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| 1 | Silymarin in non alcoholic fatty liver disease显示文摘AIM: This study was undertaken to evaluate the hepatic effects of silybum marianum on non alcoholic fatty liver disease (NAFLD). METHODS: In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). The brightness of liver echography texture (hepatorenal ratio brightness) was also defined at same time. These evaluations were repeated after 6 mo of treatment. RESULTS: Serum levels of some metabolic and anti-inflammatory data nonsignificantly lowered after 6 mo of silymarin. On the contrary, Steato test, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase were significantly (P < 0.001) reduced. Instead, the AST/ALT ratio unchanged. Finally, the hepatorenal brightness ratio, as an index of hepatic steatosis, significantly (P < 0.05) dropped. CONCLUSION: The obtained results indicate that silymarin appears to be effective to reduce the biochemical, inflammatory and ultrasonic indices of hepatic steatosis. Some parameters indicative of early stage of atherosclerosis were also lowered. | Fulvio Cacciapuoti Anna Scognamiglio Rossella Palumbo Raffaele Forte Federico Cacciapuoti | 2013 | World Journal of Hepatology2013，5，3： | 17 |
| 2 | Primary hepatic carcinoid:A case report and literature review显示文摘Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide hormones.Approximately 54.5% arise in the gastrointestinal tract and frequently metastasize to the liver.Primary hepatic carcinoid tumors(PHCT) are extremely rare;only 95 cases have been reported.A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical manifestations.His previous medical history,since 2003,included an echotomography of the dishomogeneous parenchymal area but no focal lesions.A computed tomography scan performed in 2005 showed an enhanced pseudonodular-like lesion of about 2 cm.Cholangio-magnetic resonance imaging identified the lesion as a possible cholangiocarcinoma.No positive findings were obtained with positron emission tomography.Histology suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine tumor.Immunohistochemistry was positive for anti chromogranin antibodies,Ki67 antibodies and synaptophysin.Octreoscan scintigraphy indicated intense activity in the lesion.Endoscopic investigations were performed to exclude the presence of extrahepatic neoplasms.Diagnosis of PHCT was established.The patient underwent left hepatectomy,followed by hormone therapy with sandostatine LAR.Two months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe,which was histologically confirmed.The postoperative clinical course was uneventful,with a negative follow-up for hematochemical,clinical and radiological investigations at 18 mo post-surgery.Diagnosis of PHCT is based principally on the histopathological confi rmation of a carcinoid tumor and the exclusion of a non-hepatic primary tumor.Surgical resection is the recommended primary treatment for PHCT.Recurrence rate and survival rate in patients treated with resection were 18% and 74%,respectively. | Luigi Maria Fenoglio Sara Severini Domenico Ferrigno Giovanni Gollè Cristina Serraino Christian Bracco Elisabetta Castagna Chiara Brignone Fulvio Pomero Elena Migliore Ezio David Mauro Salizzoni | 2009 | World Journal of Gastroenterology2009，15，19： | 14 |
| 3 | Polymer-coated nanoporous carbons for trace seawater uranium adsorption显示文摘Polymer-coated mesoporous carbon nanocomposites were prepared from the immobilization of acrylonitrile and acrylic acid copolymers with divinylbenzene as a crosslinker onto a mesoporous carbon framework.High surface areas were maintained after polymerization with accessible porosity.This functional nanocomposite was tested as an adsorbent for uranium from high salinity solutions.Uranium adsorption results have shown that the adsorption capacities are strongly influenced by the density of the amidoxime groups and the specific surface area. | YUE YanFeng SUN XiaoGuang MAYES Richard T. KIM Jungseung FULVIO Pasquale F. QIAO ZhenAn BROWN Suree TSOURIS Costas OYOLA Yatsandra DAI Sheng | 2013 | Science China Chemistry2013，56，11： | 9 |
| 4 | Theoretical and numerical studies of chorus waves: A review显示文摘Theoretical and numerical models of chorus waves are reviewed in this paper. Specifically, we focus on the nonlinear wave particle interactions and the current understanding of the frequency chirping of rising tone chorus waves. Various other related topics, such as the optimal excitation condition of chorus, the formation of subpackets, and the non-adiabaticity of the nonlinear interaction are also discussed. We end this review paper with a short list of questions of chorus waves that are still under research and debate. | Xin TAO Fulvio ZONCA Liu CHEN Yifan WU | 2020 | Science China Earth Sciences2020，63，1： | 5 |
| 5 | Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a widespread pathology described for the first time by Alois Alzheimer in 1907.It can be classified as a neurodegenerative disease consisting in a progressive loss of memory and cognitive functions,whose prevalence is estimated to grow due to the increasing life expectancies all over the world.To date,the only treatments available for this disease are symptomatic and no actual effective cure is available.The main effect of the drugs commonly used in therapeutic protocols is to temporarily delay the onset of the disease and to slightly improve the patients’cognitive capabilities(Piemontese,2017)(Figure 1). | Leonardo Brunetti Antonio Laghezza Fulvio Loiodice Paolo Tortorella Luca Piemontese | 2020 | Neural Regeneration Research2020，15，1： | 5 |
| 6 | Thermally reconfigurable quantum photonic circuits at telecom wavelength by femtosecond laser micromachining显示文摘The importance of integrated quantum photonics in the telecom band is based on the possibility of interfacing with the optical network infrastructure that was developed for classical communications.In this framework,femtosecond laser-written integrated photonic circuits,which have already been assessed for use in quantum information experiments in the 800-nm wavelength range,have great potential.In fact,these circuits,being written in glass,can be perfectly mode-matched at telecom wavelength to the in/out coupling fibers,which is a key requirement for a low-loss processing node in future quantum optical networks.In addition,for several applications,quantum photonic devices must be dynamically reconfigurable.Here,we experimentally demonstrate the high performance of femtosecond laser-written photonic circuits for use in quantum experiments in the telecom band,and we demonstrate the use of thermal shifters,which were also fabricated using the same femtosecond laser,to accurately tune such circuits.State-of-the-art manipulation of single-and two-photon states is demonstrated,with fringe visibilities greater than 95%.The results of this work open the way to the realization of reconfigurable quantum photonic circuits based on this technological platform. | Fulvio Flamini Lorenzo Magrini Adil S Rab Nicolo Spagnolo Vincenzo D’Ambrosio Paolo Mataloni Fabio Sciarrino Tommaso Zandrini Andrea Crespi Roberta Ramponi Roberto Osellame | 2015 | Light(Science & Applications)2015，4，1： | 5 |
| 7 | LYVE-1 is'on stage'now:an emerging player in dendritic cell docking to lymphatic endothelial cells显示文摘The lymphatic system consists of a network of lymph capillaries and vessels deputed to drain the interstitial fluid(containing floating macromolecules,such as nutrients,cellular debris and tissue-infiltrating pathogens)and to transport tissue-patrolling lymphocytes and dendritic cells(DCs)to draining lymph nodes(drLNs).1 Knowledge of the mechanisms associated with cellular transmigration into the lymphatic system could offer the opportunity to manipulate the immune response in a wide range of diseases,such as autoimmune diseases and cancer.2,3 In this research highlight,we discuss a recent study that sheds light on our understanding of the molecules involved in DCs docking to lymphatic endothelial cells,a critical step prior to their subsequent endothelial transmigration into lymphatic vessels.DC docking occurs through the interaction between hyaluronan(hyaluronic acid,HA)molecules on the plasma membrane and lymphatic-vessel endothelial protein(LYVE-1). | Elena Rinaldi Fulvio Baggi | 2018 | Cellular & Molecular Immunology2018，15，7： | 3 |
| 8 | Parkinson’s disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkinmediated mitophagy显示文摘Background:Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease(PD),and several genes linked to familial PD,including PINK1(encoding PTEN-induced putative kinase 1[PINK1])and PARK2(encoding the E3 ubiquitin ligase Parkin),are directly involved in processes such as mitophagy that maintain mitochondrial health.The dominant p.D620N variant of vacuolar protein sorting 35 ortholog(VPS35)gene is also associated with familial PD but has not been functionally connected to PINK1 and PARK2.Methods:To better mimic and study the patient situation,we used CRISPR-Cas9 to generate heterozygous human SH-SY5Y cells carrying the PD-associated D620N variant of VPS35.These cells were treated with a protonophore carbonyl cyanide m-chlorophenylhydrazone(CCCP)to induce the PINK1/Parkin-mediated mitophagy,which was assessed using biochemical and microscopy approaches.Results:Mitochondria in the VPS35-D620N cells exhibited reduced mitochondrial membrane potential and appeared to already be damaged at steady state.As a result,the mitochondria of these cells were desensitized to the CCCPinduced collapse in mitochondrial potential,as they displayed altered fragmentation and were unable to accumulate PINK1 at their surface upon this insult.Consequently,Parkin recruitment to the cell surface was inhibited and initiation of the PINK1/Parkin-dependent mitophagy was impaired.Conclusion:Our findings extend the pool of evidence that the p.D620N mutation of VPS35 causes mitochondrial dysfunction and suggest a converging pathogenic mechanism among VPS35,PINK1 and Parkin in PD. | Kai Yu Ma Michiel R.Fokkens Fulvio Reggiori Muriel Mari Dineke S.Verbeek | 2021 | Translational Neurodegeneration2021，10，2： | 3 |
| 9 | Visualization by PIV of dynamic stall on a vertical axis wind turbine显示文摘 | Carlos Sim?o Ferreira Gijs Kuik Gerard Bussel Fulvio Scarano | 2009 | Experiments in Fluids2009，，1： | 3 |
| 10 | Discrete-Time Volatility Forecasting With Persistent Leverage Effect and the Link With Continuous-Time Volatility Modeling显示文摘 | Fulvio Corsi Roberto Renò | 2012 | Journal of Business & Economic Statistics2012，，3： | 2 |
| 11 | Face stability and required support pressure for TBM driven tunnels with ideal face membrane – Drained case显示文摘 | Seung Han Kim Fulvio Tonon | 2010 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2010，，5： | 2 |
| 12 | Venous Lower-Limb Evaluation in Patients With Acute Pulmonary Embolism显示文摘 | Fulvio Pomero Chiara Brignone Cristina Serraino Sergio Panzone Christian Bracco Elena Migliore Paola Dalmasso Paolo Cavallo Perin Luigi Maria Fenoglio | 2011 | Southern Medical Journal2011，，6： | 2 |
| 13 | Phosphorylated mesoporous carbon as effective catalyst for the selective fructose dehydration to HMF显示文摘Phosphorylated mesoporous carbons (PMCs) were investigated as catalysts in the dehydration of fructose to hydroxymethylfurfural (HMF). The acidic PMCs show better selectivity to HMF compared to sulfonated carbon catalyst (SC) despite lower activity. The concentration of P-O groups on the PMC was correlated with the activity/selectivity of the catalysts; the higher the P-O concentration, the higher the activity. However, the higher the P-O content, the lower the selectivity to HMF. Indeed, a lower concentration of the P-O groups minimized the degradation of HMF to levulinic acid and the formation of by-products, such as humines. Stability tests showed that these systems deactivate due to the formation of humines and water insoluble by-products derived from the dehydration of fructose which blocked the catalytically active sites. | A. Villa M. Schiavoni P. F. Fulvio S. M. Mahurin S. Dai R. T. Mayes G. M. Veith L. Prati | 2013 | Journal of Energy Chemistry2013，22，2： | 2 |
| 14 | Physical basis for the symmetries in the Friedmann-Robert son-Walker metric显示文摘 | Fulvio Melia | 2016 | Frontiers of physics2016，11，4： | 2 |
| 15 | A Meta-Analysis of the Renal Safety of Isosmolar Iodixanol Compared With Low-Osmolar Contrast Media显示文摘 | Peter A. McCullough Michel E. Bertrand Jeffrey A. Brinker Fulvio Stacul | 2006 | Journal of the American College of Cardiology2006，，4： | 2 |
| 16 | The dynamics of national innovation systems: A panel cointegration analysis of the coevolution between innovative capability and absorptive capacity显示文摘 | Fulvio Castellacci Jose Miguel Natera | 2012 | Research Policy2012，，： | 2 |
| 17 | Adipokines in Nonalcoholic Steatohepatitis: From Pathogenesis to Implications in Diagnosis and Therapy显示文摘 | Emmanuel A. Tsochatzis George V. Papatheodoridis Athanasios J. Archimandritis Fulvio D’Acquisto | 2009 | Mediators of Inflammation2009，，： | 2 |
| 18 | Adjustable Intragastric Balloon vs Non-Adjustable Intragastric Balloon: Case–Control Study on Complications, Tolerance, and Efficacy显示文摘 | Alfredo Genco Daniela Dellepiane Giovanni Baglio Fulvio Cappelletti Francesca Frangella Roberta Maselli Maria Chiara Dante Romina Camoirano Michele Lorenzo Nicola Basso | 2013 | Obesity Surgery2013，，7： | 2 |
| 19 | Threshold bipower variation and the impact of jumps on volatility forecasting显示文摘 | Fulvio Corsi Davide Pirino Roberto Renò | 2010 | Journal of Econometrics2010，，2： | 2 |
| 20 | Carbon Materials for Chemical Capacitive Energy Storage显示文摘 | Yunpu Zhai Yuqian Dou Dongyuan Zhao Pasquale F. Fulvio Richard T. Mayes Sheng Dai | 2011 | Adv. Mater2011，，42： | 2 |
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