realm of optics,offering fundamentally new design principles for lasers with enhanced robustness.In analogy to the well-known Majorana fermions in topological superconductors,Dirac-vortex states have recently been investigated in passive photonic systems and are now considered as a promising candidate for robust lasers.Here,we experimentally realize the topological Diracvortex microcavity lasers in InAs/InGaAs quantum-dot materials monolithically grown on a silicon substrate.We observe room-temperature continuous-wave linearly polarized vertical laser emission at a telecom wavelength.We confirm that the wavelength of the Dirac-vortex laser is topologically robust against variations in the cavity size,and its free spectral range defies the universal inverse scaling law with the cavity size.These lasers will play an important role in CMOS-compatible photonic and optoelectronic systems on a chip. | Jingwen Ma Taojie Zhou Mingchu Tang Haochuan Li Zhan Zhang Xiang Xi Mickael Martin Thierry Baron Huiyun Liu Zhaoyu Zhang Siming Chen Xiankai Sun | 2023 | Light(Science & Applications)2023，12，11： | 0 |
| 10 | Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like cells:a preclinical study显示文摘Human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)possess various advantageous properties,including self-renewal,extended proliferation potential,multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cells in certain conditions.However,little is known about the effect of clinical-grade culture conditions on these properties and on the differentiative potential of hUC-MSCs.In this study,we sought to investigate the properties of hUC-MSCs expanded with animal serum free culture media(ASFCM)in order to determine their potential for differentiation into sweat gland-like cells.We found that primary cultures of hUC-MSCs could be established with ASFCM.Moreover,cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown in classical culture conditions containing fetal bovine serum(FBS).Morphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture conditions,and hUC-MSCs grown in both of the two culture conditions tested showed the typical antigen profile of MSCs—positive for CD29,CD44,CD90,and CD105,and negative for CD34 and CD45,as expected.Chromosomal aberration assay revealed that the cells were stable after long-term culture under both culture conditions.Like normal cultured MSCs,hUC-MSCs induced under ASFCM conditions exhibited expression of the same markers(CEA,CK14 and CK19)and developmental genes(EDA and EDAR)that are characteristic of normal sweat gland cells.Taken together,our findings indicate that the classical culture medium used to differentiate hUC-MSCs into sweat gland-like cells can be replaced safely by ASFCM for clinical purposes. | Siming Yang Kui Ma Changjiang Feng Yan Wu Yao Wang Sha Huang Xiaobing Fu | 2013 | Frontiers of Medicine2013，7，3： | 0 |
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