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| 1 | Incidence and mortality of female breast cancer in the AsiaPacific region显示文摘Objective: To provide an overview of the incidence and mortality of female breast cancer for countries in the Asia-Pacific region.Methods: Statistical information about breast cancer was obtained from publicly available cancer registry and mortality databases(such as GLOBOCAN), and supplemented with data requested from individual cancer registries. Rates were directly age-standardised to the Segi World Standard population and trends were analysed using joinpoint models.Results: Breast cancer was the most common type of cancer among females in the region, accounting for 18% of all cases in 2012, and was the fourth most common cause of cancer-related deaths(9%). Although incidence rates remain much higher in New Zealand and Australia, rapid rises in recent years were observed in several Asian countries. Large increases in breast cancer mortality rates also occurred in many areas, particularly Malaysia and Thailand, in contrast to stabilising trends in Hong Kong and Singapore, while decreases have been recorded in Australia and New Zealand. Mortality trends tended to be more favourable for women aged under 50 compared to those who were 50 years or older. Conclusion: It is anticipated that incidence rates of breast cancer in developing countries throughout the Asia-Pacific region will continue to increase. Early detection and access to optimal treatment are the keys to reducing breast cancerrelated mortality, but cultural and economic obstacles persist. Consequently, the challenge is to customise breast cancer control initiatives to the particular needs of each country to ensure the best possible outcomes. | Danny R.Youlden Susanna M.Cramb Cheng Har Yip Peter D.Baade | 2014 | Cancer Biology & Medicine2014，11，2： | 35 |
| 2 | 中国大陆地区精神分裂症患者奥氮平治疗引起体质量增加的相关因素分析显示文摘目的 分析中国大陆地区精神分裂症患者奥氮平治疗期间体质量增加的相关因素.方法 采用事后分析方法,对1项多国家及地区关于奥氮平治疗的观察性研究中国大陆地区330例精神分裂症患者的临床数据进行分析.结果 奥氮平治疗6个月,中国大陆地区患者平均体质量增加(4.5±4.0)kg,145例(47.2%)患者出现有临床意义的体质量增加(CSWG);其中,94例(29.6%)患者在治疗2个月后出现早期CSWG,其6个月时体质量增加的总体幅度(7.5 kg)大于无早期CSWG患者(2.7 kg),二者比较差异有统计学意义(P〈0.01).有10项因素与治疗中体质量增加相关,分别为思想沉湎于食物(5.1 kg)、晚上吃零食(5.4 kg)、需过量进食方有饱感(4.9 kg)、进食红肉(5.0 kg)、餐后有舒适的饱感(5.0 kg)、每天的连续行走量(4.9 kg)、最主要进餐场所(4.9 kg)、社交活动(5.6 kg)、性别和进餐规律性(男性5.1 kg,女性4.5 kg,进餐无规律5.0 kg).结论 思想沉湎于食物、晚上吃零食、需过量进食方有饱感、进食红肉、餐后有舒适的饱感、每天的连续行走量、最主要进餐场所、社交活动、性别和进餐规律性与中国大陆地区精神分裂症患者奥氮平治疗期间体质量相关. | 昂秋青 唐济生 赵靖平 胡建 江开达 李惠春 李鸣 王刚 王高华 谢世平 杨甫德 张晋碚 Pritibha Singh Susanna Holt Tamás Treuer | 2011 | 中华精神科杂志2011，44，3： | 13 |
| 3 | Prevention of vertical transmission of hepatitis B virus infection显示文摘Hepatitis B virus(HBV)is the leading cause of chronic viral hepatitis.Annually,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early life.Vertical transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative mothers.Maternal viraemia is a preeminent risk factor for vertical transmission of HBV.Maternal screening is the first step to prevent vertical transmission of HBV.Hepatitis B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV infection.Strategies are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest. | Piero Veronese Icilio Dodi Susanna Esposito Giuseppe Indolfi | 2021 | World Journal of Gastroenterology2021，27，26： | 10 |
| 4 | A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong显示文摘We conducted a six-year epidemiological study on human coronaviruses(HCoVs) circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77(0.93%) of the samples by a pan-HCoV RT-PCR assay. The most frequently detected HCoV species was HCoV-OC43(0.58%), followed by HCoV-229E(0.15%),HCoV-HKU1(0.13%) and HCoV-NL63(0.07%). HCoVs were detected throughout the study period(September 2008–August 2014), with the highest detection rate from September 2010 to August2011(22/1500, 1.47%). Different seasonal patterns of each HCoV species in Hong Kong were noted.HCoV-OC43 was predominant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and summer. HCoV-229 E mainly occurred in winter and spring, while HCoV-NL63 was predominant in summer and autumn. HCoVs most commonly infect the elderly and young children, with median age of 79.5 years(range, 22 days to 95 years).Intriguingly, the detection rate of HCoV-OC43 in the age group of > 80 years(26/2380, 1.09%) was significantly higher than that in the age group of 0–10 years(12/2529, 0.47%)(P < 0.05). These data provides new insight into the epidemiology of coronaviruses. | Cyril C.Y.Yip Carol S.F.Lam Hayes K.H.Luk Emily Y.M.Wong Rodney A.Lee Lok-Yee So Kwok-Hung Chan Vincent C.C.Cheng Kwok-Yung Yuen Patrick C.Y.Woo Susanna K.P.Lau | 2016 | Virologica Sinica2016，31，1： | 9 |
| 5 | Viral manipulation of cellular protein conjugation pathways: The SUMO lesson显示文摘Small ubiquitin-like modifier(SUMO)ylation is a key posttranslational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle. | Domenico Mattoscio Chiara V Segré Susanna Chiocca | 2013 | World Journal of Virology2013，2，2： | 8 |
| 6 | The Glucosinolate Biosynthetic Gene A OP2 Mediates Feed-back Regulation of Jasmonic Acid Signaling in Arabidopsis显示文摘在改变并且质问环境的幸存要求一个有机体高效地获得并且使用它的资源。由于他们的无柄的性质,植物动态地优化他们的新陈代谢是特别地批评的。在植物主要新陈代谢,新陈代谢的调整包含一条小径的输出控制它的输入产生精确、柔韧的回答到环境变化的反馈机制。由对比,很少研究为第二等的新陈代谢的反馈规定探讨了潜力。在 Arabidopsis,防卫混合物 glucosinolates 的累积以前在 glucosinolate biosynthetic 基因 AOP2 被连接了到基因变化。AOP2 表示能增加小径的二个已知的管理者(MYB28 和 MYB29 ) 的抄本层次,建议 AOP2 起在控制 glucosinolate 生合成的积极反馈规定的一个作用。我们产生了影响 AOP2, MYB28/29,或两个的异种。这些异种的 Transcriptome 分析识别了在表明 MYB28 和 MYB29 的独立人士的 AOP2 和 jasmonic 酸(JA ) 之间的一个到目前为止未被认出的连接。因此, AOP2 是连接 glucosinolate 生合成并且 JA 发信号的一个规章的反馈环的部分并且从而允许 glucosinolate 小径影响 JA 敏感。这个规章的反馈环的发现提供植物怎么为防御代谢物优化资源的使用的卓见。 | Meike Burow Susanna Atwell Marta Francisco Rachel E. Kerwin Barbara A. Halkier Daniel J. Kliebenstein | 2015 | Molecular Plant2015，8，8： | 6 |
| 7 | Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?显示文摘AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July 2012.The mean age of the patients was 72.28 years.Abdominal CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal plane.CT and MRI examinations were analysed for the presence of colonic abnormalities and associated findings.RESULTS:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR examinations.The MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT examination.Type Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT examination.In the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared normal.CONCLUSION:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC. | Maria Antonietta Mazzei Susanna Guerrini Nevada Cioffi Squitieri Giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe Mazzei Luca Volterrani | 2013 | World Journal of Gastroenterology2013，19，8： | 5 |
| 8 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 9 | Design and preliminary validation of a tool for the simulation of train braking performance显示文摘Train braking performance is important for the safety and reliability of railway systems.The availability of a tool that allows evaluating such performance on the basis of the main train features can be useful for train system designers to choose proper dimensions for and optimize train's subsystems.This paper presents a modular tool for the prediction of train braking performance,with a particular attention to the accurate prediction of stopping distances.The tool takes into account different loading and operating conditions,in order to verify the safety requirements prescribed by European technical specifications for interoperability of high-speed trains and the corresponding EN regulations.The numerical results given by the tool were verified and validated by comparison with experimental data,considering as benchmark case an Ansaldo EMU V250 train—a European high-speed train—currently developed for Belgium and Netherlands high-speed lines,on which technical information and experimental data directly recorded during the preliminary tests were available.An accurate identification of the influence of the braking pad friction factor on braking performances allowed obtaining reliable results. | Luca Pugi Monica Malvezzi Susanna Papini Gregorio Vettori | 2013 | Journal of Modern Transportation2013，21，4： | 5 |
| 10 | MRI,^18F—FDG PET/CT及PET/MR成像评估妇科肿瘤显示文摘MRI和^18F-脱氧葡萄糖(FDG)PET/CT在妇科癌症患者的诊疗中扮演着核心和互补角色。由于治疗通常需要联合手术、放疗以及化疗,因此成像对病情分期和评估预后非常重要。该文综述了运用上述2种成像模式在早期评估3种常见妇科肿瘤(宫颈癌、子宫内膜癌和卵巢上皮肿瘤)中的应用。重点提出了影响治疗的影像特征,以及2种成像方式的相对优势和不足。影像评估先期治疗后肿瘤复发以及后续姑息治疗方法的选择。并对MRI和PET中较新的功能和分子技术进行效果评估。最后,该文还介绍PET/MR成像的初期经验,PET/MR是一种新型技术,很有潜力成为个体化妇科肿瘤治疗方案制订的重要方法。 | 王玉 彭新桂 滕皋军 Susanna I. Lee Catalano OA Dehdashti F | 2018 | 中华核医学与分子影像杂志2018，38，4： | 4 |
| 11 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 12 | The Compositae Tree of Life in the age of phylogenomics显示文摘包括超过 25000 种类,葵花家庭(Compositae 或 Asteraceae ) 是 flowering 植物的最大的家庭。许多它的系经历了最近、快速的放射,和家庭有大规模基因复制和 polyploidy 的深、普遍的历史。许多由于对发展史的主要节点的支持的差的分辨率和缺乏关于家庭差异的最重要的进化问题仍然保持未答复。我们的组用包括定序 1000 低拷贝的数字的 Hyb-Seq 采用了一条 phylogenomics 途径原子标记,为大量种类的正部分 plastomes。这里,我们讨论我们的进步标明日期并且介绍包括九个亚科和 25 个部落用的二发展史并置并且基于结合的分析。我们为合并高质量的参考染色体和 transcriptomes 在 Compositae 推进系统、进化的研究讨论未来计划。当我们向为采用 phylogenomics 并且在 Compositae 以内解决关系开发工具做了大迈进时,许多工作留下。最近形成的全球合伙将工作 megafamily 为这解决未答复的进化问题。 | Jennifer R. Mandel Michael S. Barker Randall J. Bayer Rebecca B. Dikow Tian-Gang Gao Katy E. Jones Sterling Keeley Norbert Kilian Hong Ma Carolina M. Siniscalchi Alfonso Susanna Ramhari Thapa Linda Watson Vicki A. Funk | 2017 | Journal of Systematics and Evolution2017，55，4： | 4 |
| 13 | Silvicultural alternatives to conventional even-aged forest man-agement-what limits global adoption?显示文摘Background: The development of forestry as a scientific and management discipline over the last two centuries has mainly emphasized intensive management operations focused on increased commodity production, mostly wood. This 'conventional' forest management approach has typically favored production of even-aged, single-species stands. While alternative management regimes have generally received less attention, this has been changing over the last three decades, especially in countries with developed economies. Reasons for this change include a combination of new information and concerns about the ecological consequences of intensive forestry practices and a willingness on the part of many forest owners and society to embrace a wider set of management objectives. Alternative silvicultural approaches are characterized by a set of fundamental principles, including avoidance of clearcutting, an emphasis on structural diversity and small-scale variability, deployment of mixed species with natural regeneration,and avoidance of intensive site-preparation methods.Methods: Our compilation of the authors' experiences and perspectives from various parts of the world aims to initiate a larger discussion concerning the constraints to and the potential of adopting alternative silvicultural practices.Results: The results suggest that a wider adoption of alternative silvicultural practices is currently hindered by a suite of ecological, economic, logistical, informational, cultural, and historical constraints. Individual contexts display their own unique combinations and relative significance of these constraints, and accordingly, targeted efforts, such as regulations and incentives, may help to overcome specific challenges.Conclusions: In a broader context, we propose that less emphases on strict applications of principles and on stand structures might provide additional flexibility and facilitate the adoption of alternative silvicultural regimes in a broader set of circumstances. At the same time, the acceptance of alternative silvicultural systems as the 'preferred or default mode of management' wil necessitate and benefit from the continued development of the scientific basis and valuation of a variety of ecosystem goods and services. This publication is aimed to further the discussion in this context. | Klaus J Puettmann Scott McG Wilson Susan C Baker Pablo J Donoso Lars Dr?ssler Girma Amente Brian D Harvey Thomas Knoke Yuanchang Lu Susanna Nocentini Francis E Putz Toshiya Yoshida Jürgen Bauhus | 2015 | Forest Ecosystems2015，2，2： | 4 |
| 14 | Transcriptional Activation and Production of Tryptophan-Derived Secondary Metabolites in Arabidopsis Roots Contributes to the Defense against the Fungal Vascular Pathogen Verticillium Iongisporum显示文摘忍受土壤的真菌的病原体 Verticillium longisporum 在象 oilseed 强奸那样的 Brassicaceae 主人植物上引起脉管的疾病。真菌开拓殖民地于根木部并且向上搬到疾病症状变得可见的叶子。为早基因正式就职把 Arabidopsis 用作一个模型,我们分别地在孢子萌芽以后并且在根外皮的穿入期间立即响应菌丝的生长执行了根 transcriptome 分析。感染的根显示出象抄写因素的激活那样的基因表示的快速的 reprogramming,应力 -- ,并且防卫相关的基因。这里,我们集中了于导致导出色氨酸的第二等的代谢物的生产的高度协调的基因正式就职。在叶子的以前的研究证明 CYP81F2 和 PEN2 (PENETRATION2 ) 编码的酶执行抗真菌的吲哚 glucosinolate (IGS ) 的形成代谢物。在感染 Verticillium 的根,我们发现 transcriptional CYP81F2 和 PEN2 的激活相当或相同的事物 PEL1 (PEN2-LIKE1 ) ,而是抗真菌的 IGS 故障产品的没有增加。相反, indole-3-carboxylic 酸(I3CA ) 和 phytoalexin camalexin 在感染的根积累了,但是仅仅 camalexin 在 vitro 禁止了 Verticillium 生长。而导致 camalexin 或 CYP81F2 依赖的 IGS 代谢物的单个新陈代谢的小径的基因混乱没改变导致 Verticillium 的疾病症状, cyp79b2 cyp79b3 异种在两个分支损害了导致了显著地提高的危险性。因此,我们的数据提供卓见进根特定的早防卫并且对脉管的病原体作为活跃抗真菌的混合物建议导出色氨酸的代谢物。 | Tim Iven Stefanie Konig Seema Singh Susanna A. Braus-Stromeyer Matthias Bischoff Lutz F. Tietze Gerhard H. Braus Volker Lipka Ivo Feussner Wolfgang Droge-Laser | 2012 | Molecular Plant2012，5，6： | 4 |
| 15 | Two-dimensional gel electrophoresis in bacterial proteomics显示文摘Two-dimensional gel electrophoresis(2-DE)is a gel-based technique widely used for analyzing the pro-tein composition of biological samples.It is capable of resolving complex mixtures containing more than a thousand protein components into individual protein spots through the coupling of two orthogonal bio-physical separation techniques:isoelectric focusing(first dimension)and polyacrylamide gel electrophore-sis(second dimension).2-DE is ideally suited for ana-lyzing the entire expressed protein complement of a bacterial cell:its proteome.Its relative simplicity and good reproducibility have led to 2-DE being widely used for exploring proteomics within a wide range of envi-ronmental and medically-relevant bacteria.Here we give a broad overview of the basic principles and his-torical development of gel-based proteomics,and how this powerful approach can be applied for studying bacterial biology and physiology.We highlight specific 2-DE applications that can be used to analyze when,where and how much proteins are expressed.The links between proteomics,genomics and mass spectrometry are discussed.We explore how proteomics involving tandem mass spectrometry can be used to analyze(post-translational)protein modifications or to identify proteins of unknown origin by de novo peptide se-quencing.The use of proteome fractionation tech-niques and non-gel-based proteomic approaches are also discussed.We highlight how the analysis of pro-teins secreted by bacterial cells(secretomes or exo-proteomes)can be used to study infection processes or the immune response.This review is aimed at non-specialists who wish to gain a concise,compre-hensive and contemporary overview of the nature and applications of bacterial proteomics. | Shirly O.T.Curreem Rory M.Watt Susanna K.P.Lau Patrick C.Y.Woo | 2012 | Protein & Cell2012，3，5： | 4 |
| 16 | Folate Intake, MTHFR Polymorphisms, and Risk of Esophageal, Gastric, and Pancreatic Cancer: A Meta-analysis显示文摘 | Susanna C. Larsson Edward Giovannucci Alicja Wolk | 2006 | Gastroenterology2006，，4： | 3 |
| 17 | Insights from human sleep research on neural mechanisms of Alzheimer’s disease显示文摘Alzheimer's disease(AD)is considered as the major cause of dementia and affects about 50 million people in world population,with an expected increase of 27%in the coming decades,as reported by the most recent AD statistics.The fast-growing empirical evidence is highlighting the close relationship between sleep and AD since the preclinical stage of the disease,pointing to an important role of sleep in the occurrence and progression of AD. | Susanna Cordone Luigi De Gennaro | 2020 | Neural Regeneration Research2020，15，7： | 3 |
| 18 | High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS显示文摘Highly active antiretroviral treatment(HAART) has had a significant impact on survival of individuals with acquired immunodeficiency syndrome(AIDS);however,with the longer life-span of patients with AIDS,there is increasing prevalence of AIDS dementia complex(ADC) and other non-AIDS-defining illness,and cardiovascular diseases(CVD) are also common.The influence of these varied disease processes on HIV-1 DNA concentration in brain tissues has not been thoroughly assessed in the post-HAART era.The purpose of the current study is to clarify the impacts of ADC and other complications of HIV disease on the viral load in the brains in AIDS patients with post-HARRT.We examined autopsy specimens from the brains of thirteen patients who died from complications of AIDS with quantitative polymerase chain reaction(QPCR).All but one patient had received HAART prior to death since 1995.Two patients died with severe CVD,multiple cerebrovascular atherosclerosis(CVA) throughout the brain and five patients died with ADC.Six patients had no ADC/CVA.A QPCR was used to measure the presence of HIV-1 DNA in six brain tissues(meninges,frontal grey matter,frontal white matter,temporal subcortex,cerebellum and basal ganglia).In the post-HARRT era,for non-ADC/CVA patients,HIV-1 DNA concentration in brain tissues was statistically higher than that in patients with ADC.In a new finding,two patients who suffered from severe CVD,especially CVA,also had high concentrations of HIV-1 in brain compartments not showing ADC related changes.To our knowledge,this is the first report of a relationship between the CVA and HIV-1 viral burden in brain.The current observations suggest that HAART-resistant HIV reservoirs may survive within ADC lesions of the brain as well as the macrophage rich atherosclerosis,which needs to be confirmed by more AIDS cases with CVA. | GALLIGAN Derek C. LAMERS Susanna L. YU Stephanie SHAGRUN Lamia SALEMI Marco MCGRATH Michael S. | 2009 | Science China(Life Sciences)2009，52，7： | 3 |
| 19 | Incidental extravascular findings in computed tomographic angiography for planning or monitoring endovascular aortic aneurysm repair: Smoker patients, increased lung cancer prevalence?显示文摘AIM To validate the feasibility of high resolution computed tomography(HRCT) of the lung prior to computed tomography angiography(CTA) in assessing incidental thoracic findings during endovascular aortic aneurysm repair(EVAR) planning or follow-up.METHODS We conducted a retrospective study among 181 patients(143 men, mean age 71 years, range 50-94) referred to our centre for CTA EVAR planning or followup. HRCT and CTA were performed before or after 1 or 12 mo respectively to EVAR in all patients. All HRCT examinations were reviewed by two radiologists with 15 and 8 years experience in thoracic imaging. The results were compared with histology, bronchoscopy or follow-up HRCT in 12, 8 and 82 nodules respectively. RESULTS There were a total of 102 suspected nodules in 92 HRCT examinations, with a mean of 1.79 nodules per patient and an average diameter of 9.2 mm(range 4-56 mm). Eightynine out of 181 HRCTs resulted negative for the presence of suspected nodules with a mean smoking history of 10 pack-years(p-y, range 5-18 p-y). Eighty-two out of 102(76.4%) of the nodules met criteria for computed tomography follow-up, to exclude the malignant evolution. Of the remaining 20 nodules, 10 out of 20(50%) nodules, suspected for malignancy, underwent biopsy and then surgical intervention that confirmed the neoplastic nature: 4(20%) adenocarcinomas, 4(20%) squamous cell carcinomas, 1(5%) small cell lung cancer and 1(5%) breast cancer metastasis); 8 out of 20(40%) underwent bronchoscopy(8 pneumonia) and 2 out of 20(10%) underwent biopsy with the diagnosis of sarcoidosis.CONCLUSION HRCT in EVAR planning and follow-up allows to correctly identify patients requiring additional treatments, especially in case of lung cancer. | Maria Antonietta Mazzei Susanna Guerrini Francesco Gentili Giuseppe Galzerano Francesco Setacci Domenico Benevento Francesco Giuseppe Mazzei Luca Volterrani Carlo Setacci | 2017 | World Journal of Radiology2017，9，7： | 3 |
| 20 | Adaptive link layer security architecture for telecommand communications in space networks显示文摘Impressive advances in space technology are enabling complex missions, with potentially significant and long term impacts on human life and activities. In the vision of future space exploration, communication links among planets, satellites,spacecrafts and crewed vehicles will be designed according to a new paradigm, known as the disruption tolerant networking. In this scenario, space channel peculiarities impose a massive reengineering of many of the protocols usually adopted in terrestrial networks; among them, security solutions are to be deeply reviewed, and tailored to the specific space requirements. Security is to be provided not only to the payload data exchanged on the network, but also to the telecommands sent to a spacecraft,along possibly differentiated paths. Starting from the secure space telecommand design developed by the Consultative Committee for Space Data Systems as a response to agency-based requirements, an adaptive link layer security architecture is proposed to address some of the challenges for future space networks. Based on the analysis of the communication environment and the error diffusion properties of the authentication algorithms, a suitable mechanism is proposed to classify frame retransmission requests on the basis of the originating event(error or security attack) and reduce the impact of security operations. An adaptive algorithm to optimize the space control protocol, based on estimates of the time varying space channel, is also presented. The simulation results clearly demonstrate that the proposed architecture is feasible and efficient, especially when facing malicious attacks against frame transmission. | Lei Zhang Chengjin An Susanna Spinsante Chaojing Tang | 2014 | Journal of Systems Engineering and Electronics2014，25，3： | 3 |
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