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| 1 | Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection:A study from northern India显示文摘AIM: To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non- ulcer dyspepsia (NUD). METHODS: We enrolled 348 adult patients (62 gastric adenocarcinoma, 45 PUD and 241 NUD) undergoing upper gastrointestinal endoscopy at two referral centers between September, 2002 and May, 2007. H pylori infection was diagnosed when any of the four tests (RUT, culture, histopathology and PCR) were positive. Genotyping for -765G > C polymorphism of COX-2 was performed by PCR-RFLP analysis. RESULTS: Frequency of C carrier had significantassociation with gastric adenocarcinoma as compared to NUD [77.4% vs 29%, P < 0.001, odds ratio (OR) 8.20; 95% confidence interval (95% CI), 4.08-16.47] and PUD (77.4% vs 31.1%, P < 0.001; OR 8.04; 95% CI, 3.25-19.90). Risk of gastric adenocarcinoma was significantly higher in patients having C carrier with (OR 7.83; 95% CI 3.09-19.85) and without H pylori infection (OR 7.06; 95% CI, 2.61-19.09). Patients with C carrier and H pylori infection had significant risk for the development of PUD (P < 0.001; OR 5.65; 95% CI, 2.07-15.34). CONCLUSION: -765G > C COX-2 polymorphism with or without H pylori could be a marker for genetic susceptibility to gastric adenocarcinoma. COX-2 polymorphism in presence of H pylori infection might be useful in predicting the risk of PUD. | Ashish Saxena Kashi Nath Prasad Uday Chand Ghoshal Monty Roshan Bhagat Narendra Krishnani Nuzhat Husain | 2008 | World Journal of Gastroenterology2008，14，10： | 18 |
| 2 | Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom显示文摘The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are pending.As evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME. | Sameh Hany Emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand | 2018 | World Journal of Gastrointestinal Surgery2018，10，3： | 18 |
| 3 | Systematic review of prognostic importance of extramuralvenous invasion in rectal cancer显示文摘AIM: To systematically review the survival outcomes relating to extramural venous invasion in rectal cancer.METHODS: A systematic review was conducted using PRISMA guidelines. An electronic search was carried out using MEDLINE, EMBASE, CINAHL, Cochrane library databases, Google scholar and Pub Med until October 2014. Search terms were used in combination to yield articles on extramural venous invasion in rectal cancer. Outcome measures included prevalence and 5-year survival rates. These were graphically displayed using Forest plots. Statistical analysis of the data was carried out.RESULTS: Fourteen studies reported the prevalence of extramural venous invasion(EMVI) positive patients. Prevalence ranged from 9%-61%. The pooled prevalence of EMVI positivity was 26% [Random effects: Event rate 0.26(0.18, 0.36)]. Most studies showed that EMVI related to worse oncological outcomes. The pooled overall survival was 39.5% [Random effects: Event rate 0.395(0.29, 0.51)].CONCLUSION: Historically, there has been huge variation in the prevalence of EMVI through inconsistent reporting. However the presence of EMVI clearly leads to worse survival outcomes. As detection rates become more consistent, EMVI may be considered as part of risk-stratification in rectal cancer. Standardised histopathological definitions and the use of magnetic resonance imaging to identify EMVI will improve detection rates in the future. | Manish Chand Muhammed RS Siddiqui Ian Swift Gina Brown | 2016 | World Journal of Gastroenterology2016，22，4： | 15 |
| 4 | Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia:a molecular docking study exploring possible neuroprotection显示文摘The main pathophysiology of cerebral ischemia is the structural alteration in the neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been reported to be one of the most potent chemopreventive agents that can inhibit cellular processes associated with ischemic stroke. Matrix metalloproteinases(MMPs) has been considered as a potential drug target for the treatment of cerebral ischemia. To explore this, we tried to investigate the interaction of resveratrol with MMPs through molecular docking studies. At 30 minutes before and 2 hours after cerebral ischemia/reperfusion induced by occlusion of the middle cerebral artery, 40 mg/kg resveratrol was intraperitoneally administered. After resveratrol administration, neurological function and brain edema were significantly alleviated, cerebral infarct volume was significantly reduced, and nitrite and malondialdehyde levels in the cortical and striatal regions were significantly decreased. The molecular docking study of resveratrol and MMPs revealed that resveratrol occupied the active site of MMP-2 and MMP-9. The binding energy of the complexes was –37.848672 k J/mol and –36.6345 k J/mol for MMP-2 and MMP-9, respectively. In case of MMP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of MMP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues. These findings collectively reveal that resveratrol exhibits neuroprotective effects on cerebral ischemia through inhibiting MMP-2 and MMP-9 activity. | Anand Kumar Pandey Pallab Bhattacharya Swet Chand Shukla Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，4： | 12 |
| 5 | Buttress plating for a rare case of comminuted medial condylar Hoffa fracture associated with patellar fracture显示文摘Hoffa 骨折是不平常的 injury.In 文学,侧面的 condylar Hoffa 骨折比中间的 condylar Hoffa 骨折作为一个更普通的损害模式被提及。损害的机制和处理的方法很好没在文学被描述。我们与 ipsilateral 正在介绍弄碎的中间的 condylar Hoffa 骨折的一个稀罕盒子膝盖骨的骨折。损害的机制没在文学被描述。落后螺丝钉固定,是处理的最可接受的方法,不由于粉碎是可能的。我们解释损害的可能的机制并且与 L-but-tress 板修理破裂。 | Ashwani Soni Ramesh K Sen Uttam Chand Saini Dajjit Singh Sushil Chaudhary | 2012 | Chinese Journal of Traumatology2012，15，4： | 9 |
| 6 | Applications of phototheranostic nanoagents in photodynamic therapy显示文摘Nanotherapeutics 在象癌症那样的疾病的治疗有一个增加的角色。在光力学的治疗(太平洋夏季时间) ,治疗学地不活跃的 photosensitizer 混合物被光有选择地激活生产能够杀死 diseased 房间和病原体的分子。一个 phototheranostic 代理人能为指向的交货,光成像和疾病的光力学的治疗与能力被定义为单个 nanoentity。恶意的房间,纸巾和微生物引起的 etiologic 代理人能被太平洋夏季时间有效地指向。光力学的治疗是 noninvasive,或最低限度地侵略,并且当健康织物的损坏被最小化,杀死的效果是局部性的,有很少副作用。癌症,粉刺和另外的疾病的各种各样的形式可以被对待。在里面 photosensitizers 的 vivo 功效被把他们纳入能够指向 diseased 地点的 nanostructures 进一步改进。如此的 photosensitizer-functionalized nanostructures,或 nanotherapeutics,为改进 phototheranostic 性能允许成像和治疗学的代理人的地点特定的交货。这评论在诊断和治疗探索 phototheranostic nanostructures 的潜在的应用。 | Jayeeta Bhaumik Amit Kumar Mittal Avik Banedee Yusuf Chisti Uttam Chand Banerjee | 2015 | Nano Research2015，8，5： | 8 |
| 7 | Systematic review of emergent laparoscopic colorectal surgery for benign and malignant disease显示文摘Laparoscopic surgery has become well established in the management of both and malignant colorectal disease.The last decade has seen increasing numbers of surgeons trained to a high standard in minimallyinvasive surgery.However there has not been the same enthusiasm for the use of laparoscopy in emergency colorectal surgery.There is a perception that emergent surgery is technically more difficult and may lead to worse outcomes.The present review aims to provide a comprehensive and critical appraisal of the available literature on the use of laparoscopic colorectal surgery(LCS)in the emergency setting.The literature is broadly divided by the underlying pathology;that is,inflammatory bowel disease,diverticulitis and malignant obstruction.There were no randomized trials and the majority of the studies were case-matched series or comparative studies.The overall trend was that LCS is associated with shorter hospital stay,par or fewer complications but an increased operating time.Emergency LCS can be safely undertaken for both benign and malignant disease providing there is appropriate patient selection,the surgeon is adequately experienced and there are sufficient resources to allow for a potentially more complex operation. | Manish Chand Muhammed RS Siddiqui Ashish Gupta Shahnawaz Rasheed Paris Tekkis Amjad Parvaiz Alex H Mirnezami Tahseen Qureshi | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 8 | Attenuation of Collagen Induced Arthritis by Centella asiatica Methanol Fraction via Modulation of Cytokines and Oxidative Stress显示文摘Objective To investigate the anti-inflammatory, antioxidant and anti-arthritic effects of Centella asiatica methanolfraction(CaM E) on collagen-induced arthritis(CIA), an animal model of rheumatoid arthritis. Methods Arthritis was induced in female wistar rats by immunization with porcine type II collagen. The CIA rats were treated orally with CaM E(50, 150, and 250 mg/kg/day) for 15 d(beginning on day 21 of the experimental period). The clinical, histological, biochemical, and immunological parameters were assessed. Results CaM E treatment(150 and 250 mg/kg) significantly attenuated the severity of CIA and reduced the synovial inflammation, cartilage erosion, and bone erosion as evident from both histological and radiographic data. The escalated plasma levels of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-12 alongwith nitric oxide in CIA rats decreased significantly on CaM E treatment. The serum levels of type-II collagen antibody were significantly lower in rats of CaM E(150 and 250 mg/kg) treated group than those in the arthritic group. Furthermore, by inhibiting the above mediators, CaM E also contributed towards the reversal of the disturbed antioxidant levels and peroxidative damage. Conclusion Our results clearly indicate that oral administration of CaM E suppresses joint inflammation, cytokine expression as well as antioxidant imbalance, thereby contributing to an amelioration of arthritis severity in CIA rats. | Shikha Sharma Ritu Gupta Sonu Chand Thaku | 2014 | Biomedical and Environmental Sciences2014，27，12： | 6 |
| 9 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 10 | Enhanced visible-light photocatalytic activity of samarium-doped zinc oxide nanostructures显示文摘In the present work,we have synthesized samarium doped zinc oxide nanostructures(Zn1-xSmxO;x=0.00,0.02,0.04 and 0.06) via chemical precipitation method and studied their structural,morphological,optical and photocatalytic properties.X-ray diffraction(XRD) patterns,PL and Raman spectra results indicate that the undoped and Sm-doped ZnO nanostructures are crystallized in a hexagonal wurtzite structure.FESEM images show that the morphology of the sample changes from cubical to hexagonal nanostructures with increase in Sm3+doping concentration.The EDX spectra confirm the incorporation of Sm3+ion in ZnO.The influence of Sm3+doping on the structure,morphology,absorption,emission and photocatalytic activity of ZnO nanostructures were investigated systematically.The addition of Sm3+ion leads to a red shift in the optical energy band gap from 3.19 to 2.67 eV and hence,increases the visible light absorption ability.The presence of E2(H) and E1(LO) modes in microRaman spectra confirms the crystallinity and defects in the samples.The detailed photocatalytic experiments reveal that Sm-doped ZnO nanostructures show the maximum photodegradation efficiency for Methylene blue(MB) dye for x=0.04,i,e.,94.94%,under visible light irradiation.The photocatalytic efficiency improves by 6.98 times when ZnO is doped with rare earth metal ion(Sm3+) and is a potential candidate for practical applications.The investigation demonstrates that as-synthesized nano-sized photocatalysts act as an efficient photocatalyst for the degradation of MB dye. | Sukriti Prakash Chand Vishal Singh | 2020 | Journal of Rare Earths2020，38，1： | 5 |
| 11 | New deep eutectic solvents composed of crown ether, hydroxide and polyethylene glycol for extraction of non-basic N-compounds显示文摘Here we firstly report a series of new deep eutectic solvents(DESs) induced by small amounts of crown ether complex and mainly formed by polyethylene glycol. These DESs not only presented the ultra-deep extraction of non-basic N-compounds from fuel oils, but also opened up the possibility of other new applications in chemistry and materials science. | Mohammad Chand Ali Ruirui Liu Jia Chen Tianpei Cai Haijuan Zhang Zhan Li Honglin Zhai Hongdeng Qiu | 2019 | Chinese Chemical Letters2019，30，4： | 5 |
| 12 | Potential of plant growth-promoting rhizobacteria-plant interactions in mitigating salt stress for sustainable agriculture:A review显示文摘Soil salinization affecting different crops is one of the serious threats to global food security.Soil salinity affects 20%and 33%of the total cultivated and irrigated agricultural lands,respectively,and has been reported to caused a global crop production loss of 27.3 billion USD.The conventional approaches,such as using salt-tolerant varieties,saline soil scrapping,flushing,leaching,and adding supplements (e.g.,gypsum and lime),often fail to alleviate stress.In this context,developing diverse arrays of microbes enhancing crop productivity under saline soil conditions without harming soil health is necessary.Various advanced omics approaches have enabled gaining new insights into the structure and metabolic functions of plant-associated beneficial microbes.Various genera of salt-tolerating rhizobacteria ameliorating biotic and abiotic stresses have been isolated from different legumes,cereals,vegetables,and oil seeds under extreme alkaline and saline soil conditions.Rapid progress in rhizosphere microbiome research has revived the belief that plants may be more benefited from their association with interacting diverse microbial communities as compared with individual members in a community.In the last decade,several salt-tolerating plant growth-promoting rhizobacteria (PGPR) that improve crop production under salt stress have been exploited for the reclamation of saline agrosystems.This review highlights that the interaction of salt-tolerating microbes with plants improves crop productivity under salinity stress along with potential salt tolerance mechanisms involved and will open new avenues for capitalizing on cultivable diverse microbial communities to strengthen plant salt tolerance and,thus,to refine agricultural practices and production under saline conditions. | Kailash Chand KUMAWAT Sharon NAGPAL Poonam SHARMA | 2022 | Pedosphere2022，32，2： | 5 |
| 13 | Discrete element method study of shear-driven granular segregation in a slowly rotating horizontal drum显示文摘 | Ram Chand Sithi V. Muniandy Chiow San Wong Jasbir Singh | 2017 | Particuology2017，15，3： | 4 |
| 14 | Soil organic carbon and phosphorus availability regulate abundance of culturable phosphate-solubilizing bacteria in paddy fields显示文摘Low availability of phosphorus(P) is a major constraint for optimal crop production, as P is mostly present in its insoluble form in soil. Therefore,phosphate-solubilizing bacteria(PSB) from paddy field soils of the Indo-Gangetic Plain, India were isolated, and their abundance was attempted to be correlated with the physicochemical characteristics of the soils. Ninety-four PSB were isolated on Pikovskaya’s agar medium, and quantitative phosphate solubilization was evaluated using NBRIP medium. The isolates solubilized P up to a concentration of 1 006 μg mL-1 from tricalcium phosphate with the secretion of organic acids. These isolates were identified by 16 S rRNA gene sequence comparison, and they belonged to Gammaproteobacteria(56 isolates),Firmicutes(28 isolates), Actinobacteria(8 isolates), and Alphaproteobacteria(2 isolates). Phylogenetic analysis confirmed the identification by clustering the isolates in the clade of the respective reference organisms. The correlation analysis between PSB abundance and physicochemical characteristics revealed that the PSB population increased with increasing levels of soil organic carbon, insoluble P, K+, and Mg2+. The promising PSB explored in this study can be further evaluated for their biofertilizer potential in the field and for their use as potent bio-inoculants. | Arvind KUMAR Lal Chand RAI | 2020 | Pedosphere2020，30，3： | 4 |
| 15 | Role of Joshi's external stabilization system with percutaneous screw fixation in high-energy tibial condylar fractures associated with severe soft tissue injuries显示文摘Purpose: The treatment of high-energy tibial condylar fractures which are associated with severe soft tissue injuries remains contentious and challenging. In this study, we assessed the results of Joshi's external stabilization system (JESS) by using the principle of ligamentotaxis and percutaneous screw fixation for managing high-energy tibial condylar fractures associated with severe soft tissue injuries. Methods: Between June 2008 and June 2010, 25 consecutive patients who were 17-71 years (mean, 39.7), underwent the JESS fixation for high-energy tibial condylar fractures associated with severe soft tissue injuries. Out of 25 patients, 2 were lost during follow-up and in 1 case early removal of frame was done, leaving 22 cases for final follow-up. Among them, 11 had poor skin condition with abrasions and blisters and 2 were open injuries (Gustilo-Anderson grade I & 11). The injury mechanisms were motor vehicle accidents (n - 19), fall from a height (n = 2) and assault (n - 1). The fractures were classified according to Schatzker classification system. Results: There were 7 type-V, 14 type-Vl and 1 type-IV Schatzker's tibial plateau fractures. The average interval between the injury and surgery was 6.8 days (range 2-13). The average hospital stay was 13 days (range, 7-22). The average interval between the surgery and full weight bearing was 13.6 weeks (range 11-20). The average range of knee flexion was 121° (range 105°-135°). The normal extension of the knee was observed in 20 patients, and an extensor lag of 5°-8° was noted in 2 patients. The complications included superficial pin tract infections (n 4) with no knee stiffness. Conclusion: JESS with lag screw fixation combines the benefit of traction, external fixation, and limited internal fixation, at the same time as allowing the ease of access to the soft tissue for wound checks, pin care, dressing changes, measurement of compartment pressure, and the monitoring of the neurovascular status. In a nutshell, JESS along with screw fixation offers a promising alternative treatment for high- energy tibial condylar fractures associated with severe soft tissue injuries. | Ashish Kumar Gupta Rahul Sapra Rakesh Kumar Som Prakash Gupta Devwart Kaushik Sahil Gaba Mahesh Chand Bansal Ratan Lal Dayma | 2015 | Chinese Journal of Traumatology2015，18，6： | 4 |
| 16 | Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario显示文摘AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,P<0.01. Delay from symptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators. | Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 17 | Use of gentamicin-loaded collagen sponge in internal fixation of open fractures显示文摘ObjectiveTo 经由逐渐地在介绍给我们的开的破裂的外科的治疗局部地释放抗菌素的使妊娠的骨胶原敲诈的抗菌素(gentamicin骨胶原和抗菌素海绵)的申请估计立即的板 osteosynthesis 的结果在 injury.MethodsAll 盒子以后的 6 个小时包括 35 个病人在我们的第三级的水平损伤中心和教学医院被对待与开的破裂被立即的开的减小和板固定从2008年1月对待到 Augu 在他们之中, 31 个病人为足够的后续和评价是可得到的。所有破裂被灌溉对待,与释放抗菌素的骨胶原的放置一起的清创术,立即的开的减小和板固定就在创伤的闭合前在板附近敲诈。病人们被估计决定手术后的感染,推迟的联合或不属于工会并且另外的手术后的复杂并发症的开发。在彻底的清创术和本地抗菌素以后的立即的板 osteosynthesis 将在开的 fractures.ResultsThe 的治疗给安全、可接受的临床的结果,这被假设有足够的最后的后续的 31 个病人在 40 个星期(15-160 星期) 的一吝啬的时间被估计。大多数破裂根据参与的区域首先在一个可接受的时间时期联合起来。本地创伤复杂并发症(表面的感染和皮损失) 在 3 个病人(9.67%) 被发现。深感染在 2 个病人(6.45%) 被注意。任何一个都需要不这些病人植入在到期的时间统一的移动和两个破裂。推迟的联合在 5 个病人(16.13%) 被注意。没有病人进行了到不属于工会或在长期的后续植入失败。过多的结疤在 2 被开发在骨胶原电影 elut-ing 抗菌素的足够的清创术和放置以后的病人(6.45%).ConclusionsImmediate 板 osteosynthesis 局部地关于骨头联合和深感染的缺席生产优秀结果并且是在开的骨头损害的管理的一种安全技术。这些海绵能与内部固定的任何形式容易被使用,自从他们是 bioabsorbable,没有为这些抗菌素搬运人的移动的第二个手术的需要。与为 3 ~ 5 天的全身的抗菌素一起的本地使抗菌素妊娠的骨胶原海绵在开的破裂管理提供有希望的结果。 | Chaudhary Susheel Sen Ramesh Saini Uttam Chand Soni Ashwani Gahlot Nitesh Singh Daljit | 2011 | Chinese Journal of Traumatology2011，14，4： | 4 |
| 18 | Modal analysis of prestressed draft pad of freight wagons using finite element method显示文摘The present work intends to investigate dynamic behaviour of draft gear using finite element method. The longitudinal force that the draft gear absorbs usually leads to the failure of its components, especially, the load bearing draft pads. Dynamic behaviour of an individual draft pad and a draft gear is determined and characterized with exciting frequencies and corresponding mode shapes. The effect of compressive prestress load on the dynamic behaviour of an individual draft pad is also determined as the draft pads in assembled state are under constant axial compressive force in the draft gear. The vibration characteristics of individual draft pad are compared with draft pads that are part of draft gear. The modal analysis gives us a basis for subjecting a draft pad to higher frequency loading for determining its fatigue behaviour. | Sachin Sudhakar Harak Satish Chand Sharma Suraj Prakash Harsha | 2015 | Journal of Modern Transportation2015，23，1： | 4 |
| 19 | Internal fixation and bone grafting for intraarticular nonunion of tibial plateau: a report of four cases显示文摘胫骨的高原不属于工会的 Intraarticular 是稀罕的。在文学,仅仅 9 个病人被发现为不属于工会的胫骨的高原和他们得到了改变结果的 intraarticular 被对待。与骨头 grafting 一起的内部固定在所有情况中作为标准治疗被做。我们对待 intraarticular 的 4 个不同侧面案例在我们由 4 个不同方法的机构不属于工会的胫骨的高原。我们与骨头接枝,有 K 钉子的 arthrodesis 和全部的膝代替一起与巴黎扔的、内部固定的灰浆对待这些案例。大小写 1 与当病人拒绝了外科,扔的巴黎(流行音乐) 的灰浆被对待。破裂被统一,尽管有外翻足 malalignment,病人充分对运动的完整的范围满意。大小写 2 与开的减小被管理与骨头 grafting 一起的内部固定。病人有一个好工会并且在膝关节得到了运动的完整的范围。大小写 3 由于她的老年与全部的膝关节造形术被对待并且得到了令人满意的结果。大小写 4 是一感染不属于工会。Arthrodesis 被做,病人能与忍受 independently.We 的完整的重量走断定与骨头 grafting 一起的那内部固定不能在胫骨的高原不属于工会的 intraarticular 的所有情况中是合适的。不属于工会的、现在的状况的原因和膝关节的运动的范围都应该被考虑,治疗应该根据每种 patient’s 状况是 individualised。 | Ramesh K Sen Ashwani Soni Uttam Chand Saini Daljit Singh | 2011 | Chinese Journal of Traumatology2011，14，6： | 4 |
| 20 | Obese patients have similar short-term outcomes to nonobese in laparoscopic colorectal surgery显示文摘AIM: To determine whether obese patients undergoing laparoscopic surgery within an enhanced recovery program had worse short-term outcomes.METHODS: A prospective study of consecutive patients undergoing laparoscopic colorectal resection was carried out between 2008 and 2011 in a single institution. Patients were divided in groups based on body mass index(BMI). Short-term outcomes including operative data, length of stay, complications and readmission rates were recorded and compared between the groups. Continuous data were analysed using t-test or oneway Analysis of Variance. χ2 test was used to compare categorical data.RESULTS: Two hundred and fifty four patients were included over the study period. The majority of individuals(41.7%) recruited were of a healthy weight(BMI < 25), whilst 50 patients were classified as obese(19.6%). Patients were matched in terms of the presence of comorbidities and previous abdominal surgery. Obese patients were found to have a statistically significant difference in The American Society of Anesthesiologists grade. Length of surgery and intra-operative blood loss were no different according to BMI.CONCLUSION: Obesity(BMI > 25) does not lead to worse short-term outcomes in laparoscopic colorectal surgery and therefore such patients should not be precluded from laparoscopic surgery. | Manish Chand Henry D De'Ath Muhammed Siddiqui Chetanya Mehta Shahnawaz Rasheed James Bromilow Tahseen Qureshi | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 4 |
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