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| 1 | 关于“混凝土硫酸盐结晶破坏”理论的研究进展显示文摘当混凝土构件半掩埋在含有硫酸盐的土壤或地下水中时,暴露在空气中的混凝土会发生类似于其他多孔材料(如岩石、多孔砖等)的破坏方式。混凝土科技工作者认为是硫酸盐结晶导致了混凝土破坏,对这方面的研究也越来越受到重视。但是,对于'混凝土硫酸盐结晶破坏'这一课题未有系统的研究报道,并缺乏对已有研究成果的总结和理论分析。本文详细分析了已有相关试验室和野外长期试验结果,对比多孔材料盐结晶经典理论发现,有关'混凝土硫酸盐结晶破坏'的试验结果和现象与盐结晶经典理论存在很大的争议,并没有充分的理由说明硫酸盐结晶破坏是导致混凝土破坏的主要原因,而通常所说的硫酸盐化学侵蚀依然可能是其主要破坏机理。最后,针对存有争议的试验结果,提出了需要进一步研究的一些问题。 | 邓德华 刘赞群 Geert DE SCHUTTER 刘运华 | 2012 | 硅酸盐学报2012，40，2： | 60 |
| 2 | 高性能混凝土高温微观结构演化研究显示文摘通过热重分析、电镜扫描和汞压力测孔等方法,对高温过程中高性能混凝土材料的物理化学变化以及由此造成的微观结果变化进行了分析.相关试验和分析表明:造成升温过程中材料质量损失的主要原因是脱水和各种分解反应.在400℃之前,材料孔隙结构的变化主要来自材料内部水分的散失;400-500℃之间,由于材料发生分解反应,氢氧化钙的分解将提供大量的孔隙.这些结论将为进一步解释爆裂现象提供更为本质的试验支持,同时也为进一步建立高温情况下材料微观结构演化模型提供了试验基础. | 柳献 袁勇 叶光 Geert De Schutter | 2008 | 同济大学学报(自然科学版)2008，36，11： | 45 |
| 3 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 4 | 高性能混凝土高温爆裂的机理探讨显示文摘研究不同纤维掺量的高强和自密实混凝土的高温性能。试验过程中通过差热分析研究升温过程中材料的物相组成变化,采用环境扫描电镜和汞压力测孔法对材料进行微观性能研究,并量测高温后材料的气渗性能。探讨升温过程中材料内部的物相变化、材料微观结构变化以及气渗性能的变化规律。基于试验结果,分析导致升温过程中材料微观结构变化的原因,同时对纤维的熔解过程中以及纤维熔解后对材料微观结构的影响也进行了探讨。最后,分析微观结构和材料宏观性能之间的联系,并探讨高温时影响材料气渗性能的相关因素。研究成果加深了对高性能混凝土高温爆裂现象的理解,有助于高性能混凝土的进一步应用。 | 柳献 袁勇 叶光 Geert De Schutter | 2008 | 土木工程学报2008，41，6： | 38 |
| 5 | “混凝土硫酸盐结晶破坏”微观分析(Ⅰ)——水泥净浆显示文摘在多孔材料内部检测发现硫酸盐晶体是证明盐结晶破坏最直接的证据。运用环境扫描电子显微镜、扫描电子显微镜、能谱仪和X射线衍射等微观分析手段,研究了稳定环境和变化环境中,硫酸钠溶液对半浸泡纯水泥净浆和水泥粉煤灰净浆的破坏作用,结果表明:在破坏的净浆试件中并没有发现硫酸钠晶体,反而发现大量的混凝土硫酸盐化学侵蚀产物(钙矾石和石膏等)晶体,硫酸盐化学侵蚀依然是引起净浆试件破坏的主要原因。 | 刘赞群 邓德华 Geert DE SCHUTTER 刘运华 | 2012 | 硅酸盐学报2012，40，2： | 31 |
| 6 | “混凝土硫酸盐结晶破坏”微观分析(Ⅱ)-混凝土显示文摘运用环境扫描电镜、能谱仪和X射线衍射等微观分析手段研究了稳定环境中,半浸泡混凝土试件在硫酸钠和硫酸镁溶液中的劣化破坏特征,以及混凝土碳化对'混凝土硫酸盐结晶破坏'的影响。结果表明:粗骨料界面过渡区生成的大量钙矾石和石膏等晶体是引起混凝土试件劣化的原因;在碳化混凝土内发现了硫酸钠结晶破坏现象。 | 刘赞群 邓德华 Geert De Schutter 刘运华 | 2012 | 硅酸盐学报2012，40，5： | 29 |
| 7 | 石膏种类对硅酸盐–铝酸盐混合水泥强度的影响机理显示文摘用量热仪、X射线衍射仪、环境扫描电子显微镜分析了无水石膏、半水石膏及二水石膏对硅酸盐–铝酸盐混合水泥强度发展的影响机理。结果表明:石膏种类决定了其溶解度和溶解速度,而石膏掺量决定了混合水泥浆体中可反应的硫酸根总量,两者影响着水化产物钙矾石(AFt)的生成量、生成时间及形状,从而直接影响着浆体的体积稳定性,最终决定了浆体的强度发展。石膏掺量为7.5%时,AFt生成量先增后减,但达到最大值的时间及尺寸与石膏种类有关:掺无水石膏时,AFt转变为单硫型(AFm)的时间最晚,AFt形状较掺其他石膏时更加细长,且水化前8h的AFt生成量明显低于掺其他石膏时的,因此早期强度较低。而石膏掺量为15%时,掺半水石膏时浆体中除AFt外还易生成尺寸比其大数十倍的二水石膏,导致三元体系在宏观上表现为体积膨胀,水化后期甚至因膨胀过度而丧失强度。 | 徐玲琳 王培铭 张国防 Geert de SCHUTTER | 2013 | 硅酸盐学报2013，41，11： | 25 |
| 8 | 黄芪对鲤头肾中巨噬细胞的增殖和一氧化氮产量的影响:离体研究(英文)显示文摘用密度梯度离心分离鲤头肾中的巨噬细胞和嗜中性粒细胞。用RPMI细胞培养液对分离的细胞进行原代培养,在细胞培养液中加入不同浓度的黄芪水提取液来研究黄芪对鲤头肾中免疫细胞非特异性免疫应答的影响。黄芪水提取液单独使用时能刺激鲤头肾中巨噬细胞的增殖,但不能刺激巨噬细胞的氮暴发活性。用黄芪和脂多糖(LPS)混合刺激巨噬细胞和中性粒细胞时,黄芪水提取液能显著提高脂多糖刺激所产生的一氧化氮的产量。研究结果表明,黄芪不仅能刺激巨噬细胞数量的增加,而且能协同脂多糖增强头肾中免疫细胞的功能,从而对机体的非特异性免疫起调节作用。 | 殷国俊 Geert Wiegertjes LI Yue-ming Johan Schrama Johan Verreth 徐跑 周洪琪 | 2004 | 水产学报2004，28，6： | 14 |
| 9 | 聚丙烯纤维高温阻裂机理显示文摘通过研究不同纤维掺量自密实混凝土高温情况下的宏微观性能,探讨高温时材料内部的物理化学变化,以及不同温度状况下由微观结构变化所带来的宏观性能变化.试验中,待试样进行不同的高温处理过后,采用汞压力测孔法和扫描电镜对材料进行微观性能研究,并量测了高温后材料的气渗性能.同时,聚丙烯纤维的作用机理也得到了探讨.试验结果表明,纤维熔解能改善材料内部孔隙的连通性能,从而提高材料的气渗性能,降低了材料内部由升温集聚的孔隙压力.进一步,气渗性能的测量能作为评价纤维添加效果的有效手段.同时,研究中还发现熔解过程中聚丙烯纤维的工作机制,将有助于进一步的相关研究. | 柳献 袁勇 叶光 Geert De Schutter | 2007 | 同济大学学报(自然科学版)2007，35，7： | 14 |
| 10 | Connect & Drive:design and evaluation of cooperative adaptive cruise control for congestion reduction显示文摘Road throughput can be increased by driving at small inter-vehicle time gaps.The amplification of velocity disturbances in upstream direction,however,poses limitations to the minimum feasible time gap.This effect is covered by the notion of string stability.String-stable behavior is thus considered an essential requirement for the design of automatic distance control systems,which are needed to allow for safe driving at time gaps well below 1 s.Using wireless inter-vehicle communications to provide real-time information of the preceding vehicle,in addition to the information obtained by common Adaptive Cruise Control(ACC) sensors,appears to significantly decrease the feasible time gap,which is shown by practical experiments with a test fleet consisting of six passenger vehicles.The large-scale deployment of this system,known as Cooperative ACC(CACC),however,poses challenges with respect to the reliability of the wireless communication system.A solution for this scalability problem can be found in decreasing the transmission power and/or beaconing rate,or adapting the communications protocol.Although the main CACC objective is to increase road throughput,the first commercial application of CACC is foreseen to be in truck platooning,since short distance following is expected to yield significant fuel savings in this case. | Jeroen PLOEG Alex F.A.SERRARENS Geert J.HEIJENK | 2011 | Journal of Modern Transportation2011，19，3： | 9 |
| 11 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 12 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 13 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 14 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 15 | Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks显示文摘AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. | Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen Marc Van Ranst Frank Buntinx | 2007 | World Journal of Gastroenterology2007，13，43： | 4 |
| 16 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 4 |
| 17 | RNA-Based Biocontrols--A New Paradigm in Crop Protection显示文摘Modern agribusiness plays a vital role in safeguarding and improving the production,quality,and quantity of food,feed,fiber,and fuel.Growing concerns over the impact of chemical pesticides on health and the environment have stimulated the industry to search for alternative and greener solutions.Over the last years,the RNA interference(RNAi)process has been identified as a very promising new approach to complement the arsenal of foliar spray,soil,or seed treatments applied as chemical and biological pest control agents,and of plant-incorporated protectants(PIPs).RNA-based active ingredients(AIs)possess a unique mode of action and can be implemented via both genetic modification(GM)and biocontrol approaches.RNA-based AIs promise to deliver the selectivity and sustainability desired in future crop protection agents.This is due to their utilization of a natural process to exert control and their high level of selectivity,which leads to reduced risk for non-target organisms(NTOs).This review discusses the advantages and limitations of RNA-based solutions in crop protection and recent research progress toward RNA-based biocontrols against the Colorado potato beetle(CPB),corn rootworm(CRW),and soy stink bug(SSB).Many challenges still exist on the road to the implementation of a broad range of RNA-based products and their widespread use and application.Despite these challenges,it can be expected that RNA-based AIs will become valuable new tools complementing the current arsenal of crop-protection solutions. | Matthew Bramlett Geert Plaetinck Peter Maienfisch | 2020 | Engineering2020，6，5： | 4 |
| 18 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 19 | 氯盐浸泡的水泥基材料的表面氯离子浓度(英文)显示文摘水泥基材料的表面氯离子浓度(cs)是Fick’s第二定律寿命预测模型的1个重要参数,它通过将Fick’s第二定律与氯离子浓度分布拟合而得到。当水泥基材料浸泡在一定浓度的氯盐溶液中时,水泥基材料的cs和浸泡溶液的氯离子浓度(c)之间的关系仍未得到很好的理解。一些发表的文献表明cs要高于c,Nagataki将其称为浓缩现象。本文研究了cs和c之间的关系,并探索了其机理。将普通Portland水泥、80%(质量分数,下同)水泥+20%粉煤灰和60%水泥+40%矿渣3种5 mm厚的硬化水泥浆体薄片分别浸泡于氯离子浓度为0.15 mol/L,0.5 mol/L,1 mol/L的3种氯化钠溶液中,浸泡35 d和120 d后,采用压滤法将硬化水泥浆中的孔溶液压滤出来,测量其氯离子浓度,并与c进行对比。结果表明:c较低时(0.15 mol/L),压滤法得到的孔溶液的氯离子浓度约比c高30%;当c较高时(>0.5 mol/L),压滤法得到的孔溶液的氯离子浓度与浸泡溶液浓度相当。分析认为双电层是产生该现象的关键因素。 | 元强 史才军 GEERT De Schutter 邓德华 何富强 | 2011 | 硅酸盐学报2011，39，3： | 4 |
| 20 | Prediction of vibrations induced by trains on line 8 of Beijing metro显示文摘This paper mainly discusses the problem of ground-borne vibrations due to the planned line 8 of Beijing metro which passes under the National Measurement Laboratory.A lot of vibration sensitive equipments are placed in the laboratory.It is therefore necessary to study the impact of vibrations induced by metro trains on sensitive equipments and important to propound a feasible vibration mitigation measure.Based on the coupled periodic finite element-boundary element (FE-BE) method,a 3D dynamic track-tunnel-soil interaction model for metro line 8 has been used to predict vibrations in the free field induced by trains running at variable speeds between 30 km/h and 80 km/h.Four types of track structures commonly used on the Beijing metro network have been considered:(1) high resilience direct fixation fasteners,(2) Vanguard fasteners,(3) a floating slab track and (4) a floating ladder track.For each of these track types,the vibration isolation efficiency has been compared.The results of the numerical study can be used to predict vibrations in nearby buildings and to decide upon effective vibration countermeasures. | De-yun DING Shashank GUPTA Wei-ning LIU Geert LOMBAERT Geert DEGRANDE | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，4： | 4 |
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