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| 1 | Protective effects of trilinolein extracted from Panax notoginseng against cardiovascular disease显示文摘Trilinolein is a triacylglycerol purified from a commonly used traditional Chinese medicine Panax notoginseng,Trilinolein has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability.Additionally,trilinolein has been reported to be an antioxidant,which can counteract free radical damage associated with atherogenesis,and myocardial damage seen with ischaemia and reperfusion.These pharmacologic effects may explain the perceived benefits derived from treating circulatory disorders with the herb over the centuries. | Paul CHAN G Neil THOMAS Brian TOMLINSON | 2002 | Acta Pharmacologica Sinica2002，23，12： | 45 |
| 2 | Relationship between obesity and cardiovascular risk factors in elderly Chinese subjects显示文摘Objective To investigate the relative effects of degree and distribution of body fat with several cardiovascular disease (CVD) risk factors in elderly Chinese subjects.Methods One-hundred and thirty-five elderly Chinese individuals (age range, 60-65 y) without any history of significant renal, hepatic or cardiac disease were recruited. Seated blood pressure, anthropometric and fasting plasma biochemical parameters were measured. Student’s t-test was used to compare the differences in biochemical and anthropometric markers between cohorts.Results Males were heavier (64.6±8.6, 57.2±8.2?kg, P<0.001), taller (1.65±0.06, 1.51± 0.05 m, P<0.001) and their greater body fat was predominantly deposited centrally (Waist-to-hip ratio, 0.91±0.06, 0.88±0.07, P<0.05). Females were more generally obese with increased body mass index (BMI, 23.8±4.6, 25.0±3.5 kg/m 2, P<0.05) and percentage body fat [26.3% (24.5%-28.1%) vs 37.2% (36.0%-38.9%), P<0.001] than the males. However, despite an 11% higher proportion of body fat in females, no significant differences were identified in blood pressure, lipid profile, indices of insulin resistance or albumin-to-creatinine ratios.Conclusion It is likely that central adiposity contributes disproportionately to these metabolic disorders in males even though they are much leaner than elderly Chinese females. | G Neil THOMAS 赵海潞 马艳青 Wilson YS LEUNG Juliana CN CHAN Brian TOMLINSON Julian AJH CRITCHLEY 梁润成 陈重娥 汤宁信 郭志良 | 2002 | Chinese Medical Journal2002，，6： | 11 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice With Tumor Necrosis Factor-α–Induced Cardiomyopathy显示文摘 | Yoshihiro Higuchi Charles F. McTiernan Carole B. Frye Brian S. McGowan Tung O. Chan Arthur M. Feldman | 2004 | Circulation: Journal of the American Heart Association2004，，15： | 2 |
| 5 | Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF -Mutated Colorectal Cancer显示文摘 | Kopetz Scott Desai Jayesh Chan Emily Hecht Joel Randolph O’Dwyer Peter J. Maru Dipen Morris Van Janku Filip Dasari Arvind Chung Woonbook Issa Jean-Pierre J. Gibbs Peter James Brian Powis Garth Nolop Keith B. Bhattacharya Suman Saltz Leonard | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 6 | Consensus Statements on the Risk, Prevention, and Treatment of Venous Thromboembolism in Inflammatory Bowel Disease: Canadian Association of Gastroenterology显示文摘 | Geoffrey C. Nguyen Charles N. Bernstein Alain Bitton Anthony K. Chan Anne M. Griffiths Grigorios I. Leontiadis William Geerts Brian Bressler J. Decker Butzner Marc Carrier Nilesh Chande John K. Marshall Chadwick Williams Clive Kearon | 2014 | Gastroenterology2014，，3： | 2 |
| 7 | A Framework for Verifying SLA Compliance in Coposed Services 显示文摘 | Hua Xiao Brian Chan Ying Zou Jay W Benayon Bill O'Farrell Elena Litani Jen Hawkins | 2008 | IEEE Com- puter Society2008，，： | 1 |
| 8 | Acute Variceal Bleed in a Patient with Idiopathic Myelofibrosis Successfully Treated with Endoscopic Variceal Band Ligation显示文摘 | Brian K. P. Goh MBBS MRCS MMed Juliana J. C. Chen MBBS MRCS MMed Hiang-Khoon Tan MBBS FRCS PhD Wei-Sean Yong MBBS FRCS Weng-Hoong Chan MBBS FRCS | 2007 | Digestive Diseases and Sciences2007，，1： | 1 |
| 9 | The hydrodynamics of water strider locomotion显示文摘 | David L.Hu Brian Chan John.W.M.Bush | | 0，，6949： | 1 |
| 10 | Prognostic significance of the total dose of cisplatin administered during concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma显示文摘 | Herbert H. Loong Brigette B.Y. Ma Sing-Fai Leung Frankie Mo Edwin P. Hui Michael K. Kam Stephen L. Chan Brian K.H. Yu Anthony T.C. Chan | 2012 | Radiotherapy and Oncology2012，，3： | 1 |
| 11 | Factors contributing to the efficacy of concurrent–adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Combined analyses of NPC-9901 and NPC-9902 Trials显示文摘 | Anne W.M. Lee Stewart Y. Tung Roger K.C. Ngan Rick Chappell Daniel T.T. Chua T.X. Lu Lillian Siu Terence Tan L.K. Chan W.T. Ng T.W. Leung Y.T. Fu Gordon K.H. Au C. Zhao Brian O’Sullivan E.H. Tan W.H. Lau | 2010 | European Journal of Cancer2010，，5： | 1 |
| 12 | Toxicity of Complementary Therapies: An Eastern Perspective显示文摘 | Brian Tomlinson Thomas Y. K. Chan Juliana C. N. Chan Julian A.J.H. Critchley Paul P. H. But | 2000 | The Journal of Clinical Pharmacology2000，，5： | 1 |
| 13 | A prospective evaluation of preoperative localization by technetium-99m sestamibi scintigraphy and ultrasonography in primary hyperparathyroidism显示文摘 | Chung-Yau Lo Brian H. Lang W.F. Chan Annie W.C. Kung Karen S.L. Lam | 2007 | The American Journal of Surgery2007，，2： | 1 |
| 14 | Feasibility and Accuracy of Different Techniques of Two-Dimensional Speckle Based Strain and Validation With Harmonic Phase Magnetic Resonance Imaging显示文摘 | Manish Bansal Goo-Yeong Cho Jonathan Chan Rodel Leano Brian A. Haluska Thomas H. Marwick | 2008 | Journal of the American Society of Echocardiography2008，，12： | 1 |
| 15 | Cholecystectomy for asymptomatic gallstones:Markov decision tree analysis显示文摘Gallstones are a common public health problem,especially in developed countries.There are an increasing number of patients who are diagnosed with gallstones due to increasing awareness and liberal use of imaging,with 22.6%-80% of gallstone patients being asymptomatic at the time of diagnosis.Despite being asymptomatic,this group of patients are still at life-long risk of developing symptoms and complications such as acute cholangitis and acute biliary pancreatitis.Hence,while early prophylactic cholecystectomy may have some benefits in selected groups of patients,the current standard practice is to recommend cholecystectomy only after symptoms or complications occur.After reviewing the current evidence about the natural course of asymptomatic gallstones,complications of cholecystectomy,quality of life outcomes,and economic outcomes,we recommend that the option of cholecystectomy should be discussed with all asymptomatic gallstone patients.Disclosure of material information is essential for patients to make an informed choice for prophylactic cholecystectomy.It is for the patient to decide on watchful waiting or prophylactic cholecystectomy,and not for the medical community to make a blanket policy of watchful waiting for asymptomatic gallstone patients.For patients with high-risk profiles,it is clinically justifiable to advocate cholecystectomy to minimize the likelihood of morbidity due to complications. | Brian Juin Hsien Lee Qai Ven Yap Jee Keem Low Yiong Huak Chan Vishal G Shelat | 2022 | World Journal of Clinical Cases2022，10，29： | 1 |
| 16 | Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants显示文摘Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections. | Zhuoran Wu Brian Chan Jessalyn Low Justin Jang Hann Chu Hwee Weng Dennis Hey Andy Tay | 2022 | Bioactive Materials2022，7，10： | 1 |
| 17 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 18 | Prognostic significance of the total dose of cisplatin administered during concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma显示文摘 | Herbert H. Loong Brigette B.Y. Ma Sing-Fai Leung Frankie Mo Edwin P. Hui Michael K. Kam Stephen L. Chan Brian K.H. Yu Anthony T.C. Chan | 2012 | Radiotherapy and Oncology2012，，3： | 1 |
| 19 | Probe-based confocal laser endomicroscopy in the pancreatic duct provides direct visualization of ductal structures and aids in clinical management显示文摘 | Michel Kahaleh Brian G. Turner Karl Bezak Reem Z. Sharaiha Savreet Sarkaria Michael Lieberman Armeen Jamal-Kabani Jennifer E. Millman Subha V. Sundararajan Ching Chan Shivani Mehta Jessica L. Widmer Monica Gaidhane Marc Giovannini | 2014 | Digestive and Liver Disease2014，，： | 1 |
| 20 | Restaging of Differentiated Thyroid Carcinoma by the Sixth Edition AJCC/UICC TNM Staging System: Stage Migration and Predictability显示文摘 | Brian Lang MS FRACS Chung-Yau Lo MS FRCS (Edin) FACS Wai-Fan Chan MBBS FRCS King-Yin Lam MD FRCPA Koon-Yat Wan MBBS FRCR | 2007 | Annals of Surgical Oncology2007，，5： | 1 |
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