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| 1 | Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity显示文摘Breast cancer(BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common treatment for BC includes breast-conserving surgery followed by a standard radiotherapy(RT) regimen. However, radiation hypersensitivity and the occurrence of RT-induced toxicity in normal tissue may affect patients' treatment. The role of DNA repair in cancer has been extensively investigated, and an impaired DNA damage response may increase the risk of BC and individual radiosensitivity. Single nucleotide polymorphisms(SNPs) in DNA repair genes may alter protein function and modulate DNA repair efficiency, influencing the development of various cancers, including BC. SNPs in DNA repair genes have also been studied as potential predictive factors for the risk of RT-induced side effects. Here, we review the literature on the association between SNPs in base excision repair(BER) genes and BC risk. We focusedon X-ray repair cross complementing group 1(XRCC1), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly(ADP-ribose) polymerase-1, which encode three important BER enzymes that interact with XRCC1. Although no association between SNPs and radiation toxicity has been validated thus far, we also report published studies on XRCC1 SNPs and variants in other BER genes and RT-induced side effects in BC patients, emphasising that large well-designed studies are needed to determine the genetic components of individual radiosensitivity. | Clarice Patrono Silvia Sterpone Antonella Testa Renata Cozzi | 2014 | World Journal of Clinical Oncology2014，5，5： | 8 |
| 2 | Evolution of Microstructure and Mechanical Property during Long-Term Aging in Udimet 720Li显示文摘Thermal stabilities of microstructure and mechanical property have been investigated on super- alloy U72OLi, which is of great interest of application for jet engine and land-based turbine disc. The results showed that, the primary and secondary γ’?particles maintain good thermal stability at 650 and 7000C with aging time up to 3000 h, while the tertiary γ’?is apparently dependent on aging temperature and time. The tertiary γ’?particles undergo a procedure of coarsening, dissolution and eventually complete disappearance with the increasing of aging time and temper- ature. They exhibit unusual high sensibility upon aging temperature, which is attributed to the lattice misfit between the γ’?precipitates and the matrix in the alloy. The grain boundary phase M23C6 remains stable without forming of sigma phase even with aging time up to 3000 h at 700℃. Microhardness decreases apparently with increasing aging time and aging temperature. Theoretical analysis based on dislocation mechanism indicates that the change of microhardness should be attributed to the evolution of the tertiary γ’?during aging. | Lanzhang ZHOU and Valentino LUPINC CNR-TeMPE, Via R. Cozzi 53, 20125 Milano, Italy Jianting GUO Institute of Metal Research, CAS, 72 Wenhua Road, Shenyang 110016, China | 2001 | Journal of Materials Science & Technology2001，17，6： | 6 |
| 3 | Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients显示文摘A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human plasma.For the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of plasma.The chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run time.Calibration curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all analytes.Mean intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs analysed.The solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in plasma.Good extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring. | Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo Emilio Clementi | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 4 |
| 4 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 5 | Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor显示文摘 | Ilaria Marigo Erika Bosio Samantha Solito Circe Mesa Audry Fernandez Luigi Dolcetti Stefano Ugel Nada Sonda Silvio Bicciato Erika Falisi Fiorella Calabrese Giuseppe Basso Paola Zanovello Emanuele Cozzi Susanna Mandruzzato Vincenzo Bronte | 2010 | Immunity2010，，6： | 2 |
| 6 | A treatment planning study comparing volumetric are modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy显示文摘 | Cozzi L Dinshaw K A Shrivastava S K | 2008 | Radiother Oncol2008，89，2： | 1 |
| 7 | A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours显示文摘 | Luca Cozzi Antonella Fogliata | 2001 | Radiotherapy and Oncology2001，61，3： | 1 |
| 8 | Polymer-supported organic catalysts显示文摘 | Benaglia M Puglisi A Cozzi F | 2003 | Chem Rev2003，103，9： | 1 |
| 9 | Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery显示文摘 | Gemma M Tommasino C Cozzi S | 2002 | Anesth Analg2002，94，： | 1 |
| 10 | Percutaneous transhepatic biliary drainage in the management of postsurgical biliary leaks in patients with nondilated intrahepatic bile ducts显示文摘 | Cozzi G Severini A Civelli E | 2006 | Cardiovasc In- tervent Radiol2006，29，3： | 1 |
| 11 | Evaluation of different polyrnerase chain reaction methods for the identification of Vibrio parahaemolyticus strains isolated by culturalmethods 显示文摘 | CROCI L SUFFREDINI E COZZI L | 2007 | JAOAC Int2007，90，： | 1 |
| 12 | Developments in automation system design for steelplants显示文摘 | Romito L Cozzi A | 1995 | Steel Times International1995，19，2： | 1 |
| 13 | Sequence and functional characterization of feline interleukin - 2 显示文摘 | Cozzi P J Padrid P A Takeda J | 1993 | Biochem Biophys Res Commun1993，194，3： | 1 |
| 14 | TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents 显示文摘 | Valerio A Cardile A Cozzi V | 2006 | J Clin Invest2006，116，10： | 1 |
| 15 | The generation of transgenic pigs as potential organ donors for humans显示文摘 | Cozzi E White DJ | 1995 | Nat Med1995，1，： | 1 |
| 16 | Toxicology and pharmacokinetics of intravesical gemcitabine: a preclinical study in dogs显示文摘 | Bajorin DF Tong W | 1999 | Clin Cancer Res1999，5，9： | 1 |
| 17 | When to start highly active antiretroviral therapy in chronically HIVinfected patients: evidence from the ICONA study显示文摘 | Cozzi Lepri A Phillips AN d'Arminio Monteforte A | 2001 | AIDS2001，15，8： | 1 |
| 18 | R&D Cooperction and Growth显示文摘 | GUIDO COZZI | 1999 | Journal of Economic Theory1999，86，： | 1 |
| 19 | Long term survival of nonhuman primates receiving life supporting transgenic porcine kidney xenografts显示文摘 | Cozzi E Bhatti F Schmoekel M | 2000 | Transplantation2000，1，： | 1 |
| 20 | Mouse offspring after microinjeetion of heated spermatozoa 显示文摘 | Cozzi J Monier-Gavelle F Lievre N | 2001 | Biol Reprod2001，65，5： | 1 |
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