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| 1 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 2 | Jane Eyre显示文摘《简·爱》是十九世纪英国着名女作家夏洛蒂、勃朗持的代表作。小说通过对孤女简、爱坎珂不平的人生经历的描述,成功地塑造了一个不安于现状、不甘爱辱、敢于抗争的女性形象。奉文节选自原着简写版第一章。 | Charlotte Bronte | 2011 | 英语画刊(高一、高二综合版)2011，，11： | 8 |
| 3 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 4 | Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review显示文摘Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute appendicitis.In recent years,multiple biomarkers have emerged as potential diagnostic tools.This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis.Methods We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria.Methodological quality of the selected article was rated using the QUADAS2 index.Data extraction was performed by two independent reviewers.Results The research in the medical bibliography databases resulted in 68 articles.We removed 26 duplicates.Among the remaining 42 articles,we excluded 33 following the inclusion and exclusion criteria.Of the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and specificity.Conclusions The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited.The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis.There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis.The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis.We consider that this may be an avenue of research to explore in the future. | Javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea Martin-Calvo | 2022 | World Journal of Pediatrics2022，18，2： | 3 |
| 5 | Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor显示文摘 | Ilaria Marigo Erika Bosio Samantha Solito Circe Mesa Audry Fernandez Luigi Dolcetti Stefano Ugel Nada Sonda Silvio Bicciato Erika Falisi Fiorella Calabrese Giuseppe Basso Paola Zanovello Emanuele Cozzi Susanna Mandruzzato Vincenzo Bronte | 2010 | Immunity2010，，6： | 2 |
| 6 | Wuthering Heights显示文摘 | Emily Bronte | 2011 | 英语画刊(高一、高二综合版)2011，，6： | 2 |
| 7 | Parapneumonic pleural effusion: an 11-year review显示文摘 | Deiros Bronte L Baquero-Artigao F Garcia-Miguel MJ et ol | 2006 | Anales de Pediatria2006，64，1： | 1 |
| 8 | Myeloid suppressor cells in cancer recruitment, phenotype, properties, and mechanisms of immune suppression显示文摘 | Serafini P Borrello I Bronte V | 2006 | Semin Cancer Biol2006，16，1： | 1 |
| 9 | High frequency deep brain stimulation and neural rhythms in Parkinson's disease 显示文摘 | Blumenfeld Z Bront - Stewart H | 2015 | Neuropsyehology Review2015，25，4： | 1 |
| 10 | Suppressive influences in the immune response to cancer显示文摘 | Bronte V Mocellin S | 2009 | J Immunother2009，32，1： | 1 |
| 11 | The terminology issue for myeloid-derived suppressor ceils 显示文摘 | Gabrilovich D I Bronte V Chen S H | 2007 | Cancer Res2007，67，1： | 1 |
| 12 | Coordinated regulation of myeloid cells by tumours显示文摘 | Gabrilovich DI Ostrand-Rosenberg S Bronte V | 2012 | Nat Rev Immunol2012，12，4： | 1 |
| 13 | Coordinated regulation of myeloid ceils by tumours 显示文摘 | Gabrilovich DI Ostrand-Rosenberg S Bronte V | 2012 | Nat Rev Immunol2012，12，4： | 1 |
| 14 | Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism显示文摘 | Mazzoni A Bronte V Visintin A | 2002 | J Immunol2002，168，2： | 1 |
| 15 | Parapneumonic leural effusion: an 11 year review 显示文摘 | Deiros Bronte L Baquero-Artigao F Garcia-Miguel MJ | 2006 | An Pediatr (Bare)2006，64，1： | 1 |
| 16 | Th17 and cancer:friends or foes显示文摘 | Bronte V | 2008 | Blood2008，112，2： | 1 |
| 17 | L - arginine metabolism inmyeloid cells controls T - lymphocyte functions显示文摘 | Bronte V Serafini P Mazzoni A | 2003 | Trends Immu-nol2003，24，6： | 1 |
| 18 | Control ofimmtme response by amino acid metabolism 显示文摘 | Ursula Grohmann Vincenzo Bronte | 2010 | Immunological Reviews2010，，236： | 1 |
| 19 | The role of tar- geted therapy for gastrointestinal tumors显示文摘 | Rolfo C Bronte G Sortino G | 2014 | Expert Rev Gastroenterol Hepatol2014，8，8： | 1 |
| 20 | Coordinated regulation of myeloid cells by tumours 显示文摘 | Gabrilovich DI Ostrand-Rosenberg S Bronte V | 2012 | Nat Rev Immunol2012，12，4： | 1 |
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