|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 2 | Inorganic nanoparticles and the microbiome显示文摘 | Kunyu Qiu Phillip G. Durham Aaron C. Anselmo | 2018 | Nano Research2018，11，10： | 6 |
| 3 | Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis显示文摘 | Federica Zoratto Luigi Rossi Monica Verrico Anselmo Papa Enrico Basso Angelo Zullo Luigi Tomao Adriana Romiti Giuseppe Lo Russo Silverio Tomao | 2014 | Tumor Biology2014，，7： | 3 |
| 4 | Prevalence and risk factors of Campylobacter infection in broiler flocks from southern Spain显示文摘 | Alicia Torralbo Carmen Borge Alberto Allepuz Ignacio García-Bocanegra Samuel K. Sheppard Anselmo Perea Alfonso Carbonero | 2014 | Preventive Veterinary Medicine2014，，： | 2 |
| 5 | Pretransplant Model to Predict Posttransplant Survival in Liver Transplant Patients显示文摘 | Rafik M. Ghobrial Jeffery Gornbein Randy Steadman Natale Danino James F. Markmann Curtis Holt Dean Anselmo Farin Amersi Pauline Chen Douglas G. Farmer Steve Han Francisco Derazo Sammy Saab Leonard I. Goldstein Sue V. McDiarmid Ronald W. Busuttil | 2002 | Annals of Surgery2002，，3： | 2 |
| 6 | The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy显示文摘Leprosy is a chronic infectious disease caused by Mycobacterium leprae.According to official reports from 121 countries across five WHO regions,there were 213899 newly diagnosed cases in 2014.Although leprosy affects the skin and peripheral nerves,it can present across a spectrum of clinical and histopathological forms that are strongly influenced by the immune response of the infected individuals.These forms comprise the extremes of tuberculoid leprosy(TT),with a M.leprae-specific Th1,but also a Th17,response that limits M.leprae multiplication,through to lepromatous leprosy(LL),with M.leprae-specific Th2 and T regulatory responses that do not control M.leprae replication but rather allow bacterial dissemination.The interpolar borderline clinical forms present with similar,but less extreme,immune biases.Acute inflammatory episodes,known as leprosy reactions,are complications that may occur before,during or after treatment,and cause further neurological damages that can cause irreversible chronic disabilities.This review discusses the innate and adaptive immune responses,and their interactions,that are known to affect pathogenesis and influence the clinical outcome of leprosy. | Adriana Barbosa de Lima Fonseca Marise do Vale Simon Rodrigo Anselmo Cazzaniga Tatiana Rodrigues de Moura Roque Pacheco de Almeida Malcolm S.Duthie Steven G.Reed Amelia Ribeiro de Jesus | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 7 | Multifunctional flexible optical waveguide sensor: on the bioinspiration for ultrasensitive sensors development显示文摘This paper presents the development of a bioinspired multifunctional flexible optical sensor(BioMFOS)as an ultrasensitive tool for force(intensity and location)and orientation sensing.The sensor structure is bioinspired in orb webs,which are multifunctional devices for prey capturing and vibration transmission.The multifunctional feature of the structure is achieved by using transparent resins that present both mechanical and optical properties for structural integrity and strain/deflection transmission as well as the optical signal transmission properties with core/cladding configuration of a waveguide.In this case,photocurable and polydimethylsiloxane(PDMS)resins are used for the core and cladding,respectively.The optical transmission,tensile tests,and dynamic mechanical analysis are performed in the resins and show the possibility of light transmission at the visible wavelength range in conjunction with high flexibility and a dynamic range up to 150 Hz,suitable for wearable applications.The BioMFOS has small dimensions(around 2 cm)and lightweight(0.8 g),making it suitable for wearable application and clothing integration.Characterization tests are performed in the structure by means of applying forces at different locations of the structure.The results show an ultra-high sensitivity and resolution,where forces in theμN range can be detected and the location of the applied force can also be detected with a sub-millimeter spatial resolution.Then,the BioMFOS is tested on the orientation detection in 3D plane,where a correlation coefficient higher than 0.9 is obtained when compared with a gold-standard inertial measurement unit(IMU).Furthermore,the device also shows its capabilities on the movement analysis and classification in two protocols:finger position detection(with the BioMFOS positioned on the top of the hand)and trunk orientation assessment(with the sensor integrated on the clothing).In both cases,the sensor is able of classifying the movement,especially when analyzed in conjunction with preprocessing and clustering techniques.As another wearable application,the respiratory rate is successfully estimated with the BioMFOS integrated into the clothing.Thus,the proposed multifunctional device opens new avenues for novel bioinspired photonic devices and can be used in many applications of biomedical,biomechanics,and micro/nanotechnology. | Arnaldo Leal-Junior Leticia Avellar Vitorino Biazi M.Simone Soares Anselmo Frizera Carlos Marques | 2022 | Opto-Electronic Advances2022，5，10： | 2 |
| 8 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
| 9 | Finite automata and non-self-embedding grammars显示文摘 | Anselmo M Giammarresi D Varricchio S | 2003 | Lecture Notes in Computer Science2003，2608，： | 1 |
| 10 | CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation 显示文摘 | Bumeister R Rosse C Anselmo A | 2004 | Curr Biol2004，14，5： | 1 |
| 11 | Impact risk analysis for a spacecraft in Cosmo-Skymed orbit显示文摘 | Cinzia Giacomuzzo Alessandro Francesconi Luciano Anselmo | 2010 | Advances in Space Research2010，，7： | 1 |
| 12 | Inhibition of cellular effiux pumps involved in multi xenobiotic re- sistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures 显示文摘 | Anselmo H M van den Berg J H Rietjens I M | 2012 | Ecotoxicology2012，21，： | 1 |
| 13 | The survivability of space tether sys-tems in orbit around the earth 显示文摘 | ANSELMO L PARDINI C | 2005 | Acta Astronautica2005，56，3： | 1 |
| 14 | Efficiency of the laser texturing on the adhesion of the coated twist drills 显示文摘 | Davi Neves Anselmo Eduardo Diniz Milton Sergio Fernandes de Lima | 2006 | Journal of Materials Processing Technology2006，179，： | 1 |
| 15 | Fetal loss associated with excess thyroid hormone exposure 显示文摘 | Anselmo J Caod Karrison T | 2004 | J American Med Association2004，292，6： | 1 |
| 16 | Automatic detection of small lung nodules in 3D CT data using Gaussian mixture models, Tsallis entropy and SVM显示文摘 | Alex Martins Santos Antonio Oseas de Carvalho Filho Aristófanes Corrêa Silva Anselmo Cardoso de Paiva Rodolfo Acatauassú Nunes Marcelo Gattass | 2014 | Engineering Applications of Artificial Intelligence2014，，： | 1 |
| 17 | Topical fluoride for caries prevention:Executive summary of the updated clinical recommendations and supporting systematic review显示文摘 | Weyant RJ Tracy SL Anselmo T(Tracy) | 2013 | J Am Dent Assoc2013，144，11： | 1 |
| 18 | Liver transplantation for fulminant hepatic failure: experience with more than 200 patients over a 17 - year period显示文摘 | Farmer DG Anselmo DM Ghobrial RM | 2003 | Ann Surg2003，237，5： | 1 |
| 19 | Rituximab ( B - cell depleting antibody) associated lung injury( RALI):A pediatric case and systematic review of the literature 显示文摘 | Bitzan M Anselmo M Carpineta L | 2009 | Pediatr Pulmonol2009，44，9： | 1 |
| 20 | The survivability of space tether systems in orbit around the earth显示文摘 | Anselmo L Pardini G | | 0，，06： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员