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| 1 | Pathophysiology of constipation in the older adult显示文摘This review provides information on the definition of constipation, normal continence and defecation and a description of the pathophysiologic mechanisms of constipation. In addition, changes in the anatomy and physiology of the lower gastrointestinal tract associated with aging that may contribute to constipation are described. MEDLINE (1966-2007) and CINAHL (1980-2007) were searched. The following MeSH terms were used: constipation/etiology OR constipation/ physiology OR constipation/physiopathology) AND (age factors OR aged OR older OR 80 and over OR middle age). Constipation is not well defined in the literature. While self-reported constipation increases with age, findings from a limited number of clinical studies that utilized objective measures do not support this association. Dysmotility and pelvic floor dysfunction are important mechanisms associated with constipation. Changes in GI function associated with aging appear to be relatively subtle based on a limited amount of conflicting data. Additional research is warranted on the effects of aging on GI function, as well as on the timing of these changes. | G Lindsay McCrea Christine Miaskowski Nancy A Stotts Liz Macera Madhulika G Varma | 2008 | World Journal of Gastroenterology2008，14，17： | 21 |
| 2 | Surgery for inflammatory bowel disease显示文摘Despite the new and ever expanding array of medications for the treatment of inflammatory bowel disease (IBD), there are still clear indications for operative management of IBD and its complications. We present an overview of indications, procedures, considerations, and controversies in the surgical therapy of IBD. | John M Hwang Madhulika G Varma | 2008 | World Journal of Gastroenterology2008，14，17： | 13 |
| 3 | 2017 ISHNE/HRS动态心电图和体外心电监测/远程监测专家共识(2):诊断适应证及临床预测显示文摘动态心电图(ambulatory ECG,AECG)在临床中被广泛用于检测心律失常和识别常规心电图不易捕捉的心律失常特征性表现。AECG记录系统可采集到大量的心律信息,为临床提供可靠的诊断依据。本文介绍了动态监测技术在心血管疾病诊断及管理中的适应证,评价了该技术在特定临床环境中用于危险分层的预测价值。 | Steinberg JS Varma N Cygankiewicz I 高洁(译) 肖美凤(译) 王新康(译) 卢喜烈(译) 薛求真(译) | 2019 | 实用心电学杂志2019，28，4： | 10 |
| 4 | Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events显示文摘AIM: To compare thromboembolism rates between hospitalized patients with a diagnosis of ulcerative colitis and other hospitalized patients at high risk for thromboembolism. To compare thromboembolism rates between patients with ulcerative colitis undergoing a colorectal operation and other patients undergoing colorectal operations. METHODS: Data from the National Hospital Discharge Survey was used to compare thromboembolism rates between (1) hospitalized patients with a discharge diagnosis of ulcerative colitis and those with diverticulitis or acute respiratory failure, and (2) hospitalized patients with a discharge diagnosis of ulcerative colitis who underwent colectomy and those with diverticulitis or colorectal cancer who underwent colorectal operations. RESULTS: Patients diagnosed with ulcerative colitis had similar or higher rates of combined venous thromboembolism (2.03%) than their counterparts with diverticulitis (0.76%) or respiratory failure (1.99%), despite the overall greater prevalence of thromboembolic risk factors in the latter groups. Discharged patients with colitis that were treated surgically did not have signifi cantly different rates of venous or arterial thromboembolism than those with surgery for diverticulitis or colorectal cancer.CONCLUSION: Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism. | Jennifer Y Wang Jonathan P Terdiman Eric Vittinghoff Tracy Minichiello Madhulika G Varma | 2009 | World Journal of Gastroenterology2009，15，8： | 8 |
| 5 | Recent advances in catalytic combustion of AP-based composite solid propellants显示文摘Composite solid propellants(CSPs) have widely been used as main energy source for propelling the rockets in both space and military applications. Internal ballistic parameters of rockets like characteristic exhaust velocity, specific impulse, thrust, burning rate etc., are measured to assess and control the performance of rocket motors. The burn rate of solid propellants has been considered as most vital parameter for design of solid rocket motors to meet specific mission requirements. The burning rate of solid propellants can be tailored by using different constituents, extent of oxidizer loading and its particle size and more commonly by incorporating suitable combustion catalysts. Various metal oxides(MOs),complexes, metal powders and metal alloys have shown positive catalytic behaviour during the combustion of CSPs. These are usually solid-state catalysts that play multiple roles in combustion of CSPs such as reduction in activation energy, enhancement of rate of reaction, modification of sequences in reaction-phase, influence on condensed-phase combustion and participation in combustion process in gas-phase reactions. The application of nanoscale catalysts in CSPs has increased considerably in recent past due to their superior catalytic properties as compared to their bulk-sized counterparts. A large surface-to-volume ratio and quantum size effect of nanocatalysts are considered to be plausible reasons for improving the combustion characteristics of propellants. Several efforts have been made to produce nanoscale combustion catalysts for advanced propellant formulations to improve their energetics. The work done so far is largely scattered. In this review, an effort has been made to introduce various combustion catalysts having at least a metallic entity. Recent developments of nanoscale combustion catalysts with their specific merits are discussed. The combustion chemistry of a typical CSP is briefly discussed for providing a better understanding on role of combustion catalysts in burning rate enhancement. Available information on different types of combustion nanocatalysts is also presented with critical comments. | Narendra Yadav Prem Kumar Srivastava Mohan Varma | 2021 | Defence Technology(防务技术)2021，17，3： | 8 |
| 6 | Liver transplantation for alcoholic liver disease显示文摘Alcoholic liver disease(ALD) is the second commonest indication for liver transplantation after viral hepatitis in the United States and Europe.Controversies surround the indications and allocation of scarce and expensive resource for this so called self inflicted disease.Controversies stem from the apprehension that alcoholic recipients are likely to relapse and cause damage to the graft.There is a need to select those candidates with lower risk for relapse with the available predictive factors and scores.Substance abuse specialist and psychiatrists are mandatory in the pre-transplant evaluation and in the post-transplant follow-up.There is conflicting evidence to support a fixed period of pretransplant abstinence,although most units do follow this.Alcoholic hepatitis(AH) continues to be a contraindication for transplantation,however there is a need for further research in this f ield as a subset of patients with AH who do not respond to medical treatment,have high early mortality and could benefit from transplantation.One year,3-year,and 5-year survival post-transplant is similar for both ALD and non-ALD recipients.The incidence of post-transplant rejection and retransplantation is also similar to other recipients.ALD with viral hepatitis especially hepatitis C virus leads to a more aggressive liver disease with early presentation for transplantation.ALD patients are more prone to develop de-novo malignancy;this is attributed to the long term effect of alcohol,tobacco combined with immunosuppression.Post-transplant surveillance is important to detect early relapse to alcoholism,presence of de-novo malignancy and treat the same adequately. | Vibha Varma Kerry Webb Darius F Mirza | 2010 | World Journal of Gastroenterology2010，16，35： | 6 |
| 7 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 8 | 2017 ISHNE/HRS动态心电图和体外心电监测/远程监测专家共识(4):心脏远程监测的现状、前景与建议显示文摘动态心电图(ambulatory ECG,AECG)在临床中不仅被广泛用于检测心律失常,还能满足多种临床需求,涉及多领域的临床人员,因此需要深入了解AECG的优点和局限性。本文详细介绍了现有心脏监测技术具体实现方式、心电数据管理及新兴技术等,并总结了编写委员会对AECG适应证和分级的共识。 | Steinberg JS Varma N Crgankiewicz I 高洁 张炜鑫 王新康 卢喜烈 薛求真 | 2019 | 实用心电学杂志2019，28，6： | 4 |
| 9 | 2017 ISHNE/HRS动态心电图和体外心电监测/远程监测专家共识(1):动态心电监测方法显示文摘动态心电图(ambulatory ECG,AECG)在临床中被广泛用于检测心律失常及识别不易从常规心电图中捕捉到的心律失常特征性表现。从不同AECG记录系统中采集到的心律信息可为临床诊断提供可靠的依据,因此,准确记录和精确分析动态心电图至关重要。本文介绍了动态心电监测技术的发展历程,总结了各类动态心电监测设备的特点;从动态设备的导线选择,信号的采集、处理和判读等方面,强调了在临床实践以及临床研究中AECG技术的应用要点。 | Steinberg JS Varma N Cygankiewicz I 高洁 张炜鑫 王新康 卢喜烈 薛求真(译) | 2019 | 实用心电学杂志2019，28，3： | 4 |
| 10 | 对职业技术教育的几点新认识显示文摘职业技术教育最早被看作是培养产业后备军的途径,后来被看作是提高人力资本构成、生产力和就业的手段,今天,人们又认识到它对人的充分发展具有重要作用.人的发展既是国家发展的手段又是国家发展的目的,发展中国家需要一支有熟练技能和适应性强的劳动大军才能抓住发展机会,然而,发展中国家与发达国家的差距还在继续扩大,部分原因是虽然发展中国家注意到了对人的投资,认识到了职业教育与培训的重要性,但发展速度还太慢.职业教育与培训对于降低失业至关重要,但其作用的充分发挥必须依赖于职业教育与培训自身的改善、政府行为的改善、经济形势的好转和妇女就业领域的扩大等前提条件. | Parmanand Varma 唐克胜 | 2003 | 中国职业技术教育2003，，26： | 3 |
| 11 | Larvicidal and adulticidal activities of some medicinal plants against the Malarial Vector, Anopheles stephensi (Liston)显示文摘 | N. Senthilkumar Pushkala Varma G. Gurusubramanian | 2009 | Parasitology Research2009，，2： | 3 |
| 12 | Retinol Binding Protein 4 Expression in Humans: Relationship to Insulin Resistance, Inflammation, and Response to Pioglitazone显示文摘 | Aiwei Yao-Borengasser Vijayalakshmi Varma Angela M. Bodles Neda Rasouli Bounleut Phanavanh Mi-Jeong Lee Tasha Starks Leslie M. Kern Horace J. Spencer Amir Adel Rashidi Robert E. McGehee Susan K. Fried Philip A. Kern | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，7： | 3 |
| 13 | 2017 ISHNE/HRS动态心电图和体外心电监测/远程监测专家共识(3):基于动态心电的标志物及临床疗效分析显示文摘动态心电图(ambulatory ECG,AECG)在临床中不仅被广泛用于检测心律失常,还可采集到大量的心律信息,为临床提供可靠的诊断依据。本文对基于动态心电监测的自主神经张力及复极标志物、药物试验和安全性评估、心脏植入设备患者的动态心电图监测等特定临床背景下药物和非药物治疗心律失常的疗效评价都进行了详细的阐述。 | Steinberg JS Varma N Crgankiewicz I 高洁(译) 杨燕秋(译) 王新康(译) 卢喜烈(译) 薛求真(译) | 2019 | 实用心电学杂志2019，28，5： | 3 |
| 14 | Metal complexation by chitosan and its derivatives: a review显示文摘 | A.J Varma S.V Deshpande J.F Kennedy | 2003 | Carbohydrate Polymers2003，，1： | 3 |
| 15 | CFD modeling to study the effect of particle size on dispersion in 20l explosion chamber: An overview显示文摘Mine disasters occur predominantly due to methane or coal dust explosion or a combination of both.Among the top ten worst coal mine disasters in India, nine are due to coal dust explosion. The current paper describes a general overview of the parameters causing dispersion leading to coal dust explosion,and computational fluid dynamics(CFD) simulation study to observe the effects of particle size on dispersion in Indian coal mines. Turbulent kinetic energy(TKE) and velocity vector path of dust-air mixture and dust-free air were simulated to understand their effects on coal dust dispersion. The TKE contours and velocity vector paths for dust-free air were uniform and symmetrical due to resistance-free path available. The TKE contours and velocity vector paths for dust-air mixture shows the asymmetrical distribution of contours, due to entrainment of air with dust particles. Vortices were observed in velocity vector paths which gradually diminish on increment of time sequence. These vortices are dead centres where velocity and coal dust particles concentration are both zero. | Santosh Kumar Ray Niroj Kumar Mohalik Asfar Mobin Khan Debashish Mishra Nikhil Kumar Varma Jai Krishna Pandey Pradeep Kumar Singh | 2020 | International Journal of Mining Science and Technology2020，30，3： | 3 |
| 16 | Correlation of Brain Biomarker Neuron Specific Enolase (NSE) with Degree of Disability and Neurological Worsening in Cerebrovascular Stroke显示文摘 | Anuradha Bharosay Vivek Bharosay Meena Varma Kiran Saxena Ajoy Sodani Ravi Saxena | 2012 | Indian Journal of Clinical Biochemistry2012，，2： | 2 |
| 17 | Forming-Induced Residual Stress and Material Properties of Roll-Formed High-Strength Steels显示文摘Martensitic steels are widely used in the automotive lightweight application but less understood in aspects of post-forming material properties.The steels show good ductility in roll forming but occasionally experience delayed(hydrogen)fracture issues,which are believed to be due to the formation of localized residual stress and a reduced product of strength and elongation.To characterize the effect of roll forming process on the formation of residual stress and material properties variation of martensitic steel components,this paper investigates the forming-induced longitudinal residual stress and material property variation in a roll-formed high-strength MS1180 automotive rocker panel.The finite element analysis results for residual stress are validated by neutron diffraction measurements.The numerical model is used to analyze the full evolution of residual stress during the roll forming process and the effect on material properties with major focus on the product of strength and elongation.It is found that the flower design,in particular the overbending stages,play a significant role in the formation of residual stress and the change in material properties.The product of strength and elongation is significantly reduced across the profile,in particular in the corners.The achieved understanding will assist researchers comprehend the material properties of roll-formed component and therefore assist future studies aimed at preventing the occurrence of hydrogen fracture. | Yong Sun VladimirLuzin Yixin Duan Rameshkumar Varma Lei Shi Matthias Weiss | 2020 | Automotive Innovation2020，3，3： | 2 |
| 18 | Concurrent dengue and malaria due to Plasmodium falciparum and P. vivax显示文摘 | Rajeev M. Kaushik Amit Varma Reshma Kaushik Kunwar J.B.S. Gaur | 2007 | Transactions of the Royal Society of Tropical Medicine and Hygiene2007，，10： | 2 |
| 19 | Hepatic Artery Pseudoaneurysms: A Single-Center Experience显示文摘 | Raghavendra Nagaraja Mahendran Govindasamy Vibha Varma Amitabh Yadav Naimish Mehta Vinay Kumaran Arun Gupta Samiran Nundy | 2013 | Annals of Vascular Surgery2013，，6： | 2 |
| 20 | Intraocular Pressure Control and Long-term Visual Field Loss in the Collaborative Initial Glaucoma Treatment Study显示文摘 | David C. Musch Brenda W. Gillespie Leslie M. Niziol Paul R. Lichter Rohit Varma | 2011 | Ophthalmology2011，，9： | 2 |
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