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| 1 | Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies显示文摘The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies. | Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli | 2007 | World Journal of Gastroenterology2007，13，30： | 16 |
| 2 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 3 | Gastrointestinal motility disorders in inflammatory bowel diseases显示文摘The relationship between motility and inflammatory gastrointestinal disorders is at the same time complex and intriguing since these conditions might share some genetic,environmental,immunological and microbial predisposing factors.In addition,significant symptom overlapping may occur,muddling the waters within the clinical context.Although on one hand this represents a challenge for the clinician for a potential under-or over-treatment and diagnostic delay,on the other hand it possibly represents an opportunity for the researcher to better disclose the intimate relationship between chronic(often low-grade)inflammation,motor disorders and deranged sensory function.The best example is probably represented by Crohn’s disease and ulcerative colitis.In fact,a number of gastrointestinal motor disorders have been described in association with these diseases,disorders which span from the esophagus to the anorectum,and which will be extensively covered in this review.It is conceivable that at least part of this derangement is strictly related to inflammatory cytokine trafficking and neuromuscular changes;however,given the high prevalence of functional gastrointestinal disorders in the general population,this overlap might also be serendipitous.However,it is worth noting that literature data on this topic are relatively scarce,sometimes quite outdated,and mostly focused on the interplay between irritable bowel syndrome and inflammatory bowel disease.Nevertheless,both researchers and clinicians must be aware that symptoms related to gastrointestinal motility disorders may be highly prevalent in both active and inactive inflammatory bowel disease,correlate with greater psychological comorbidity and poorer quality of life,and may negatively influence the therapeutic approaches. | Gabrio Bassotti Elisabetta Antonelli Vincenzo Villanacci Marianna Salemme Manuela Coppola Vito Annese | 2014 | World Journal of Gastroenterology2014，20，1： | 11 |
| 4 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 5 | Intravascular contrast agents in diagnostic applications: Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents显示文摘在药,在病理和正常区域之间的辨别是很重要的,并且在大多数情况中,如此的辨别被新奇成像技术使可能。众多的形式被开发了在心血管的疾病或在 angiogenic 和 vasculogenic 过程期间设想组织 vascularization。这里,我们在 vasculature 成像报导最近的进展,提供在为对容器疾病的预示的评价的生物医学的诊断和潜在的未来策略的当前的非侵略的途径的概述,例如动脉瘤和导致心肌的梗塞的冠的动脉吸藏。有几个对比代理人(CA ) 对可得到在疾病的早阶段改进特定的纸巾的可见性,允许快速的治疗。然而, CA 被众多的限制也妨碍,包括从直到空隙的空间,毒性,和低敏感的血容器的快速的散开。从血容器的溢出导致图象的快速的损失。如果对比媒介能充分被限制到脉管的空间,高分辨率的结构、功能的脉管的成像能被获得。许多科学家贡献了新材料或新搬运人系统。例如,红血房间(RBC ) 的使用作为 CA 交货系统看起来提供一种可伸缩的选择给允许足够的脉管的成像的当前的过程。当 biomimetic CA 搬运人,和这种技术应该临床上被验证,从发行量的 CA 的识别和移动能被使用 RBC 阻止或推迟。 | Antonella Antonelli Carla Sfara Mauro Magnani | 2017 | Nano Research2017，10，3： | 5 |
| 6 | SMARCB1/INI1与儿童脊索瘤:基因突变及免疫组化分析显示文摘脊索瘤好发于颅底和脊柱的浸润性骨肿瘤,起源于残留的胚胎脊索。通常发生在成人,儿童罕见,20岁以下的患者〈5%。组织学显示儿童脊索瘤常为低分化,出现细胞异型性、细胞数量增加、核分裂常见,具有侵袭性、转移扩散率高、生存率低等特点。目前分析认为低分化的脊索瘤与SMARCB1/INI1基因缺失有关。为更清楚了解SMARCB1/INI1表达缺失的生物学意义,作者选择8例儿童脊索瘤(7例经典型和1例低分化型)进行分析。 | Antonelli M Raso A Mascelli S 黄爱清 余英豪 | 2017 | 临床与实验病理学杂志2017，33，5： | 4 |
| 7 | Novel oral-targeted therapies for mucosal healing in ulcerative colitis显示文摘Ulcerative colitis(UC), a chronic, relapsing, remitting disease of the colon and rectum, is characterized by inflammatory ulceration of the mucosa. Current UC therapy relies on controlling acute episodes and preventing relapse. To predict modifications in the natural course of UC, mucosal healing(MH) has emerged as a major treatment goal. Endoscopic evaluation is considered the gold standard for assessing MH, which can be achieved by conventional drugs and biologics in many, but not all, patients. Consequently, interest is focusing on the development of new substances for UC therapy, and new oral agents are in the pipeline. This review will focus on the ability of newly developed oral drugs to induce and maintain MH in UC patients. | Elisabetta Antonelli Vincenzo Villanacci Gabrio Bassotti | 2018 | World Journal of Gastroenterology2018，24，47： | 4 |
| 8 | Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus显示文摘The morphogen Sonic Hedgehog(Shh)plays a critical role in the development of different tissues,both in invertebrates and vertebrates.Shh mediates its action via a receptor complex associating two transmembrane proteins:Patched1(Ptch1)and Smoothened(Smo).The repression exerted by Ptch1 on Smo is relieved when Shh,the ligand,binds to Ptch1,which leads to a complex signaling cascade involving the transcription factors of the Gli family and finally,to | Francesca Antonelli Arianna Casciati Simonetta Pazzaglia | 2019 | Neural Regeneration Research2019，14，1： | 4 |
| 9 | NGF, DCX, and NSE upregulation correlates with severity and outcome of head trauma in children显示文摘 | A Chiaretti G Barone R Riccardi A Antonelli P Pezzotti O Genovese L Tortorolo G Conti | 2009 | Neurology2009，，7： | 3 |
| 10 | Cognitive impairment in chronic obstructive pulmonary disease显示文摘 | Raffaele Antonelli Incalzi Camillo Marra Alessandro Giordano Maria Lucia Calcagni Antonella Cappa Salvatore Basso Gabriella Pagliari Leonello Fuso | 2003 | Journal of Neurology2003，，3： | 2 |
| 11 | 3,5-diiodo- l -thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet显示文摘 | Maria Pina Mollica Lillà Lionetti Maria Moreno Assunta Lombardi Pieter De Lange Alessandro Antonelli Antonia Lanni Gina Cavaliere Antonio Barletta Fernando Goglia | 2009 | Journal of Hepatology2009，，2： | 2 |
| 12 | Histological healing in inflammatory bowel disease:A still unfulfilled promise显示文摘Treatment of inflammatory bowel disease(IBD) is traditionally based on several drugs,including salicylates,corticosteroids,and antibiotics;in addition,the therapeutic armamentarium has considerably evolved with the advent of newer,effective therapeutic measures(such as the biological agents) that are able to improve in a considerable manner both the clinical and endoscopic variables.Thus,mucosal healing,at least considered from an endoscopic point of view,is today regarded as the ultimate endpoint for treatment of these conditions.However,it is also increasingly clear that endoscopic healing is not necessarily paralleled by histological healing;There are few doubts that the latter should be considered as a true,objective healing and the ultimate goal to reach when treating patients with IBD.Unfortunately,and surprisingly,only a few,incomplete,and somewhat conflicting data exist on this topic,especially because there is still the need to standardize both histological assessment and the severity grading of these disorders;Issues that have not been yet been resolved for clinical practice and therapeutic trials.Hopefully,with the help of an increased awareness on the clinical researchers' side,and the availability of dedicated pathologists on the other side,this matter will be effectively faced and resolved in the near future. | Vincenzo Villanacci Elisabetta Antonelli Karel Geboes Giovanni Casella Gabrio Bassotti | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 13 | Sedation with sufentanil in pantiens receiving pressure support ventilation has no effects on respiration : a pilot study 显示文摘 | Conti G Arcangeli A Antonelli M | 2004 | Can J Anaesth2004，51，5： | 1 |
| 14 | Protective effects of 6-ethyl cheno-deoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis显示文摘 | Fiorucci S Clerici C Antonelli E | 2005 | J Pharmacol Exp Ther2005，313，2： | 1 |
| 15 | Hearing loss with cochlear modiolar defects and large vestibular aqueducts 显示文摘 | ANTONELLI PJ NALL AV LEMMERLING MM | 1998 | Am J Otol1998，19，： | 1 |
| 16 | The third gas:H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis显示文摘 | Fiorucci S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 17 | Therapeutic approach to bronchiolitis: why pediatricians continue to overprescribe drugs? 显示文摘 | De BD Pannuti F Antonelli F | 2010 | Ital J Pediatr2010，36，1： | 1 |
| 18 | Nitric oxide-releasing NSAIDs:a review of their current status 显示文摘 | Iomcci S Antonelli E Burgaud JL | 2001 | Drug Saf2001，24，11： | 1 |
| 19 | Yeast influence on volatile composition of wines显示文摘 | Antonelli A Castellari L Zambonelli C | 1999 | J Agric Food Chem1999，47，： | 1 |
| 20 | Autoimmunity to CD38 and GAD in type I and type II diabetes: CD38 and HLA genotypes and clinical phenotypes 显示文摘 | Antonelli A Tuomi T Nannipieri M | 2002 | Diabetologia2002，45，9： | 1 |
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