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| 1 | A SPECTRAL METHOD FOR PANTOGRAPH-TYPE DELAY DIFFERENTIAL EQUATIONS AND ITS CONVERGENCE ANALYSIS显示文摘We propose a novel numerical approach for delay differential equations with vanishingproportional delays based on spectral methods.A Legendre-collocation method is em-ployed to obtain highly accurate numerical approximations to the exact solution.It isproved theoretically and demonstrated numerically that the proposed method convergesexponentially provided that the data in the given pantograph delay differential equationare smooth. | Ishtiaq Ali Hermann Brunner | 2009 | Journal of Computational Mathematics2009，27，2： | 13 |
| 2 | 经鼻持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者睡眠结构近远期的影响显示文摘目的 观察经鼻持续气道正压 (nCPAP)通气对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠结构近远期的影响。方法 17例对照者行多导睡眠图 (PSG)监测 ,对 30例经PSG诊断的OSAHS患者行nCPAP治疗 ,治疗第 1夜行PSG监测 ,连续家庭nCPAP治疗 6个月后行第 2次PSG监测 ,分析比较睡眠结构的变化。结果 OSAHS患者治疗前睡眠转换次数、1期、2期睡眠比例较对照组增加 (P <0 0 5 ) ,慢波睡眠期、快动眼 (REM )期比例较对照组低 (P <0 0 5 ) ;nCPAP治疗第 1夜睡眠转换次数、1期、2期睡眠比例较治疗前降低 (P <0 0 5 ) ,慢波睡眠期、REM期比例较治疗前升高 (P <0 0 5 ) ;nCPAP治疗 6个月后睡眠转换次数、1期、2期、慢波睡眠期比例与治疗第 1夜比较差异均无显著性 (P >0 0 5 ) ,而REM期比例较治疗第 1夜降低 (P <0 0 5 )。结论 OSAHS患者睡眠转换次数明显增多 ,1期睡眠增加而REM期睡眠减少 ,睡眠结构紊乱。nCPAP治疗第 1夜及6个月后睡眠结构得到有效纠正 ,是OSAHS长期有效的治疗方法之一。 | 肖永龙 Frank Richter Fulk Brunner Birgid Lerche 张德平 郑培德 | 2004 | 中华内科杂志2004，43，9： | 8 |
| 3 | 肥胖和动脉老化:Whitehall Ⅱ队列主动脉僵硬度纵向研究显示文摘该研究旨在确定肥胖症是否中年后动脉硬化加速的独立预测因子。纳入Whitehall Ⅱ研究受试者男性3789例,女性1383例,平均年龄66岁,均接受颈-股动脉压检测,4年后再次进行测定。一般肥胖状况由体质量指数,中心肥胖由腰围和腰臀比,脂肪含量百分比由身体阻抗来评估。通过线性混合模型,对年龄、性别、种族和平均动脉压进行调整后,所有肥胖症测量指标与主动脉硬化[通过随访的脉搏波传导速度(pulse wave velocity,PWV)较基线增加值来确定]相关。 | 刘莉 叶鹏 Brunner EJ Shipley MJ Ahmadi-Abhari S Tabak AG McEniery CM Wilkinson IB Marmot MG Singh-Manoux A Kivimaki M | 2015 | 中华高血压杂志2015，23，6： | 8 |
| 4 | S-enriched porous polymer derived N-doped porous carbons for electrochemical energy storage and conversion显示文摘 | Chao Zhang Chenbao Lu Shuai Bi Yang Hou Fan Zhang Ming Cai Yafei He Silvia Paasch Xinliang Feng Eike Brunner Xiaodong Zhuang | 2018 | Frontiers of Chemical Science and Engineering2018，12，3： | 4 |
| 5 | Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration显示文摘Parathyroid hormone(PTH) is well-known as the principal regulator of calcium homeostasis in the human body and controls bone metabolism via actions on the survival and activation of osteoblasts. The intermittent administration of PTH has been shown to stimulate bone production in mice and men and therefore PTH administration has been recently approved for the treatment of osteoporosis. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche where hematopoietic stem cells, capable of both self-renewal and differentiation, reside. Moreover, intermittent PTH treatment is capable to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived stem cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders. | Bruno C Huber Ulrich Grabmaier Stefan Brunner | 2014 | World Journal of Stem Cells2014，6，5： | 4 |
| 6 | 肺癌的化学治疗显示文摘肺癌是全世界面临的主要健康问题之一,其发生率正在逐年上升,美国1988年约有15万肺癌新患者,有11万人死于肺癌。 小细胞肺癌 现在小细胞肺癌的治疗目标是:标准方案的完全缓解率+部分缓解率应高于80%;对于局限期患者,完全缓解率应超过50%,中数生存期12~16个月;2年无病生存率为15~20%;对于广泛期。 | K. W. Brunner 丘秋 | 1989 | 癌症1989，8，2： | 4 |
| 7 | Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population显示文摘在有 TAXUS 和心脏的外科(句法) 的经皮的冠的干预之间的 BackgroundThe 协同作用分数在有复杂冠的动脉疾病的病人是为风险层化和 revascularization 策略选择的一个验证工具。学习是分析它的年龄相关的预示的 value.MethodsSYNTAX 分数的这的目的在经历经皮的冠的干预(一种总线标准) 的 1331 个所有来者病人被计算:463 个病人 75 年和 868 个病人 < 75 年。兴趣的结果是在一个和二 years.ResultsA 点的所有原因死亡为死亡的年龄和句法分数的重要相互作用被观察在二年(P 相互作用 = 0.019 ) 然而并非在一个年后续(P 相互作用 = 0.594 ) 。在 multivariable 分析,句法分数独立地在两个年龄组预言了 1 年的死亡(< 75 年,危险比率(HR ) :1.43, 95% 信心间隔(CI ) :1.03-2.00, P = 0.034;并且 75 年, HR:1.37, 95% CI:1.01-1.85, P = 0.042 ) ,但是在更年轻的病人之中的仅仅二年的死亡(< 75 年, HR:1.33, 95% CI:1.01-1.76, P = 0.041;并且 75 年, HR:1.11, 95% CI:0.87-1.41, P = 0.394 ) 。句法分数 tertiles 是有用的成层在两个的 1 年的死亡,病人 < 75 年(句法分数 < 9, 3.8% ;9-20, 5.3% ;20, 10.3% ;P = 0.004 ) 并且 75 年(句法分数 < 11, 5.7% ;11-22.5, 16.1% ;22.5, 18.7% ;P = 0.003 ) ,但是仅仅在病人之中的二年的死亡 < 75 年(句法分数 < 9, 6.5% ;9-20, 7.6% ;20, 15% ;P < 0.001 ) 并且不在 75 个岁病人之中(句法分数 < 11, 19.4% ;11-22.5, 26.3% ;22.5, 27.9% ;P = 0.138 ).ConclusionsAge 在一种总线标准以后在长术语的死亡上修改句法分数的影响。在病人之中 < 75 年,句法分数独立地在一种总线标准以后在一个和二年点预言死亡的风险,当时在病人之中它的预兆的角色在一种总线标准以后被限制到第一年的 75 年。进一步的研究被需要为在老病人之中选择最适当的 revascularization 策略评估句法分数的价值。 | Madeleine Eickhoff Stefanie Schupke Alexander Khandoga Julia Fabian Moritz Baquet David Jochheim David Grundmann Manuela Thienel Axel Bauer Hans Theiss Stefan Brunner Jorg Hausleiter Steffen Massberg Julinda Mehilli | 2018 | Journal of Geriatric Cardiology2018，15，9： | 3 |
| 8 | Wound Complications in 1145 Consecutive Transumbilical Single-Incision Laparoscopic Procedures显示文摘 | Helmut G. Weiss Walter Brunner Matthias O. Biebl Jan Schirnhofer Katharina Pimpl Christof Mittermair Christian Obrist Eberhard Brunner Tobias Hell | 2014 | Annals of Surgery2014，，1： | 3 |
| 9 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 10 | Single port laparoscopy in gastroenterology and hepatology: A fine step forward显示文摘Single incision laparoscopy(SIL) has become an emerging technology aiming at a further reduction of abdominal wall trauma in minimally invasive surgery. Available data is encouraging for the safe application of standardized SIL in a wide range of procedures in gastroenterology and hepatology. Compared to technically simple SIL procedures, the merit of SIL in advanced surgeries, such as liver or colorectal interventions, compared to conventional laparsocopy is self-evident without any doubt. SIL has already passed the learning curve and is routinely utilized in expert centers. This minimized approach has allowed to enter a new era of surgical management that can not be acceded without a fruitful combination of prudent training, consistent day-to-day work and enthusiastic motivation for technical innovations. Both, basic and novel technical specifics as well as particular procedures are described herein. The focus is on the most important surgical interventions in gastroenterology and aims at reviewingthe current literature and shares our experience in a high volume center. | Christof Mittermair Jan Schirnhofer Eberhard Brunner Katharina Pimpl Christian Obrist Michael Weiss Helmut G Weiss | 2014 | World Journal of Gastroenterology2014，20，42： | 3 |
| 11 | Effect of the Troposphere on GPS Measurements显示文摘 | BRUNNER F K | 1993 | GPS WORLD1993，，1： | 2 |
| 12 | Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli , but S. aureus fails to both activate NF-κB in mammary epithelial cells and to quickly induce TNFα and interleukin-8 (CXCL8) expression in the udder显示文摘 | Wei Yang Holm Zerbe Wolfram Petzl Ronald Marco Brunner Juliane Günther Christian Draing Sonja von Aulock Hans-Joachim Schuberth Hans-Martin Seyfert | 2007 | Molecular Immunology2007，，5： | 2 |
| 13 | Immunohistochemical Expression of SOX2 in Vulvar Intraepithelial Neoplasia and Squamous Cell Carcinoma显示文摘 | Hermann Brustmann Andreas Brunner | 2013 | International Journal of Gynecological Pathology2013，，3： | 2 |
| 14 | Near critical and supercritical water. Part I. Hydrolytic and hydrothermal processes显示文摘 | G. Brunner | 2008 | The Journal of Supercritical Fluids2008，，3： | 2 |
| 15 | Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging显示文摘 | M. Leach B. Morgan P. Tofts D. Buckley W. Huang M. Horsfield T. Chenevert D. Collins A. Jackson D. Lomas B. Whitcher L. Clarke R. Plummer I. Judson R. Jones R. Alonzi T. Brunner D. Koh P. Murphy J. Waterton G. Parker M. Graves T. Scheenen T. Redpath M. Or | 2012 | European Radiology2012，，7： | 2 |
| 16 | Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: a closed cohort study显示文摘 | Christine N. Manser Lucas M. Bachmann Jakob Brunner Fritz Hunold Peter Bauerfeind Urs A. Marbet | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 17 | Risk of dementia in diabetes mellitus: a systematic review显示文摘 | Geert Jan Biessels Salka Staekenborg Eric Brunner Carol Brayne Philip Scheltens | 2006 | Lancet Neurology2006，，1： | 2 |
| 18 | Open reduction and fixation of medial Moore type II fractures of the tibial plateau by a direct dorsal approach显示文摘 | Alexander Brunner Philipp Honigmann Monika Horisberger Reto Babst | 2009 | Archives of Orthopaedic and Trauma Surgery2009，，9： | 2 |
| 19 | Fas ligand- induced apoptosis as a mechanism of immune privilege显示文摘 | GriffithTS Brunner T Fletcher SM | | 0，，： | 2 |
| 20 | Fas ligand-induced apoptosis as a mechanism of immune privilege显示文摘 | Griffith T S Brunner T Fletcher S M | | 0，，： | 2 |
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