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| 1 | Topical delivery of nerve growth factor for treatment of ocular and brain disorders显示文摘Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity. Nerve growth factor is one of the best-described neurotrophins and has advanced to clinical trials for treatment of ocular and brain diseases due to its trophic and regenerative properties. Prior trials over the past few decades have produced conflicting results, which have principally been ascribed to adverse effects of systemic nerve growth factor administration, together with poor penetrance of the blood-brain barrier that impairs drug delivery. Contrastingly, recent studies have revealed that topical ocular and intranasal nerve growth factor administration are safe and effective, suggesting that topical nerve growth factor delivery is a potential alternative to both systemic and invasive intracerebral delivery. The therapeutic effects of local nerve growth factor delivery have been extensively investigated for different ophthalmic diseases, including neurotrophic keratitis, glaucoma, retinitis pigmentosa, and dry eye disease. Further, promising pharmacologic effects were reported in an optic glioma model, which indicated that topically administered nerve growth factor diffused far beyond where it was topically applied. These findings support the therapeutic potential of delivering topical nerve growth factor preparations intranasally for acquired and degenerative brain disorders. Preliminary clinical findings in both traumatic and non-traumatic acquired brain injuries are encouraging, especially in pediatric patients, and clinical trials are ongoing. The present review will focus on the therapeutic effects of both ocular and intranasal nerve growth factor delivery for diseases of the brain and eye. | Gemma Eftimiadi Marzia Soligo Luigi Manni Daniela Di Giuda Maria Lucia Calcagni Antonio Chiaretti | 2021 | Neural Regeneration Research2021，16，9： | 11 |
| 2 | Cognitive impairment in chronic obstructive pulmonary disease显示文摘 | Raffaele Antonelli Incalzi Camillo Marra Alessandro Giordano Maria Lucia Calcagni Antonella Cappa Salvatore Basso Gabriella Pagliari Leonello Fuso | 2003 | Journal of Neurology2003，，3： | 2 |
| 3 | Bioavailability of amlodipine besylate/atorvastatin calcium combination tablet显示文摘 | Chung M Calcagni A Glue P | 2006 | J Clin Pharmacol2006，46，： | 1 |
| 4 | CT demonstration of 'chicken trachea' resulting from complete cartilaginous rings of the trachea in ring-sling complex 显示文摘 | CALCAGNI G BRUNELLE F VOUHE P | 2008 | Pediatr Radiol2008，38，7： | 1 |
| 5 | Three-dimensional CT scanning: a new diagnostic modality in congenital heart disease显示文摘 | Ou P Celermajer DS Calcagni G | 2007 | Heart2007，93，8： | 1 |
| 6 | N-aeetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD 显示文摘 | Pela R Calcagni AM Subiaco S | 1999 | Respiration1999，66，： | 1 |
| 7 | Hydrolysis of N phenyl-acetyl-a-methyl-alpha-amino acids by benzylpenicillinacylase显示文摘 | Rossi D Calcagni A | 1985 | Experien- tia1985，41，1： | 1 |
| 8 | 18F_FOG PET-CT during chemo-radiotherapy in patients with non-small cell lung cancer: the early metabolic response correlates with the delivered radiation dose显示文摘 | Massaccesi M Calcagni ML Spitilli MG | 2012 | Radiat Oncol2012，7，： | 1 |
| 9 | Three-dimensional CT scanning: a new diagnostic modality in congenital heart disease 显示文摘 | OU P CELERMAJER D S CALCAGNI G | 2007 | Heart2007，93，： | 1 |
| 10 | N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD显示文摘 | Pela R Calcagni AM Subiaco S | 1999 | Respiration1999，66，： | 1 |
| 11 | N-acetyicysteine reduces the exacerbation rate in patients with moderate to severe COPD显示文摘 | Peal R Calcagni A M Subiaco | 1999 | Respiration1999，66，6： | 1 |
| 12 | N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD显示文摘 | Pela R Calcagni AM Subiaco S | | 0，，： | 1 |
| 13 | Imaging of peritoneal carcinomatosis with FDG PET-CT: diagnostic patterns, case examples and pitfalls显示文摘 | Anna Maria Gaetano Maria Lucia Calcagni Vittoria Rufini Venanzio Valenza Alessandro Giordano Lorenzo Bonomo | 2009 | Abdominal Imaging2009，，3： | 1 |
| 14 | Versorgung yon finger-kuppendefekten mit palmarer Lappenund dorsaler Eponychiumplastik显示文摘 | Biraima AM Kach KP Calcagni M | | 0，，： | 1 |
| 15 | CT demonstration of ' chich- en trachea' resulting from complete cartilaginous rings of the trachea in ringsling complex显示文摘 | Calcagni G Brunelle F Vouhe P | 2008 | Pediatr Radio12008，38，7： | 1 |
| 16 | CT demonstration of 'chicken trachea' resulting from complete cartilaginous rings ofthe trachea in ring-sling complex 显示文摘 | Calcagni G Brunelle F Vouhe P | 2008 | Pediatr Radiol2008，38，7： | 1 |
| 17 | Assessment of sympathetic innervation of the heart in diabetes mellitus using 123I-MIBG显示文摘 | Giordano A Calcagni ML Verrillo A | 2000 | Diabetes Nutr Metab2000，13，6： | 1 |
| 18 | The hemi-hamate au- tograft arthroplasty in proximal interphalangeal juint reconstruction: a systematic review显示文摘 | Frueh FS Calcagni M Lindenhlatt N | 2014 | J Hand Surg Eur Voi2014，22，： | 1 |
| 19 | Battlefield medical information system-Tactical (BMIST): the application of mobile computing technologies to support health surveillance in the department of defense显示文摘 | Morris T J Pajak J Havlik F Kenyon J Calcagni D | 2006 | Telemed e-Health2006，12，： | 1 |
| 20 | Time accurate modelling of the secondary air system response to rapid transients显示文摘 | Gallar L Calcagni C | 2011 | Journal of Aerospace Engineering2011，225，8： | 1 |
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