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| 1 | Pancreatic insulinoma:current issues and trends显示文摘BACKGROUND:Although insulinomas are very rare tumors, they are the most common pancreatic neuroendocrine neoplasms.The incidence in general population is 1-4 per 1 000 000 yearly but the incidence is higher in autopsy studies. The malignancy of insulinomas is difficult to be predicted on the basis of their histological features,and the current WHO classification has been re-evaluated.This review aimed to summarize classical knowledge with current trends in the diagnosis and treatment of insulinomas. DATA SOURCES:A Medline search using terms'insulinoma', 'treatment'and'neuroendocrine tumors'was conducted. Additional references were sourced from key articles. RESULTS:Surgery is the treatment of choice for insulinoma and has an extremely high success rate.Medical treatment is also available but only for patients who are unable or unwilling to undergo surgical treatment.Preoperative localization is necessary for planning the surgical approach.Many methods exist for localization of an insulinoma and can be invasive and non-invasive.The combination of biphasic thin section helical CT and endoscopic ultrasonography(EUS)has an almost 100% sensitivity in localizing insulinomas.Laparoscopic ultrasound is mandatory to localize intraoperatively these tumors.EUS-guided fine needle tattoing is an alternative method of localization in case of lack of laparoscopic ultrasound. CONCLUSION:Laparoscopic resection for benign insulinomas is the procedure of choice,whereas pancreatectomy is reserved for large,potentially malignant tumors. | Dennis Vaidakis John Karoubalis Theodora Pappa George Piaditis George N Zografos | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 22 |
| 2 | Molecular basis of the irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a functional disorder characterized by abdominal pain,discomfort and bloating.The pathophysiology of IBS is poorly understood,but the presence of psychosocial basis is now known.There is an increasing number of publications supporting the role of genetics in IBS.Most of the variations are found in genes associated with the brain-gut axis,revealing the strong correlation of brain-gut axis and IBS.miRNAs,which play critical roles in physiological processes,are not well studied in IBS.However,so far there is found an involvement of alterations in miRNA expression or sequence,in IBS symptoms.IBS phenotype is affected by epigenetic alteration and environment.Changes in DNA and histone methylation are observed in patients who suffered childhood trauma or abuse,resulting in altered gene expression,such as the glucocorticoid receptor gene.Finally,diet is another factor associated with IBS,which may contribute to symptom onset.Certain foods may affect on bacterial metabolism and epigenetic modifications,predisposing to IBS. | Anna Vaiopoulou Georgios Karamanolis Theodora Psaltopoulou George Karatzias Maria Gazouli | 2014 | World Journal of Gastroenterology2014，20，2： | 21 |
| 3 | Clinical impact of microbiome in patients with decompensated cirrhosis显示文摘Cirrhosis is an increasing cause of morbidity and mortality. Recent studies are trying to clarify the role of microbiome in clinical exacerbation of patients with decompensated cirrhosis. Nowadays, it is accepted that patients with cirrhosis have altered salivary and enteric microbiome, characterized by the presence of dysbiosis. This altered microbiome along with small bowel bacterial overgrowth, through translocation across the gut, is associated with the development of decompensating complications. Studies have analyzed the correlation of certain bacterial families with the development of hepatic encephalopathy in cirrhotics. In general, stool and saliva dysbiosis with reduction of autochthonous bacteria in patients with cirrhosis incites changes in bacterial defenses and higher risk for bacterial infections, such as spontaneous bacterial peritonitis, and sepsis. Gut microbiome has even been associated with oncogenic pathways and under circumstances might promote the development of hepatocarcinogenesis. Lately, the existence of the oral-gutliver axis has been related with the development of decompensating events. This link between the liver and the oral cavity could be via the gut through impaired intestinal permeability that allows direct translocation of bacteria from the oral cavity to the systemic circulation. Overall, the contribution of the microbiome to pathogenesis becomes more pronounced with progressive disease and therefore may represent an important therapeutic target in the management of cirrhosis. | Theodora Oikonomou George V Papatheodoridis Michael Samarkos Ioannis Goulis Evangelos Cholongitas | 2018 | World Journal of Gastroenterology2018，24，34： | 16 |
| 4 | Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis显示文摘Functional gastrointestinal disorders(FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin's gene shows genetic polymorphism, while its protein product undergoes complex regulation and metabolism in the human body. Numerous studies have studied ghrelin's relation to the emergence of FGIDs, its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment. Despite the mixed results currently available in scientific literature, the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis. The aim of this paper is to review current literature studying these associations, in an effort to uncover certain patterns of alterations in both genetics and expression, which could delineate its true contribution to FGID emergence, either as a causative agent or as a pathogenetic intermediate. | Tilemachos Koutouratsas Theodora Kalli Georgios Karamanolis Maria Gazouli | 2019 | World Journal of Gastroenterology2019，25，5： | 14 |
| 5 | Factors affecting breastfeeding duration in Greece:What is important?显示文摘AIM:To investigate factors associated with breastfeeding duration(BD) in a sample of mothers living in Greece.METHODS:Four hundred and twenty-eight mothers(438 infants) were initially recruited in a tertiary University Hospital.Monthly telephone interviews(1665in total) using a structured questionnaire(one for each infant) were conducted until the sixth postpartum month.Cox regression analysis was used to assess factors influencing any BD.RESULTS:Any breastfeeding rates in the first,third,and sixth month of the infant's life reached 87.5%,57.0%and 38.75%,respectively.In the multivariate analysis,maternal smoking in the lactation period[hazard-ratio(HR) = 4.20]and psychological status(HR = 1.72),and the introduction of a pacifier(HR =2.08),were inversely associated,while higher maternal education(HR_(university/college vs primary/high school) = 0.53,HR_(master's vs primary/high school) = 0.20),and being an immigrant(HR = 0.35) were positively associated with BD.CONCLUSION:Public health interventions should focus on campaigns against smoking during lactation,target women of lower educational status,and endorse the delayed introduction of pacifiers. | Evangelia-Filothei Tavoulari Vassiliki Benetou Petros V Vlastarakos Theodora Psaltopoulou George Chrousos George Kreatsas Alexandras Gryparis Athena Linos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 12 |
| 6 | Stem cell-derived exosomes-an emerging tool for myocardial regeneration显示文摘Cardiovascular diseases(CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction(AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, loss of functional cardiomyocytes as a result of ischaemic injury leads to ventricular failure, resulting in significant alteration to quality of life and increased mortality. Therefore, many attempts have been made in recent years to identify new tools for the regeneration of functional cardiomyocytes. Regenerative therapy currently represents the ultimate goal for restoring the function of damaged myocardium by stimulating the regeneration of the infarcted tissue or by providing cellsthat can generate new myocardial tissue to replace the damaged tissue. Stem cells(SCs) have been proposed as a viable therapy option in these cases. However, despite the great enthusiasm at the beginning of the SC era, justified by promising initial results, this therapy has failed to demonstrate a significant benefit in large clinical trials. One interesting finding of SC studies is that exosomes released by mesenchymal SCs(MSCs) are able to enhance the viability of cardiomyocytes after ischaemia/reperfusion injury, suggesting that the beneficial effects of MSCs in the recovery of functional myocardium could be related to their capacity to secrete exosomes. Ten years ago, it was discovered that exosomes have the unique property of transferring miRNA between cells, acting as miRNA nanocarriers. Therefore, exosomebased therapy has recently been proposed as an emerging tool for cardiac regeneration as an alternative to SC therapy in the post-infarction period. This review aims to discuss the emerging role of exosomes in developing innovative therapies for cardiac regeneration as well as their potential role as candidate biomarkers or for developing new diagnostic tools. | Erzsebet Lazar Theodora Benedek Szilamer Korodi Nora Rat Jocelyn Lo Imre Benedek | 2018 | World Journal of Stem Cells2018，10，8： | 12 |
| 7 | Helicobacter pylori neutrophil activating protein as target for new drugs against H.pylori inflammation显示文摘Helicobacter pylori(H.pylori) infection is among the most common human infections and the major risk factor for peptic ulcer disease and gastric cancer.With-in this work we present the implication of C-terminal region of H.pylori neutrophil activating protein in the stimulation of neutrophil activation as well as the evi-dence that the C-terminal region of H.pylori activating protein is indispensable for neutrophil adhesion to endothelial cells,a step necessary to H.pylori inflammation.In addition we show that arabino galactan proteins derived from chios mastic gum,the natural resin of the plant Pistacia lentiscus var.Chia inhibit neutrophil activation in vitro. | Theodora Choli-Papadopoulou Filippos Kottakis Georgios Papadopoulos Stefanos Pendas | 2011 | World Journal of Gastroenterology2011，17，21： | 5 |
| 8 | Landscape spatial configuration is a key driver of wild bee demographics显示文摘 | Lazaros Neokosmidis Thomas Tscheulin Jelle Devalez Theodora Petanidou | 2018 | Insect Science2018，25，1： | 4 |
| 9 | 超高压技术辅助优化牛皮胶原低脂牛肉饼工艺显示文摘以超高压技术辅助制备的牛皮胶原为脂肪替代物,制作低脂牛肉饼。结合质构、烹饪损失和感官评分结果,探究超高压压力(200、250、300、350、400 MPa)、超高压时间(5、10、15、20、25 min)、NaCl添加量(1%、1.3%、1.5%、1.7%、1.9%,质量分数)和复合磷酸盐添加量(0.1%、0.2%、0.3%、0.4%、0.5%,质量分数)对牛肉饼品质的影响。通过单因素和响应面试验优化,最终确定牛皮胶原低脂牛肉饼的最佳工艺配方。结果表明,在超高压压力为360 MPa、超高压时间为21 min、NaCl添加量为1.5%以及复合磷酸盐添加量为0.3%的条件下,牛肉饼的感官评分为84.1,弹性为0.8%,综合品质较佳。 | 高艳蕾 OJANGBA THEODORA 杨超 王拙 张丽 余群力 郭兆斌 | 2022 | 食品与发酵工业2022，48，2： | 3 |
| 10 | Adrenal insufficiency in patients with decompensated cirrhosis显示文摘Adrenal reserve depletion and overstimulation of the hypothalamus-pituitary-adrenal(HPA) axis are causes for adrenal insufficiency(AI) in critically ill individuals. Cirrhosis is a predisposing condition for AI in cirrhotics aswell. Both stable cirrhotics and liver transplant patients(early and later after transplantation) have been reported to present AI. The mechanisms leading to reduced cortisol production in cirrhotics are the combination of low cholesterol levels(the primary source of cortisol), the increased cytokines production that overstimulate and exhaust HPA axis and the destruction of adrenal glands due to coagulopathy. AI has been recorded in 10%-82% cirrhotics depending on the test used to evaluate adrenal function and in 9%-83% stable cirrhotics. The similarity of those proportions support the assumption that AI is an endogenous characteristic of liver disease. However, the lack of a gold standard method for AI assessment and the limitation of precise thresholds in cirrhotics make difficult the recording of the real prevalence of AI. This review aims to summarize the present data over AI in stable, critically ill cirrhotics and liver transplant recipients. Moreover, it provides information about the current knowledge in the used diagnostic tools and the possible effectiveness of corticosteroids administration in critically ill cirrhotics with AI. | Apostolos KA Karagiannis Theodora Nakouti Chrysoula Pipili Evangelos Cholongitas | 2015 | World Journal of Hepatology2015，7，8： | 2 |
| 11 | Statin escape phenomenon: Fact or fiction?显示文摘AIM To evaluate the presence of the so called 'statin escape' phenomenon among hyperlipidemic subjects attending a lipid clinic. METHODS This was a retrospective analysis of 1240 hyperlipidemic individuals followed-up for ≥ 3 years. We excluded those individuals meeting one of the following criteria: Use of statin therapy at baseline visit, discontinuation of statin treatment at most recent visit, change in statin treatment during follow-up and poor compliance to treatment. Statin escape phenomenon was defined as an increase in lowdensity lipoprotein cholesterol(LDL-C) levels at the most recent visit by > 10% compared with the value at 6 mo following initiation of statin treatment. RESULTS Of 181 eligible subjects, 31% exhibited the statin escape phenomenon. No major differences regarding baseline characteristics were found between statin escapers and non-statin escapers. Both escapes and non-escapes had similar baseline LDL-C levels [174(152-189) and 177(152-205) mg/d L, respectively]. In comparison with nonescapers, statin escapers demonstrated lower LDL-C levels at 6 mo after treatment initiation [88(78-97) mg/d L vs 109(91-129) mg/d L, P < 0.05], but higher levels at the most recent visit [103(96-118) mg/d L vs 94(79-114) mg/d L, P < 0.05]. CONCLUSION These data confirm the existence of an escape phenomenon among statin-treated individuals. The clinical significance of this phenomenon remains uncertain. | Fotios Barkas Moses Elisaf Eleftherios Klouras Theodora Dimitriou Nikolaos Tentolouris Evangelos Liberopoulos | 2017 | World Journal of Experimental Medicine2017，7，1： | 2 |
| 12 | 数学模型模拟高血压患者对降压药物收缩压反应的探索研究显示文摘目的 运用建立数学模型的方法,探讨高血压患者对于降压药物收缩压反应的协同影响因素.方法以MRC35-64、MRC65-74、STEP及SYST-EU四个随机口服降压药治疗高血压研究为数据库,患者接受口服利尿剂、β受体阻滞剂或钙通道阻滞剂单种类药物治疗,对照组服安慰剂.分析年龄、性别、身高、体重、吸烟、基础收缩压、舒张压、总胆固醇水平、既往心肌梗死病史等指标,应用SAS(R)及R两种软件建立数学模型,获得药物治疗的协同影响因素.结果共纳入31 140例原发性高血压患者,年龄(60±11)岁,男性47%.降压药是收缩压降低的直接影响因素.(1)利尿剂组年龄、基础收缩压和舒张压为正协同于收缩压下降值的影响因素(β值依次为0.17、0.09、0.14);(2)β受体阻滞剂组:基础收缩压正协同于药物降压疗效,年龄负协同于药物降压疗效,非吸烟者治疗后血压下降较吸烟者明显(β值依次为-0.17、0.37、-2.07);(3)钙通道阻滞剂组:基础收缩压与体重为正协同于收缩压下降的影响因素(β值依次为0.18、0.06).除钙通道阻滞剂组体重(P=0.050)外,P值均为0.000.结论运用数学模型研究方法预测降压药物血压反应是可行的. | 吴瑛 李一石 Bejan-Angoulvant Theodora Gueyffier Francois | 2011 | 中华心血管病杂志2011，39，4： | 2 |
| 13 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 2 |
| 14 | Indoleamine 2,3-dioxygenase (IDO) expression in lung cancer 显示文摘 | Vaios K Maria Z Theodora K et ol | 2007 | Cancer Biology & Therapy2007，6，8： | 1 |
| 15 | Increased Intimal-Medial Thickness in Newly Detected Type 2 Diabetes 显示文摘 | Theodora S Elena H Carsta K | 1999 | Diabetes Care1999，22，： | 1 |
| 16 | Kinetics of adsorption and desorption of some organochlorine compounds on black carbon in a sediment显示文摘 | Bea A.Vrind Theodora E. M.ten Hulscher Paul C. M.van Noort | 2009 | Environmental Toxicology and Chemistry2009，，4： | 1 |
| 17 | Seroepidemiology of Hepatitis B and C Viruses in the General Population of Burkina Faso显示文摘 | Issoufou Tao Tegwindé R. Compaoré Birama Diarra Florencia Djigma Theodora M. Zohoncon Maléki Assih Djeneba Ouermi Virginio Pietra Simplice D. Karou Jacques Simpore Annarosa Floreani | 2014 | Hepatitis Research and Treatment2014，，： | 1 |
| 18 | Calcium regulates the PI3K-Akt pathway in stretched osteoblasts显示文摘 | Theodora Danciu Rosalyn | 2003 | FEBS Letters2003，536，： | 1 |
| 19 | Photocatalytic and sonolytic oxidationof Acid Orange 7 in aqueous solution 显示文摘 | Theodora Velegraki Ioannis Poulios Magdalini Cha-ralababki | 2006 | Appl CatalB: Environ2006，62，： | 1 |
| 20 | Role of the ubiq uitin-protea-some pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 显示文摘 | Tam SW Theodoras AM | 1995 | Science1995，269，5224： | 1 |
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