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| 1 | Current trends in management of hepatitis B virus reactivation in the biologic therapy era显示文摘Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk ofHBV reactivation is heightened by the use monoclonalantibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and longlasting immunosuppression. Emerging data indicatethat HBV reactivation could also develop following theuse of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is di-agnosed, it is mandatory to suspend biologic treatmentand start antiviral agents immediately. However, preemptive antiviral therapy prior to monoclonal antibodyadministration is crucial in preventing HBV reactivationand its clinical consequences. Several lines of evidencehave shown that risk of HBV reactivation is greatlyreduced by the identifi cation of high-risk patients andthe use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists. | Claudio M Mastroianni Miriam Lichtner Rita Citton Cosmo Del Borgo Angela Rago Helene Martini Giuseppe Cimino Vincenzo Vullo | 2011 | World Journal of Gastroenterology2011，17，34： | 12 |
| 2 | 基本药物今昔25年显示文摘 | Jonathan D.Quick Hans V. Hogerzeil German Velasquez Lembit Rago 卢军 | 2003 | 中国循证医学杂志2003，3，2： | 2 |
| 3 | Elastography: New Developments in Ultrasound for Predicting Malignancy in Thyroid Nodules显示文摘 | T Rago F Santini M Scutari A Pinchera P Vitti | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，8： | 2 |
| 4 | 猪精子细胞中胰岛素诱导产生的一氧化氮自由基促进精子获能显示文摘近期,胰岛素被证实具有诱导猪精子获能的能力。在不同的哺乳动物中,精子获能被认为与一氧化氮信号通路相关;因此,本研究使用荧光激活细胞分选技术探究经胰岛素处理的猪精子中一氧化氮水平。在同一样本中,用金霉素染色、蛋白质酪氨酸磷酸化模式和顶体状态来评估精子获能。结果显示经胰岛素处理的精子内一氧化氮水平及三种评价精子获能的指标均有显著提高;相反,用一氧化氮合成酶抑制剂(N-硝基-L-精氨酸甲酯)或抗胰岛素受体β抗体预处理的精子中胰岛素相关的作用全被逆转。这些结果表明胰岛素具有增强猪精子细胞内一氧化氮浓聚的能力并且提示胰岛素可能通过一氧化氮促进精子获能。 | Saveria Aquila Francesca Giordano Carmela Guido Vittoria Rago Amalia Carpino | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 5 | Role of conventional ultrasonography and color flow-Doppler sonography in predicting malignancy in 'cold' thyroid nodules 显示文摘 | Rago T Vitti P Chiovato L | 1998 | Eur J Endocrinol1998，138，： | 1 |
| 6 | Identification of c-myc as a target of the APC pathway显示文摘 | He TC Sparks AB Rago C | 1998 | Scince1998，281，5382： | 1 |
| 7 | Identification of c-myc as a target of APC pathway显示文摘 | He T C Sparks A B Rago C | 1998 | Science1998，281，5382： | 1 |
| 8 | Identification of c-myc as a target of the APC pathway 显示文摘 | He TC Sparks AB Rago C | 1998 | Science1998，281，： | 1 |
| 9 | The devel- opment of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS- 1 gene显示文摘 | Metcall D Di Rago L Mifsud S | 2000 | Proc Natl Acad Sci U S A2000，97，： | 1 |
| 10 | Real-Time elastosonog- raphy: useful tool for refining the presurgical diagnosisin thy roid nodules with indeterminate or nondiagnostic cytology 显示文摘 | Rago T Scutari M Santini F etal | 2010 | J Clin Endocrinol Metab2010，95，12： | 1 |
| 11 | Solitary plasmacytoma of tibia:a possible correlation with younger age显示文摘 | Rago A Miraglia A Mecarocci S | | 0，，08： | 1 |
| 12 | Role of conventional ultrasonography and color flow-Doppler sonography in predicting malignancy in 'cold' thyroid nodules显示文摘 | Rago T Vitti P Chiovato L | 1998 | Eur J Endocrinol1998，138，： | 1 |
| 13 | Elastography: new develop- ments in ultrasound for predicting malignancy in thyroid nodules 显示文摘 | Rago T Santini F Scutari M | 2007 | J Clin Endocrinol Metab2007，92，8： | 1 |
| 14 | Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics显示文摘 | Cécile Sauvanet Stéphane Duvezin-Caubet Jean-Paul di Rago Manuel Rojo | 2010 | Seminars in Cell and Developmental Biology2010，，6： | 1 |
| 15 | Genes expressed in human tumor endothelium显示文摘 | St-Croix B Rago C Velculescu V | 2000 | Science2000，289，5482： | 1 |
| 16 | A survey of ratoon stunting disease (Leifsonia xyli subsp, xyli) in commercial sugarcane fields at Tucuman(Argentina) 显示文摘 | Rago A M Acreche M M Sopena R A | 2004 | Sugar Cane International2004，22，6： | 1 |
| 17 | Identification of c-myc as a target of the APC pathway显示文摘 | He TC Sparks AB Rago C | 1998 | Science1998，281，5382： | 1 |
| 18 | Elastography:new d- evelopments in ultrasound for predicting malignancy inthyroid nodules 显示文摘 | RAGO T SANTINI F SCUTARI M | 2007 | ClinEndocrinol Metab2007，92，8： | 1 |
| 19 | Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules 显示文摘 | Rago T Santini F Scutari M | 2007 | J Clin Endocrinol Metab2007，92，8： | 1 |
| 20 | Inactivation of hCDC4 can cause chromosomal instability 显示文摘 | Rajagopalan H Jallepalli PV Rago C | 2004 | Nature2004，428，6978： | 1 |
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