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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line显示文摘Worldwide prevalence of Helicobacter pylori(H.pylori) infection is approximately 50%,with the highest being in developing countries.We compared cure rates and tolerability(SE) of second-line anti-H.pylori levofloxacin/amoxicillin(LA)-based triple regimens vs standard quadruple therapy(QT).An English language literature search was performed up to October 2010.A meta-analysis was performed including randomized clinical trials comparing 7-or 10-d LA with 7-d QT.In total,10 articles and four abstracts were identified.Overall eradication rate in LA was 76.5%(95% CI:64.4%-97.6%).When only 7-d regimens were included,cure rate was 70.6%(95% CI:40.2%-99.1%),whereas for 10-d combinations,cure rate was significantly higher(88.7%;95% CI:56.1%-109.9%;P < 0.05).Main eradication rate for QT was 67.4%(95% CI:49.7%-67.9%).The 7-d LA and QT showed comparable efficacy [odds ratio(OR):1.09;95% CI:0.63-1.87],whereas the 10-d LA regimen was significantly more effective than QT(OR:5.05;95% CI:2.74-9.31;P < 0.001;I 2 = 75%).No differences were reported in QT eradication rates among Asian and European studies,whereas LA regimens were more effective in European populations(78.3% vs 67.7%;P = 0.05).Incidence of SE was lower in LA therapy than QT(OR:0.39;95% CI:0.18-0.85;P = 0.02).A higher rate of side effects was reported in Asian patients who received QT.Our findings support the use of 10-d LA as a simple second-line treatment for H.pylori eradication with an excellent eradication rate and tolerability.The optimal second-line alternative scheme might differ among countries depending on quinolone resistance. | Simona Di Caro Lucia Fini Yayha Daoud Fabio Grizzi Antonio Gasbarrini Antonino De Lorenzo Laura Di Renzo Sara McCartney Stuart Bloom | 2012 | World Journal of Gastroenterology2012，18，40： | 9 |
| 3 | Tumor budding as a potential histopathological biomarker in colorectal cancer:Hype or hope?显示文摘Colorectal cancer(CRC),the third most commonly diagnosed type of cancer in men and women worldwide is recognized as a complex multi-pathway disease,an observation sustained by the fact that histologically identical tumors may have different outcome,including various response to therapy.Therefore,particularly in early and intermediate stage(stages Ⅱ and Ⅲ,respectively) CRC,there is a compelling need for biomarkers helpful of selecting patients with aggressive disease that might benefit from adjuvant and targeted therapy.Histopathological examination shows that likely other solid tumors the development and progression of human CRC is not only determined by genetically abnormal cells,but also by intricate interactions between malignant cells and the surrounding microenvironment.This has led to reconsider the features of tumor microenvironment as potential predictive and prognostic biomarkers.Among the histopathological biomarkers,tumor budding(i.e.,the presence of individual cells and small clusters of tumor cells at the tumor invasive front) has received much recent attention,particularly in the setting of CRC.Although its acceptance as a reportable factor has been held back by a lack of uniformity with respect to qualitative and quantitative aspects,tumor budding is now considered as an independent adverse prognostic factor in CRC that may allow for stratification of patients into risk categories more meaningful than those defined by tumor-node-metastasis staging alone,and also potentially guide treatment decisions,especially in T2-T3 N0(stage Ⅱ) CRCs. | Fabio Grizzi Giuseppe Celesti Gianluca Basso Luigi Laghi | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 4 | Metrically measuring liver biopsy:A chronic hepatitis B and C computer-aided morphologic description显示文摘AIM: To describe a quantitative analysis method for liver biopsy sections with a machine that we have named 'Dioguardi Histological Metriser' which au- tomatically measures the residual hepatocyte mass (including hepatocytes vacuolization), inflammation, fibrosis and the loss of liver tissue tectonics. METHODS: We analysed digitised images of liver bi- opsy sections taken from 398 patients. The analysis with Dioguardi Histological Metriser was validated by comparison with semi-quantitative scoring system. RESULTS: The method provides: (1) the metrical ex- tension in two-dimensions (the plane) of the residual hepatocellular set, including the area of vacuoles pertinent to abnormal lipid accumulation; (2) the geo- metric measure of the inflammation basin, which dis- tinguishes intra-basin space and extra-basin dispersed parenchymal leukocytes; (3) the magnitude of collagen islets, (which were considered truncated fractals and classified into three degrees of magnitude); and (4) the tectonic index that quantifies alterations (disorders) in the organization of liver tissue. Dioguardi Histologi- cal Metriser machine allows to work at a speed of 0.1 mm2/s, scanning a whole section in 6-8 min.CONCLUSION: The results are the first standardized metrical evaluation of the geometric properties of the parenchyma, inflammation, fibrosis, and alterations in liver tissue tectonics of the biopsy sections. The present study confirms that biopsies are still valuable, not only for diagnosing chronic hepatitis, but also for quantifying changes in the organization and order of liver tissue structure. | Nicola Dioguardi Fabio Grizzi Barbara Fiamengo Carlo Russo | 2008 | World Journal of Gastroenterology2008，14，48： | 5 |
| 5 | Prognostic value of innate and adaptive immunity in colorectal cancer显示文摘Colorectal cancer(CRC) remains one of the major public health problems throughout the world.Originally depicted as a multi-step dynamical disease,CRC develops slowly over several years and progresses through cytologically distinct benign and malignant states,from single crypt lesions through adenoma,to malignant carcinoma with the potential for invasion and metastasis.Moving from histological observations since a long time,it has been recognized that inflammation and immunity actively participate in the pathogenesis,surveillance and progression of CRC.The advent of immunohistochemical techniques and of animal models has improved our understanding of the immune dynamical system in CRC.It is well known that immune cells have variable behavior controlled by complex interactions in the tumor microenvironment.Advances in immunology and molecular biology have shown that CRC is immunogenic and that host immune responses influence survival.Several lines of evidence support the concept that tumor stromal cells,are not merely a scaffold,but rather they influence growth,survival,and invasiveness of cancer cells,dynamically contributing to the tumor microenvironment,together with immune cells.Different types of immune cells infiltrate CRC,comprising cells of both the innate and adaptive immune system.A relevant issue is to unravel the discrepancy between the inhibitory effects on cancer growth exerted by the local immune response and the promoting effects on cancer proliferation,invasion,and dissemination induced by some types of inflammatory cells.Here,we sought to discuss the role played by innate and adaptive immune system in the local progression and metastasis of CRC,and the prognostic information that we can currently understand and exploit. | Fabio Grizzi Paolo Bianchi Alberto Malesci Luigi Laghi | 2013 | World Journal of Gastroenterology2013，19，2： | 4 |
| 6 | Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: A case report显示文摘Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract. Although rare, it is the most common primary tumor of the mesentery and can develop at any age. We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST). This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall. Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors. | Piergiuseppe Colombo Daoud Rahal Fabio Grizzi Vittorio Quagliuolo Massimo Roncalli | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 7 | Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent显示文摘瞄准:提供在最新形成的骨胶原的颠倒上监视新抗病毒的药的效果的精确其他的韵律的工具。方法:与纤维变性或肝硬化的不同等级与长期的 C 病毒性肝炎从 209 个病人拿的数字化的组织学的活体检视节,基于用分数维的原则修正的国际系统米借助于一个新、快速的、用户友好的、充分电脑辅助的方法被测量。结果:下列被描述:几何周界,区域和纤维变性的起皱的海角;Knodell, Sheuer, Ishak 和 METAVIR 的核对与修正分数维图形的公制的大小得分;在与骨胶原小岛的大小的关系的纤维变性的物理作文的意思;intra 活体检视和这些参数的内部活体检视的样品可变性;显示小径的活体检视节的“阶段”向它的最大的已知的价值由纤维变性形成盖住;量的肝织物有林中小丘代表的建筑上的变化。结论:我们的模型提供纤维变性的几何性质和肝织物的量的建筑上的变化的第一韵律的评估。整个肝的组织学的节的代表性的海角也根据与林中小丘系数获得的结果被讨论。 | Nicola Dioguardi Fabio Grizzi Barbara Franceschini Paola Bossi Carlo Russo | 2006 | World Journal of Gastroenterology2006，12，14： | 2 |
| 8 | Immunological treatment of liver tumors显示文摘Although multiple options for the treatment of liver tumors have often been described in the past, including liver resection, radiofrequency ablation with or without hepatic pump insertion, laparoscopic liver resection and the use of chemotherapy, the potential of immunotherapy and gene manipulation is still largely unexplored.Immunological therapy by gene manipulation is based on the interaction between virus-based gene delivery systems and dendritic cells. Using viruses as vectors, it is possible to transduce dendritic cells with genes encoding tumor-associated antigens, thus inducing strong humoral and cellular immunity against the antigens themselves.Both chemotherapy and radiation therapy have the disadvantage of destroying healthy cells, thus causing severe side-effects. We need more precisely targeted therapies capable of killing cancer cells while sparing healthy cells. Our goal is to establish a new treatment for solid liver tumors based on the concept of cytoreduction,and propose an innovative algorithm. | Maurizio Chiriva-Internati Fabio Grizzi Cynthia A Jumper Everardo Cobos Paul L Hermonat Eldo E Frezza | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
| 9 | Sampling variability of computer-aided fractal-corrected measures of liver fibrosis in needle biopsy specimens显示文摘瞄准:估计采样可变性电脑辅助,在肝活体检视的纤维变性的 fractal-correctedmeasures。方法:样品从与经历 orthotopic 肝移植的临床上并且组织学地证明的肝硬化从 12 个病人移开的肝的六~八不同部分被导出。有 2 妈妈的厚度的天狼星染色红的节用自动地测量纤维变性,以及它的轮廓的表面的一个电脑辅助的图象分析系统被数字化周界,分数维的表面和轮廓尺寸,起皱的海角,和林中小丘系数。结果:我们在表面的大小发现了内部样品的可变性的高度[变化(CV ) 的系数 =43%+/-13%] 并且起皱的海角(CV =28%+/-9%) 纤维变性,而是林中小丘的内部样品的可变性“ s 代表是低的(CV =14%+/-2%) 。结论:这研究建议那林中小丘“ s 代表可能在整个机关在临床的实践被用作纤维变性的最好的组织学的估计,并且证实事实活体检视节,为长期的肝炎的质的诊断基本,在肝织物在建筑上的变化的量的估计起一个关键作用。 | Fabio Grizzi Carlo Russo Barbara Franceschini Mariagrazia Di Rocco Valter Torri Emanuela Morenghi Luigi Rainiero Fassati Nicola Dioguardi | 2006 | World Journal of Gastroenterology2006，12，47： | 1 |
| 10 | Enhanced endoscopic ultrasound imaging for pancreatic lesions: The road to artificial intelligence显示文摘Early detection of pancreatic cancer has long eluded clinicians because of its insidious nature and onset.Often metastatic or locally invasive when symptomatic,most patients are deemed inoperable.In those who are symptomatic,multi-modal imaging modalities evaluate and confirm pancreatic ductal adenocarcinoma.In asymptomatic patients,detected pancreatic lesions can be either solid or cystic.The clinical implications of identifying small asymptomatic solid pancreatic lesions(SPLs)of<2 cm are tantamount to a better outcome.The accurate detection of SPLs undoubtedly promotes higher life expectancy when resected early,driving the development of existing imaging tools while promoting more comprehensive screening programs.An imaging tool that has matured in its reiterations and received many image-enhancing adjuncts is endoscopic ultrasound(EUS).It carries significant importance when risk stratifying cystic lesions and has substantial diagnostic value when combined with fine needle aspiration/biopsy(FNA/FNB).Adjuncts to EUS imaging include contrast-enhanced harmonic EUS and EUS-elastography,both having improved the specificity of FNA and FNB.This review intends to compile all existing enhancement modalities and explore ongoing research around the most promising of all adjuncts in the field of EUS imaging,artificial intelligence. | Marco Spadaccini Glenn Koleth James Emmanuel Kareem Khalaf Antonio Facciorusso Fabio Grizzi Cesare Hassan Matteo Colombo Benedetto Mangiavillano Alessandro Fugazza Andrea Anderloni Silvia Carrara Alessandro Repici | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 11 | Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma?显示文摘Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. | GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，4： | 1 |
| 12 | Immune cells: plastic players along colorectal cancer progression显示文摘 | Giuseppe Di Caro Federica Marchesi Luigi Laghi Fabio Grizzi | 2013 | J. Cell. Mol. Med2013，，9： | 1 |
| 13 | The Complex Functions of Mast Cells in Chronic Human Liver Diseases显示文摘 | Barbara Franceschini Giorgia Ceva-Grimaldi Carlo Russo Nicola Dioguardi Fabio Grizzi | 2006 | Digestive Diseases and Sciences2006，，12： | 1 |
| 14 | Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma:A systematic review显示文摘AIM: To summarize the current knowledge about the potential relationship between hepatitis C virus(HCV) infection and the risk of several extra-liver cancers. METHODS: We performed a systematic review of the literature, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis(PRISMA) Statement. We extracted the pertinent articles, published in MEDLINE and the Cochrane Library, using the following search terms: neoplasm/cancer/malignancy/tumor/carcinoma/adeno-carcinoma and non-Hodgkin lymphomas, kidney/renal-, cholangio-, pancreatic-, thyroid-, breast-,oral-, skin-, prostate-, lung-, colon-, stomach-, haematologic. Case series, case-series with control-group, case-control, cohort-studies as well as meta-analyses, written in English were collected. Some of the main characteristics of retrieved trials, which were designed to investigate the prevalence of HCV infection in each type of the above-mentioned human malignancies were summarised. A main table was defined and included a short description in the text for each of these tumours, whether at least five studies about a specific neoplasm, meeting inclusion criteria, were available in literature. According to these criteria, we created the following sections and the corresponding tables and we indicated the number of included or excluded articles, as well as of meta-analyses and reviews:(1) HCV and haematopoietic malignancies;(2) HCV and cholangiocarcinoma;(3) HCV and pancreatic cancer;(4) HCV and breast cancer;(5) HCV and kidney cancer;(6) HCV and skin or oral cancer; and(7) HCV and thyroid cancer. RESULTS: According to available data, a clear correlation between regions of HCV prevalence and risk of extra-liver cancers has emerged only for a very small group of types and histological subtypes of malignancies. In particular, HCV infection has been associated with:(1) a higher incidence of some B-cell Non-HodgkinLymphoma types, in countries, where an elevated prevalence of this pathogen is detectable, accounting to a percentage of about 10%;(2) an increased risk of intra-hepatic cholangiocarcinoma; and(3) a correlation between HCV prevalence and pancreatic cancer(PAC) incidence. CONCLUSION: To date no definitive conclusions may be obtained from the analysis of relationship between HCV and extra-hepatic cancers. Further studies, recruiting an adequate number of patients are requiredto confirm or deny this association. | Sirio Fiorino Letizia Bacchi-Reggiani Dario de Biase Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Giorgia Acquaviva Luca di Tommaso Arrigo Bondi Michela Visani Sergio Sabbatani Laura Pontoriero Carlo Fabbri Andrea Cuppini Annalisa Pession Elio Jovine | 2015 | World Journal of Gastroenterology2015，21，45： | 1 |
| 15 | The Complex Functions of Mast Cells in Chronic Human Liver Diseases显示文摘 | Barbara Franceschini Giorgia Ceva-Grimaldi Carlo Russo Nicola Dioguardi Fabio Grizzi | 2006 | Digestive Diseases and Sciences2006，，12： | 1 |
| 16 | The Complex Functions of Mast Cells in Chronic Human Liver Diseases显示文摘 | Barbara Franceschini Giorgia Ceva-Grimaldi Carlo Russo Nicola Dioguardi Fabio Grizzi | 2006 | Digestive Diseases and Sciences2006，，12： | 1 |
| 17 | Celiac disease: From pathophysiology to treatment显示文摘Celiac disease, also known as 'celiac sprue', is a chronic inflammatory disorder of the small intestine, produced by the ingestion of dietary gluten products in susceptible people. It is a multifactorial disease, including genetic and environmental factors. Environmental trigger is represented by gluten while the genetic predisposition has been identified in the major histocompatibility complex region. Celiac disease is not a rare disorder like previously thought, with a global prevalence around 1%. The reason of its under-recognition is mainly referable to the fact that about half of affected people do not have the classic gastrointestinal symptoms, but they present nonspecific manifestations of nutritional deficiency or have no symptoms at all. Here we review the most recent data concerning epidemiology, pathogenesis, clinical presentation, available diagnostic tests and therapeutic management of celiac disease. | Ilaria Parzanese Dorina Qehajaj Federica Patrinicola Merica Aralica Maurizio Chiriva-Internati Sanja Stifter Luca Elli Fabio Grizzi | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 1 |
| 18 | Presence of Twist1-Positive Neoplastic Cells in the Stroma of Chromosome-Unstable Colorectal Tumors显示文摘 | Giuseppe Celesti Giuseppe Di Caro Paolo Bianchi Fabio Grizzi Gianluca Basso Federica Marchesi Andrea Doni Giancarlo Marra Massimo Roncalli Alberto Mantovani Alberto Malesci Luigi Laghi | 2013 | Gastroenterology2013，，3： | 1 |
| 19 | Magnetic resonance elastography: a general overview of its current and future applications in brain imaging显示文摘 | Antonio Di Ieva Fabio Grizzi Elisa Rognone Zion Tsz Ho Tse Tassanai Parittotokkaporn Ferdinando Rodriguez y Baena Manfred Tschabitscher Christian Matula Siegfrid Trattnig Riccardo Rodriguez y Baena | 2010 | Neurosurgical Review2010，，： | 1 |
| 20 | Fractal nature of human gastrointestinal system:Exploring a new era显示文摘The morphological complexity of cells and tissues,whether normal or pathological,is characterized by two primary attributes:Irregularity and self-similarity across different scales.When an object exhibits self-similarity,its shape remains unchanged as the scales of measurement vary because any part of it resembles the whole.On the other hand,the size and geometric characteristics of an irregular object vary as the resolution increases,revealing more intricate details.Despite numerous attempts,a reliable and accurate method for quantifying the morphological features of gastrointestinal organs,tissues,cells,their dynamic changes,and pathological disorders has not yet been established.However,fractal geometry,which studies shapes and patterns that exhibit self-similarity,holds promise in providing a quantitative measure of the irregularly shaped morphologies and their underlying self-similar temporal behaviors.In this context,we explore the fractal nature of the gastrointestinal system and the potential of fractal geometry as a robust descriptor of its complex forms and functions.Additionally,we examine the practical applications of fractal geometry in clinical gastroenterology and hepatology practice. | Fabio Grizzi Marco Spadaccini Maurizio Chiriva-Internati Mohamed A A A Hegazi Robert S Bresalier Cesare Hassan Alessandro Repici Silvia Carrara | 2023 | World Journal of Gastroenterology2023，29，25： | 0 |
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