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| 1 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 2 | Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C显示文摘 | Michael T. Dill Francois H.T. Duong Julia E. Vogt Stéphanie Bibert Pierre–Yves Bochud Luigi Terracciano Andreas Papassotiropoulos Volker Roth Markus H. Heim | 2011 | Gastroenterology2011，，3： | 2 |
| 3 | Repeated Multiview Imaging for Estimating Seedling Tiller Counts of Wheat Genotypes Using Drones显示文摘Early generation breeding nurseries with thousands of genotypes in single-row plots are well suited to capitalize on high throughput phenotyping.Nevertheless,methods to monitor the intrinsically hard-to-phenotype early development of wheat are yet rare.We aimed to develop proxy measures for the rate of plant emergence,the number of tillers,and the beginning of stem elongation using drone-based imagery.We used RGB images(ground sampling distance of 3mm pixel-1)acquired by repeated flights(≥2 flights per week)to quantify temporal changes of visible leaf area.To exploit the information contained in the multitude of viewing angles within the RGB images,we processed them to multiview ground cover images showing plant pixel fractions.Based on these images,we trained a support vector machine for the beginning of stem elongation(GS30).Using the GS30 as key point,we subsequently extracted plant and tiller counts using a watershed algorithm and growth modeling,respectively.Our results show that determination coefficients of predictions are moderate for plant count(R^(2)=0:52),but strong for tiller count(R^(2)=0:86)and GS30(R^(2)=0:77).Heritabilities are superior to manual measurements for plant count and tiller count,but inferior for GS30 measurements.Increasing the selection intensity due to throughput may overcome this limitation.Multiview image traits can replace hand measurements with high efficiency(85-223%).We therefore conclude that multiview images have a high potential to become a standard tool in plant phenomics. | Lukas Roth Moritz Camenzind Helge Aasen Lukas Kronenberg Christoph Barendregt Karl-Heinz Camp Achim Walter Norbert Kirchgessner Andreas Hund | 2020 | Plant Phenomics2020，2，1： | 2 |
| 4 | Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks显示文摘Microfluidics is becoming a technology of growing interest for building microphysiological systems with integrated read-out functionalities.Here we present the integration of enzyme-based multi-analyte biosensors into a multi-tissue culture platform for‘body-on-a-chip’applications.The microfluidic platform is based on the technology of hanging-drop networks,which is designed for the formation,cultivation,and analysis of fluidically interconnected organotypic spherical three-dimensional(3D)microtissues of multiple cell types.The sensor modules were designed as small glass plug-ins featuring four platinum working electrodes,a platinum counter electrode,and an Ag/AgCl reference electrode.They were placed directly into the ceiling substrate from which the hanging drops that host the spheroid cultures are suspended.The electrodes were functionalized with oxidase enzymes to enable continuous monitoring of lactate and glucose through amperometry.The biosensors featured high sensitivities of 322±41 nA mM^(−1) mm^(−2) for glucose and 443±37 nA mM^(−1) mm^(−2) for lactate;the corresponding limits of detection were below 10μM.The proposed technology enabled tissue-size-dependent,real-time detection of lactate secretion from single human colon cancer microtissues cultured in the hanging drops.Furthermore,glucose consumption and lactate secretion were monitored in parallel,and the impact of different culture conditions on the metabolism of cancer microtissues was recorded in real-time. | Patrick M.Misun Jörg Rothe Yannick R.F.Schmid Andreas Hierlemann Olivier Frey | 2016 | Microsystems & Nanoengineering2016，2，1： | 1 |
| 5 | HgTe量子阱中的量子自旋霍尔绝缘态显示文摘近来,理论研究预言量子霍尔效应,在外加磁场为0的情况下物质出现的一种全新的量子态可以在HgTe/(Hg,Cd)Te量子阱中实现。我们制造了低密度高迁移率的样品结构,在样品中我们可以通过外加栅极电压调节载流子从n型穿过绝缘区到p型。对于宽度d<6.3nm的薄量子阱,绝缘区在低温下具有常规的难以察觉的微小电导。然而,对于厚的量子阱(d>6.3nm),在绝缘层中也出现接近2e2/h的剩余电导,其中e是电子电荷,h是Planck常数.剩余电导与样品宽度无关,证明这是由边缘态引起的.此外剩余电导可以被微小的外加磁场所破坏.在临界厚度d=6.3nm处发生的量子相变也与磁场诱发的绝缘-金属转变互相独立.这些观察结果为量子自旋霍尔效应提供了实验证据。 | Markus Konig Steffen Wiedmann Christoph Brüne Andreas Roth Hartmut Buhmann Laurens W.Molenkamp 黄光耀 赵安 | 2007 | 中山大学研究生学刊(自然科学与医学版)2007，28，4： | 1 |
| 6 | A novel expression system for intracellular production and purification of recombinant affinity-tagged proteins in Aspergillus niger显示文摘 | Andreas H. F. J. Roth Petra Dersch | 2010 | Applied Microbiology and Biotechnology2010，，2： | 1 |
| 7 | Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks显示文摘The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection.To define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering analyses.In our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies.The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19.Changes within this sign ature were associated with either disease progression or recovery.In summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity. | Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 8 | Elektrophysiology of hrainstem reflcxc显示文摘 | Christian Roth Andreas Ferbert | 2007 | Das Neurophysiologie-Labor2007，29，3： | 1 |
| 9 | Discrimination between random and non-random processes in early bacterial colonization on biomaterial surfaces: application of point pattern analysis显示文摘 | Daniel Siegismund Anja Schroeter Claudia Lüdecke Andreas Undisz Klaus D. Jandt Martin Roth Markus Rettenmayr Stefan Schuster Sebastian Germerodt | 2014 | Biofouling2014，，9： | 1 |
| 10 | Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C显示文摘 | Michael T. Dill Francois H.T. Duong Julia E. Vogt Stéphanie Bibert Pierre–Yves Bochud Luigi Terracciano Andreas Papassotiropoulos Volker Roth Markus H. Heim | 2011 | Gastroenterology2011，，3： | 1 |
| 11 | The impact of variation in scale on the behavior of a cellular automata used for land use change modeling显示文摘 | Ying Pan Andreas Roth | 2010 | Computers Environment and Urban Systems2010，34，： | 1 |
| 12 | Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma显示文摘 | Markus Brunner Claus Krenn Georg Roth Bernhard Moser Martin Dworschak Erika Jensen-Jarolim Andreas Spittler Thomas Sautner Nico Bonaros Ernst Wolner George Boltz-Nitulescu Hendrik Jan Ankersmit | 2004 | Intensive Care Medicine2004，，7： | 1 |
| 13 | The impact of variation in scale on the behavior of a cellular automata used for land use change modeling显示文摘 | Ying Pan Andreas Roth Zhenrong Yu Reiner Doluschitz | 2010 | Computers Environment and Urban Systems2010，，5： | 1 |
| 14 | Lymph Node Metastases in Rectal Cancer After Preoperative Radiochemotherapy: Impact of Intramesorectal Distribution and Residual Micrometastatic Involvement显示文摘 | Thilo Sprenger Hilka Rothe Heinz Becker Tim Beissbarth Kia Homayounfar Korbinian Gauss Julia Kitz Hendrik Wolff Andreas H. Scheel Michael Ghadimi Claus R?del Lena-Christin Conradi Torsten Liersch | 2013 | The American Journal of Surgical Pathology2013，，8： | 1 |
| 15 | Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party显示文摘 | Judith C. Marsh Andrea Bacigalupo Hubert Schrezenmeier Andre Tichelli Antonio M. Risitano Jakob R. Passweg Sally B. Killick Alan J. Warren Theodora Foukaneli Mahmoud Aljurf H. A. Al-Zahrani Philip Schafhausen Alexander Roth Anke Franzke Tim H. Brummendorf | 2012 | Blood2012，，23： | 1 |
| 16 | Copeptin Improves Early Diagnosis of Acute Myocardial Infarction显示文摘 | Till Keller Stergios Tzikas Tanja Zeller Ewa Czyz Lars Lillpopp Francisco M. Ojeda Alexander Roth Christoph Bickel Stephan Baldus Christoph R. Sinning Philipp S. Wild Edith Lubos Dirk Peetz Jan Kunde Oliver Hartmann Andreas Bergmann Felix Post Karl J. Lac | 2010 | Journal of the American College of Cardiology2010，，19： | 1 |
| 17 | Arterial Versus Portal Venous Embolization for Induction of Hepatic Hypertrophy before Extended Right Hemihepatectomy in Hilar Cholangiocarcinomas: A Prospective Randomized Study显示文摘 | Timm Denecke Daniel Seehofer Ingo G. Steffen Christian Grieser Lars Stelter Dirk Schnapauff Jan Holger Rothe Andreas Weigelt Maciej Pech Jan Langrehr Pietr Podrabsky Peter Neuhaus Enrique Lopez H?nninen | 2011 | Journal of Vascular and Interventional Radiology2011，，9： | 1 |
| 18 | Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status显示文摘 | Delia Kurzwelly Martin Glas Patrick Roth Elke Weimann Hanns Lohner Andreas Waha Martin Schabet Guido Reifenberger Michael Weller Ulrich Herrlinger | 2010 | Journal of Neuro - Oncology2010，，3： | 1 |
| 19 | Salvage of the upper extremity in cases of tumorous destruction of the proximal humerus显示文摘 | Renée A. Fuhrmann Andreas Roth Rolf A. Venbrocks | 2000 | Journal of Cancer Research and Clinical Oncology2000，，6： | 1 |
| 20 | The Giant Radio Array for Neutrino Detection(GRAND):Science and design显示文摘The Giant Radio Array for Neutrino Detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHE)cosmic particles,with energies exceeding 10~8 Ge V.Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays.To do this,GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity.GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere.Its design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals early.Here we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND. | Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier Ismael Cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 1 |
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