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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | 多色荧光碳量子点的合成及不同链长度烃的功能化改性(英文)显示文摘以多壁碳纳米管(MWCNTs)为原料,经肽键形成氨基功能化后合成出新型多色荧光碳量子点(CQDs)。所制CQDs由准球形石墨纳米晶体(平均尺寸为10 nm)包裹不同烃类,如丙胺、辛胺、十二胺和八乙胺得到的氨基。在CQDs表面引入氮原子和烃类对其荧光性能、量子产率和溶解性起重要影响。这种新型有机-溶解CQDs的荧光发射波长取决于激发波长。荧光量子产率根据CQDs表面上烃类取代物的链长而变化。 | Kayo Oliveira Vieira Jefferson Bettini Luiz Fernando Cappa de Oliveira Jefferson Luis Ferrari Marco Antonio Schiavon | 2017 | 新型炭材料2017，32，4： | 5 |
| 4 | Fault activation and induced seismicity in geological carbon storage--Lessons learned from recent modeling studies显示文摘In the light of current concerns related to induced seismicity associated with geological carbon sequestration(GCS),this paper summarizes lessons learned from recent modeling studies on fault activation,induced seismicity,and potential for leakage associated with deep underground carbon dioxide(CO_2) injection.Model simulations demonstrate that seismic events large enough to be felt by humans require brittle fault properties and continuous fault permeability allowing pressure to be distributed over a large fault patch to be ruptured at once.Heterogeneous fault properties,which are commonly encountered in faults intersecting multilayered shale/sandstone sequences,effectively reduce the likelihood of inducing felt seismicity and also effectively impede upward CO_2 leakage.A number of simulations show that even a sizable seismic event that could be felt may not be capable of opening a new flow path across the entire thickness of an overlying caprock and it is very unlikely to cross a system of multiple overlying caprock units.Site-specific model simulations of the In Salah CO_2 storage demonstration site showed that deep fractured zone responses and associated microseismicity occurred in the brittle fractured sandstone reservoir,but at a very substantial reservoir overpressure close to the magnitude of the least principal stress.We conclude by emphasizing the importance of site investigation to characterize rock properties and if at all possible to avoid brittle rock such as proximity of crystalline basement or sites in hard and brittle sedimentary sequences that are more prone to injection-induced seismicity and permanent damage. | Jonny Rutqvist Antonio P. Rinaldi Frederic Cappa Pierre Jeanne Alberto Mazzoldi Luca Urpi Yves Guglielmi Victor Vilarrasa | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，6： | 4 |
| 5 | Cognitive impairment in chronic obstructive pulmonary disease显示文摘 | Raffaele Antonelli Incalzi Camillo Marra Alessandro Giordano Maria Lucia Calcagni Antonella Cappa Salvatore Basso Gabriella Pagliari Leonello Fuso | 2003 | Journal of Neurology2003，，3： | 2 |
| 6 | Estimating maximum sustainable injection pressure during geological sequestration of CO 2 using coupled fluid flow and geomechanical fault-slip analysis显示文摘 | J. Rutqvist J. Birkholzer F. Cappa C.-F. Tsang | 2007 | Energy Conversion and Management2007，，6： | 2 |
| 7 | Autoimmune thyroid diseases in children显示文摘 | Cappa M Bizzarri C Crea F | | 0，，： | 1 |
| 8 | A PET follow-up study of recovery after stroke in acute aphasics显示文摘 | Perani D Grassi F | 1997 | Brain Lang1997，56，： | 1 |
| 9 | Oxiracetam in dementia a double-blind placebo-controlled study 显示文摘 | Bottini G Vallar G Cappa S | 1992 | Acta Neurol& and1992，86，3： | 1 |
| 10 | A PET follow-up study of recovery after stroke in acute aphasics显示文摘 | CAPPA SF PERANI D GRASSI F | 1997 | Brain-lang1997，56，1： | 1 |
| 11 | Idiom Comprehen- sion: A Prefrontal Task? 显示文摘 | Lauro L J R Tettamanti M Cappa S | 2008 | Cerebral Cortext2008，，18： | 1 |
| 12 | Acute suppurative thyroiditis in childhood relative frequency among thyroid inflammatory diseases显示文摘 | Wasniewska M Vigone MC Cappa M | 2007 | J Endocfinol Hat2007，30，4： | 1 |
| 13 | The neural correlates of verb and noun processing: A PET study 显示文摘 | DANIELA PERANI STEFANO F CAPPA | 1999 | Brain1999，122，12： | 1 |
| 14 | EFNS guidelines on cognitive rehabitation: report of an EFNS tast force 显示文摘 | Cappa SF Benke T Clakes | 2005 | Eur J Neurel2005，12，9： | 1 |
| 15 | Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment 显示文摘 | Canessa N Castronovo V Cappa SF | 2011 | Am J Respir Crit Care Med2011，183，： | 1 |
| 16 | Estimating Maximum Sustainable Injection Pressure During Geo- logical Sequestration of CO2 Using Coupled Fluid Flow and Geomechanical Fault-Slip Analysis 显示文摘 | Rutqvist J Birkholzer J Cappa F | 2007 | Energy Conversion and Management2007，48，： | 1 |
| 17 | Further delineation of the Simpson-Golabi-Behmel (SGB) syndrome显示文摘 | Gurrieri F Cappa M Neri G | 1992 | Am J Med Genet1992，44，2： | 1 |
| 18 | Behavioral profile of a heter-ozygous mutant mouse model for EGF-like domain neuregulin-1显示文摘 | Duffy L Cappas E Scimone A | 2008 | Behav Neurosci2008，122，4： | 1 |
| 19 | Bioavailability and degradation of phenanthrene in compost amended soils 显示文摘 | Puglisi E Cappa F Fragoulis G | 2007 | Chemosphere2007，67，： | 1 |
| 20 | Injury severity and outcome: a meta-analysis of prospective studies on TBI outcome 显示文摘 | CAPPA KA CONGER JC CONGER AJ | 2011 | Health Psychol2011，30，5： | 1 |
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