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| 1 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 2 | Adjustable Intragastric Balloon vs Non-Adjustable Intragastric Balloon: Case–Control Study on Complications, Tolerance, and Efficacy显示文摘 | Alfredo Genco Daniela Dellepiane Giovanni Baglio Fulvio Cappelletti Francesca Frangella Roberta Maselli Maria Chiara Dante Romina Camoirano Michele Lorenzo Nicola Basso | 2013 | Obesity Surgery2013，，7： | 2 |
| 3 | Pro-and anti-inflammatory eytokines gene polymorphisms and Heli- cobacter pylori infection : interactions influence outcome 显示文摘 | CARLO-F ZAMBON DANIELA BASSO FILIPPO NAVAGLIA et al | 2005 | Cytokine2005，29，4： | 1 |
| 4 | ME-PCR for the identification of mutated K-ras in serum and bile of pancreatic cancer patients: an unsatisfactory technique for clinical applications显示文摘 | Carlo-Federico Zambon Filippo Navaglia Daniela Basso Nicoletta Gallo Eliana Greco Maria Grazia Piva Paola Fogar Claudio Pasquali Sergio Pedrazzoli Mario Plebani | 2000 | Clinica Chimica Acta2000，，1： | 1 |
| 5 | Non-invasive assessment of chronic liver and gastric diseases显示文摘 | Mario Plebani Daniela Basso | 2007 | Clinica Chimica Acta2007，，1： | 1 |
| 6 | Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome显示文摘 | Carlo-F. Zambon Daniela Basso Filippo Navaglia Claudio Belluco Alessandra Falda Paola Fogar Eliana Greco Nicoletta Gallo Massimo Rugge Francesco Di Mario Mario Plebani | 2004 | Cytokine2004，，4： | 1 |
| 7 | Clinical Relevance of Helicobacter pylori cagA and vacA Gene Polymorphisms显示文摘 | Daniela Basso Carlo–Federico Zambon Darren P. Letley Alessia Stranges Alberto Marchet Joanne L. Rhead Stefania Schiavon Graziella Guariso Marco Ceroti Donato Nitti Massimo Rugge Mario Plebani John C. Atherton | 2008 | Gastroenterology2008，，1： | 1 |
| 8 | ERCC1 C8092A (rs3212986) polymorphism as a predictive marker in esophageal cancer patients treated with cisplatin/5-FU-based neoadjuvant therapy显示文摘 | Enrica Rumiato Francesco Cavallin Elisa Boldrin Matteo Cagol Rita Alfieri Daniela Basso Carlo Castoro Ermanno Ancona Alberto Amadori Alberto Ruol Daniela Saggioro | 2013 | Pharmacogenetics and Genomics2013，，11： | 1 |
| 9 | Alkaline hydrolyzable nitrogen and properties that dictate its distribution in paddy soil profiles显示文摘Nitrogen(N) is a key nutrient for rice production, and its bioavailability in paddy soils is strongly coupled to soil organic matter(SOM) cycling. A better understanding of potentially available N forms in soil, such as alkaline hydrolyzable N(AH-N), and their depth distribution will support the development of best management practices to improve the N use efficiency of rice while minimizing adverse environmental effects. Fifteen rice(Oryza sativa L.) fields from Southern Brazil were selected, and stratified soil samples were taken to a depth of 60 cm before crop establishment. Selected soil physical and chemical properties were analyzed to evaluate their relationships with AH-N contents in the soil profile. The AH-N contents below 20 cm varied extensively(increased,reduced, or constant) compared with that above 20 cm. Although clay and clay + silt contents were highly correlated to AH-N for some soils, the major property dictating AH-N distribution by depth was total N(TN), as the correlation between TN and AH-N was mainly by direct effect. The proportion of TN recovered as AH-N across sites and depths presented high amplitude, and thus AH-N was not a constant N pool across depths, indicating that AH-N can be affected by soil management practices even when TN showed no major changes. The distinct distribution of AH-N across soil sampling sites and depths indicates that depths greater than 20 cm should be considered when calibrating the AH-N index for N fertilizer recommendations for flooded rice in Southern Brazil. | Gerson Laerson DRESCHER Leandro Souza DA SILVA Qamar SARFARAZ Gustavo DAL MOLIN Laura Brondani MARZARI Augusto Ferreira LOPES Cesar CELLA Daniela Basso FACCO Rodrigo Knevitz HAMMERSCHMITT | 2020 | Pedosphere2020，30，3： | 0 |
| 10 | Chemical speciation of copper and manganese in solution of a copper-contaminated soil and young grapevine growth with amendment application显示文摘Copper(Cu)-based fungicide application to control foliar diseases in grapevine(Vitis vinifera L.)can increase soil Cu availability.Brazilian soils have high natural Cu and manganese(Mn)concentrations,increasing the potential for toxicity to grapevine plants.Application of amendment substances can reduce the concentrations of toxic chemical species of Cu and Mn in soil solution,especially for the soils grown with young plants.We evaluated the chemical speciation of Cu and Mn in soil solution and young grapevine growth using a contaminated soil with amendment application.Grapevine seedlings of Paulsen 1103rootstock were grown for 12 months on an old vineyard(>30 years of cultivation)soil without(control)and with vermicompost or limestone application.Grapevine dry matter,root morphological characteristics,and plant tissue Cu and Mn concentrations were evaluated.The cation and anion concentrations,dissolved organic carbon,p H,and chemical speciation of Cu and Mn in soil solution from different soil layers were analyzed.Vermicompost application did not reduce Cu and Mn phytotoxicity,and grapevine plants died after winter pruning.High soluble Mn concentration in soil(5.56 mg L-1in 0–45 cm soil layer)and Mn concentration in plant tissue at pruning(380.8 mg kg-1)might be the primary cause of plant death.Limestone application reduced Cu2+and Mn2+chemical species in soil solution,thereby increasing plant growth.The Cu2+and Mn2+species were negatively correlated(P<0.05)with grapevine shoot production at pruning(r=-0.92 and-0.97,respectively)and at the end of the trial(r=-0.73 and-0.51,respectively).Limestone application increased grapevine shoot and root dry matter production by 36%and 41%,respectively,while also presenting the highest root length and volume in the 5–10 cm soil layer.Limestone application is a viable and profitable alternative for reducing soil Cu and Mn availability and their phytotoxic effects. | Daniela Basso FACCO Edicarla TRENTIN Gerson Laerson DRESCHER Rodrigo Knevitz HAMMERSCHMITT Carlos Alberto CERETTA Leandro Souza DA SILVA Gustavo BRUNETTO Paulo Ademar Avelar FERREIRA | 2023 | Pedosphere2023，33，3： | 0 |
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