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| 1 | untreatable hepatocellular 癌的自然历史: 回顾的队研究显示文摘 AIM:To investigate the clinical course of untreatable hepatocellular carcinoma(HCC) identified at any stage and to identify factors associated with mortality.METHODS:From January 1999 to December 2010,320 out of 825 consecutive patients with a diagnosis of HCC and not appropriate for curative or palliative treatments were followed and managed with supportive therapy.Cirrhosis was diagnosed by histological or clinical features and liver function was evaluated according to Child-Pugh score.The diagnosis of HCC was performed by Ultra-Sound guided biopsy or by multiphasic contrast-enhanced computed tomography or gadolinium-enhanced magnetic resonance imaging.Data were collected for each patient including all clinical,laboratory and imaging variables necessary for the outcome prediction staging systems considered.HCC staging was performed according Barcelona Clinic Liver Cancer(BCLC) and Cancer of the Liver Italian Program scores.Follow-up time was defined as the number of months from the diagnosis of HCC to death.Prognostic baseline variables were analyzed by multivariate Cox analysis to identify the independent predictors of survival.RESULTS:Seventy-five per cent of patients had hepatitis C.Ascites was present in 169 patients(53%),while hepatic encephalopathy was present in 49 patients(15%).The Child-Pugh score was class A in 105 patients(33%),class B in 142 patients(44%),and class C in 73 patients(23%).One hundred patients(31%) had macroscopic vascular invasion and/or extrahepatic spread of the tumor.A single lesion > 10 cm was observed in 34 patients(11%),while multinodular HCC was present in 189 patients(59%).Thirty nine patients(12%) were BCLC early(A) stage,55(17%) were BCLC intermediate(B) stage,124(39%) were BCLC advanced(C) stage,and 102(32%) were endstage BCLC(D).At the time of this analysis(July 2011),28(9%) patients were still alive.Six(2%) patients who were lost during follow-up were censored at the last visit.The overall median survival was 6.8 mo,and the 1-year survival was 32%.The 1-year survival according to BCLC classes was 100%,79%,12% and 0%,for BCLC A,B,C and D,respectively.There was a significant difference in survival between each BCLC class.The median survival of patients of BCLC stages A,B,C and D was 33,17.4,6.9,and 1.8 mo,respectively(P < 0.05 for comparison between stages).The median survival of Child-Pugh A,B and C classes were 9.8 mo(range 6.4-13),6.1(range 4.9-7.3),and 3.7(range 1.5-6),respectively(P < 0.05 for comparison between stages).By univariate analysis,the variables significantly associated to an increased liklihood of mortality were Eastern Cooperative Oncology Group performance status(PS),presence of ascites,low level of albumin,elevated level of bilirubin,international normalized ratio(INR) and Log-[(α fetoprotein(AFP)].At multivariate analysis,mortality was independently predicted by bad PS(P < 0.0001),high INR values(P = 0.0001) and elevated Log-(AFP) levels(P = 0.009).CONCLUSION:This study confirms the heterogeneous behavior of untreated HCC.BCLC staging remains an important prognostic guide and may be important in decision-making for palliative treatment. | Giuseppe Cabibbo Marcello Maida Chiara Genco Pietro Parisi Marco Peralta Michela Antonucci Giuseppe Brancatelli Calogero Cammà Antonio Craxì Vito Di Marco | 2012 | World Journal of Hepatology2012，4，9： | 11 |
| 2 | Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B显示文摘BACKGROUND Hepatitis B virus is a universal health problem.There are approximately 250 million people living with hepatitis B worldwide,and approximately 600000 of these people die every year due to the virus.AIM To compare the pretreatment and post-treatment histopathological results of patients with hepatitis be antigen(HBeAg)-negative chronic hepatitis B(CHB)who had been receiving tenofovir disoproxil fumarate(TDF)treatment at our clinic for at least 5 years.METHODS Patients with HBeAg-negative CHB who were being treated with TDF(245 mg/d)were included in the study.Liver biopsies of patients before TDF treatment and liver biopsies after 5 years of TDF treatment were retrospectively compared.RESULTS A total of 50 HBeAg-negative CHB patients were included in the study(mean age:47.9±10.4 years,men:27.54%).Histological improvement was observed in 78%(39)of the patients after 5 years of treatment.After the 5 years of treatment,the mean Ishak score of the patients was 1.3±1.3,and the mean histologic activity index score was 4.1±2.8.A 1.53 point reduction in Ishak fibrosis score was detected after long-term TDF treatment.CONCLUSION Liver biopsies after 5 years of TDF treatment revealed a significant histological response and a regression of the necroinflammatory score compared to pretreatment liver biopsies.To better understand the effects of antiviral treatments on the improvement of liver histology,long-term studies involving larger numbers of patients are needed. | Bahri Abayli Cansu Abaylı Genco Gencdal | 2021 | World Journal of Gastrointestinal Pharmacology and Therapeutics2021，12，2： | 4 |
| 3 | Headache, anxiety and depressive disorders: the HADAS study显示文摘 | Ettore Beghi Gennaro Bussone Domenico D’Amico Pietro Cortelli Sabina Cevoli Gian Camillo Manzoni Paola Torelli Maria Clara Tonini Giovanni Allais Roberto Simone Florindo D’Onofrio Sergio Genco Franca Moschiano Massimiliano Beghi Sara Salvi | 2010 | The Journal of Headache and Pain2010，，2： | 3 |
| 4 | Adjustable Intragastric Balloon vs Non-Adjustable Intragastric Balloon: Case–Control Study on Complications, Tolerance, and Efficacy显示文摘 | Alfredo Genco Daniela Dellepiane Giovanni Baglio Fulvio Cappelletti Francesca Frangella Roberta Maselli Maria Chiara Dante Romina Camoirano Michele Lorenzo Nicola Basso | 2013 | Obesity Surgery2013，，7： | 2 |
| 5 | Multi-Centre European Experience with Intragastric Balloon in Overweight Populations: 13 Years of Experience显示文摘 | Alfredo Genco Gontrand López-Nava Christian Wahlen Roberta Maselli Massimiliano Cipriano Maria Mara Arenas Sanchez Chantal Jacobs Michele Lorenzo | 2013 | Obesity Surgery2013，，4： | 2 |
| 6 | FbpC is not Essential for Iron Acquisition in Neisseria Gonorrhoeae显示文摘 | Sebastian S Genco C A | | 0，，： | 1 |
| 7 | Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery 显示文摘 | Soricelli E Basso N Genco A | 2009 | Surg Endosc2009，23，11： | 1 |
| 8 | Periodontal microflorarecuted to the risk of myocardial infarction : a case control study ( abstract281 1 ) 显示文摘 | Genco R J Wu T Grossi S | 1999 | J Dent Res1999，781，： | 1 |
| 9 | The role of systemic conditions and disorders in periodontal disease 显示文摘 | Genco R J Loe H | 1993 | Periodontol 20001993，2，： | 1 |
| 10 | Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis显示文摘 | Deshpande RG Khan MB Genco CA | 1998 | Infect Immun1998，66，11： | 1 |
| 11 | Periodontal infections contribute to elevated systemic C-reactive protein level 显示文摘 | Noack B Genco R J Trcvisan M | 2001 | J Periodontol2001，72，9： | 1 |
| 12 | Effect of Shear Forces on Fine Particle Retention显示文摘 | Arslan K Bousgield D W Genco J M | 1995 | Tappi1995，78，4： | 1 |
| 13 | Hepatocellular carcinoma enhancement on contrast-enhanced CT and MR imaging: response assessment after treatment with sorafenib: preliminary results显示文摘 | Giuseppe Salvaggio Alessandro Furlan Francesco Agnello Giuseppe Cabibbo Daniele Marin Lydia Giannitrapani Chiara Genco Massimo Midiri Roberto Lagalla Giuseppe Brancatelli | 2014 | La radiologia medica2014，，4： | 1 |
| 14 | Role of thyrotropin-releasing hormone in stress ulcer formation in the rat显示文摘 | Nicola Basso MD Maurizio Bagarani MD A. Eugene Pekary MD Alfredo Genco MD Alberto Materia MD | 1988 | Digestive Diseases and Sciences1988，，7： | 1 |
| 15 | Ralationship of stress, distress and inadequate coping behaviors to periodontal disease 显示文摘 | Genco RJ Ho AW Grossi SG | 1999 | J Periodontol1999，70，7： | 1 |
| 16 | Periodontal infections contribute to elevated systemic C-reactive protein level 显示文摘 | Noack B Genco RJ | 2001 | J Periodontol2001，72，9： | 1 |
| 17 | Spectoscopy of the world ocean tides from a finite element hudrodynamic model显示文摘 | Provost C Le Genco M L Lyard F | 1994 | J Geophys Res1994，99，24： | 1 |
| 18 | Platelet-derived growth factor-modulated guided tissue regenerative therapy 显示文摘 | Cho MI Lin WL Genco RJ | 1995 | J Periodontol1995，66，6： | 1 |
| 19 | Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis 显示文摘 | Deshpande RG Khan MB Genco CA | 1998 | Infect Imrnun1998，66，11： | 1 |
| 20 | Diabetes and periodontal diseases:consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases显示文摘 | Chapple IL Genco R working group 2 of the joint EFP/AAP workshop | | 0，，4： | 1 |
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