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| 1 | Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases:A cross-sectional and longitudinal analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is common in the German population,with an even higher prevalence in inflammatory bowel disease patients.AIM To investigate the risk factors for NAFLD in inflammatory bowel disease patients.METHODS This monocentric retrospective study with a cross-sectional and a longitudinal part included 694 patients.Inclusion criteria were diagnosed inflammatory bowel disease,age≥18 years,availability of at least one abdominal ultrasound.Patients with infectious or suspected alcoholic fatty liver disease were excluded.NAFLD was defined by increased echogenicity at liver ultrasound.Demographic characteristics,disease activity and medications were analyzed as potential risk factors.Parameters influencing the course of NAFLD were identified by a generalized linear mixed model.RESULTS Forty-eight percent of Crohn’s disease(CD)patients and 44%of ulcerative colitis patients suffered from NAFLD.Its occurrence was associated with greater age,hypertension and body mass index(BMI)in both groups,and with higher disease activity and dyslipidemia in CD.2467 ultrasound results were included in the longitudinal analysis.Risk factors for NAFLD were age,BMI,higher disease activity,bowel resection(s),endoscopic activity and azathioprine use in CD;and BMI and endoscopic activity in ulcerative colitis.CONCLUSION NAFLD was highly prevalent in this cohort of German inflammatory bowel disease patients.Its risk increased mainly with rising age and BMI.This analysis provides a rationale for non-invasive liver screening in inflammatory bowel disease patients. | Peter Hoffmann Victoria Jung Rouven Behnisch Annika Gauss | 2020 | World Journal of Gastroenterology2020，26，46： | 8 |
| 2 | Biliary phosphatidylcholine and lysophosphatidylcholine profiles in sclerosing cholangitis显示文摘AIM:To analyze phospholipid profiles in intrahepatic bile from patients with primary sclerosing cholangitis(PSC)and secondary sclerosing cholangitis(SSC).METHODS:Intrahepatic bile specimens collected via endoscopic retrograde cholangiography from 41 patients were analyzed.Fourteen of these patients were diagnosed with PSC,10 with SSC,11 with choledocholithiasis or no identifiable biliary disease,and 6 with cholangiocellular carcinoma(CCC).Bile acid,cholesterol,protein,and bilirubin contents as well as pancreas lipase activity in bile were determined by biochemical methods.Phosphatidylcholine(PC)and lysophosphatidylcholine(LPC)species were quantified using nanoelectrospray ionization tandem mass spectrometry.RESULTS:Bile from all the examined patient groups showed a remarkably similar PC and LPC species composition,with only minor statistical differences.Total biliary PC concentrations were highest in controls(8030±1843 mol/L)and lowest in patients with CCC(1969±981 mol/L)(P=0.005,controls vs SSC and CCC,respectively,P<0.05).LPC contents in bile were overall low(4.2%±1.8%).Biliary LPC/PC ratios and ratios of biliary PC to bilirubin,PC to cholesterol,PC to protein,and PC to bile acids showed no intergroup differences.CONCLUSION:PC and LPC profiles being similar in patients with or without sclerosing cholangitis,these phospholipids are likely not of major pathogenetic importance in this disease group. | Annika Gauss Robert Ehehalt Wolf-Dieter Lehmann Gerhard Erben Karl-Heinz Weiss Yvonne Schaefer Petra Kloeters-Plachky Adolf Stiehl Wolfgang Stremmel Peter Sauer Daniel Nils Gotthardt | 2013 | World Journal of Gastroenterology2013，19，33： | 3 |
| 3 | Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis显示文摘BACKGROUND Acute severe ulcerative colitis unresponsive to systemic steroid treatment is a lifethreatening medical condition requiring hospitalization and often colectomy.Despite the increasing choice of medical therapy options for ulcerative colitis, the condition remains a great challenge in the field of inflammatory bowel diseases(IBD). The performance of the calcineurin inhibitor tacrolimus in this clinical setting is insufficiently elucidated.AIM To evaluate the short and long-term outcomes of tacrolimus therapy in adult inpatients with steroid-refractory acute severe ulcerative colitis.METHODS We conducted a retrospective monocentric study enrolling 22 patients at a tertiary care center for the treatment of IBD. All patients who were admitted to one of the wards of the Department of Gastroenterology and Hepatology of the Heidelberg University Hospital with acute severe ulcerative colitis between 2007 and 2018, and who received oral or intravenous tacrolimus for steroid-refractory disease were included. Baseline characteristics and data on the disease courses were retrieved from entirely computerized patient charts. The primary study endpoint was clinical response to tacrolimus therapy, resulting in discharge from the hospital. Secondary study endpoints were colectomy rate and time to colectomy, achievement of clinical remission under tacrolimus therapy, and the occurrence of side effects.RESULTSIn the majority of the 22 included patients(68.2%), tacrolimus therapy was initiated intravenously and subsequently converted to oral administration. The treatment duration was 128 ± 28.5 d(mean ± SEM), and the patients were followed up for 705 ± 110 d after treatment initiation. Among all patients, 86.4%were discharged from the hospital under continued oral tacrolimus therapy. In36.4% of the patients, the administration of tacrolimus resulted in clinical remission at some point during the treatment. Thirty-two percent of the patients underwent colectomy between 5 and 194 d after the initiation of tacrolimus treatment(mean: 97.4 ± 20.8 d). Colectomy-free survival rates at 1, 3, 6 and 12 mo after the initiation of tacrolimus therapy were 90.9%, 86.4%, 77.3% and 68.2%,respectively. The safety profile of tacrolimus was overall favorable. Only two patients discontinued the treatment due to side effects.CONCLUSION The short-term outcome of tacrolimus in steroid-refractory acute severe ulcerative colitis was beneficial, and side effects were rare. In all, tacrolimus therapy appears to be a viable option for short-term treatment of steroidrefractory acute severe ulcerative colitis besides ciclosporin and anti-tumor necrosis factor α treatment. | Peter Hoffmann Cyrill Wehling Johannes Krisam Jan Pfeiffenberger Nina Belling Annika Gauss Department of | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Anharmonic force fields from analytic CCSD (T) second derivatives: HOF and F2O 显示文摘 | Breidung J Thiel W Gauss J | 1999 | J Chem Phys1999，110，8： | 1 |
| 6 | The Effects of intraabdominally insufflated carbon dioxide on hepatic blood flow during laparoscopie surgery assessed by transesophageal echocardiography显示文摘 | Meierhenrich R Gauss A Vandenesch P | 2005 | Anesth Analg2005，100，2： | 1 |
| 7 | Radiotherapy of lymphatic fistula and lymphocele显示文摘 | NEU B GAUSS G HAASE W | 2000 | Strahlenther Onkol2000，176，： | 1 |
| 8 | Coupled cluster methods with noniterative triple excitations for restricted open-shell Hartree-Foek and other general single determinant reference functions energies and analytical gradients 显示文摘 | WATTS J D GAUSS J BARTLETT R J | 1993 | J Chem Phys1993，98，： | 1 |
| 9 | Tracheal suctioning is associated with prolonged disturbances of cerebral hemodynamics in very low birth weight infants显示文摘 | Kaiser JR Gauss CH Williams DK | 2008 | Journal of Perinatology2008，28，： | 1 |
| 10 | Molecular identification of a hyperpolarization-activated channel in sea urchin sperm 显示文摘 | Gauss R Seifert R Kaupp UB | 1998 | Nature1998，393，： | 1 |
| 11 | Seroprevalenee of Toxoplasma gondii antibodies in domestic eats from Barcelona, Spain 显示文摘 | Gauss CB Almeria S Ortuno A | 2003 | J Parasitol2003，89，5： | 1 |
| 12 | Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases显示文摘 | MARK T QUINN KATHERINE A GAUSS | 2004 | J Leukoc Biol2004，，76： | 1 |
| 13 | Assessment of coronary artery remodelling by dual-source CT: a head-to-head comparison with intravascular ultrasound显示文摘 | Gauss S Achenbach S Pflederer T | 2011 | Heart2011，97，12： | 1 |
| 14 | Comparison of central and mixed venous saturation during liver transplantation in cirrhotic patients:a pilot study 显示文摘 | Dahmani S Paugam-Burtz C Gauss T | 2010 | Eur J Anaesthesiol2010，27，8： | 1 |
| 15 | Echocardiographic assessment of the hemodynamic effects of propofol:A comparison with etomidate and thiopentone显示文摘 | Gauss A Heinrioh H Wilder-Smith OHG | 1991 | Anethesia1991，46，： | 1 |
| 16 | Assessment of coronary artery remodelling by dual-source CT: a head to head comparison with intravascular ultrasound显示文摘 | Gauss S Achenbach S Pflederer T | 2011 | Heart2011，97，： | 1 |
| 17 | Analytical evaluation of energy gradients in quadratic configuration interaction theory 显示文摘 | Gauss J Cremer C | 1988 | Chem Phys Lett1988，150，34： | 1 |
| 18 | Hypereapnia during the first 3 days of life is associated with severe intraventrieular hemorrhage in very low birth weight infants 显示文摘 | Kaiser JR Gauss CH Pont MM | 2006 | J Perinatol2006，26，5： | 1 |
| 19 | Seroprevalence of Toxoplasma gondii in wild pigs (Sus scrofa) from Spain显示文摘 | Gauss C B Dubey J P Vidal D | 2005 | Vet parasitol2005，131，12： | 1 |
| 20 | The effects of intraabdominally insufflated carbon dioxide on hepatic blood flow during laparoscopic surgery assessed by transesophageal echocardiography显示文摘 | Meierhenrich R Gauss A Vandenesch P | 2005 | Anesth Analg2005，100，2： | 1 |
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