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| 1 | Follow-up of intestinal metaplasia in the stomach: When, how and why显示文摘Gastric cancer remains the second most frequent cause of cancer-related mortality in the world. Screening programs in some Asian countries are impractical in the majority of other countries worldwide. Therefore, follow-up of precancerous lesions is advisable for secondary gastric cancer prevention. Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is highly prevalent in the general population, being detected in nearly 1 of every 4 patients undergoing upper endoscopy. The IM prevalence rate is significantly higher in patients with Helicobacter pylori (H. pylori) infection, in first-degree relatives of gastric cancer patients, in smokers and it increases with patient age. IM is the 'breaking point' in the gastric carcinogenesis cascade and does not appear to regress following H. pylori eradication, although the cure of infection may slow its progression. Gastric cancer risk is higher in patients with incomplete-type IM, in those with both antral and gastric body involvement, and the risk significantly increases with IM extension over 20% of the gastric mucosa. Scheduled endoscopic control could be cost-effective in IM patients, depending on the yearly incidence of gastric cancer in IM patients, the stage of gastric cancer at diagnosis discovered at surveillance, and the cost of endoscopy. As a pragmatic behavior, yearly endoscopic control would appear justified in all IM patients with at least one of these conditions: (1) IM extension > 20%; (2) the presence of incomplete type IM; (3) first-degree relative of gastric cancer patients; and (4) smokers. In the remaining IM patients, a less intensive (2-3 years) could be proposed. | Angelo Zullo Cesare Hassan Adriana Romiti Michela Giusto Carmine Guerriero Roberto Lorenzetti Salvatore MA Campo Silverio Tomao | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 25 |
| 2 | New Insights into Aluminum Tolerance in Rice: The ASR5 Protein Binds the STAR1 Promoter and Other Aluminum-Responsive Genes显示文摘在植物的铝(艾尔) 毒性是在庄稼生产的主要限制之一。艾尔 3+, 最艾尔的有毒的形式,在酸的条件和原因下面被释放进土壤植物的广泛的损坏, especiallyin 根。在米饭,艾尔忍耐要求 ASR5 基因,而是 ASR5 的分子的功能仍然保持未知。这里,我们执行染色体宽的分析在米饭识别 ASR5-dependentAl-responsive 基因。在植物把 silencing 基于 ASR5_RNAi,全球 transcriptome 分析识别了全部的 of961 对在野类型的米饭根的艾尔处理应答的基因。这些基因, 909 没在 ASR5_RNAiplants 对艾尔作出回应,显示为在 Al 应答的基因表示的 ASR5 的一个中央角色。在正常条件下面,没有艾尔处理, ASR5_RNAi 植物与野类型的植物相比表示了 1.756 基因差别,并且在野类型的植物的 446 这些基因 respondedto 艾尔处理。深定序跟随的染色质 immunoprecipitation 识别了被对他们的倡导者有约束力的 ASR5 直接调整的 104 putativetarget 基因,包括 STAR1 基因,它编码为艾尔忍耐要求的 ABC transporter。有约束力的山峰序列的主题分析为 ASR5 揭示了 thebinding 主题,它在 vitro 被证实经由用 STAR1 倡导者的 DNA 有约束力的试金。这些结果证明 ASR5 充当在 rice.Key 词为 Al 应答的 geneexpression 和艾尔忍耐是必要的一个关键抄写因素: | Rafael Augusto Arenhart Yang Bai Luiz Felipe Valter de Oliveira Lauro Bucker Neto Mariana Schunemann Felipe dos Santos Maraschin Jorge Mariath Adriano Silverio Gilberto Sachetto-Martins Rogerio Margis Zhi-Yong Wang Marcia Margis-Pinheiro | 2014 | Molecular Plant2014，7，4： | 12 |
| 3 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 4 | Helicobacter pylori and functional dyspepsia: An unsolved issue?显示文摘Patients with Helicobacter pylori(H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small(10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this | Angelo Zullo Cesare Hassan Vincenzo De Francesco Alessro Repici Raffaele Manta Silverio Tomao Bruno Annibale Dino Vaira | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 5 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 3 |
| 6 | Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis显示文摘 | Federica Zoratto Luigi Rossi Monica Verrico Anselmo Papa Enrico Basso Angelo Zullo Luigi Tomao Adriana Romiti Giuseppe Lo Russo Silverio Tomao | 2014 | Tumor Biology2014，，7： | 3 |
| 7 | Colorectal cancer metastatic to the breast:A case report显示文摘BACKGROUND Breast metastases from colorectal cancer(CRC)are very uncommon.There is no unanimous consensus regarding the best treatment for this rare condition,and management is,especially in elderly patients,limited to diagnosis and palliative care.Capecitabine,an oral fluoropyrimidine derivative,might be helpful in controlling the disease and may be a treatment option for patients unable to receive more aggressive chemotherapy.CASE SUMMARY We report a case of synchronous massive breast metastasis from CRC in an 85 year old patient who came to the hospital presenting a huge mass originating from the axillary extension of the right breast.A whole body computed tomography also showed a mass in the right colon.The patient underwent a simple right mastectomy along with right hemicolectomy.The resected breast showed massive metastasis from CRC with intense and homogeneous nuclear CDX2 staining,while the colon specimen revealed poorly differentiated adenocarcinoma stage pT4a pN0 pM1(breast)(Tumor Node Metastasis 2017).Three months later she developed a subcutaneous mass at the site of the previous mastectomy.An ultrasound guided biopsy was carried out again and revealed a metastasis from CRC.The patient then started treatment with capecitabine plus bevacizumab,obtaining stable disease(RECIST criteria)and a clinical benefit after 3 mo of therapy.CONCLUSION In our experience,capecitabine and bevacizumab may be a useful treatment option for breast metastases from primary CRC in elderly patients. | Silvia Taccogna Elisa Gozzi Luigi Rossi Davide Caruso Davide Conte Patrizia Trenta Valentina Leoni Silverio Tomao Lucrezia Raimondi Francesco Angelini | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 2 |
| 8 | Measurement planning for circular cross-section tunnels using terrestrial laser scanning显示文摘 | Ramón Argüelles-Fraga Celestino Ordó?ez Silverio García-Cortés Javier Roca-Pardi?as | 2013 | Automation in Construction2013，，： | 2 |
| 9 | Intermittent androgen deprivationg (IAD) in patients with biochemical failure after radical retropubic prostatectomy (RRP) for clinically lacalized prostate cancer 显示文摘 | SCIARRA A DI CHIRO C DI SILVERIO F | 2000 | World J Urol2000，18，6： | 1 |
| 10 | Glacial cover mapping ( 1987 - 1996) of the Cordillera Blanca ( Peru ) using satellite imagery 显示文摘 | Silverio W Jaquet M | 2005 | Remote Sensing of Environment2005，95，： | 1 |
| 11 | The effect of temperature cycling on the amylopectin retrogradation of starches with different amylopection unit-chain length distribution显示文摘 | Fredriksson H | 2000 | Carbohydrate Polymers2000，，42： | 1 |
| 12 | The influence of amylose and amylopctin characteristirs (m gelatinizadon and relrogradation properties of different starches显示文摘 | Fredriksson H Silverio J Andersson R | 1998 | Carbohydrate Polymers1998，35，34： | 1 |
| 13 | The influence of amylose and amylopectin characteristics on gelatinization and retrogradation properties of different starches显示文摘 | FREDRIKSSON H SILVERIO J ANDERSSON R | 1998 | Carbohydrate Polymers1998，35，3： | 1 |
| 14 | Repetitive-control-base selfcommissioning procedure for inverter nonidealities compensation 显示文摘 | SILVERIO B LUCA P MAURO Z | 2008 | IEEE Transaction on Industry Applications2008，44，15： | 1 |
| 15 | Design techniques for reducing the cogging torque in surface-mounted PM motors显示文摘 | Bianchi Nicola Bolognani Silverio | 2002 | IEEE Trans on Ind Applications2002，38，12： | 1 |
| 16 | Tubular linear permanent magnet motors:an overall compari- son显示文摘 | Nicola Bianchi Silverio Bolognani Dario Dalla Corle | 2003 | IEEE Transactions on Industry Applieations2003，39，2： | 1 |
| 17 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 1 |
| 18 | The influence of amylose and amylopectin characteristics on gelatinization and retrogradation properties of different starches 显示文摘 | Fredriksson H Silverio J Andersson R | 1998 | Carbohydrate Polymers1998，35，3： | 1 |
| 19 | Estimates of benthic fluxes of nutrients across the sediment-water interface (Guarapiranga reservoir,Sao Paulo,Brazil)显示文摘 | Mozeto A A Silverio P F Soares A | 2001 | The Science of the Total Environment2001，266，： | 1 |
| 20 | Sensorless Full-Digital PMSM Drive With EKF Estimation of Speed and Rotor Position显示文摘 | Silverio Bolognani Roberto Oboe Mauro Zigliotto | 1999 | Industrial Electronics IEEE Transactions on (S0278-0046)1999，46，1： | 1 |
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