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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor显示文摘 | Ilaria Marigo Erika Bosio Samantha Solito Circe Mesa Audry Fernandez Luigi Dolcetti Stefano Ugel Nada Sonda Silvio Bicciato Erika Falisi Fiorella Calabrese Giuseppe Basso Paola Zanovello Emanuele Cozzi Susanna Mandruzzato Vincenzo Bronte | 2010 | Immunity2010，，6： | 2 |
| 3 | Targeting molecular pathways for the treatment of inherited retinal degeneration显示文摘Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells.Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity with several genes mutated in patients affected by these genetic diseases.The high genetic heterogeneity of these diseases hampers the development of effective therapeutic interventions for the cure of a large cohort of patients.Common cell demise mechanisms can be envisioned as targets to treat patients regardless the specific mutation.One of these targets is the increase of intracellular calcium ions,that has been detected in several murine models of inherited retinal degeneration.Recently,neurotrophic factors that favor the efflux of calcium ions to concentrations below toxic levels have been identified as promising molecules that should be evaluated as new treatments for retinal degeneration.Here,we discuss therapeutic options for inherited retinal degeneration and we will focus on neuroprotective approaches,such as the neuroprotective activity of the Pigment epithelium-derived factor.The characterization of specific targets for neuroprotection opens new perspectives together with many questions that require deep analyses to take advantage of this knowledge and develop new therapeutic approaches.We believe that minimizing cell demise by neuroprotection may represent a promising treatment strategy for retinal degeneration. | Meltem Kutluer Li Huang Valeria Marigo | 2020 | Neural Regeneration Research2020，15，10： | 2 |
| 4 | In- fluence of thermal treatments, molecular weight, and mo lecular weight distribution on the crystallization of Isotac tic polypropylenc显示文摘 | Antonio Marigo Carla Marega Valerio Causin | 2004 | Journal of Applied Polymer Science2004，91，2： | 1 |
| 5 | Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanoma-specific CD8 + T lymphocytes 显示文摘 | De Palma R Marigo I Del Galdo F | 2004 | Cancer Res2004，64，21： | 1 |
| 6 | Identification and charac- terization of microRNAs expressed in the mouse eye显示文摘 | Karali M Peluso I Marigo V Banff S | 2007 | Invest Ophthalmol Vis Sci2007，48，2： | 1 |
| 7 | Synthesis methods of fluorinated polyurethanes(2):Effects on morphology and microstructure显示文摘 | Tonelli C Ajroldi G Marigo A | 2001 | Polymer2001，42，24： | 1 |
| 8 | Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells显示文摘 | Marigo I Dolcetti L Serafini P | 2008 | Immunol Rev2008，222，： | 1 |
| 9 | Ni-troaspirin corrects immune dysfunction in tu mor-bearinghosts and promotes tumor eradication by cancer vaccination显示文摘 | DE SANTO C SERAFINI P MARIGO I | 2005 | Proc Natl Acad Sci U S A2005，102，11： | 1 |
| 10 | Role of arginine metabolism in immunity and immunopathology显示文摘 | Peranzoni E Marigo I Dolcetti L | 2007 | Immunobiology2007，212，910： | 1 |
| 11 | Ant System: Optimization by a Colony of Cooperating Agents显示文摘 | Marigo M Maniezzo V Colomi A | 1996 | IEEE Trans on SMC1996，26，1： | 1 |
| 12 | Anterior segment tumors:current concepts and innovationa显示文摘 | MARIGO F A FINGER P T | 2003 | Survey Ophthalmol2003，48，： | 1 |
| 13 | Synthesis methods of fluorinated polyurethanes (2) : Effect on mor- phology and microstructure显示文摘 | TONELLI C AJROLDI G MARIGO A | 2001 | Polymer2001，42，24： | 1 |
| 14 | The TP-AGB phase:a new model显示文摘 | MARIGO P BRESSAN A CHIOSI C | 1996 | Astronomy & Astrophysics1996，313，： | 1 |
| 15 | Differential diagnosis of anterior segment cysts by ultrasound biomicroscopy显示文摘 | Marigo FA Esaki K Finger PT | | 0，，： | 1 |
| 16 | Identification and characteriza- tion of microRNAs expressed in the mouse eye 显示文摘 | Karali M Peluso I Marigo V | 2007 | Invest Ophthal- mol Vis Sci2007，48，2： | 1 |
| 17 | Biochemical evidence that patched is the Hedgehog receptor显示文摘 | Marigo V DaveyRA Zuo Y Cunningham J.M.Tabin C.J | | 0，，6605： | 1 |
| 18 | Ultrasound biomicros- copy after vitrectomy in eyes with normal intraocular pressure and in eyes with chronic hypotony显示文摘 | Nehemy MB Zisman M Marigo FA | 2008 | Eur J Ophthalmol2008，18，4： | 1 |
| 19 | Nitroaspirin corrects immune dys- function in tumor-bearing hosts and promotes tumor eradication by cancer vaccination显示文摘 | De Santo C Serafini P Marigo I | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 20 | The TP-AGB phase:A new model 显示文摘 | MARIGO P BRESSAN A CHIOSO C | 1996 | A&A1996，313，： | 1 |
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