|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | More stories on Th17 cells显示文摘为超过二十年,免疫学者一直在使用所谓的 Th1/Th2 范例解释大多数与适应免疫有关的现象。Th1/Th2 范例暗示了存在二不同,互相调整了, CD4+ T 助手子集:Th1 房间,涉及织物损坏的开车调停房间的有免疫力的回答和对细胞内部的寄生虫的战斗感染;并且调停的 Th2 房间 IgE 生产并且特别地涉及肠虫的感染的嗜曙红的发炎,过敏症和清理。设置的 T 助手,的第三个成员 IL-17-producing CD4+ T 房间,现在叫的 Th17 房间,最近被描述为做自己分内的事的一个不同的系有 Th1 或 Th2 房间的发展小径。Th17 子集被连接了到自体免疫的混乱,能在另外的煽动性的 cytokines 之中生产 IL-17, IL-17F 和 IL-21。有趣地,有,这被报导了不仅一在 Th1, Th2 和 Th17 受动器房间之中跨规定但是也在 Th17 和 T 的产生有两分规章的房间。因此, Treg 和 Th17 受动器房间以一种互相独占的方式产生,取决于他们是否面对加象 IL-6 那样的煽动性的 cytokines 的 TGF- 尾或 TGF- 尾被激活。这评论将在他们的发展和规定探讨 Th17 房间,和最近的进步的发现。 | Alexandre S Basso Hilde Cheroutre Daniel Mucida | 2009 | Cell Research2009，19，4： | 19 |
| 2 | Current medical treatment of estrogen receptor-positive breast cancer显示文摘Approximately 80% of breast cancers(BC) are estrogen receptor(ER)-positive and thus endocrine therapy(ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of(1) ovarian function suppression(OFS), usually obtained using gonadotropinreleasing hormone agonists(Gn RHa);(2) selective estrogen receptor modulators or down-regulators(SERMs or SERDs); and(3) aromatase inhibitors(AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs(i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs(i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type Ⅰ are permanent steroidal inhibitors of aromatase, while type Ⅱ are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs(i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors(palbociclib) and mammalian target of rapamycin(m TOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness. | Franco Lumachi Davide A Santeufemia Stefano MM Basso | 2015 | World Journal of Biological Chemistry2015，6，3： | 16 |
| 3 | Extent of lymphadenectomy and perioperative therapies:two open issues in gastric cancer显示文摘Gastric cancer is one of the leading causes of death for cancer worldwide,although geographical variations in incidence exist.Over the last decades,its incidence and mortality have gradually decreased in Western countries,while these have increased,or remained stable,in the other world regions.Gastric cancer is often diagnosed at an advanced stage,with the only notable exception of Japan,where nationwide screening programs are enforced,due to local high incidence.Curativeintent surgery(i.e.,gastrectomy,total or partial,and lymphadenectomy)remains the cornerstone of treatment of gastric cancer.Much has been debated about the extent of lymph node dissection and,although it is a valuable contribution to staging and cure,operative treatment only represents one aspect of overall effective management,as the risk of both locoregional and distant recurrences are high,and bear a poor prognosis.As a matter of fact,surgery,as a single modality treatment,has probably achieved its maximum efficacy for local control and survival,while other accompanying nonsurgical treatment modalities have to be taken into account,although their role is still the subject of considerable debate.The authors in this review present an update on the outcome of treatment of gastric cancer in relation to the extent of lymphadenectomy and of various nonsurgical preoperative,intraoperative,and postoperative strategies. | Andrea Giuliani Michelangelo Miccini Luigi Basso | 2014 | World Journal of Gastroenterology2014，20，14： | 14 |
| 4 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 5 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | Tumor budding as a potential histopathological biomarker in colorectal cancer:Hype or hope?显示文摘Colorectal cancer(CRC),the third most commonly diagnosed type of cancer in men and women worldwide is recognized as a complex multi-pathway disease,an observation sustained by the fact that histologically identical tumors may have different outcome,including various response to therapy.Therefore,particularly in early and intermediate stage(stages Ⅱ and Ⅲ,respectively) CRC,there is a compelling need for biomarkers helpful of selecting patients with aggressive disease that might benefit from adjuvant and targeted therapy.Histopathological examination shows that likely other solid tumors the development and progression of human CRC is not only determined by genetically abnormal cells,but also by intricate interactions between malignant cells and the surrounding microenvironment.This has led to reconsider the features of tumor microenvironment as potential predictive and prognostic biomarkers.Among the histopathological biomarkers,tumor budding(i.e.,the presence of individual cells and small clusters of tumor cells at the tumor invasive front) has received much recent attention,particularly in the setting of CRC.Although its acceptance as a reportable factor has been held back by a lack of uniformity with respect to qualitative and quantitative aspects,tumor budding is now considered as an independent adverse prognostic factor in CRC that may allow for stratification of patients into risk categories more meaningful than those defined by tumor-node-metastasis staging alone,and also potentially guide treatment decisions,especially in T2-T3 N0(stage Ⅱ) CRCs. | Fabio Grizzi Giuseppe Celesti Gianluca Basso Luigi Laghi | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 8 | 开关电源环路中的TL431显示文摘本文介绍了TL431的内部示意图,讨论了TL431这一器件的一些基本操作,并对一些重要参数的设定进行了分析。 | Christophe Basso | 2009 | 电子设计应用2009，，3： | 5 |
| 9 | Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis显示文摘 | Federica Zoratto Luigi Rossi Monica Verrico Anselmo Papa Enrico Basso Angelo Zullo Luigi Tomao Adriana Romiti Giuseppe Lo Russo Silverio Tomao | 2014 | Tumor Biology2014，，7： | 3 |
| 10 | 可变R-L-C元件的SPICE模拟行为建模显示文摘一些仿真器没有包含LRC元件的ABM方程,采用本文所述的简单子电路,可以根据复杂的分析表达式(包括逻辑表达式)创建无源元件,比如建立非线性电容、时变电阻等。 | Christophe Basso | 2005 | 今日电子2005，，9： | 3 |
| 11 | Cognitive impairment in chronic obstructive pulmonary disease显示文摘 | Raffaele Antonelli Incalzi Camillo Marra Alessandro Giordano Maria Lucia Calcagni Antonella Cappa Salvatore Basso Gabriella Pagliari Leonello Fuso | 2003 | Journal of Neurology2003，，3： | 2 |
| 12 | Compound and Digenic Heterozygosity Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Tianhong Xu Zhao Yang Matteo Vatta Alessandra Rampazzo Giorgia Beffagna Kalliopi Pillichou Steven E. Scherer Jeffrey Saffitz Joshua Kravitz Wojciech Zareba Gian Antonio Danieli Alessandra Lorenzon Andrea Nava Barbara Bauce Gaetano Thiene Cristina Basso Hu | 2010 | Journal of the American College of Cardiology2010，，6： | 2 |
| 13 | Palpatory Method Used to Identify the Recurrent Laryngeal Nerve during Thyroidectomy显示文摘 | Fabio Procacciante Pietro Picozzi Massimo Pacifici Stefania Picconi Sandro Ruggeri Aldo Fantini Nicola Basso | 2000 | World Journal of Surgery2000，，5： | 2 |
| 14 | Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor显示文摘 | Ilaria Marigo Erika Bosio Samantha Solito Circe Mesa Audry Fernandez Luigi Dolcetti Stefano Ugel Nada Sonda Silvio Bicciato Erika Falisi Fiorella Calabrese Giuseppe Basso Paola Zanovello Emanuele Cozzi Susanna Mandruzzato Vincenzo Bronte | 2010 | Immunity2010，，6： | 2 |
| 15 | Frequency of Bicuspid Aortic Valve in Young Male Conscripts by Echocardiogram显示文摘 | Stefano Nistri Cristina Basso Chiara Marzari Paolo Mormino Gaetano Thiene | 2005 | The American Journal of Cardiology2005，，5： | 2 |
| 16 | 开关电源环路中的TL431显示文摘虽然上一期文章介绍了如何以TL431实现2类补偿器。然而在补偿电路方面,TL431并非万能药。由于原极点和零点之间以固定系数相关联,采用运放构建的补偿器时,运放的灵活性会降低,而这个运放中可以创建自选的中频带增益。为解决LED串联电阻对可能的增益变化进行钳位的问题,1类补偿器将提供稳定所选转换器时的灵活性,符合期望。然而,这种1类补偿器也有局限,即它不提供任何相位提升。 | Christophe Basso | 2009 | 电子设计应用2009，，5： | 2 |
| 17 | Cloning and expression of functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv显示文摘 | Magalhaes M L B Pereira C P Basso L A | 2002 | Protein Expression and Purification2002，26，： | 2 |
| 18 | Adjustable Intragastric Balloon vs Non-Adjustable Intragastric Balloon: Case–Control Study on Complications, Tolerance, and Efficacy显示文摘 | Alfredo Genco Daniela Dellepiane Giovanni Baglio Fulvio Cappelletti Francesca Frangella Roberta Maselli Maria Chiara Dante Romina Camoirano Michele Lorenzo Nicola Basso | 2013 | Obesity Surgery2013，，7： | 2 |
| 19 | Hypertrophic cardiomyopathy and sudden death in the young: Pathologic evidence of myocardial ischemia显示文摘 | Cristina Basso Gaetano Thiene Domenico Corrado Gianfranco Buja Paola Melacini Andrea Nava | 2000 | Human Pathology2000，，8： | 2 |
| 20 | Positive impact of blocking tumor necrosis factor α on the nutritional status in pediatric Crohn’s disease patients显示文摘 | A. Diamanti M. S. Basso M. Gambarara B. Papadatou F. Bracci C. Noto M. Castro | 2009 | International Journal of Colorectal Disease2009，，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员