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| 1 | Chronic hepatitis C:This and the new era of treatment显示文摘Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects. | Gaetano Bertino Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Shirin Demma MariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta Bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone Mariano Malaguarnera Emanuele Bertino Michele Malaguarnera | 2016 | World Journal of Hepatology2016，8，2： | 10 |
| 2 | Hepatocellular carcinoma and the risk of occupational exposure显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. | Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino | 2016 | World Journal of Hepatology2016，8，13： | 5 |
| 3 | Thrombosis prophylaxis in pediatric liver transplantation: A systematic review显示文摘AIM To review current literature of thrombosis prophylaxis in pediatric liver transplantation(PLT) as thrombosis remains a critical complication.METHODS Studies were identified by electronic search of MEDLINE, EMBASE and Cochrane Library(CENTRAL) databases until March 2018. The search was supplemented by manually reviewing the references of included studies and the references of the main published systematic reviews on thrombosis and PLT. We excluded from this review case report, small case series, commentaries, conference abstracts, papers which describing less than 10 pediatric liver transplants/year and articles published before 1990. Two reviewers performed study selection independently, with disagreements solved through discussion and by the opinion of a third reviewer when necessary.RESULTS Nine retrospective studies were included in this review. The overall quality of studies was poor. A pooled analysis of results from studies was not possible due to the retrospective design and heterogeneity of included studies. We found an incidence of portal vein thrombosis(PVT) ranging from 2% to 10% in pediatric living donorliver transplantation(LDLT) and from 4% to 33% in pediatric deceased donor liver transplantation(DDLT). Hepatic artery thrombosis(HAT) was observed mostly in mixed LDLT and DDLT pediatric population with an incidence ranging from 0% to 29%. In most of the studies Doppler ultrasonography was used as a first line diagnostic screening for thrombosis. Four different surgical techniques for portal vein anastomosis were reported with similar efficacy in terms of PVT reduction. Reduced size liver transplant was associated with a low risk of both PVT(incidence 4%) and HAT(incidence 0%, P < 0.05). Similarly, aortic arterial anastomosis without graft interposition and microsurgical hepatic arterial reconstruction were associated with a significant reduced HAT incidence(6% and 0%, respectively). According to our inclusion and exclusion criteria, we did not find eligible studies that evaluated pharmacological prevention of thrombosis. CONCLUSION Poor quality retrospective studies show the use of tailored surgical strategies might be useful to reduce HAT and PVT after PLT; prospective studies are urgently needed. | Mirco Nacoti Giulia Maria Ruggeri Giovanna Colombo Ezio Bonanomi Federico Lussana | 2018 | World Journal of Hepatology2018，10，10： | 3 |
| 4 | Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome显示文摘 | Laura Zanotti Eliana Bignotti Stefano Calza Elisabetta Bandiera Giuseppina Ruggeri Claudio Galli Germana Tognon Monica Ragnoli Chiara Romani Renata A. Tassi Luigi Caimi Franco E. Odicino Enrico Sartori Sergio Pecorelli Antonella Ravaggi | 2012 | Clinical Chemistry and Laboratory Medicine2012，，12： | 2 |
| 5 | Palpatory Method Used to Identify the Recurrent Laryngeal Nerve during Thyroidectomy显示文摘 | Fabio Procacciante Pietro Picozzi Massimo Pacifici Stefania Picconi Sandro Ruggeri Aldo Fantini Nicola Basso | 2000 | World Journal of Surgery2000，，5： | 2 |
| 6 | Bioavailability of Desmin, a low molecular weight dermatan sulfate, after subcutaneous administration to healthy volunteers显示文摘 | Miglioli M Pironi L Ruggeri E | 1997 | Int J Clin Lab Res1997，27，3： | 2 |
| 7 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 8 | Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants显示文摘 | Ruggeri L Capanni M Urbani E | 2002 | Science2002，295，6： | 2 |
| 9 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 10 | Role of natural killer cell alloreactivity in HLA - mismatched hematopoietic stem- cell transplantation显示文摘 | Ruggeri L Capanni M Casucci M | 1999 | Blood1999，94，1： | 2 |
| 11 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 12 | Von Willebrand factor, platelets and endothelial cell interactions显示文摘 | Ruggeri ZM | 2003 | J Thromb Haemost2003，1，7： | 1 |
| 13 | Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants显示文摘 | Ruggeri L Capanni M Urbani E | 2002 | Science2002，295，5562： | 1 |
| 14 | Development of vascularendothelial growth factor receptor (VEGFR) kinase inhibitors asantiangiogenic agents in cancer therapy显示文摘 | Underiner TL Ruggeri B Gingrich DE | 2004 | Curr Med Chem2004，11，6： | 1 |
| 15 | Cellular therapy: exploiting NK cell alloreactivity in transplantation显示文摘 | Ruggeri L Capanni M Martelli MF | 2001 | Curt Opin Hematol2001，8，6： | 1 |
| 16 | Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation显示文摘 | Ruggeri L Capanni M Casucci M | 1999 | Blood1999，94，1： | 1 |
| 17 | Natural killer cell receptors:new biology and insights into the graftversus-leukemia effect显示文摘 | Farag SS Fehniger TA Ruggeri L | 2002 | Blood2002，100，6： | 1 |
| 18 | Laminotomy in adults: technique and results显示文摘 | Ruggeri A Pichierri A Marotta N | 2012 | Eur Spine J2012，21，： | 1 |
| 19 | Evolution of the surgical management of bowel atresia in newborn:laparoscopically assisted treatment显示文摘 | Lima M Ruggeri G Domini M | | 0，，05： | 1 |
| 20 | Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia:challenging its predictive value显示文摘 | Ruggeri L Mancusi A Capanni M | 2007 | Blood2007，110，1： | 1 |
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