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| 1 | Intestinal inflammation and colorectal cancer:A doubleedged sword?显示文摘Chronic inflammation is thought to be the leading cause of many human cancers including colorectal cancer(CRC).Accordingly,epidemiologic and clinical studies indicate that patients affected by ulcerative colitis and Crohn's disease,the two major forms of inflammatory bowel disease,have an increased risk of developing CRC.In recent years,the role of immune cells and their products have been shown to be pivotal in initiation and progression of colitis-associated CRC.On the other hand,activation of the immune system has been shown to cause dysplastic cell elimination and cancer suppression in other settings.Clinical and experimental data herein reviewed,while confirming chronic inflammation as a risk factor for colon carcinogenesis,do not completely rule out the possibility that under certain conditions the chronic activation of the mucosal immune system might protect from colonic dysplasia. | Angelamaria Rizzo Francesco Pallone Giovanni Monteleone Massimo Claudio Fantini | 2011 | World Journal of Gastroenterology2011，17，26： | 25 |
| 2 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 3 | Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies显示文摘Spondyloarthropathies(SpA) are commonly observed extra-intestinal manifestations of both Crohn's disease(CD) and ulcerative colitis(UC), the two major forms of inflammatory bowel diseases(IBD).However, the immunological link between these two clinical entities is still poorly understood.Several lines of evidence indicate that SpA may originate from the relocation to the joints of the immune process primarily induced in the gut.The transfer of the intestinal inflammatory process into the joints implicates that immune cells activated in the gut-draining lymph nodes can localize, at a certain point of the intestinal disease, either into the gut or into the joints.This is indicated by the over-lapping expression of adhesion molecules observed on the surface of intestinal and synovial endothelial cells during inflammation.Moreover bacterial antigens and HLA-B27 expression may be implicated in the reactivation of T cells at the articular level.Finally, accumulating evidence indicates that a T helper 17 cell-mediated immune response may contribute to IBD and IBD-related SpA with a crucial role played by tumor necrosis factor-α in CD and to a lesser extent in UC. | Massimo C Fantini Francesco Pallone Giovanni Monteleone | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 4 | Access related complications during anterior exposure of the lumbar spine显示文摘The new millennium has witnessed the emergence of minimally invasive, non-posterior based surgery of the lumbar spine, in particular via lateral based methodologies to discectomy and fusion. In contrast, and perhaps for a variety of reasons, anterior motion preservation(non-fusion) technologies are playing a comparatively lesser, though incompletely defined, role at present. Lateral based motion preservation technologies await definition of their eventual role in the armamentarium of minimally invasive surgical therapies of the lumbar spine. While injury to the major vascular structures remains the most serious and feared complication of the anterior approach, this occurrence has been nearly eliminated by the use of lateral based approaches for discectomy and fusion cephalad to L5-S1. Whether anterior or lateral based, non-posterior approaches to the lumbar spine share certain access related pitfalls and complications, including damage to the urologic and neurologic structures, as well as gastrointestinal and abdominal wall issues. This review will focus on the recognition, management and prevention of these anterior and lateral access related complications. | Gary A Fantini Abhijit Y Pawar | 2013 | World Journal of Orthopedics2013，4，1： | 4 |
| 5 | Laparoscopic and open surgical treatment of left-sided pancreatic lesions: clinical outcomes and cost-effectiveness analysis显示文摘 | Paolo Limongelli Andrea Belli Gianluca Russo Luigi Cioffi Alberto D’Agostino Corrado Fantini Giulio Belli | 2012 | Surgical Endoscopy2012，，7： | 4 |
| 6 | Regulation of Homeostasis and Inflammation in the Intestine显示文摘 | Thomas T. MacDonald Ivan Monteleone Massimo Claudio Fantini Giovanni Monteleone | 2011 | Gastroenterology2011，，6： | 2 |
| 7 | Effects of prostaglandin E1α cyclodestrin treatment on endothelial dysfunction in patients with systemic sclerosis显示文摘 | Cristina Giannattasio MariaRosa Pozzi Marco Gradinali Elisabetta Montemerlo Francesca Citterio Silvia Maestroni Elena Fantini Monica Failla Maria Robuschi Salvatore Bianco Giuseppe Mancia | 2007 | Journal of Hypertension2007，，4： | 2 |
| 8 | Palpatory Method Used to Identify the Recurrent Laryngeal Nerve during Thyroidectomy显示文摘 | Fabio Procacciante Pietro Picozzi Massimo Pacifici Stefania Picconi Sandro Ruggeri Aldo Fantini Nicola Basso | 2000 | World Journal of Surgery2000，，5： | 2 |
| 9 | Fecal calprotectin and elastase 1 determinations in patients with pancreatic diseases: a possible link between pancreatic insufficiency and intestinal inflammation显示文摘 | Raffaele Pezzilli Alessandra Barassi Antonio M. Morselli-Labate Lorenzo Fantini Paola Tomassetti Davide Campana Riccardo Casadei Sergio Finazzi Gianvico Melzi d'Eril Roberto Corinaldesi | 2007 | Journal of Gastroenterology2007，，9： | 2 |
| 10 | Possible Correlation between Blood Glucose Concentration and the Reduced Scattering Coefficient of Tissues in the Near Infrared 显示文摘 | MAIER S WALKER A FANTINI | 1994 | Optics letters1994，19，24： | 1 |
| 11 | Regulation of gut inflammation and th17 cell response by interleu- kin-21显示文摘 | Fina D Sarra M Fantini MC | 2008 | Gastroenterology2008，134，4： | 1 |
| 12 | Effects of hormone replacement therapy on C-reactive protein levels in healthy postmenopausal women: comparison between oral and trans?dermal administration of estrogen显示文摘 | Modena M G Bursi F Fantini G | 2002 | AmJ Med2002，113，4： | 1 |
| 13 | Laparoscopic hepatic resection for completely exophytic hepatocellular carcinoma on cirrhosis显示文摘 | Giulio Belli Corrado Fantini Alberto D’Agostino Andrea Belli Serena Langella | 2005 | Journal of Hepato - Biliary - Pancreatic Surgery2005，，6： | 1 |
| 14 | Idiopathic REM sleep behaviour disorder:toward a better nosologic definition显示文摘 | Fantini ML Ferini-Strambi L Montplaisir J | | 0，，05： | 1 |
| 15 | 4G Communication Based on High Altitude Stratospheric Platforms: Channel Modeling and Performance Evaluation 显示文摘 | Fabio Dovis Roberto Fantini Marina Mondin Patrizia Savi | 2001 | Global Telecommunication Conference2001，1，： | 1 |
| 16 | New players in the cytokine orchestra of inflammatory bowel disease显示文摘 | FANTINI M C MONTELEONE G MACDONALD T T | 2007 | Inflamm Bowel Dis2007，13，： | 1 |
| 17 | Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and re-oxygenation 显示文摘 | FANTINI E DAMAISON L SENTEX E | 1994 | J Mol Cell Cardiol1994，26，8： | 1 |
| 18 | Epi- demiology of obstructive sleep apnea syndrome 显示文摘 | Ferini-Strambi L Fantini ML Castronovo C | 2004 | Minerva medica2004，95，3： | 1 |
| 19 | Longitudinal study of cognitive function in idiopathic REM sleep behaviour disorder 显示文摘 | Fantini ML Farini E Ortelli P | 2011 | Sleep2011，34，5： | 1 |
| 20 | Laparoscopic hepatic resection for completely exophytic hepatocellular carcinoma on cirrhosis显示文摘 | Belli G Fantini C Dagostino A | 2005 | J Hepatobiliary Pancreat Surg2005，12，6： | 1 |
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